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Aryl ethynyl anthraquinones have been synthesized by Sonogashira cross-coupling and evaluated as telomeric G-quadruplex ligands, by the FRET melting assay, circular dichroism, the DNA synthesis arrest assay and molecular docking. Both the binding properties and G-quadruplex vs. duplex selectivity are controlled by the structures of the aryl ethynyl moieties

Aryl ethynyl anthraquinones: a useful platform for targeting telomeric G-quadruplex structures

PERCIVALLE, CLAUDIA;MARIANI, ANGELICA;FRECCERO, MAURO
2014-01-01

Abstract

Aryl ethynyl anthraquinones have been synthesized by Sonogashira cross-coupling and evaluated as telomeric G-quadruplex ligands, by the FRET melting assay, circular dichroism, the DNA synthesis arrest assay and molecular docking. Both the binding properties and G-quadruplex vs. duplex selectivity are controlled by the structures of the aryl ethynyl moieties
2014
The Organic Chemistry/Polymer Science category includes resources concerned with the related fields of organic chemistry and polymer science. The organic chemistry resources deal with compounds of carbon with the exception of certain simple ones, such as the carbon oxides, carbonates, cyanides and cyanates (see Inorganic & Nuclear Chemistry). This category includes research on synthetic and natural organic compounds that may include other elements, such as hydrogen and oxygen, but also nitrogen, halogens, sulphur and phosphorous. Resources concerned with hydrocarbons, organic compounds containing only the elements carbon and hydrogen, are also included in this category. Examples are the alkanes, alkenes, alkynes and aromatics, such as benzene and naphthalene. Polymer science includes all resources dealing with the study, production and technology of polymers, which are compounds composed of very large molecules made up of repeating molecular units (monomers). Polymers may be natural substances, such as polysaccharides or proteins, or synthetic materials, such as nylon or polyethylene.
ORGANIC & BIOMOLECULAR CHEMISTRY
sì
WOS:000336782000028
2-s2.0-84900813310
Esperti anonimi
Inglese
Internazionale
ELETTRONICO
12
3744
3754
11
Anthraquinones; Sonogashira cross-coupling; Nucleic acids; G-quadruplex structures
10
info:eu-repo/semantics/article
262
Percivalle, Claudia; Claudia, Sissi; Maria Laura, Greco; Caterina, Musetti; Mariani, Angelica; Anna, Artese; Giosuè, Costa; Maria Lucia, Perrore; Stef...espandi
1 Contributo su Rivista::1.1 Articolo in rivista
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1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/986078
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