Isoxazolino-carbocyclic anthracene nor-nucleosides were prepared through nitrosocarbonyl chemistry and tested for their inhibitory activity against some viruses, such as Herpes simplex viruses of type 1 and 2, Zoster virus and Hepatitis B and C. The activities were almost negligible in most of the cases. A remarkable antiviral activity was found for a specific regioisomer with no cellular toxicity at 1–100 lM dose concentration in the case of Human Papilloma virus.
Synthesis and antiviral activity of anthracene derivatives of isoxazolino-carbocyclic nucleoside analogues
MEMEO, MISAL GIUSEPPE;MAGA, GIOVANNI;QUADRELLI, PAOLO
2015-01-01
Abstract
Isoxazolino-carbocyclic anthracene nor-nucleosides were prepared through nitrosocarbonyl chemistry and tested for their inhibitory activity against some viruses, such as Herpes simplex viruses of type 1 and 2, Zoster virus and Hepatitis B and C. The activities were almost negligible in most of the cases. A remarkable antiviral activity was found for a specific regioisomer with no cellular toxicity at 1–100 lM dose concentration in the case of Human Papilloma virus.File in questo prodotto:
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