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Isoxazolino-carbocyclic anthracene nor-nucleosides were prepared through nitrosocarbonyl chemistry and tested for their inhibitory activity against some viruses, such as Herpes simplex viruses of type 1 and 2, Zoster virus and Hepatitis B and C. The activities were almost negligible in most of the cases. A remarkable antiviral activity was found for a specific regioisomer with no cellular toxicity at 1–100 lM dose concentration in the case of Human Papilloma virus.

Synthesis and antiviral activity of anthracene derivatives of isoxazolino-carbocyclic nucleoside analogues

MEMEO, MISAL GIUSEPPE;MAGA, GIOVANNI;QUADRELLI, PAOLO
2015-01-01

Abstract

Isoxazolino-carbocyclic anthracene nor-nucleosides were prepared through nitrosocarbonyl chemistry and tested for their inhibitory activity against some viruses, such as Herpes simplex viruses of type 1 and 2, Zoster virus and Hepatitis B and C. The activities were almost negligible in most of the cases. A remarkable antiviral activity was found for a specific regioisomer with no cellular toxicity at 1–100 lM dose concentration in the case of Human Papilloma virus.
2015
The Organic Chemistry/Polymer Science category includes resources concerned with the related fields of organic chemistry and polymer science. The organic chemistry resources deal with compounds of carbon with the exception of certain simple ones, such as the carbon oxides, carbonates, cyanides and cyanates (see Inorganic & Nuclear Chemistry). This category includes research on synthetic and natural organic compounds that may include other elements, such as hydrogen and oxygen, but also nitrogen, halogens, sulphur and phosphorous. Resources concerned with hydrocarbons, organic compounds containing only the elements carbon and hydrogen, are also included in this category. Examples are the alkanes, alkenes, alkynes and aromatics, such as benzene and naphthalene. Polymer science includes all resources dealing with the study, production and technology of polymers, which are compounds composed of very large molecules made up of repeating molecular units (monomers). Polymers may be natural substances, such as polysaccharides or proteins, or synthetic materials, such as nylon or polyethylene.
TETRAHEDRON LETTERS
000352678900014
2-s2.0-84924386562
Esperti anonimi
Inglese
Internazionale
STAMPA
56
1986
1990
5
1; 3-Dipolar cycloadditions; Nitrile oxides; Nitrosocarbonyls; Nucleoside analogues; Antivirals
4
info:eu-repo/semantics/article
262
Memeo, MISAL GIUSEPPE; Lapolla, F.; Maga, Giovanni; Quadrelli, Paolo
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/1092385
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