Objective: The aim of this study was to evaluate the effects of a 12-wk ketogenic diet (KD) on inflammatory status, adipose tissue activity biomarkers, and abdominal visceral (VAT) and subcutaneous fat (SAT) in children affected by glucose transporter 1 deficiency syndrome GLUT1 DS. Methods: We carried out a short-term longitudinal study on 10 children (mean age: 8.4 y, range 3.3–12 y, 5 girls, 5 boys) to determine fasting serum proinflammatory cytokines (high sensitivity C-reactive protein, tumor necrosis factor-a interleukin-6), adipocyte-derived chemokines (leptin and adiponectin), lipid profile, homeostatic model assessment-insulin resistance (HOMA-IR), quantitative insulin sensitivity index (QUICKI), anthropometric measurements, and VAT and SAT (by ultrasonography). Results: Children showed no significant changes in inflammatory and adipose tissue activity biomarkers, blood glucose, lipid profile, anthropometric measurements, VAT, and SAT. Fasting insulin decreased (6 3.2 mU/mL versus 3 2 mU/mL; P ¼ 0.001), and both HOMA-IR and QUICKI indexes were significantly modified (1.2 0.6 versus 0.6 0.4; P ¼ 0.002; 0.38 0.03 versus 0.44 0.05; P ¼ 0.002, respectively). Conclusions: Only HOMA-IR and QUICKI indexes changed after 12 wk on a KD, suggesting that over a short period of time KD does not affect inflammatory cytokines production and abdominal fat distribution despite being a high-fat diet. Long-term studies are needed to provide answers concerning adaptive metabolic changes during KD

Short-term effects of ketogenic diet on anthropometric parameters, body fat distribution, and inflammatory cytokine production in GLUT1 deficiency syndrome

TRENTANI, CLAUDIA;FERRARIS, CINZIA;VEGGIOTTI, PIERANGELO;DE GIORGIS, VALENTINA;TAGLIABUE, ANNA
2015-01-01

Abstract

Objective: The aim of this study was to evaluate the effects of a 12-wk ketogenic diet (KD) on inflammatory status, adipose tissue activity biomarkers, and abdominal visceral (VAT) and subcutaneous fat (SAT) in children affected by glucose transporter 1 deficiency syndrome GLUT1 DS. Methods: We carried out a short-term longitudinal study on 10 children (mean age: 8.4 y, range 3.3–12 y, 5 girls, 5 boys) to determine fasting serum proinflammatory cytokines (high sensitivity C-reactive protein, tumor necrosis factor-a interleukin-6), adipocyte-derived chemokines (leptin and adiponectin), lipid profile, homeostatic model assessment-insulin resistance (HOMA-IR), quantitative insulin sensitivity index (QUICKI), anthropometric measurements, and VAT and SAT (by ultrasonography). Results: Children showed no significant changes in inflammatory and adipose tissue activity biomarkers, blood glucose, lipid profile, anthropometric measurements, VAT, and SAT. Fasting insulin decreased (6 3.2 mU/mL versus 3 2 mU/mL; P ¼ 0.001), and both HOMA-IR and QUICKI indexes were significantly modified (1.2 0.6 versus 0.6 0.4; P ¼ 0.002; 0.38 0.03 versus 0.44 0.05; P ¼ 0.002, respectively). Conclusions: Only HOMA-IR and QUICKI indexes changed after 12 wk on a KD, suggesting that over a short period of time KD does not affect inflammatory cytokines production and abdominal fat distribution despite being a high-fat diet. Long-term studies are needed to provide answers concerning adaptive metabolic changes during KD
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/1104755
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