Introduction: The ends of lineal chromosomes are organized in ribonucleoproteic complexes called telomeres, essential to maintain genome integrity. Furthermore, in oogenesis telomeres play an important role throughout meiotic chromosome events since they tether telomeres together promoting alignment, synapsis and recombination between homologue chromosomes. The recently discovered telomeric repeat-containing RNA (TERRA) is a structural component of the telomeric complex that also acts as a telomerase inhibitor. Until now, TERRA has been described in several somatic cell lines and tissues of different eukaryotic organisms. In this study, TERRA was identified for the first time at telomeres of human oocytes, and its presence and localization was established all through the first stages of meiotic prophase I.
Description of the telomeric RNA, TERRA, in human oocytes
GIULOTTO, ELENA
2011-01-01
Abstract
Introduction: The ends of lineal chromosomes are organized in ribonucleoproteic complexes called telomeres, essential to maintain genome integrity. Furthermore, in oogenesis telomeres play an important role throughout meiotic chromosome events since they tether telomeres together promoting alignment, synapsis and recombination between homologue chromosomes. The recently discovered telomeric repeat-containing RNA (TERRA) is a structural component of the telomeric complex that also acts as a telomerase inhibitor. Until now, TERRA has been described in several somatic cell lines and tissues of different eukaryotic organisms. In this study, TERRA was identified for the first time at telomeres of human oocytes, and its presence and localization was established all through the first stages of meiotic prophase I.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
