Objectives: The aim of this study was to assess the burden of peripheral arte- riopathy (PA) in diabetic patients. Methods: Eligible patients were identified through a data warehouse (DENALI), which matches clinical and economic data of about 9.9 million individuals of Lombardy, a northern Italian region which represent 16.4% of the Italian population. The study population was made of all individuals over 40 with a diagnosis of diabetes who during the period 1-1-2002 to 31-12-2009 had an hospital admission (index event) attributable to PA disease. The identified individuals were followed-up from the index event to a maximum of 7 years. We evaluated demographic characteristics of the study population and costs (hospitalizations, drugs and outpatient examinations/visits) from the National Health Service’s perspective. Results: During the observational period 18,344 subjects (5% of the diabetic source population) had at least one hospital admission of interest. Median age (min-max) at the index date was 73(40-102) and 31% of the study population had a Charlson comorbidity index higher than 3. The overall mortality was 11.3 deaths every 100 patient-years (95%C.I., 11.1-11.6). Forty-four percent of the study population had at least one procedure among vascularization, minor and major amputation. Mean cost and corresponding 95% C.I. (€/patient-year) for PA diabetic patients was 14,085(12,344-16,400) in the index year and around 7,000 in the following periods of observation. Hospitalizations represented the driver of total costs. Conclusions: This study attempted to describe the epidemiologic and economic burden of diabetes patients with PA complications, showing the relevance of related epidemiologic and economic aspects.

Epidemiology and Costs of Peripheral Arteriopathy In Diabetic Patients: A Population-Based Study.

MARONE, ENRICO MARIA;
2015-01-01

Abstract

Objectives: The aim of this study was to assess the burden of peripheral arte- riopathy (PA) in diabetic patients. Methods: Eligible patients were identified through a data warehouse (DENALI), which matches clinical and economic data of about 9.9 million individuals of Lombardy, a northern Italian region which represent 16.4% of the Italian population. The study population was made of all individuals over 40 with a diagnosis of diabetes who during the period 1-1-2002 to 31-12-2009 had an hospital admission (index event) attributable to PA disease. The identified individuals were followed-up from the index event to a maximum of 7 years. We evaluated demographic characteristics of the study population and costs (hospitalizations, drugs and outpatient examinations/visits) from the National Health Service’s perspective. Results: During the observational period 18,344 subjects (5% of the diabetic source population) had at least one hospital admission of interest. Median age (min-max) at the index date was 73(40-102) and 31% of the study population had a Charlson comorbidity index higher than 3. The overall mortality was 11.3 deaths every 100 patient-years (95%C.I., 11.1-11.6). Forty-four percent of the study population had at least one procedure among vascularization, minor and major amputation. Mean cost and corresponding 95% C.I. (€/patient-year) for PA diabetic patients was 14,085(12,344-16,400) in the index year and around 7,000 in the following periods of observation. Hospitalizations represented the driver of total costs. Conclusions: This study attempted to describe the epidemiologic and economic burden of diabetes patients with PA complications, showing the relevance of related epidemiologic and economic aspects.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/1149842
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