(1)H dynamic nuclear polarization and nuclear spin-lattice relaxation rates have been studied in amorphous complexes of β-cyclodextrins doped with different concentrations of the TEMPO radical. Nuclear polarization increased up to 10% in the optimal case, with a behavior of the buildup rate (1/TPOL) and of the nuclear spin-lattice relaxation rate (1/T1n) consistent with a thermal mixing regime. The temperature dependence of 1/T1n and its increase with the radical concentration indicate a relaxation process arising from the modulation of the electron-nucleus coupling by the glassy dynamics. The high-temperature relaxation is driven by molecular motions, and 1/T1n was studied at room temperature in liquid solutions for dilution levels close to the ones typically used for in vivo studies.

Dynamic Nuclear Polarization of β-Cyclodextrin Macromolecules

CARACCIOLO, FILIPPO;CARRETTA, PIETRO;FILIBIAN, MARTA;
2017

Abstract

(1)H dynamic nuclear polarization and nuclear spin-lattice relaxation rates have been studied in amorphous complexes of β-cyclodextrins doped with different concentrations of the TEMPO radical. Nuclear polarization increased up to 10% in the optimal case, with a behavior of the buildup rate (1/TPOL) and of the nuclear spin-lattice relaxation rate (1/T1n) consistent with a thermal mixing regime. The temperature dependence of 1/T1n and its increase with the radical concentration indicate a relaxation process arising from the modulation of the electron-nucleus coupling by the glassy dynamics. The high-temperature relaxation is driven by molecular motions, and 1/T1n was studied at room temperature in liquid solutions for dilution levels close to the ones typically used for in vivo studies.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/1179512
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 5
social impact