Osteosarcoma is the most frequent primary malignant bone tumour, and its incidence is higher in children and adolescents, for whom it represents more than 10% of solid cancers. Despite the introduction of adjuvant and neo-adjuvant chemotherapy that markedly increased the success rate in the treatment, aggressive surgery is still needed and a considerable percentage of patients do not survive due to recurrences or metastases. Being a tumour that affects preferentially a young age population, the psychological and social cost of the treatment is still very high. Osteosarcoma is an infiltrative tumour. Thus, a negative surgical margin is the requirement to reduce undesirable tumour spreads associated with a very poor prognosis. For this reason, BNCT is studied as an adjuvant therapy that would allow for a less aggressive surgery by selectively killing infiltrated tumour cells in the surrounding healthy tissues.

Feasibility Study of Boron Neutron Capture Therapy for the Treatment of Osteosarcoma

BORTOLUSSI, SILVA;POSTUMA, IAN;ALTIERI, SAVERIO;PROTTI, NICOLETTA;FERRARI, CINZIA;CANSOLINO, LAURA;CLERICI, ANNA MARIA;
2016-01-01

Abstract

Osteosarcoma is the most frequent primary malignant bone tumour, and its incidence is higher in children and adolescents, for whom it represents more than 10% of solid cancers. Despite the introduction of adjuvant and neo-adjuvant chemotherapy that markedly increased the success rate in the treatment, aggressive surgery is still needed and a considerable percentage of patients do not survive due to recurrences or metastases. Being a tumour that affects preferentially a young age population, the psychological and social cost of the treatment is still very high. Osteosarcoma is an infiltrative tumour. Thus, a negative surgical margin is the requirement to reduce undesirable tumour spreads associated with a very poor prognosis. For this reason, BNCT is studied as an adjuvant therapy that would allow for a less aggressive surgery by selectively killing infiltrated tumour cells in the surrounding healthy tissues.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/1187633
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