In the last decades, the electromagnetic stimulation in vitro and in vivo has become a promising research field because it allows to modulate the behavior of cells and tissues. In particular, when the cells are exposed to a time-varying magnetic field, an electric field is induced and thus a current density arises, because the cell culture is in contact with a conductive medium. The interaction between the induced current density and the time-varying magnetic field gives rise to mechanical stress acting on the cells. In this paper, new kind of wells for obtaining a homogeneous stress and stimulation of a considerable large number of cells are designed. This design problem is formulated as a multi-objective one and its solution is found by means of the μ-BiMO algorithm.

Automated Optimal Design of Wells for Electromagnetic Cell Stimulation

Di Barba P;Fassina L;Magenes G;Mognaschi ME
2019

Abstract

In the last decades, the electromagnetic stimulation in vitro and in vivo has become a promising research field because it allows to modulate the behavior of cells and tissues. In particular, when the cells are exposed to a time-varying magnetic field, an electric field is induced and thus a current density arises, because the cell culture is in contact with a conductive medium. The interaction between the induced current density and the time-varying magnetic field gives rise to mechanical stress acting on the cells. In this paper, new kind of wells for obtaining a homogeneous stress and stimulation of a considerable large number of cells are designed. This design problem is formulated as a multi-objective one and its solution is found by means of the μ-BiMO algorithm.
978-961-286-241-1
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/1258506
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