In the last decades, the electromagnetic stimulation in vitro and in vivo has become a promising research field because it allows to modulate the behavior of cells and tissues. In particular, when the cells are exposed to a time-varying magnetic field, an electric field is induced and thus a current density arises, because the cell culture is in contact with a conductive medium. The interaction between the induced current density and the time-varying magnetic field gives rise to mechanical stress acting on the cells. In this paper, new kind of wells for obtaining a homogeneous stress and stimulation of a considerable large number of cells are designed. This design problem is formulated as a multi-objective one and its solution is found by means of the μ-BiMO algorithm.
Automated Optimal Design of Wells for Electromagnetic Cell Stimulation
Di Barba P;Fassina L;Magenes G;Mognaschi ME
2019-01-01
Abstract
In the last decades, the electromagnetic stimulation in vitro and in vivo has become a promising research field because it allows to modulate the behavior of cells and tissues. In particular, when the cells are exposed to a time-varying magnetic field, an electric field is induced and thus a current density arises, because the cell culture is in contact with a conductive medium. The interaction between the induced current density and the time-varying magnetic field gives rise to mechanical stress acting on the cells. In this paper, new kind of wells for obtaining a homogeneous stress and stimulation of a considerable large number of cells are designed. This design problem is formulated as a multi-objective one and its solution is found by means of the μ-BiMO algorithm.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
