Many drugs have long been known to be photoreactive. In recent years there has been an increasing concern on the possible toxic effects arising from the sunlight in conjunction with the assumption of drugs as well on the actual photostability of drug preparations when exposed to light.We considered some classes of drugs in order to rationalize the mechanism of photodegradation. This is important to understand why a drug is phototoxic. As an example the Fluoroquinolones, an important class of antibiotics, show an interesting reaction of defluorination when they are irradiated in aqueous solution.
Sunlight induced photoreactivity of drugs
DONDI, DANIELE;RICCI, ANDREA;FASANI, ELISA;ALBINI, ANGELO
2003-01-01
Abstract
Many drugs have long been known to be photoreactive. In recent years there has been an increasing concern on the possible toxic effects arising from the sunlight in conjunction with the assumption of drugs as well on the actual photostability of drug preparations when exposed to light.We considered some classes of drugs in order to rationalize the mechanism of photodegradation. This is important to understand why a drug is phototoxic. As an example the Fluoroquinolones, an important class of antibiotics, show an interesting reaction of defluorination when they are irradiated in aqueous solution.File in questo prodotto:
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