Lung carcinoma is the leading cause of cancer mortality worldwide; despite the introduction over the last few years of new therapeutic agents, very little progress has been made in terms of survival, and the overall prognosis for these patients remains poor. For these reasons any efforts to find and validate new effective therapeutic procedures for lung cancer are very timely and essential. To study the possibility to apply BNCT in the cure of diffuse pulmonary tumours, we created a BNCT Lung Project in Pavia, supported by Ministry of Education, University and Research (MIUR), in which Physicists, Medical Doctors and Biologists are involved. The first steps were: i. development of an animal model for Boron uptake measurements in healthy and tumor lung tissues; ii. evaluation of the possibility to treat patients with epithermal neutron beams (See S.Altieri et al., this Conference); iii. in-vitro study of BNCT efficacy (see A.Zonta et al.). Imaging of spatial Boron distribution by neutron radiography is presented; furthermore preliminary results of Boron concentration measures in lung metastases from Colon Adenocarcinoma are reported. The measures were performed using alpha spectrometry in thin tissue samples.
Boron Uptake Measurements in Metastatic Tumours in Rat Lung
BORTOLUSSI, SILVA;ALTIERI, SAVERIO;BRUSCHI, PIERO;CHIARI, PATRIZIA;FOSSATI, FRANCESCA;FACOETTI, ANGELICA;NANO, ROSANNA;CLERICI, ANNA MARIA;FERRARI, CINZIA;ZONTA, ARIS;ZONTA, CECILIA;SOLCIA, ENRICO;
2006-01-01
Abstract
Lung carcinoma is the leading cause of cancer mortality worldwide; despite the introduction over the last few years of new therapeutic agents, very little progress has been made in terms of survival, and the overall prognosis for these patients remains poor. For these reasons any efforts to find and validate new effective therapeutic procedures for lung cancer are very timely and essential. To study the possibility to apply BNCT in the cure of diffuse pulmonary tumours, we created a BNCT Lung Project in Pavia, supported by Ministry of Education, University and Research (MIUR), in which Physicists, Medical Doctors and Biologists are involved. The first steps were: i. development of an animal model for Boron uptake measurements in healthy and tumor lung tissues; ii. evaluation of the possibility to treat patients with epithermal neutron beams (See S.Altieri et al., this Conference); iii. in-vitro study of BNCT efficacy (see A.Zonta et al.). Imaging of spatial Boron distribution by neutron radiography is presented; furthermore preliminary results of Boron concentration measures in lung metastases from Colon Adenocarcinoma are reported. The measures were performed using alpha spectrometry in thin tissue samples.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
