The BIANCA biophysical model was used to simulate cell survival curves by protons, He- and C-ions over a wide LET range and for several doses. Each simulated curve was then fitted by a linear-quadratic exponential function of the form S(D)=exp(-αD-βD2). This allowed to produce an almost continuous set of α and β values as a function of LET for each ion type. The same procedure was repeated for chromosome aberration dose-response curves, using the following fitting function: A(D)=αAD+βAD2. In the context of hadrontherapy, the tables of α and β (as well as αA and βA) were read by the FLUKA radiation transport code, which provides the necessary information about particle type, LET and absorbed dose, thus allowing fast computing of biological outputs in every position of a therapeutic dose profile. Some examples of the variation of the two considered biological quantities, i.e. probability of cell survival and chromosome aberrations, along Spread Out Bragg Peaks in water are reported as preliminary results.
A radiobiological database produced by the BIANCA model to predict the biological effectiveness of hadrontherapy beams
Carante M. P.
;Tello Cajiao J. J.;Ballarini F.
2018-01-01
Abstract
The BIANCA biophysical model was used to simulate cell survival curves by protons, He- and C-ions over a wide LET range and for several doses. Each simulated curve was then fitted by a linear-quadratic exponential function of the form S(D)=exp(-αD-βD2). This allowed to produce an almost continuous set of α and β values as a function of LET for each ion type. The same procedure was repeated for chromosome aberration dose-response curves, using the following fitting function: A(D)=αAD+βAD2. In the context of hadrontherapy, the tables of α and β (as well as αA and βA) were read by the FLUKA radiation transport code, which provides the necessary information about particle type, LET and absorbed dose, thus allowing fast computing of biological outputs in every position of a therapeutic dose profile. Some examples of the variation of the two considered biological quantities, i.e. probability of cell survival and chromosome aberrations, along Spread Out Bragg Peaks in water are reported as preliminary results.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
