Boron Neutron Capture Therapy (BNCT) is a binary radiotherapy based on the reaction 10B(n,α)7Li induced by thermal neutrons. 10B selectively loads cancer cells through a boronated drug injected into patient few hours before neutron irradiation. The secondary charged particles have short ranges in tissues (less than the mean cell diameter of few tens of μm), thus they deposit their whole kinetic energy (up to 2.79 MeV) inside the cell where the capture reaction took place. In this way it is possible to selectively damage the malignant cells sparing the surrounding healthy ones.To take full advantage of BNCT selectivity a precise knowledge of 10B spatial distribution is required. This quantity can be measured by Single Photon Emission Computed Tomography (SPECT) thanks to the emission of a 478 keV γ ray in the 94% of 10B capture reactions. Notably, the counting rate of this photon is meaningful of the dose rate due to the neutron captures in the patient thus allowing an in vivo, real time dose monitoring.In the present study we evaluated the capabilities of a small prototype of CdZnTe (CZT) photon detector to reconstruct the tomographic image of tissue equivalent phantoms loaded with point like γ sources (such as 22Na, 137Cs and 57Co), activated detectors (Cu and Au wires) and 18F water solutions.
Prompt gamma tomography for BNCT-SPECT: A feasibility study using small animal phantoms
Bortolussi S.;Magni C.;Postuma I.;Altieri S.;Protti N.
2018-01-01
Abstract
Boron Neutron Capture Therapy (BNCT) is a binary radiotherapy based on the reaction 10B(n,α)7Li induced by thermal neutrons. 10B selectively loads cancer cells through a boronated drug injected into patient few hours before neutron irradiation. The secondary charged particles have short ranges in tissues (less than the mean cell diameter of few tens of μm), thus they deposit their whole kinetic energy (up to 2.79 MeV) inside the cell where the capture reaction took place. In this way it is possible to selectively damage the malignant cells sparing the surrounding healthy ones.To take full advantage of BNCT selectivity a precise knowledge of 10B spatial distribution is required. This quantity can be measured by Single Photon Emission Computed Tomography (SPECT) thanks to the emission of a 478 keV γ ray in the 94% of 10B capture reactions. Notably, the counting rate of this photon is meaningful of the dose rate due to the neutron captures in the patient thus allowing an in vivo, real time dose monitoring.In the present study we evaluated the capabilities of a small prototype of CdZnTe (CZT) photon detector to reconstruct the tomographic image of tissue equivalent phantoms loaded with point like γ sources (such as 22Na, 137Cs and 57Co), activated detectors (Cu and Au wires) and 18F water solutions.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
