Biologics in Children with Allergic Diseases

The prevalence of allergic diseases prevalence has been remarkably increased in the last decades. The global health burden of these conditions is substantial, since patients may experience disability, anxiety and emotional distress, social restrictions, and reduced quality of life and productivity, in particular in the most severe cases. Recent advances in understanding the pathophysiology of allergic disorders have allowed to identify novel therapeutic strategies for the treatment of severe and uncontrolled allergic diseases. Although the most studies have been performed in allergic asthma, biological drugs targeting other allergic diseases such as chronic spontaneous urticaria, atopic dermatitis, and food allergy are showing promising results. In this review, we will present the most recent evidence on biologic therapies for allergic diseases, focusing on the pediatric age.