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The Mycobacterium tuberculosis mmpL7 gene, encoding a hypothetical resistance nodulation division transporter, confers a high resistance level to isoniazid when overexpressed in Mycobacterium smegmatis. The resistance level decreased in the presence of the efflux pump inhibitors reserpine and CCCP (carbonyl cyanide m-chlorophenylhydrazone). Energy-dependent efflux of isoniazid from M. smegmatis cells expressing the mmpL7 gene was observed.

mmpL7 gene of Mycobacterium tuberculosis is responsible for isoniazid efflux in Mycobacterium smegmatis

PASCA, MARIA ROSALIA;GUGLIERAME, PAOLA;DE ROSSI, EDDA;ZARA, FRANCESCA;RICCARDI, GIOVANNA
2005-01-01

Abstract

The Mycobacterium tuberculosis mmpL7 gene, encoding a hypothetical resistance nodulation division transporter, confers a high resistance level to isoniazid when overexpressed in Mycobacterium smegmatis. The resistance level decreased in the presence of the efflux pump inhibitors reserpine and CCCP (carbonyl cyanide m-chlorophenylhydrazone). Energy-dependent efflux of isoniazid from M. smegmatis cells expressing the mmpL7 gene was observed.
2005
Microbiology covers the biology and biochemistry of microorganisms, bacterial, viral, and parasitic, as well as the medical implications and treatments of the subset of these organisms known to cause disease in humans and/or animals. Biotechnology applications of microorganisms for basic science or clinical use are also covered. Resources that emphasize immune response to pathogens and its modulation by clinical intervention are excluded and are covered in the Immunology category.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
sì
000233020900050
2-s2.0-27644475760
Esperti anonimi
Inglese
Internazionale
STAMPA
49
11
4775
4777
3
16251328
Tematica Ex SIR: Pompe di efflusso e resistenza multipla agli antibiotici nei micobatteri (Classif. Ex SIR:Articoli su riviste ISI )
mmpL7; Mycobacterium tuberculosis; efflux pump; drug resistance; isoniazid
no
5
info:eu-repo/semantics/article
262
Pasca, MARIA ROSALIA; Guglierame, Paola; DE ROSSI, Edda; Zara, Francesca; Riccardi, Giovanna
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/137135
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