In Boron Neutron Capture Therapy, the boronated drug plays a leading role in delivering a lethal dose to the tumour. The effectiveness depends on the boron macroscopic concentration and on its distribution at sub-cellular level. This work shows a way to colocalize alpha particles and lithium ions tracks with cells. A neutron autoradiography technique is used, which combines images of cells with images of tracks produced in a solid-state nuclear track detector.
Colocalization of tracks from boron neutron capture reactions and images of isolated cells
Postuma I.;Sommi P.;Vitali A.;Cansolino L.;Ferrari C.;Ricci V.;Magni C.;Protti N.;Fatemi S.;Bortolussi S.;Altieri S.
2021-01-01
Abstract
In Boron Neutron Capture Therapy, the boronated drug plays a leading role in delivering a lethal dose to the tumour. The effectiveness depends on the boron macroscopic concentration and on its distribution at sub-cellular level. This work shows a way to colocalize alpha particles and lithium ions tracks with cells. A neutron autoradiography technique is used, which combines images of cells with images of tracks produced in a solid-state nuclear track detector.File in questo prodotto:
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