Several studies suggest that the modification of a titanium surface could play an important role in bone tissue engineering. In this study we have followed a biomimetic strategy where ultrasonically or electromagnetically stimulated human SAOS-2 osteoblasts proliferated and built their extracellular matrix on a titanium plasma-spray surface. In comparison with control conditions, the ultrasonic stimulus (power, 149 mW; frequency, 1.5 MHz) and the electromagnetic stimulus (magnetic field, 2 mT; frequency, 75 Hz) increased the cell proliferation and the surface coating with type-I collagen. The physical stimuli aimed at obtaining a better modification of the rough titanium plasma-spray surface in terms of cell colonization and coating with bone matrix. The superficially modified biomaterial could be used, in clinical applications, as an implant for bone repair.
Physically enhanced coating of a titanium plasma-spray surface with human SAOS-2 osteoblasts and extracellular matrix
Fassina L;Saino E;Visai L;Magenes G.
2007-01-01
Abstract
Several studies suggest that the modification of a titanium surface could play an important role in bone tissue engineering. In this study we have followed a biomimetic strategy where ultrasonically or electromagnetically stimulated human SAOS-2 osteoblasts proliferated and built their extracellular matrix on a titanium plasma-spray surface. In comparison with control conditions, the ultrasonic stimulus (power, 149 mW; frequency, 1.5 MHz) and the electromagnetic stimulus (magnetic field, 2 mT; frequency, 75 Hz) increased the cell proliferation and the surface coating with type-I collagen. The physical stimuli aimed at obtaining a better modification of the rough titanium plasma-spray surface in terms of cell colonization and coating with bone matrix. The superficially modified biomaterial could be used, in clinical applications, as an implant for bone repair.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
