Aim of this study is to achieve better bone quality using steroids since many attempts to find factors useful in boosting bone regeneration has failed. In a preliminary study performed in a mini-pig model we analyzed the effect of stanazolol. Greater amount of newly formed bone surrounding the implants and active osteoblasts covering bone surfaces were found in mini-pig treated with stanazolol. The effect of nandrolone, given parenterally to adult male rabbits, was analyzed after insertion of titanium dental fixtures in the tibias of treated and control animals. Samples of blood were collected before surgery. Treatment groups, each of 4, underwent injection of nandrolone after the fixture insertion and 7 days later. Control groups (of 2 rabbits) were saline injected. Bone labelling was performed by Tetracycline injection 7 days before sacrifice. Rabbits were sacrificed after 2, 3 and 4 weeks. The organs of the animals underwent histological analysis to verify damages due to the drug administration. The undecalcified tibia specimens analyzed on microradiographs and fluorescence microscope showed an increased amount of newly formed tissue and a substantial absence of injures to organs in nandrolone-treated rabbits. The results of this research seem to confirm the capability of nandrolone on boosting bone processes.
Nandrolone and bone regeneration
RODRIGUEZ Y BAENA, RUGGERO;RIZZO, SILVANA;DI NUCCI, AMALIA;BRUSOTTI, CESARE
2006-01-01
Abstract
Aim of this study is to achieve better bone quality using steroids since many attempts to find factors useful in boosting bone regeneration has failed. In a preliminary study performed in a mini-pig model we analyzed the effect of stanazolol. Greater amount of newly formed bone surrounding the implants and active osteoblasts covering bone surfaces were found in mini-pig treated with stanazolol. The effect of nandrolone, given parenterally to adult male rabbits, was analyzed after insertion of titanium dental fixtures in the tibias of treated and control animals. Samples of blood were collected before surgery. Treatment groups, each of 4, underwent injection of nandrolone after the fixture insertion and 7 days later. Control groups (of 2 rabbits) were saline injected. Bone labelling was performed by Tetracycline injection 7 days before sacrifice. Rabbits were sacrificed after 2, 3 and 4 weeks. The organs of the animals underwent histological analysis to verify damages due to the drug administration. The undecalcified tibia specimens analyzed on microradiographs and fluorescence microscope showed an increased amount of newly formed tissue and a substantial absence of injures to organs in nandrolone-treated rabbits. The results of this research seem to confirm the capability of nandrolone on boosting bone processes.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
