Esters of sn-glycero-3-phosphoric acid (GPAE) are derivatives of glycerophospholipids in which both the fatty acid chains in sn-1 and sn-2 positions are removed. Phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), and phosphatidylserine (PS) are the most abundant glycerophospholipids in Nature. Their deacylated derivatives find application in many industrial sectors; for example, sn-glycero-3-phosphocholine (GPC) is useful as a cognitive enhancer and as a food ingredient, whereas sn-glycero-3-phosphoinositol (GPI) acts as a natural anti-inflammatory agent. This minireview covers the state-of-the-art of chemical and biocatalytic methods for the obtainment of these lipid-derived components.

Chemical and Enzymatic Approaches to Esters of sn-Glycero-3-Phosphoric Acid

Riccardo Semproli;Marina S. Robescu;Teodora Bavaro;Daniela Ubiali
;
2021-01-01

Abstract

Esters of sn-glycero-3-phosphoric acid (GPAE) are derivatives of glycerophospholipids in which both the fatty acid chains in sn-1 and sn-2 positions are removed. Phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), and phosphatidylserine (PS) are the most abundant glycerophospholipids in Nature. Their deacylated derivatives find application in many industrial sectors; for example, sn-glycero-3-phosphocholine (GPC) is useful as a cognitive enhancer and as a food ingredient, whereas sn-glycero-3-phosphoinositol (GPI) acts as a natural anti-inflammatory agent. This minireview covers the state-of-the-art of chemical and biocatalytic methods for the obtainment of these lipid-derived components.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/1451343
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 6
social impact