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We examined a set of populations mainly from Europe but also from the Middle East and North Africa for three Y-linked microsatellites YCAII, DYS19 (about 1300 individuals) and DYS392 (about 350 individuals). Three markers (YCAII a5-b1 Ht, DYS19-190 bp and DYS392-254 bp) show decreasing gradiente of frequency from western Europe toward the Middle East which paralel that of the proto-European 49a,f/TaqI Ht 15. Indeed, a strong linkage disequilibrium between these markers and the 49a,f Ht 15 is observed. We therefore suggest that the 49a,f/TaqI Ht 15, YCAII a5-b1 Ht, DYS19-190 bp and DYS392-254 bp Y chromosome could represent a component of the proto-European gene pool. This European specific compound haplotype distinctively characterizes western Europeans and its very high incidente in these populations (particularly in the Basques) is discussed.

Further characteristics of proto-European Y-chromosomes.

SEMINO, ORNELLA;BENERECETTI, AUGUSTA SILVANA
1999-01-01

Abstract

We examined a set of populations mainly from Europe but also from the Middle East and North Africa for three Y-linked microsatellites YCAII, DYS19 (about 1300 individuals) and DYS392 (about 350 individuals). Three markers (YCAII a5-b1 Ht, DYS19-190 bp and DYS392-254 bp) show decreasing gradiente of frequency from western Europe toward the Middle East which paralel that of the proto-European 49a,f/TaqI Ht 15. Indeed, a strong linkage disequilibrium between these markers and the 49a,f Ht 15 is observed. We therefore suggest that the 49a,f/TaqI Ht 15, YCAII a5-b1 Ht, DYS19-190 bp and DYS392-254 bp Y chromosome could represent a component of the proto-European gene pool. This European specific compound haplotype distinctively characterizes western Europeans and its very high incidente in these populations (particularly in the Basques) is discussed.
1999
Molecular Biology & Genetics considers all aspects of basic and applied genetics, including molecular genetics, prokaryotic and eukaryotic gene expression, mechanisms of mutagenesis, structure, function and regulation of genetic material. Also included are resources concerned with clinical genetics, patterns of inheritance, genetic cause, and screening and treatment of disease. Resources dealing specifically with developmentally regulated gene expression, or with signal transduction pathways that modulate gene expression at the cellular level are excluded and are covered in the Cell and Developmental Biology category.
EUROPEAN JOURNAL OF HUMAN GENETICS
sì
2-s2.0-0032772839
Sì, ma tipo non specificato
Inglese
Internazionale
STAMPA
7
5
603
608
Y CHROMOSOME; EUROPEAN POPULATIONS; EUROPEAN GENETIC HISTORY.
www.karger.com/journals
6
info:eu-repo/semantics/article
262
QUINTANA MURCI, L; Semino, Ornella; Minch, E; Passarimo, G; Brega, A; Benerecetti, AUGUSTA SILVANA
1 Contributo su Rivista::1.1 Articolo in rivista
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1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/1494
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