Abstract: In order to investigate the molecular features involved in sigma receptors (sigma-Rs) binding, new compounds based on arylalkylaminoalcoholic, arylalkenyl- and arylalkylaminic scaffolds were synthesized and their affinity towards sigma1- and sigma2-Rs subtypes was evaluated. The most promising compounds were also screened for their affinity at mu-opioid, delta-opioid and kappa-opioid receptors. Biological results are herein presented and discussed.

Design, synthesis and SAR analysis of novel selective sigma1 ligands (Part 2)

ROSSI, DANIELA;URBANO, MARIANGELA;PEDRALI, ALICE;SERRA, MASSIMO;AZZOLINA, ORNELLA;COLLINA, SIMONA
2010

Abstract

Abstract: In order to investigate the molecular features involved in sigma receptors (sigma-Rs) binding, new compounds based on arylalkylaminoalcoholic, arylalkenyl- and arylalkylaminic scaffolds were synthesized and their affinity towards sigma1- and sigma2-Rs subtypes was evaluated. The most promising compounds were also screened for their affinity at mu-opioid, delta-opioid and kappa-opioid receptors. Biological results are herein presented and discussed.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/209969
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 24
  • ???jsp.display-item.citation.isi??? 25
social impact