Abstract: In order to investigate the molecular features involved in sigma receptors (sigma-Rs) binding, new compounds based on arylalkylaminoalcoholic, arylalkenyl- and arylalkylaminic scaffolds were synthesized and their affinity towards sigma1- and sigma2-Rs subtypes was evaluated. The most promising compounds were also screened for their affinity at mu-opioid, delta-opioid and kappa-opioid receptors. Biological results are herein presented and discussed.
Design, synthesis and SAR analysis of novel selective sigma1 ligands (Part 2)
ROSSI, DANIELA;URBANO, MARIANGELA;PEDRALI, ALICE;SERRA, MASSIMO;AZZOLINA, ORNELLA;COLLINA, SIMONA
2010-01-01
Abstract
Abstract: In order to investigate the molecular features involved in sigma receptors (sigma-Rs) binding, new compounds based on arylalkylaminoalcoholic, arylalkenyl- and arylalkylaminic scaffolds were synthesized and their affinity towards sigma1- and sigma2-Rs subtypes was evaluated. The most promising compounds were also screened for their affinity at mu-opioid, delta-opioid and kappa-opioid receptors. Biological results are herein presented and discussed.File in questo prodotto:
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