Linezolid belongs to a class of antibiotics known as oxazolidinones. It is receiving great attention due to its activity toward multidrugs resistant bacteria, and simple and cheap methods for the analysis of this compound in pharmaceutical preparations are required. In this work, the electrochemistry of the antibiotic linezolid was investigated and a differential pulse voltammetric method based on the oxidation of the oxazolidinonic compound at a glassy carbon electrode has been developed and optimized for its determination; LOD of 50 mgL1 and a linearity up to 200 mgL1 were reported. The electrochemical process was studied by using different electrochemical techniques and confirmed by HPLC-MS/MS.
Analytical Determination and Electrochemical Characterization ofthe Oxazolidinone Antibiotic Linezolid
MERLI, DANIELE;PRETALI, LUCA;FASANI, ELISA;ALBINI, ANGELO;PROFUMO, ANTONELLA
2011-01-01
Abstract
Linezolid belongs to a class of antibiotics known as oxazolidinones. It is receiving great attention due to its activity toward multidrugs resistant bacteria, and simple and cheap methods for the analysis of this compound in pharmaceutical preparations are required. In this work, the electrochemistry of the antibiotic linezolid was investigated and a differential pulse voltammetric method based on the oxidation of the oxazolidinonic compound at a glassy carbon electrode has been developed and optimized for its determination; LOD of 50 mgL1 and a linearity up to 200 mgL1 were reported. The electrochemical process was studied by using different electrochemical techniques and confirmed by HPLC-MS/MS.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
