MSC expansion was successful in all cases; sustained complete closure (seven cases) or incomplete closure (three cases) of fistula tracks with a parallel reduction of Crohn's disease and perianal disease activity indexes (p < 0.01 for both), and rectal mucosal healing were induced by treatment without any adverse effects. The percentage of mucosal and circulating regulatory T cells significantly increased during the treatment and remained stable until the end of follow up (p < 0.0001 and p < 0.01, respectively). Furthermore, MSCs have been proven to affect mucosal T cell apoptotic rate.
Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn's disease.
CICCOCIOPPO, RACHELE;BERNARDO, MARIA ESTER;MACCARIO, RITA;VANOLI, ALESSANDRO;CALLIADA, FABRIZIO;DIONIGI, PAOLO;LOCATELLI, FRANCO;CORAZZA, GINO ROBERTO
2011
Abstract
MSC expansion was successful in all cases; sustained complete closure (seven cases) or incomplete closure (three cases) of fistula tracks with a parallel reduction of Crohn's disease and perianal disease activity indexes (p < 0.01 for both), and rectal mucosal healing were induced by treatment without any adverse effects. The percentage of mucosal and circulating regulatory T cells significantly increased during the treatment and remained stable until the end of follow up (p < 0.0001 and p < 0.01, respectively). Furthermore, MSCs have been proven to affect mucosal T cell apoptotic rate.File in questo prodotto:
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