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Although it has been shown that muscle magnetic resonance imaging (MRI) improves the phenotypic characterization of patients with neuromuscular disorders and allows accurate quantification of muscle and adipose tissue distribution, to date quantitative MRI has not been used to assess the therapeutic response in clinical trials of neuromuscular diseases. We discuss quantitative MRI findings after a 6-month course of enzyme replacement therapy administered to nine patients with adult-onset glycogenosis II.

Enzyme replacement therapy in adult-onset glycogenosis II: is quantitative muscle MRI helpful?

PICHIECCHIO, ANNA;COSTA, ALFREDO;BASTIANELLO, STEFANO
2009-01-01

Abstract

Although it has been shown that muscle magnetic resonance imaging (MRI) improves the phenotypic characterization of patients with neuromuscular disorders and allows accurate quantification of muscle and adipose tissue distribution, to date quantitative MRI has not been used to assess the therapeutic response in clinical trials of neuromuscular diseases. We discuss quantitative MRI findings after a 6-month course of enzyme replacement therapy administered to nine patients with adult-onset glycogenosis II.
2009
The Neurology category covers resources concerned with the central and peripheral nervous system including the brain, spinal cord, nerves, and fluids. Coverage includes general and clinical neurology including neurosurgery, neuropsychiatry, neuropsychology, neurophysiology, neuroradiology, neuropediatrics, neuropathology, and neurobiology. Resources on cerebrovascular diseases, movement and spinal disorders, pain, dementia, headache, aphasiology, brain injury, paraplegia, stroke, and acupuncture are also included.
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MUSCLE & NERVE
sì
WOS:000269849200019
2-s2.0-67650249525
Sì, ma tipo non specificato
Inglese
Internazionale
ELETTRONICO
40
122
125
19533640
Age of Onset, Aged, Female, Glycogen Storage Disease Type II; drug therapy/pathology, Humans, Magnetic Resonance Imaging; methods, Male, Middle Aged, Muscle; Skeletal; pathology, Recombinant Proteins; therapeutic use, alpha-Glucosidases; therapeutic use
http://dx.doi.org/10.1002/mus.21304
12
info:eu-repo/semantics/article
262
Pichiecchio, Anna; G. U., Poloni; S., Ravaglia; M., Ponzio; G., Germani; D., Maranzana; Costa, Alfredo; A., Repetto; E., Tavazzi; C., Danesino; A., Mo...espandi
1 Contributo su Rivista::1.1 Articolo in rivista
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1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/377505
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