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Recently, there has been considerable discussion regarding the classification of drugs as a function of their therapeutic index, defined as the ratio between the upper and lower limits of the therapeutic range. Pharmacologic agents with a therapeutic index < 2 are classified as "narrow therapeutic index" (NTI) drugs. One of the agents classified as an NTI drug is carbamazepine. These recent developments led us to evaluate critically the evidence supporting the classification of carbamazepine as an NTI drug to address an old question: "Does carbamazepine have a narrow therapeutic plasma concentration range?"

Does Carbamazepine Have a Narrow Therapeutic Plasma Concentration Range?

PERUCCA, EMILIO
1998-01-01

Abstract

Recently, there has been considerable discussion regarding the classification of drugs as a function of their therapeutic index, defined as the ratio between the upper and lower limits of the therapeutic range. Pharmacologic agents with a therapeutic index < 2 are classified as "narrow therapeutic index" (NTI) drugs. One of the agents classified as an NTI drug is carbamazepine. These recent developments led us to evaluate critically the evidence supporting the classification of carbamazepine as an NTI drug to address an old question: "Does carbamazepine have a narrow therapeutic plasma concentration range?"
1998
The Neurology category covers resources concerned with the central and peripheral nervous system including the brain, spinal cord, nerves, and fluids. Coverage includes general and clinical neurology including neurosurgery, neuropsychiatry, neuropsychology, neurophysiology, neuroradiology, neuropediatrics, neuropathology, and neurobiology. Resources on cerebrovascular diseases, movement and spinal disorders, pain, dementia, headache, aphasiology, brain injury, paraplegia, stroke, and acupuncture are also included.
THERAPEUTIC DRUG MONITORING
sì
Sì, ma tipo non specificato
Inglese
Internazionale
STAMPA
20
1
56
59
9485555
3
info:eu-repo/semantics/article
262
Meier, Bialer; Rene' H., Levy; Perucca, Emilio
1 Contributo su Rivista::1.1 Articolo in rivista
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1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/472622
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