Translational research projects aim at combining -omics, structural and functional studies with clinical investigation results to translate basic knowledge of genetic diseases into routine clinical practice. Biomedical informatics can fruitfully support this kind of research by implementing information technology solutions to support the multidisciplinary project team in the different phases of its investigation. In this paper we present a semantic wiki-based system purposely implemented for supporting the consortium members of the EU project Inheritance in sharing and disseminating data and knowledge about genetic dilated cardiomyopathies (DCM) [Ahamad et al., 2005]. It consists of a collaborative system that is used to track project activities, share ideas and data, foster exchange of information between the investigators to support several activities of the INHERITANCE translational research project. Moreover, it can be used to easily manage the scientific research products by adding semantic tags on the basis of the underlying knowledge model. A Natural Language Processing (NLP) based module has been developed to this aim; it extracts the relevant molecular and medical concepts from the scientific material shared by the project team and store them as RDF form by enabling the semantic querying of data.
A Semantic Collaborative System for the Management of Translational Research Projects
GABETTA, MATTEO MARIA;LARIZZA, CRISTIANA;FAVALLI, VALENTINA;ARBUSTINI, ELOISA;BELLAZZI, RICCARDO
2012-01-01
Abstract
Translational research projects aim at combining -omics, structural and functional studies with clinical investigation results to translate basic knowledge of genetic diseases into routine clinical practice. Biomedical informatics can fruitfully support this kind of research by implementing information technology solutions to support the multidisciplinary project team in the different phases of its investigation. In this paper we present a semantic wiki-based system purposely implemented for supporting the consortium members of the EU project Inheritance in sharing and disseminating data and knowledge about genetic dilated cardiomyopathies (DCM) [Ahamad et al., 2005]. It consists of a collaborative system that is used to track project activities, share ideas and data, foster exchange of information between the investigators to support several activities of the INHERITANCE translational research project. Moreover, it can be used to easily manage the scientific research products by adding semantic tags on the basis of the underlying knowledge model. A Natural Language Processing (NLP) based module has been developed to this aim; it extracts the relevant molecular and medical concepts from the scientific material shared by the project team and store them as RDF form by enabling the semantic querying of data.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
