In the present study, gelatin-based cryogels have been seeded with human SAOS-2 osteoblasts. In order to overcome the drawbacks associated with in vitro culture systems, such as limited diffusion and inhomogeneous cell-matrix distribution, this work describes the application of ultrasounds (average power, 149 mW; frequency, 1.5 MHz) to physically enhance the cell culture in vitro. The results indicate that the physical stimulation of cell-seeded gelatin-based cryogels upregulates the bone matrix production.

Ultrasound stimulus to enhance the bone regeneration capability of gelatin cryogels

Fassina L;Visai L;Magenes G;Bloise N;Riva F;Omes C;Cusella De Angelis MG;Benazzo F;
2013-01-01

Abstract

In the present study, gelatin-based cryogels have been seeded with human SAOS-2 osteoblasts. In order to overcome the drawbacks associated with in vitro culture systems, such as limited diffusion and inhomogeneous cell-matrix distribution, this work describes the application of ultrasounds (average power, 149 mW; frequency, 1.5 MHz) to physically enhance the cell culture in vitro. The results indicate that the physical stimulation of cell-seeded gelatin-based cryogels upregulates the bone matrix production.
2013
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society
9781457702167
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/701620
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