In the present paper, we report the synthesis via catalytic Michael reaction and biological results of a series of 3-heteryl substituted pyrrolidine-2,5-dione derivatives as moderate inhibitors against M. tuberculosis H37Rv growth. Some of them present also inhibition activities against InhA.
Synthesis of 3-heteryl substituted pyrrolidine-2,5-diones via catalytic Michael reaction and evaluation of their inhibitory activity against InhA and Mycobacterium tuberculosis
MORI, GIORGIA;PASCA, MARIA ROSALIA;
2014-01-01
Abstract
In the present paper, we report the synthesis via catalytic Michael reaction and biological results of a series of 3-heteryl substituted pyrrolidine-2,5-dione derivatives as moderate inhibitors against M. tuberculosis H37Rv growth. Some of them present also inhibition activities against InhA.File in questo prodotto:
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