This paper describes the procedure of design and development of a novel prototype matrix conceived to automatically and unobtrusively measure and monitor the interface pressure distribution and the centre of pressure of seated people in various fields, such as automotive, ergonomics and clinical environments. The work regards an innovative technology, that associates equal or better characteristics compared to commercial devices, with lower costs of construction (even for the prototype), better flexibility and robustness. The system is able to perform a continuous monitoring both in laboratory contexts and in more disruptive conditions, such as hospital beds.