Irradiation of a 7-piperazino-8-fluoroquinolone causes formal 1,2-fluorine migration, piperazine loss and reduction, or nucleophile addition in 8. Product study, laser flash photolysis, and computational modeling support F- detachment to yield a triplet 8-quinolyl cation that either inserts intramolecularly or is trapped by Cl-, Br-. However, iodide and pyrrole reduce it to the radical that continues the ‘redox tour’ (aryl cation - radical - radical anion - radical and then again radical or radical anion) leading to the rearranged products.
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