Low frequency electromagnetic field (LF-EMF) assays were developed to increase the clearance capability of neurotoxic beta-amyliod peptides in vitro. Specifically, LF-EMF activates endogenous autophagic pro-survival effects resulting in the autophagosome engulfment of the toxic protein aggregates. These results might address novel therapeutic strategies for neurodegenerative diseases.
A low-frequency electromagnetic (LF-EMF) exposure scheme induces autophagy activation to counteract in vitro Abeta-amyloid neurotoxicity
MANAI, FEDERICO;FASSINA, LORENZO;VENTURINI, LETIZIA;ANGELETTI, FRANCESCA;OSERA, CECILIA;MARCHESI, NICOLETTA;AMADIO, MARIALAURA;PASCALE, ALESSIA ANGELA;RICEVUTI, GIOVANNI;COMINCINI, SERGIO;CAORSI, SALVATORE
2014-01-01
Abstract
Low frequency electromagnetic field (LF-EMF) assays were developed to increase the clearance capability of neurotoxic beta-amyliod peptides in vitro. Specifically, LF-EMF activates endogenous autophagic pro-survival effects resulting in the autophagosome engulfment of the toxic protein aggregates. These results might address novel therapeutic strategies for neurodegenerative diseases.File in questo prodotto:
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