Low frequency electromagnetic field (LF-EMF) assays were developed to increase the clearance capability of neurotoxic beta-amyliod peptides in vitro. Specifically, LF-EMF activates endogenous autophagic pro-survival effects resulting in the autophagosome engulfment of the toxic protein aggregates. These results might address novel therapeutic strategies for neurodegenerative diseases.

A low-frequency electromagnetic (LF-EMF) exposure scheme induces autophagy activation to counteract in vitro Abeta-amyloid neurotoxicity

MANAI, FEDERICO;FASSINA, LORENZO;VENTURINI, LETIZIA;ANGELETTI, FRANCESCA;OSERA, CECILIA;MARCHESI, NICOLETTA;AMADIO, MARIALAURA;PASCALE, ALESSIA ANGELA;RICEVUTI, GIOVANNI;COMINCINI, SERGIO;CAORSI, SALVATORE
2014

Abstract

Low frequency electromagnetic field (LF-EMF) assays were developed to increase the clearance capability of neurotoxic beta-amyliod peptides in vitro. Specifically, LF-EMF activates endogenous autophagic pro-survival effects resulting in the autophagosome engulfment of the toxic protein aggregates. These results might address novel therapeutic strategies for neurodegenerative diseases.
9788894008906
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11571/888047
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