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EnglishMany different orders of magnitude are involved in the development of radiation-induced biological damage, both at a spatial level (from atomic dimensions to cellular and organ dimensions) and at a temporal level (from the 10−15 s of the physical interactions to the hours, and possibly years, of the biological processes). This chapter considers the very early events. The following aspects are treated: radiation interaction with matter; the Monte Carlo method; the track structure method, time evolution of the track, including the pre-chemical phase (radiolysis and radical production) and the chemical phase (diffusion and interaction with biological structures); the DNA damage; the microdosimetric approach; and the amorphous track approach. A final section is devoted to the criteria to integrate physical mechanistic investigations and approaches with a systems radiation biology approach.
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| Titolo: | Early Events Leading to Radiation-Induced Biological EffectsComprehensive Biomedical Physics |
| Autori: | |
| Data di pubblicazione: | 2014 |
| Abstract: | Many different orders of magnitude are involved in the development of radiation-induced biological damage, both at a spatial level (from atomic dimensions to cellular and organ dimensions) and at a temporal level (from the 10−15 s of the physical interactions to the hours, and possibly years, of the biological processes). This chapter considers the very early events. The following aspects are treated: radiation interaction with matter; the Monte Carlo method; the track structure method, time evolution of the track, including the pre-chemical phase (radiolysis and radical production) and the chemical phase (diffusion and interaction with biological structures); the DNA damage; the microdosimetric approach; and the amorphous track approach. A final section is devoted to the criteria to integrate physical mechanistic investigations and approaches with a systems radiation biology approach. |
| Handle: | http://hdl.handle.net/11571/985062 |
| ISBN: | 9780444536334 |
| Appare nelle tipologie: | 2.1 Contributo in volume (Capitolo o Saggio) |
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