MANGIONE, PALMA
MANGIONE, PALMA
DIPARTIMENTO DI MEDICINA MOLECOLARE
A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis
2015-01-01 Marcoux, Julien; Mangione, Palma; Porcari, Riccardo; Degiacomi, Matteo T.; Verona, Guglielmo; Taylor, Graham W; Giorgetti, Sofia; Raimondi, Sara; Sanglier Cianférani, Sarah; Benesch, Justin Lp; Cecconi, Ciro; Naqvi, Mohsin M.; Gillmore, Julian D.; Hawkins, Philip N.; Stoppini, Monica; Robinson, Carol V.; Pepys, Mark B.; Bellotti, Vittorio
A partially structured species of beta 2-microglobulin is significantly populated under physiological conditions and involved in fibrillogenesis
2001-01-01 Chiti, F.; DE LORENZI, Ersilia; Grossi, S.; Mangione, Palma; Giorgetti, Sofia; Caccialanza, Gabriele; Dobson, C. M.; Merlini, Giampaolo; Ramponi, G.; Bellotti, Vittorio
A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo
2017-01-01 Raimondi, Sara; Porcari, Riccardo; Mangione, Palma; Verona, Guglielmo; Marcoux, Julien; Giorgetti, Sofia; Taylor, Graham W.; Ellmerich, Stephan; Ballico, Maurizio; Zanini, Stefano; Pardon, Els; Al Shawi, Raya; Simons, J. Paul; Corazza, Alessandra; Fogolari, Federico; Leri, Manuela; Stefani, Massimo; Bucciantini, Monica; Gillmore, Julian D.; Hawkins, Philip N.; Valli, Maurizia; Stoppini, Monica; Robinson, Carol V.; Steyaert, Jan; Esposito, Gennaro; Bellotti, Vittorio
Affinity capillary electrophoresis is a powerful tool to identify transthyretin binding drugs for potential therapeutic use in amyloidosis
2000-01-01 DE LORENZI, Ersilia; Galbusera, C.; Bellotti, Vittorio; Mangione, Palma; Massolini, Gabriella; Tabolotti, E.; Andreola, A.; Caccialanza, Gabriele
Amyloid fibrils derived from the apolipoprotein A1 Leu174Ser variant contain elements of ordered helical structure.
2001-01-01 Mangione, Palma; Giorgetti, Sofia; Stoppini, Monica; Andreola, Alessia; Merlini, Giampaolo; Bellotti, Vittorio; Sunde, M; Esposito, G; Gianelli, L; Obici, L; Asti, L; Viglino, P.
Amyloid Formation by Globular Proteins: The Need to Narrow the Gap Between in Vitro and in Vivo Mechanisms
2022-01-01 Faravelli, G.; Mondani, V.; Mangione, P. P.; Raimondi, S.; Marchese, L.; Lavatelli, F.; Stoppini, M.; Corazza, A.; Canetti, D.; Verona, G.; Obici, L.; Taylor, G. W.; Gillmore, J. D.; Giorgetti, S.; Bellotti, V.
Amyloid persistence in decellularized liver: Biochemical and histopathological characterization
2016-01-01 Mazza, Giuseppe; Simons, J. Paul; Al Shawi, Raya; Ellmerich, Stephan; Urbani, Luca; Giorgetti, Sofia; Taylor, Graham W.; Gilbertson, Janet A.; Hall, Andrew R.; Al Akkad, Walid; Dhar, Dipok; Hawkins, Philip N.; De Coppi, Paolo; Pinzani, Massimo; Bellotti, Vittorio; Mangione, Palma
Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component
2017-01-01 Ozawa, Daisaku; Nomura, Ryo; Mangione, Palma; Hasegawa, Kazuhiro; Okoshi, Tadakazu; Porcari, Riccardo; Bellotti, Vittorio; Naiki, Hironobu
Antibodies to human serum amyloid P component eliminate visceral amyloid deposits.
2010-01-01 Bodin, K; Ellmerich, S; Kahan, Mc; Tennent, Ga; Loesch, A; Gilbertson, Ja; Hutchinson, Wl; Mangione, Palma; Gallimore, Jr; Millar, Dj; Minogue, S; Dhillon, Ap; Taylor, Gw; Bradwell, Ar; Petrie, A; Gillmore, Jd; Bellotti, Vittorio; Botto, M; Hawkins, Pn; Pepys, Mb
Benefit of doxycycline treatment on articular disability caused by dialysis related amyloidosis
2013-01-01 Montagna, G.; Cazzulani, B.; Obici, L.; Uggetti, C.; Giorgetti, Sofia; Porcari, R.; Ruggiero, R.; Mangione, Palma; Brambilla, M.; Lucchetti, J.; Guiso, G.; Gobbi, M.; Merlini, Giampaolo; Salmona, M.; Stoppini, Monica; Villa, G.; Bellotti, Vittorio
Beta 2- microglobulin can be refolded into a native state from ex vivo amyloid fibrils
1998-01-01 Bellotti, Vittorio; Stoppini, Monica; Mangione, Palma; Sunde, M; Robinson, C; Asti, L; Brancaccio, D; Ferri, Giuseppina
beta 2-microglobulin H31Y variant 3D-structure highlights the protein natural propensity towards intermolecular aggregation
2004-01-01 Rosano, C; Zuccotti, S; Mangione, Palma; Giorgetti, Sofia; Bellotti, Vittorio; Pettirossi, F; Corazza, A; Viglino, P; Esposito, G; Bolognesi, M.
Beta2-microglobulin isoforms display an heterogeneous affinity for type I collagen.
2005-01-01 Giorgetti, Sofia; Rossi, Antonio; Mangione, Palma; Raimondi, Sara; Marini, SARA FRANCESCA; Stoppini, Monica; Corazza, A.; Viglino, P.; Esposito, G.; Cetta, Giuseppe; Merlini, Giampaolo; Bellotti, Vittorio
Bifunctional crosslinking ligands for transthyretin
2015-01-01 Mangione, Palma; Deroo, Stephanie; Ellmerich, Stephan; Bellotti, Vittorio; Kolstoe, Simon; Wood, Stephen P.; Robinson, Carol V.; Smith, Martin D.; Tennent, Glenys A.; Broadbridge, Robert J.; Council, Claire E.; Thurston, Joanne R.; Steadman, Victoria A.; Vong, Antonio K.; Swain, Christopher J.; Pepys, Mark B.; Taylor, Graham W.
Binding of Monovalent and Bivalent Ligands by Transthyretin Causes Different Short- And Long-Distance Conformational Changes
2019-01-01 Corazza, A.; Verona, G.; Waudby, C. A.; Mangione, P. P.; Bingham, R.; Uings, I.; Canetti, D.; Nocerino, P.; Taylor, G. W.; Pepys, M. B.; Christodoulou, J.; Bellotti, V.
Biological activity and pathological implications of misfolded proteins.
1999-01-01 Bellotti, Vittorio; Mangione, Palma; Stoppini, Monica
C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis
2019-01-01 Faravelli, G.; Raimondi, S.; Marchese, L.; Partridge, F. A.; Soria, C.; Mangione, P. P.; Canetti, D.; Perni, M.; Aprile, F. A.; Zorzoli, I.; Di Schiavi, E.; Lomas, D. A.; Bellotti, V.; Sattelle, D. B.; Giorgetti, S.
C. elegans expressing human beta2-microglobulin: a novel model for studying the relationship between the molecular assembly and the toxic phenotype.
2012-01-01 L., Diomede; Soria, Cristina; M., Romeo; Giorgetti, Sofia; Marchese, Loredana; Mangione, Palma; Porcari, Riccardo; Zorzoli, Irene; M., Salmona; Bellotti, Vittorio; Stoppini, Monica
Calcium Binds to Transthyretin with Low Affinity
2022-01-01 Cantarutti, Cristina; Mimmi, Maria Chiara; Verona, Guglielmo; Mandaliti, Walter; Taylor, Graham W; Mangione, P Patrizia; Giorgetti, Sofia; Bellotti, Vittorio; Corazza, Alessandra
Capillary electrophoresis analysis of different variants of the amyloidogenic protein β2 -microglobulin as a simple tool for misfolding and stability studies
2015-01-01 Bertoletti, Laura; Bisceglia, Federica; Colombo, Raffaella; Giorgetti, Sofia; Raimondi, Sara; Mangione, Palma; DE LORENZI, Ersilia
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis | 1-gen-2015 | Marcoux, Julien; Mangione, Palma; Porcari, Riccardo; Degiacomi, Matteo T.; Verona, Guglielmo; Taylor, Graham W; Giorgetti, Sofia; Raimondi, Sara; Sanglier Cianférani, Sarah; Benesch, Justin Lp; Cecconi, Ciro; Naqvi, Mohsin M.; Gillmore, Julian D.; Hawkins, Philip N.; Stoppini, Monica; Robinson, Carol V.; Pepys, Mark B.; Bellotti, Vittorio | |
| A partially structured species of beta 2-microglobulin is significantly populated under physiological conditions and involved in fibrillogenesis | 1-gen-2001 | Chiti, F.; DE LORENZI, Ersilia; Grossi, S.; Mangione, Palma; Giorgetti, Sofia; Caccialanza, Gabriele; Dobson, C. M.; Merlini, Giampaolo; Ramponi, G.; Bellotti, Vittorio | |
| A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo | 1-gen-2017 | Raimondi, Sara; Porcari, Riccardo; Mangione, Palma; Verona, Guglielmo; Marcoux, Julien; Giorgetti, Sofia; Taylor, Graham W.; Ellmerich, Stephan; Ballico, Maurizio; Zanini, Stefano; Pardon, Els; Al Shawi, Raya; Simons, J. Paul; Corazza, Alessandra; Fogolari, Federico; Leri, Manuela; Stefani, Massimo; Bucciantini, Monica; Gillmore, Julian D.; Hawkins, Philip N.; Valli, Maurizia; Stoppini, Monica; Robinson, Carol V.; Steyaert, Jan; Esposito, Gennaro; Bellotti, Vittorio | |
| Affinity capillary electrophoresis is a powerful tool to identify transthyretin binding drugs for potential therapeutic use in amyloidosis | 1-gen-2000 | DE LORENZI, Ersilia; Galbusera, C.; Bellotti, Vittorio; Mangione, Palma; Massolini, Gabriella; Tabolotti, E.; Andreola, A.; Caccialanza, Gabriele | |
| Amyloid fibrils derived from the apolipoprotein A1 Leu174Ser variant contain elements of ordered helical structure. | 1-gen-2001 | Mangione, Palma; Giorgetti, Sofia; Stoppini, Monica; Andreola, Alessia; Merlini, Giampaolo; Bellotti, Vittorio; Sunde, M; Esposito, G; Gianelli, L; Obici, L; Asti, L; Viglino, P. | |
| Amyloid Formation by Globular Proteins: The Need to Narrow the Gap Between in Vitro and in Vivo Mechanisms | 1-gen-2022 | Faravelli, G.; Mondani, V.; Mangione, P. P.; Raimondi, S.; Marchese, L.; Lavatelli, F.; Stoppini, M.; Corazza, A.; Canetti, D.; Verona, G.; Obici, L.; Taylor, G. W.; Gillmore, J. D.; Giorgetti, S.; Bellotti, V. | |
| Amyloid persistence in decellularized liver: Biochemical and histopathological characterization | 1-gen-2016 | Mazza, Giuseppe; Simons, J. Paul; Al Shawi, Raya; Ellmerich, Stephan; Urbani, Luca; Giorgetti, Sofia; Taylor, Graham W.; Gilbertson, Janet A.; Hall, Andrew R.; Al Akkad, Walid; Dhar, Dipok; Hawkins, Philip N.; De Coppi, Paolo; Pinzani, Massimo; Bellotti, Vittorio; Mangione, Palma | |
| Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component | 1-gen-2017 | Ozawa, Daisaku; Nomura, Ryo; Mangione, Palma; Hasegawa, Kazuhiro; Okoshi, Tadakazu; Porcari, Riccardo; Bellotti, Vittorio; Naiki, Hironobu | |
| Antibodies to human serum amyloid P component eliminate visceral amyloid deposits. | 1-gen-2010 | Bodin, K; Ellmerich, S; Kahan, Mc; Tennent, Ga; Loesch, A; Gilbertson, Ja; Hutchinson, Wl; Mangione, Palma; Gallimore, Jr; Millar, Dj; Minogue, S; Dhillon, Ap; Taylor, Gw; Bradwell, Ar; Petrie, A; Gillmore, Jd; Bellotti, Vittorio; Botto, M; Hawkins, Pn; Pepys, Mb | |
| Benefit of doxycycline treatment on articular disability caused by dialysis related amyloidosis | 1-gen-2013 | Montagna, G.; Cazzulani, B.; Obici, L.; Uggetti, C.; Giorgetti, Sofia; Porcari, R.; Ruggiero, R.; Mangione, Palma; Brambilla, M.; Lucchetti, J.; Guiso, G.; Gobbi, M.; Merlini, Giampaolo; Salmona, M.; Stoppini, Monica; Villa, G.; Bellotti, Vittorio | |
| Beta 2- microglobulin can be refolded into a native state from ex vivo amyloid fibrils | 1-gen-1998 | Bellotti, Vittorio; Stoppini, Monica; Mangione, Palma; Sunde, M; Robinson, C; Asti, L; Brancaccio, D; Ferri, Giuseppina | |
| beta 2-microglobulin H31Y variant 3D-structure highlights the protein natural propensity towards intermolecular aggregation | 1-gen-2004 | Rosano, C; Zuccotti, S; Mangione, Palma; Giorgetti, Sofia; Bellotti, Vittorio; Pettirossi, F; Corazza, A; Viglino, P; Esposito, G; Bolognesi, M. | |
| Beta2-microglobulin isoforms display an heterogeneous affinity for type I collagen. | 1-gen-2005 | Giorgetti, Sofia; Rossi, Antonio; Mangione, Palma; Raimondi, Sara; Marini, SARA FRANCESCA; Stoppini, Monica; Corazza, A.; Viglino, P.; Esposito, G.; Cetta, Giuseppe; Merlini, Giampaolo; Bellotti, Vittorio | |
| Bifunctional crosslinking ligands for transthyretin | 1-gen-2015 | Mangione, Palma; Deroo, Stephanie; Ellmerich, Stephan; Bellotti, Vittorio; Kolstoe, Simon; Wood, Stephen P.; Robinson, Carol V.; Smith, Martin D.; Tennent, Glenys A.; Broadbridge, Robert J.; Council, Claire E.; Thurston, Joanne R.; Steadman, Victoria A.; Vong, Antonio K.; Swain, Christopher J.; Pepys, Mark B.; Taylor, Graham W. | |
| Binding of Monovalent and Bivalent Ligands by Transthyretin Causes Different Short- And Long-Distance Conformational Changes | 1-gen-2019 | Corazza, A.; Verona, G.; Waudby, C. A.; Mangione, P. P.; Bingham, R.; Uings, I.; Canetti, D.; Nocerino, P.; Taylor, G. W.; Pepys, M. B.; Christodoulou, J.; Bellotti, V. | |
| Biological activity and pathological implications of misfolded proteins. | 1-gen-1999 | Bellotti, Vittorio; Mangione, Palma; Stoppini, Monica | |
| C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis | 1-gen-2019 | Faravelli, G.; Raimondi, S.; Marchese, L.; Partridge, F. A.; Soria, C.; Mangione, P. P.; Canetti, D.; Perni, M.; Aprile, F. A.; Zorzoli, I.; Di Schiavi, E.; Lomas, D. A.; Bellotti, V.; Sattelle, D. B.; Giorgetti, S. | |
| C. elegans expressing human beta2-microglobulin: a novel model for studying the relationship between the molecular assembly and the toxic phenotype. | 1-gen-2012 | L., Diomede; Soria, Cristina; M., Romeo; Giorgetti, Sofia; Marchese, Loredana; Mangione, Palma; Porcari, Riccardo; Zorzoli, Irene; M., Salmona; Bellotti, Vittorio; Stoppini, Monica | |
| Calcium Binds to Transthyretin with Low Affinity | 1-gen-2022 | Cantarutti, Cristina; Mimmi, Maria Chiara; Verona, Guglielmo; Mandaliti, Walter; Taylor, Graham W; Mangione, P Patrizia; Giorgetti, Sofia; Bellotti, Vittorio; Corazza, Alessandra | |
| Capillary electrophoresis analysis of different variants of the amyloidogenic protein β2 -microglobulin as a simple tool for misfolding and stability studies | 1-gen-2015 | Bertoletti, Laura; Bisceglia, Federica; Colombo, Raffaella; Giorgetti, Sofia; Raimondi, Sara; Mangione, Palma; DE LORENZI, Ersilia |