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The Mycobacterium tuberculosis Rv2686c-Rv2687c-Rv2688c operon, encoding an ABC transporter, conferred resistance to ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin, and sparfloxacin to Mycobacterium smegmatis. The resistance level decreased in the presence of the efflux pump inhibitors reserpine, carbonyl cyanide m-chlorophenylhydrazone, and verapamil. Energy-dependent efflux of ciprofloxacin from M. smegmatis cells containing the Rv2686c-Rv2687c-Rv2688c operon was observed.

Rv2686c-2687c-2688c, an ABC fluoroquinolone efflux pump from Mycobacterium tuberculosis

PASCA, MARIA ROSALIA;GUGLIERAME, PAOLA;ARCESI, FABIO;BELLINZONI, MARCO;DE ROSSI, EDDA;RICCARDI, GIOVANNA
2004-01-01

Abstract

The Mycobacterium tuberculosis Rv2686c-Rv2687c-Rv2688c operon, encoding an ABC transporter, conferred resistance to ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin, and sparfloxacin to Mycobacterium smegmatis. The resistance level decreased in the presence of the efflux pump inhibitors reserpine, carbonyl cyanide m-chlorophenylhydrazone, and verapamil. Energy-dependent efflux of ciprofloxacin from M. smegmatis cells containing the Rv2686c-Rv2687c-Rv2688c operon was observed.
2004
Microbiology covers the biology and biochemistry of microorganisms, bacterial, viral, and parasitic, as well as the medical implications and treatments of the subset of these organisms known to cause disease in humans and/or animals. Biotechnology applications of microorganisms for basic science or clinical use are also covered. Resources that emphasize immune response to pathogens and its modulation by clinical intervention are excluded and are covered in the Immunology category.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
sì
000222998300063
2-s2.0-3342927606
Esperti anonimi
Inglese
Internazionale
STAMPA
48
8
3175
3178
4
15273144
Mycobacterium tuberculosis; drug resistance; efflux pump
no
6
info:eu-repo/semantics/article
262
Pasca, MARIA ROSALIA; Guglierame, Paola; Arcesi, Fabio; Bellinzoni, Marco; DE ROSSI, Edda; Riccardi, Giovanna
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/132884
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