Introduction:Small bowel adenocarcinoma (SBA) and T-cell lymphoma (TCL) are rare but aggressive malignancies associated with celiac disease (CD).Methods:We retrospectively compared 43 CD-associated SBA and 43 CD-associated TCL across international referral centers.Results:CD-associated SBA showed a significantly (p<0.01) better survival than CD-associated TCL. TCL more frequently presented with multifocal involvement and advanced stage, whereas SBA predominantly involved the jejunum. Refractoriness to a gluten-free diet was identified in 70% of TCL, but only in one SBA.Discussion:Our findings demonstrated a worse prognosis of CD-associated TCL in comparison to CD-associated SBA.
Different Survival Outcomes of Small Bowel Adenocarcinomas and T-Cell Lymphomas Associated With Celiac Disease
Santacroce, Giovanni;Vanoli, Alessandro;Aronico, Nicola;Bianchi, Paola Ilaria;Lenti, Marco Vincenzo;Corazza, Gino Roberto;Lucioni, Marco;Paulli, Marco;Di Sabatino, Antonio
2025-01-01
Abstract
Introduction:Small bowel adenocarcinoma (SBA) and T-cell lymphoma (TCL) are rare but aggressive malignancies associated with celiac disease (CD).Methods:We retrospectively compared 43 CD-associated SBA and 43 CD-associated TCL across international referral centers.Results:CD-associated SBA showed a significantly (p<0.01) better survival than CD-associated TCL. TCL more frequently presented with multifocal involvement and advanced stage, whereas SBA predominantly involved the jejunum. Refractoriness to a gluten-free diet was identified in 70% of TCL, but only in one SBA.Discussion:Our findings demonstrated a worse prognosis of CD-associated TCL in comparison to CD-associated SBA.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
