This study reports for the first time a preliminary phytochemical and biological screening of ethanolic extract (EE) from roots of Eremurus persicus (J.&S) Boiss, a Kurdish herbal remedy for treating inflammatory disorders. The phytochemical analysis was performed by thin layer chromatography and revealed the presence of flavonoids and antracenones. The total phenolic compounds were also determined. The free radical scavenging (FRS) effect was evaluated by DPPH (2, 2-diphenyl-1-picrylhydrazyl) assay and the anti-inflammatory activity investigated by evaluating the inhibition of in vitro lymphocyte proliferation. To exclude citotoxic effect of EE, cell viability tests were also performed. Overall, biological investigation showed that the Eremurus persicus (J. and S.) Boiss root ethanolic extract possess an interesting anti-inflammatory activity without cytotoxic effects.

Anti-inflammatory properties of ethanolic root extract of Eremurus persicus (Jaub and Spach) Boiss, a Kurdish herbal remedy

GAGGERI, RAFFAELLA FRANCESCA;ROSSI, DANIELA;AZZOLINA, ORNELLA;GOZZINI, DAVIDE;PAOLILLO, MAYRA;COLLINA, SIMONA
2013

Abstract

This study reports for the first time a preliminary phytochemical and biological screening of ethanolic extract (EE) from roots of Eremurus persicus (J.&S) Boiss, a Kurdish herbal remedy for treating inflammatory disorders. The phytochemical analysis was performed by thin layer chromatography and revealed the presence of flavonoids and antracenones. The total phenolic compounds were also determined. The free radical scavenging (FRS) effect was evaluated by DPPH (2, 2-diphenyl-1-picrylhydrazyl) assay and the anti-inflammatory activity investigated by evaluating the inhibition of in vitro lymphocyte proliferation. To exclude citotoxic effect of EE, cell viability tests were also performed. Overall, biological investigation showed that the Eremurus persicus (J. and S.) Boiss root ethanolic extract possess an interesting anti-inflammatory activity without cytotoxic effects.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/691626
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