Abstract— Mesenchymal stem cells (MSC) are self-renewing, multipotent cells that are present in many adult tissues, adipose, bone marrow, trabecular bone and muscle. Dermal skin-derived fibroblasts exhibit mesenchymal surface antigen immunophenotype and differentiation along the three main mesenchymal tissue (bone, fat and cartilage). We isolated human dermal fibroblasts from 4 patients with Hereditary Hemorrhagic Telangiectasia (HHT) and from 2 healthy controls. The aim of this work was to evaluate the mesenchymal property of HHT cells in comparison with the control cells. HHT cells possesses the same surface markers expression of mesenchymal stem cells, they are highly clonogenic, showing a high proliferation potential and an enhanced capacity of self renewal
Enhanced stem cells characteristic of fibroblastic mesenchymal cells from HHT patients
SILVANI, GIULIA;BENEDETTI, LAURA;CROSETTO, NICOLA;OLIVIERI, CARLA;GALLI, DANIELA;MAGNANI, BRUNO;MAGENES, GIOVANNI;CUSELLA DE ANGELIS, MARIA GABRIELLA
2010-01-01
Abstract
Abstract— Mesenchymal stem cells (MSC) are self-renewing, multipotent cells that are present in many adult tissues, adipose, bone marrow, trabecular bone and muscle. Dermal skin-derived fibroblasts exhibit mesenchymal surface antigen immunophenotype and differentiation along the three main mesenchymal tissue (bone, fat and cartilage). We isolated human dermal fibroblasts from 4 patients with Hereditary Hemorrhagic Telangiectasia (HHT) and from 2 healthy controls. The aim of this work was to evaluate the mesenchymal property of HHT cells in comparison with the control cells. HHT cells possesses the same surface markers expression of mesenchymal stem cells, they are highly clonogenic, showing a high proliferation potential and an enhanced capacity of self renewalI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
