IRIS
MANGIONE, PALMA
 Distribuzione geografica
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Continente #
NA - Nord America 2.147
EU - Europa 1.672
AS - Asia 1.357
SA - Sud America 127
AF - Africa 7
OC - Oceania 4
Continente sconosciuto - Info sul continente non disponibili 1
Totale 5.315
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Nazione #
US - Stati Uniti d'America 2.120
CN - Cina 893
IE - Irlanda 482
HK - Hong Kong 242
RU - Federazione Russa 231
FI - Finlandia 228
IT - Italia 179
UA - Ucraina 173
SG - Singapore 169
DE - Germania 125
BR - Brasile 113
SE - Svezia 88
GB - Regno Unito 73
FR - Francia 29
BE - Belgio 17
CA - Canada 17
IN - India 10
TR - Turchia 9
CZ - Repubblica Ceca 8
PL - Polonia 8
VN - Vietnam 8
NL - Olanda 7
EC - Ecuador 4
JP - Giappone 4
MX - Messico 4
PE - Perù 4
AE - Emirati Arabi Uniti 3
AR - Argentina 3
AT - Austria 3
AZ - Azerbaigian 3
CH - Svizzera 3
JM - Giamaica 3
LV - Lettonia 3
NO - Norvegia 3
PT - Portogallo 3
AU - Australia 2
HR - Croazia 2
IQ - Iraq 2
KE - Kenya 2
LA - Repubblica Popolare Democratica del Laos 2
LT - Lituania 2
MA - Marocco 2
NZ - Nuova Zelanda 2
RO - Romania 2
BD - Bangladesh 1
BO - Bolivia 1
CL - Cile 1
CO - Colombia 1
CR - Costa Rica 1
CY - Cipro 1
DK - Danimarca 1
DO - Repubblica Dominicana 1
EG - Egitto 1
EU - Europa 1
GR - Grecia 1
GT - Guatemala 1
HU - Ungheria 1
IR - Iran 1
JO - Giordania 1
KG - Kirghizistan 1
KZ - Kazakistan 1
LK - Sri Lanka 1
MU - Mauritius 1
NP - Nepal 1
PH - Filippine 1
PK - Pakistan 1
TJ - Tagikistan 1
UZ - Uzbekistan 1
ZA - Sudafrica 1
Totale 5.315
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Città #
Chandler 484
Dublin 482
Hong Kong 241
Nanjing 230
Jacksonville 228
Beijing 154
Ashburn 136
Boardman 122
Nanchang 96
Singapore 89
Helsinki 88
Princeton 87
Wilmington 79
Lawrence 78
Ann Arbor 76
Changsha 70
Hebei 68
Shenyang 65
Medford 60
Jiaxing 45
Moscow 43
Milan 38
Hangzhou 36
Shanghai 36
Tianjin 35
Woodbridge 32
New York 30
Pavia 30
Los Angeles 27
The Dalles 24
Turku 19
Brussels 17
Falls Church 15
Munich 14
Norwalk 12
Piscataway 12
Toronto 12
Chicago 10
London 10
São Paulo 10
Auburn Hills 9
Fairfield 9
Verona 9
Dallas 7
Houston 7
Washington 7
Belo Horizonte 6
Jinan 6
San Francisco 6
Florence 5
Fuzhou 5
Ankara 4
Borås 4
Charlotte 4
Formia 4
Nuremberg 4
Padova 4
Rio de Janeiro 4
Saint Albans 4
Santa Clara 4
Baku 3
Catania 3
Falkenstein 3
Haiphong 3
Hefei 3
Hyderabad 3
Kingston 3
Montreal 3
Ningbo 3
Olomouc 3
Orange 3
Oslo 3
Phoenix 3
Quito 3
Redwood City 3
Rubano 3
Seattle 3
Tokyo 3
Warsaw 3
Zhengzhou 3
Auckland 2
Augusta 2
Berlin 2
Birmingham 2
Brescia 2
Brno 2
Castino 2
Council Bluffs 2
Dearborn 2
Deiva Marina 2
Des Moines 2
Feldthurns 2
Genova 2
Groningen 2
Guangzhou 2
Ho Chi Minh City 2
Istanbul 2
Kamien 2
Lima 2
Lima region 2
Totale 3.652
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Nome #
L'ipotesi della cascata amiloide nella malattia di Alzheimer: studi su strategie di neuroprotezione. 166
Hepatitis C virus-associated cryoglobulinaemicglomerulonephritis with delayed appearance of monoclonal cryoglobulinaemia. 112
A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo 111
C. elegans expressing human beta2-microglobulin: a novel model for studying the relationship between the molecular assembly and the toxic phenotype. 110
Biological activity and pathological implications of misfolded proteins. 101
Affinity capillary electrophoresis is a powerful tool to identify transthyretin binding drugs for potential therapeutic use in amyloidosis 97
The H50Q mutation induces a tenfold decrease in the solubility of α-synuclein. 96
Capillary electrophoresis analysis of different variants of the amyloidogenic protein β2 -microglobulin as a simple tool for misfolding and stability studies 92
Beta 2- microglobulin can be refolded into a native state from ex vivo amyloid fibrils 91
Class I Major Histocompatibility Complex, the Trojan horse for secretion of amyloidogenic β2-microglobulin. 90
Antibodies to human serum amyloid P component eliminate visceral amyloid deposits. 89
Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis. 85
Capillary electrophoresis investigation of a partially unfolded conformation of Beta 2-microglobulin. 85
Sulfonated molecules that bind a partially structured species of beta2-microglobulin also influence refolding and fibrillogenesis. 85
“Separation and quantification of two beta2-microglobulin isoforms”. 84
Amyloid fibrils derived from the apolipoprotein A1 Leu174Ser variant contain elements of ordered helical structure. 84
Beta2-microglobulin isoforms display an heterogeneous affinity for type I collagen. 83
Effects of the Known Pathogenic Mutations on the Aggregation Pathway of the Amyloidogenic Peptide of Apolipoprotein A-I. 81
beta 2-microglobulin H31Y variant 3D-structure highlights the protein natural propensity towards intermolecular aggregation 78
Effect of tetracyclines on the dynamics of formation and destructuration of {beta}2-microglobulin amyloid fibrils. 78
A partially structured species of beta 2-microglobulin is significantly populated under physiological conditions and involved in fibrillogenesis 77
Co-fibrillogenesis of Wild-type and D76N β2-Microglobulin: THE CRUCIAL ROLE OF FIBRILLAR SEEDS 76
Use of anti-(beta2 microglobulin) mAb to study formation of amyloid fibrils 75
Structural basis of ligand specificity in the human pentraxins, C-reactive protein and serum amyloid P component. 75
Benefit of doxycycline treatment on articular disability caused by dialysis related amyloidosis 75
Detection of two partially structured species in the folding process of the amyloidogenic protein beta 2-microglobulin 74
Metodo per la separazione e la quantificazione di due conformazioni di beta-2-microglobulina in equilibrio dinamico 74
Citrate-stabilized gold nanoparticles hinder fibrillogenesis of a pathological variant of β2-microglobulin 74
Cinetiche di refolding e studi di affinità mediante elettroforesi capillare: effetto di ligandi di interesse farmaceutico sulla conformazione della Beta 2-microglobulina 73
Proteomics of beta2-microglobulin amyloid fibrils. 72
Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component 71
Enhanced toxicity of silver nanoparticles in transgenic Caenorhabditis elegans expressing amyloidogenic proteins 70
The two tryptophans of β2-microglobulin have distinct roles in function and folding and might represent two independent responses to evolutionary pressure. 69
Conformational dynamics of the beta2-microglobulin C terminal in the cell-membrane-anchored major histocompatibility complex type I 69
Topological investigation of amyloid fibrils obtained from beta2-microglobulin 67
Solution structure of beta(2)-microglobulin and insights into fibrillogenesis 67
Bifunctional crosslinking ligands for transthyretin 67
Amyloid persistence in decellularized liver: Biochemical and histopathological characterization 67
Plasminogen activation triggers transthyretin amyloidogenesis in vitro 66
Preliminary crystallographic characterization of the human beta2 microglobulin His31Tyr mutant in a tetrameric assembly. 65
A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis 65
C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis 65
Inhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel. 63
Structural and folding dynamics properties of T70N variant of human lysozyme. 63
Removal of the N-terminal hexapeptide from human beta2-microglobulin facilitates protein aggregation and fibril formation 62
D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile 60
Production and immunicytochemical characterization of monoclonal antibodies to SA gene product 59
Hereditary systemic amyloidosis due to Asp76Asn variant β2-microglobulin. 59
The new apolipoprotein A-I variant leu(174) --> Ser causes hereditary cardiac amyloidosis, and the amyloid fibrils are constituted by the 93-residue N-terminal polypeptide 58
Isolation and characterization of pharmaceutical grade human pentraxins, serum amyloid P component and C-reactive protein, for clinical use. 57
Misidentification of transthyretin and immunoglobulin variants by proteomics due to methyl lysine formation in formalin-fixed paraffin-embedded amyloid tissue 57
Structure, folding dynamics and amyloidogenesis of Asp76Asn β2-microglobulin: roles of shear flow, hydrophobic surfaces and α crystallin. 57
Comparative study of the stabilities of synthetic in vitro and natural ex vivo transthyretin amyloid fibrils 56
DETECTION OF FRAGMENTS OF BETA2-MICROGLOBULIN IN AMYLOID FIBRILS 56
Recombinant amyloidogenic domain of ApoA-I: analysis of its fibrillogenic potential 54
Binding of Monovalent and Bivalent Ligands by Transthyretin Causes Different Short- And Long-Distance Conformational Changes 53
Proteomic Analysis for the Diagnosis of Fibrinogen Aα-chain Amyloidosis 53
Trapping of palindromic ligands within native transthyretin prevents amyloid formation. 51
Structural and functional characterization of three human immunoglobulin kappa light chains with different pathological implications. 50
Properties of some variants of human beta 2- microglobulin and amyloidogenesis. 50
Increasing the accuracy of proteomic typing by decellularisation of amyloid tissue biopsies 50
Micro-heterogeneity and aggregation in beta2-microglobulin solutions: effects of temperature, pH, and conformational variant addition. 49
Multifaceted anti-amyloidogenic and pro-amyloidogenic effects of C-reactive protein and serum amyloid P component in vitro 49
The solution structure of human ß2-microglobulin reveals the prodromes of its amyloid transition 49
Diagnostic amyloid proteomics: Experience of the UK National Amyloidosis Centre 47
Conformational switching and fibrillogenesis in the amyloidogenic fragment of apolipoprotein A-I. 46
Clinical ApoA-IV amyloid is associated with fibrillogenic signal sequence 46
Amyloid Formation by Globular Proteins: The Need to Narrow the Gap Between in Vitro and in Vivo Mechanisms 46
Distribution and determinants of circulating complement factor H concentration determined by a high-throughput immunonephelometric assay 45
Monitoring the interaction between β2-microglobulin and the molecular chaperone αB-crystallin by NMR and mass spectrometry: αB-crystallin dissociates β2-microglobulin oligomers. 44
Lysozyme amyloid: evidence for the W64R variant by proteomics in the absence of the wild type protein 44
Immunoglobulin light chain amyloidosis--the archetype of structural and pathogenic variability. 44
The intracellular quality control system down-regulates the secretion of amyloidogenic apolipoprotein A-I variants: A possible impact on the natural history of the disease 43
The complementary role of histology and proteomics for diagnosis and typing of systemic amyloidosis 41
Effects of a vitamin E-modified dialyzer (Excebrane) on beta-2-microglobulin structure and removal. 40
Evidence that amyloidogenic light chains undergo antigen-driven selection 40
Complement factor H binds to denatured rather than to native pentameric C-reactive protein. 39
Human wild-type and D76N β2-microglobulin variants are significant proteotoxic and metabolic stressors for transgenic C. elegans 37
Decoding the structural bases of D76N β2-microglobulin high amyloidogenicity through crystallography and asn-scan mutagenesis 31
null 30
Degradation versus fibrillogenesis, two alternative pathways modulated by seeds and glycosaminoglycans 29
Truncation of the constant domain drives amyloid formation by immunoglobulin light chains 29
Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis 26
Pathogenetic mechanisms of amyloid A amyloidosis. 24
Calcium Binds to Transthyretin with Low Affinity 23
Design and Mechanistic Analysis of a Potent Bivalent Inhibitor of Transthyretin Amyloid Fibrillogenesis 6
Totale 5.466
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Categoria #
all - tutte 24.179
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 24.179
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/202013 0 0 0 0 0 0 0 0 0 0 0 13
2020/2021383 68 33 11 34 8 45 5 56 22 49 42 10
2021/2022355 5 3 8 6 11 23 7 23 24 15 47 183
2022/20231.348 158 128 14 93 134 132 0 73 561 6 28 21
2023/2024455 76 89 15 19 41 106 8 24 2 20 36 19
2024/20251.323 44 96 34 42 23 54 53 97 379 50 185 266
Totale 5.466