IRIS
MANGIONE, PALMA
 Distribuzione geografica
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Continente #
NA - Nord America 2.952
AS - Asia 2.039
EU - Europa 1.890
SA - Sud America 233
AF - Africa 22
OC - Oceania 7
Continente sconosciuto - Info sul continente non disponibili 1
Totale 7.144
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Nazione #
US - Stati Uniti d'America 2.880
CN - Cina 1.134
IE - Irlanda 483
SG - Singapore 434
HK - Hong Kong 262
FI - Finlandia 242
RU - Federazione Russa 233
IT - Italia 202
BR - Brasile 190
DE - Germania 185
UA - Ucraina 175
GB - Regno Unito 107
SE - Svezia 99
VN - Vietnam 82
FR - Francia 55
CA - Canada 38
IN - India 32
PL - Polonia 29
MX - Messico 23
BE - Belgio 18
TR - Turchia 17
ES - Italia 14
BD - Bangladesh 13
JP - Giappone 12
AR - Argentina 11
EC - Ecuador 11
IQ - Iraq 11
CO - Colombia 8
CZ - Repubblica Ceca 8
NL - Olanda 8
ZA - Sudafrica 7
ID - Indonesia 5
JM - Giamaica 5
KE - Kenya 5
LT - Lituania 5
PE - Perù 5
AT - Austria 4
CH - Svizzera 4
MA - Marocco 4
UZ - Uzbekistan 4
AE - Emirati Arabi Uniti 3
AU - Australia 3
AZ - Azerbaigian 3
CR - Costa Rica 3
LV - Lettonia 3
NO - Norvegia 3
NZ - Nuova Zelanda 3
PK - Pakistan 3
PT - Portogallo 3
PY - Paraguay 3
RO - Romania 3
BO - Bolivia 2
CL - Cile 2
EG - Egitto 2
HR - Croazia 2
IR - Iran 2
JO - Giordania 2
KG - Kirghizistan 2
LA - Repubblica Popolare Democratica del Laos 2
MK - Macedonia 2
OM - Oman 2
TH - Thailandia 2
AF - Afghanistan, Repubblica islamica di 1
AM - Armenia 1
BB - Barbados 1
CY - Cipro 1
DK - Danimarca 1
DO - Repubblica Dominicana 1
EU - Europa 1
GR - Grecia 1
GT - Guatemala 1
HU - Ungheria 1
IL - Israele 1
KR - Corea 1
KZ - Kazakistan 1
LK - Sri Lanka 1
ML - Mali 1
MN - Mongolia 1
MU - Mauritius 1
NG - Nigeria 1
NP - Nepal 1
PH - Filippine 1
SA - Arabia Saudita 1
TJ - Tagikistan 1
TN - Tunisia 1
TO - Tonga 1
VE - Venezuela 1
Totale 7.144
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Città #
Chandler 484
Dublin 482
Dallas 265
Hong Kong 261
Ashburn 254
Beijing 254
Nanjing 230
Jacksonville 228
Singapore 219
Boardman 123
Nanchang 96
Helsinki 90
Princeton 87
Los Angeles 79
Wilmington 79
Lawrence 78
Ann Arbor 76
Changsha 71
Hebei 68
Shenyang 65
Medford 60
Munich 59
New York 58
Jiaxing 45
Milan 43
Moscow 43
Shanghai 40
Tianjin 39
Hangzhou 37
Buffalo 34
Woodbridge 32
Redondo Beach 31
Turku 31
Pavia 30
Ho Chi Minh City 29
The Dalles 24
São Paulo 22
Hanoi 19
Warsaw 19
Toronto 18
Brussels 17
Chicago 17
Orem 17
Montreal 16
Falls Church 15
Houston 14
Frankfurt am Main 13
London 13
Santa Clara 13
Stockholm 13
Ankara 12
Norwalk 12
Piscataway 12
Atlanta 11
Chennai 11
Denver 11
Phoenix 11
Tokyo 11
Auburn Hills 9
Brooklyn 9
Fairfield 9
Mexico City 9
Verona 9
Belo Horizonte 8
Jinan 8
Poplar 8
Rio de Janeiro 8
Washington 8
Boston 7
Charlotte 7
San Francisco 7
San Jose 7
Sassari 7
Nuremberg 6
Seattle 6
Florence 5
Fuzhou 5
Guangzhou 5
Haiphong 5
Hefei 5
Johannesburg 5
Manchester 5
Mumbai 5
Nairobi 5
Rome 5
Shijiazhuang 5
Baghdad 4
Bogotá 4
Borås 4
Carney 4
Formia 4
Guayaquil 4
Kingston 4
Ningbo 4
Padova 4
Quito 4
Recife 4
Saint Albans 4
Tashkent 4
Asunción 3
Totale 4.783
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Nome #
L'ipotesi della cascata amiloide nella malattia di Alzheimer: studi su strategie di neuroprotezione. 184
A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo 156
C. elegans expressing human beta2-microglobulin: a novel model for studying the relationship between the molecular assembly and the toxic phenotype. 143
Affinity capillary electrophoresis is a powerful tool to identify transthyretin binding drugs for potential therapeutic use in amyloidosis 143
Hepatitis C virus-associated cryoglobulinaemicglomerulonephritis with delayed appearance of monoclonal cryoglobulinaemia. 132
Biological activity and pathological implications of misfolded proteins. 126
Capillary electrophoresis analysis of different variants of the amyloidogenic protein β2 -microglobulin as a simple tool for misfolding and stability studies 122
The H50Q mutation induces a tenfold decrease in the solubility of α-synuclein. 121
Class I Major Histocompatibility Complex, the Trojan horse for secretion of amyloidogenic β2-microglobulin. 118
Antibodies to human serum amyloid P component eliminate visceral amyloid deposits. 117
Benefit of doxycycline treatment on articular disability caused by dialysis related amyloidosis 113
Amyloid fibrils derived from the apolipoprotein A1 Leu174Ser variant contain elements of ordered helical structure. 113
Beta 2- microglobulin can be refolded into a native state from ex vivo amyloid fibrils 109
Beta2-microglobulin isoforms display an heterogeneous affinity for type I collagen. 109
Co-fibrillogenesis of Wild-type and D76N β2-Microglobulin: THE CRUCIAL ROLE OF FIBRILLAR SEEDS 108
A partially structured species of beta 2-microglobulin is significantly populated under physiological conditions and involved in fibrillogenesis 107
beta 2-microglobulin H31Y variant 3D-structure highlights the protein natural propensity towards intermolecular aggregation 106
Capillary electrophoresis investigation of a partially unfolded conformation of Beta 2-microglobulin. 106
“Separation and quantification of two beta2-microglobulin isoforms”. 105
Sulfonated molecules that bind a partially structured species of beta2-microglobulin also influence refolding and fibrillogenesis. 105
Amyloid persistence in decellularized liver: Biochemical and histopathological characterization 102
Effects of the Known Pathogenic Mutations on the Aggregation Pathway of the Amyloidogenic Peptide of Apolipoprotein A-I. 101
Use of anti-(beta2 microglobulin) mAb to study formation of amyloid fibrils 100
Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis. 100
Enhanced toxicity of silver nanoparticles in transgenic Caenorhabditis elegans expressing amyloidogenic proteins 100
Effect of tetracyclines on the dynamics of formation and destructuration of {beta}2-microglobulin amyloid fibrils. 100
Metodo per la separazione e la quantificazione di due conformazioni di beta-2-microglobulina in equilibrio dinamico 99
The two tryptophans of β2-microglobulin have distinct roles in function and folding and might represent two independent responses to evolutionary pressure. 95
Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component 95
Amyloid Formation by Globular Proteins: The Need to Narrow the Gap Between in Vitro and in Vivo Mechanisms 94
A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis 92
Plasminogen activation triggers transthyretin amyloidogenesis in vitro 92
C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis 91
Inhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel. 90
Conformational dynamics of the beta2-microglobulin C terminal in the cell-membrane-anchored major histocompatibility complex type I 90
Citrate-stabilized gold nanoparticles hinder fibrillogenesis of a pathological variant of β2-microglobulin 89
Proteomics of beta2-microglobulin amyloid fibrils. 88
Detection of two partially structured species in the folding process of the amyloidogenic protein beta 2-microglobulin 87
Cinetiche di refolding e studi di affinità mediante elettroforesi capillare: effetto di ligandi di interesse farmaceutico sulla conformazione della Beta 2-microglobulina 87
Comparative study of the stabilities of synthetic in vitro and natural ex vivo transthyretin amyloid fibrils 85
Structural basis of ligand specificity in the human pentraxins, C-reactive protein and serum amyloid P component. 84
Removal of the N-terminal hexapeptide from human beta2-microglobulin facilitates protein aggregation and fibril formation 84
DETECTION OF FRAGMENTS OF BETA2-MICROGLOBULIN IN AMYLOID FIBRILS 82
Bifunctional crosslinking ligands for transthyretin 81
Hereditary systemic amyloidosis due to Asp76Asn variant β2-microglobulin. 81
D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile 81
Binding of Monovalent and Bivalent Ligands by Transthyretin Causes Different Short- And Long-Distance Conformational Changes 81
Topological investigation of amyloid fibrils obtained from beta2-microglobulin 79
Structural and folding dynamics properties of T70N variant of human lysozyme. 79
Preliminary crystallographic characterization of the human beta2 microglobulin His31Tyr mutant in a tetrameric assembly. 78
Misidentification of transthyretin and immunoglobulin variants by proteomics due to methyl lysine formation in formalin-fixed paraffin-embedded amyloid tissue 77
Solution structure of beta(2)-microglobulin and insights into fibrillogenesis 76
Multifaceted anti-amyloidogenic and pro-amyloidogenic effects of C-reactive protein and serum amyloid P component in vitro 75
Isolation and characterization of pharmaceutical grade human pentraxins, serum amyloid P component and C-reactive protein, for clinical use. 73
Clinical ApoA-IV amyloid is associated with fibrillogenic signal sequence 73
Structure, folding dynamics and amyloidogenesis of Asp76Asn β2-microglobulin: roles of shear flow, hydrophobic surfaces and α crystallin. 71
Production and immunicytochemical characterization of monoclonal antibodies to SA gene product 70
The new apolipoprotein A-I variant leu(174) --> Ser causes hereditary cardiac amyloidosis, and the amyloid fibrils are constituted by the 93-residue N-terminal polypeptide 70
Structural and functional characterization of three human immunoglobulin kappa light chains with different pathological implications. 69
Proteomic Analysis for the Diagnosis of Fibrinogen Aα-chain Amyloidosis 69
Diagnostic amyloid proteomics: Experience of the UK National Amyloidosis Centre 69
Increasing the accuracy of proteomic typing by decellularisation of amyloid tissue biopsies 69
Recombinant amyloidogenic domain of ApoA-I: analysis of its fibrillogenic potential 67
Human wild-type and D76N β2-microglobulin variants are significant proteotoxic and metabolic stressors for transgenic C. elegans 64
The solution structure of human ß2-microglobulin reveals the prodromes of its amyloid transition 64
The complementary role of histology and proteomics for diagnosis and typing of systemic amyloidosis 64
Properties of some variants of human beta 2- microglobulin and amyloidogenesis. 63
Trapping of palindromic ligands within native transthyretin prevents amyloid formation. 63
Lysozyme amyloid: evidence for the W64R variant by proteomics in the absence of the wild type protein 61
Degradation versus fibrillogenesis, two alternative pathways modulated by seeds and glycosaminoglycans 59
Micro-heterogeneity and aggregation in beta2-microglobulin solutions: effects of temperature, pH, and conformational variant addition. 58
Calcium Binds to Transthyretin with Low Affinity 57
Distribution and determinants of circulating complement factor H concentration determined by a high-throughput immunonephelometric assay 56
Effects of a vitamin E-modified dialyzer (Excebrane) on beta-2-microglobulin structure and removal. 56
Monitoring the interaction between β2-microglobulin and the molecular chaperone αB-crystallin by NMR and mass spectrometry: αB-crystallin dissociates β2-microglobulin oligomers. 56
Immunoglobulin light chain amyloidosis--the archetype of structural and pathogenic variability. 56
Conformational switching and fibrillogenesis in the amyloidogenic fragment of apolipoprotein A-I. 54
The intracellular quality control system down-regulates the secretion of amyloidogenic apolipoprotein A-I variants: A possible impact on the natural history of the disease 53
Complement factor H binds to denatured rather than to native pentameric C-reactive protein. 52
Evidence that amyloidogenic light chains undergo antigen-driven selection 50
Design and Mechanistic Analysis of a Potent Bivalent Inhibitor of Transthyretin Amyloid Fibrillogenesis 48
Truncation of the constant domain drives amyloid formation by immunoglobulin light chains 48
Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis 43
Pathogenetic mechanisms of amyloid A amyloidosis. 41
Decoding the structural bases of D76N β2-microglobulin high amyloidogenicity through crystallography and asn-scan mutagenesis 41
null 30
Totale 7.295
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Categoria #
all - tutte 31.630
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 31.630
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021229 0 0 0 0 0 45 5 56 22 49 42 10
2021/2022355 5 3 8 6 11 23 7 23 24 15 47 183
2022/20231.348 158 128 14 93 134 132 0 73 561 6 28 21
2023/2024455 76 89 15 19 41 106 8 24 2 20 36 19
2024/20251.371 44 96 34 42 23 54 53 97 379 50 185 314
2025/20261.781 252 238 364 392 403 132 0 0 0 0 0 0
Totale 7.295