IRIS
MANGIONE, PALMA
 Distribuzione geografica
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Continente #
NA - Nord America 3.834
AS - Asia 2.507
EU - Europa 2.099
SA - Sud America 313
Continente sconosciuto - Info sul continente non disponibili 153
AF - Africa 77
OC - Oceania 9
Totale 8.992
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Nazione #
US - Stati Uniti d'America 3.739
CN - Cina 1.185
SG - Singapore 563
IE - Irlanda 484
HK - Hong Kong 302
IT - Italia 258
FI - Finlandia 244
RU - Federazione Russa 238
BR - Brasile 236
VN - Vietnam 198
DE - Germania 192
UA - Ucraina 179
FR - Francia 143
GB - Regno Unito 124
SE - Svezia 99
IN - India 67
CA - Canada 47
ZA - Sudafrica 40
BD - Bangladesh 32
PL - Polonia 32
MX - Messico 29
TR - Turchia 23
IQ - Iraq 21
AR - Argentina 19
BE - Belgio 19
ES - Italia 19
NL - Olanda 18
JP - Giappone 17
ID - Indonesia 16
CO - Colombia 14
EC - Ecuador 12
KE - Kenya 10
CZ - Repubblica Ceca 9
MA - Marocco 9
PH - Filippine 9
PK - Pakistan 9
UZ - Uzbekistan 9
CL - Cile 7
JM - Giamaica 7
PE - Perù 7
CR - Costa Rica 6
JO - Giordania 6
VE - Venezuela 6
AE - Emirati Arabi Uniti 5
AU - Australia 5
BO - Bolivia 5
CH - Svizzera 5
LT - Lituania 5
PY - Paraguay 5
AT - Austria 4
AZ - Azerbaigian 4
EG - Egitto 4
OM - Oman 4
TH - Thailandia 4
DK - Danimarca 3
HR - Croazia 3
KG - Kirghizistan 3
LV - Lettonia 3
MY - Malesia 3
NO - Norvegia 3
NZ - Nuova Zelanda 3
PT - Portogallo 3
RO - Romania 3
SA - Arabia Saudita 3
TN - Tunisia 3
BH - Bahrain 2
ET - Etiopia 2
GR - Grecia 2
HU - Ungheria 2
IL - Israele 2
IR - Iran 2
KZ - Kazakistan 2
LA - Repubblica Popolare Democratica del Laos 2
LY - Libia 2
MK - Macedonia 2
MN - Mongolia 2
PS - Palestinian Territory 2
SN - Senegal 2
SY - Repubblica araba siriana 2
AF - Afghanistan, Repubblica islamica di 1
AL - Albania 1
AM - Armenia 1
AO - Angola 1
BB - Barbados 1
CY - Cipro 1
DO - Repubblica Dominicana 1
EE - Estonia 1
EU - Europa 1
GN - Guinea 1
GT - Guatemala 1
HN - Honduras 1
KR - Corea 1
LB - Libano 1
LK - Sri Lanka 1
ML - Mali 1
MU - Mauritius 1
NG - Nigeria 1
NI - Nicaragua 1
NP - Nepal 1
RS - Serbia 1
Totale 8.835
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Città #
Chandler 484
Dublin 483
San Jose 399
Ashburn 363
Singapore 298
Hong Kong 292
Dallas 274
Beijing 263
Jacksonville 230
Nanjing 230
Boardman 127
Nanchang 96
Helsinki 92
Los Angeles 90
Princeton 87
Council Bluffs 84
Wilmington 79
Lawrence 78
Lauterbourg 77
Ann Arbor 76
Changsha 71
Hebei 68
New York 68
Shenyang 65
Hanoi 60
Medford 60
Munich 59
Ho Chi Minh City 58
Milan 48
Jiaxing 45
Moscow 43
Shanghai 40
Tianjin 39
Hangzhou 37
Buffalo 35
Orem 33
Johannesburg 32
São Paulo 32
Woodbridge 32
Redondo Beach 31
Turku 31
Pavia 30
The Dalles 26
Santa Clara 24
Chennai 22
Montreal 21
Warsaw 21
Chicago 20
Frankfurt am Main 20
Toronto 20
Brussels 18
Atlanta 17
London 17
Houston 16
Tokyo 16
Falls Church 15
Piscataway 14
Brooklyn 13
Stockholm 13
Ankara 12
Denver 12
Mexico City 12
Norwalk 12
Phoenix 12
Da Nang 11
Haiphong 11
Manchester 11
Amsterdam 10
San Francisco 10
Washington 10
Auburn Hills 9
Belo Horizonte 9
Fairfield 9
Nairobi 9
Poplar 9
Rio de Janeiro 9
Verona 9
Baghdad 8
Florence 8
Jinan 8
Mumbai 8
Tashkent 8
Boston 7
Charlotte 7
Naples 7
Rome 7
Sassari 7
Amman 6
Biên Hòa 6
Bogotá 6
Catania 6
Columbus 6
Jakarta 6
Kingston 6
Nuremberg 6
Seattle 6
Fuzhou 5
Guangzhou 5
Hefei 5
Istanbul 5
Totale 5.867
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Nome #
A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis 207
L'ipotesi della cascata amiloide nella malattia di Alzheimer: studi su strategie di neuroprotezione. 202
A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo 179
C. elegans expressing human beta2-microglobulin: a novel model for studying the relationship between the molecular assembly and the toxic phenotype. 173
Affinity capillary electrophoresis is a powerful tool to identify transthyretin binding drugs for potential therapeutic use in amyloidosis 162
Biological activity and pathological implications of misfolded proteins. 152
Hepatitis C virus-associated cryoglobulinaemicglomerulonephritis with delayed appearance of monoclonal cryoglobulinaemia. 151
Antibodies to human serum amyloid P component eliminate visceral amyloid deposits. 144
Beta 2- microglobulin can be refolded into a native state from ex vivo amyloid fibrils 141
Class I Major Histocompatibility Complex, the Trojan horse for secretion of amyloidogenic β2-microglobulin. 140
The H50Q mutation induces a tenfold decrease in the solubility of α-synuclein. 139
Amyloid fibrils derived from the apolipoprotein A1 Leu174Ser variant contain elements of ordered helical structure. 139
Capillary electrophoresis analysis of different variants of the amyloidogenic protein β2 -microglobulin as a simple tool for misfolding and stability studies 138
Benefit of doxycycline treatment on articular disability caused by dialysis related amyloidosis 133
Beta2-microglobulin isoforms display an heterogeneous affinity for type I collagen. 131
Sulfonated molecules that bind a partially structured species of beta2-microglobulin also influence refolding and fibrillogenesis. 130
A partially structured species of beta 2-microglobulin is significantly populated under physiological conditions and involved in fibrillogenesis 127
Co-fibrillogenesis of Wild-type and D76N β2-Microglobulin: THE CRUCIAL ROLE OF FIBRILLAR SEEDS 126
beta 2-microglobulin H31Y variant 3D-structure highlights the protein natural propensity towards intermolecular aggregation 124
Capillary electrophoresis investigation of a partially unfolded conformation of Beta 2-microglobulin. 124
“Separation and quantification of two beta2-microglobulin isoforms”. 122
Metodo per la separazione e la quantificazione di due conformazioni di beta-2-microglobulina in equilibrio dinamico 120
Amyloid persistence in decellularized liver: Biochemical and histopathological characterization 120
C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis 120
Effect of tetracyclines on the dynamics of formation and destructuration of {beta}2-microglobulin amyloid fibrils. 119
Plasminogen activation triggers transthyretin amyloidogenesis in vitro 119
Use of anti-(beta2 microglobulin) mAb to study formation of amyloid fibrils 117
Enhanced toxicity of silver nanoparticles in transgenic Caenorhabditis elegans expressing amyloidogenic proteins 117
Effects of the Known Pathogenic Mutations on the Aggregation Pathway of the Amyloidogenic Peptide of Apolipoprotein A-I. 117
The two tryptophans of β2-microglobulin have distinct roles in function and folding and might represent two independent responses to evolutionary pressure. 116
Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis. 115
Amyloid Formation by Globular Proteins: The Need to Narrow the Gap Between in Vitro and in Vivo Mechanisms 114
Citrate-stabilized gold nanoparticles hinder fibrillogenesis of a pathological variant of β2-microglobulin 113
Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component 113
Removal of the N-terminal hexapeptide from human beta2-microglobulin facilitates protein aggregation and fibril formation 109
Conformational dynamics of the beta2-microglobulin C terminal in the cell-membrane-anchored major histocompatibility complex type I 108
Binding of Monovalent and Bivalent Ligands by Transthyretin Causes Different Short- And Long-Distance Conformational Changes 106
Cinetiche di refolding e studi di affinità mediante elettroforesi capillare: effetto di ligandi di interesse farmaceutico sulla conformazione della Beta 2-microglobulina 105
Inhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel. 105
DETECTION OF FRAGMENTS OF BETA2-MICROGLOBULIN IN AMYLOID FIBRILS 104
Proteomics of beta2-microglobulin amyloid fibrils. 102
Hereditary systemic amyloidosis due to Asp76Asn variant β2-microglobulin. 102
Comparative study of the stabilities of synthetic in vitro and natural ex vivo transthyretin amyloid fibrils 102
Detection of two partially structured species in the folding process of the amyloidogenic protein beta 2-microglobulin 101
D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile 100
Structural basis of ligand specificity in the human pentraxins, C-reactive protein and serum amyloid P component. 97
Multifaceted anti-amyloidogenic and pro-amyloidogenic effects of C-reactive protein and serum amyloid P component in vitro 97
Proteomic Analysis for the Diagnosis of Fibrinogen Aα-chain Amyloidosis 96
Preliminary crystallographic characterization of the human beta2 microglobulin His31Tyr mutant in a tetrameric assembly. 95
Solution structure of beta(2)-microglobulin and insights into fibrillogenesis 95
Misidentification of transthyretin and immunoglobulin variants by proteomics due to methyl lysine formation in formalin-fixed paraffin-embedded amyloid tissue 95
Structural and folding dynamics properties of T70N variant of human lysozyme. 95
Bifunctional crosslinking ligands for transthyretin 93
Topological investigation of amyloid fibrils obtained from beta2-microglobulin 92
The new apolipoprotein A-I variant leu(174) --> Ser causes hereditary cardiac amyloidosis, and the amyloid fibrils are constituted by the 93-residue N-terminal polypeptide 92
Clinical ApoA-IV amyloid is associated with fibrillogenic signal sequence 91
Human wild-type and D76N β2-microglobulin variants are significant proteotoxic and metabolic stressors for transgenic C. elegans 89
Diagnostic amyloid proteomics: Experience of the UK National Amyloidosis Centre 88
Structural and functional characterization of three human immunoglobulin kappa light chains with different pathological implications. 86
Structure, folding dynamics and amyloidogenesis of Asp76Asn β2-microglobulin: roles of shear flow, hydrophobic surfaces and α crystallin. 85
Recombinant amyloidogenic domain of ApoA-I: analysis of its fibrillogenic potential 84
Degradation versus fibrillogenesis, two alternative pathways modulated by seeds and glycosaminoglycans 83
Production and immunicytochemical characterization of monoclonal antibodies to SA gene product 82
Isolation and characterization of pharmaceutical grade human pentraxins, serum amyloid P component and C-reactive protein, for clinical use. 82
Increasing the accuracy of proteomic typing by decellularisation of amyloid tissue biopsies 82
The complementary role of histology and proteomics for diagnosis and typing of systemic amyloidosis 80
Lysozyme amyloid: evidence for the W64R variant by proteomics in the absence of the wild type protein 80
Immunoglobulin light chain amyloidosis--the archetype of structural and pathogenic variability. 79
Truncation of the constant domain drives amyloid formation by immunoglobulin light chains 78
Properties of some variants of human beta 2- microglobulin and amyloidogenesis. 77
Trapping of palindromic ligands within native transthyretin prevents amyloid formation. 77
The solution structure of human ß2-microglobulin reveals the prodromes of its amyloid transition 76
Calcium Binds to Transthyretin with Low Affinity 71
Design and Mechanistic Analysis of a Potent Bivalent Inhibitor of Transthyretin Amyloid Fibrillogenesis 70
Micro-heterogeneity and aggregation in beta2-microglobulin solutions: effects of temperature, pH, and conformational variant addition. 70
Effects of a vitamin E-modified dialyzer (Excebrane) on beta-2-microglobulin structure and removal. 69
Pathogenetic mechanisms of amyloid A amyloidosis. 68
The intracellular quality control system down-regulates the secretion of amyloidogenic apolipoprotein A-I variants: A possible impact on the natural history of the disease 67
Distribution and determinants of circulating complement factor H concentration determined by a high-throughput immunonephelometric assay 65
Monitoring the interaction between β2-microglobulin and the molecular chaperone αB-crystallin by NMR and mass spectrometry: αB-crystallin dissociates β2-microglobulin oligomers. 65
Complement factor H binds to denatured rather than to native pentameric C-reactive protein. 65
Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis 65
Conformational switching and fibrillogenesis in the amyloidogenic fragment of apolipoprotein A-I. 61
Evidence that amyloidogenic light chains undergo antigen-driven selection 59
Decoding the structural bases of D76N β2-microglobulin high amyloidogenicity through crystallography and asn-scan mutagenesis 52
null 30
Role of extracellular space and matrix remodeling in cardiac amyloidosis 21
Totale 8.992
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Categoria #
all - tutte 38.061
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 38.061
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022350 0 3 8 6 11 23 7 23 24 15 47 183
2022/20231.348 158 128 14 93 134 132 0 73 561 6 28 21
2023/2024455 76 89 15 19 41 106 8 24 2 20 36 19
2024/20251.371 44 96 34 42 23 54 53 97 379 50 185 314
2025/20263.248 252 238 364 392 403 152 648 112 295 214 65 113
2026/2027230 154 76 0 0 0 0 0 0 0 0 0 0
Totale 8.992