IRIS
MANGIONE, PALMA
 Distribuzione geografica
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Continente #
NA - Nord America 1.937
EU - Europa 1.338
AS - Asia 930
OC - Oceania 3
AF - Africa 2
Continente sconosciuto - Info sul continente non disponibili 1
SA - Sud America 1
Totale 4.212
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Nazione #
US - Stati Uniti d'America 1.928
CN - Cina 835
IE - Irlanda 479
FI - Finlandia 204
UA - Ucraina 170
IT - Italia 158
DE - Germania 107
SE - Svezia 86
SG - Singapore 77
GB - Regno Unito 65
FR - Francia 27
BE - Belgio 16
CA - Canada 9
IN - India 6
CZ - Repubblica Ceca 5
HK - Hong Kong 4
PL - Polonia 4
NL - Olanda 3
AU - Australia 2
HR - Croazia 2
JP - Giappone 2
LV - Lettonia 2
NO - Norvegia 2
RO - Romania 2
RU - Federazione Russa 2
AE - Emirati Arabi Uniti 1
AT - Austria 1
CL - Cile 1
EU - Europa 1
GR - Grecia 1
IR - Iran 1
KE - Kenya 1
LT - Lituania 1
MU - Mauritius 1
NZ - Nuova Zelanda 1
PK - Pakistan 1
PT - Portogallo 1
TJ - Tagikistan 1
TR - Turchia 1
UZ - Uzbekistan 1
Totale 4.212
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Città #
Chandler 484
Dublin 479
Jacksonville 228
Nanjing 228
Ashburn 129
Boardman 121
Beijing 114
Nanchang 96
Princeton 87
Helsinki 83
Wilmington 79
Lawrence 78
Ann Arbor 76
Changsha 69
Hebei 68
Shenyang 65
Medford 60
Singapore 49
Jiaxing 45
Hangzhou 36
Shanghai 36
Milan 35
Tianjin 35
Woodbridge 32
New York 25
Pavia 25
Brussels 16
Falls Church 15
Norwalk 12
Piscataway 12
Auburn Hills 9
Toronto 9
Verona 9
Fairfield 8
Washington 7
Chicago 6
Houston 6
Jinan 6
Los Angeles 6
Fuzhou 5
London 5
Borås 4
Dallas 4
Formia 4
Munich 4
Padova 4
Saint Albans 4
Catania 3
Hefei 3
Hong Kong 3
Ningbo 3
Orange 3
Redwood City 3
Santa Clara 3
Seattle 3
Berlin 2
Birmingham 2
Brescia 2
Brno 2
Castino 2
Deiva Marina 2
Des Moines 2
Feldthurns 2
Genova 2
Groningen 2
Guangzhou 2
Hyderabad 2
Kamien 2
Lucino 2
Marsciano 2
Narbonne 2
Oslo 2
Palermo 2
Polska 2
Rho 2
Rome 2
San Francisco 2
Taizhou 2
Tappahannock 2
Zagreb 2
Zhengzhou 2
Athens 1
Auckland 1
Augusta 1
Cagliari 1
Cambridge 1
Central 1
Changchun 1
Como 1
Dearborn 1
Dushanbe 1
Falkenstein 1
Focsani 1
Forest City 1
Genoa 1
Gragnano 1
Hanover 1
Islamabad 1
Kish 1
Kunming 1
Totale 3.112
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Nome #
L'ipotesi della cascata amiloide nella malattia di Alzheimer: studi su strategie di neuroprotezione. 153
Hepatitis C virus-associated cryoglobulinaemicglomerulonephritis with delayed appearance of monoclonal cryoglobulinaemia. 97
C. elegans expressing human beta2-microglobulin: a novel model for studying the relationship between the molecular assembly and the toxic phenotype. 92
A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo 92
The H50Q mutation induces a tenfold decrease in the solubility of α-synuclein. 86
Biological activity and pathological implications of misfolded proteins. 84
Beta 2- microglobulin can be refolded into a native state from ex vivo amyloid fibrils 78
Antibodies to human serum amyloid P component eliminate visceral amyloid deposits. 78
Affinity capillary electrophoresis is a powerful tool to identify transthyretin binding drugs for potential therapeutic use in amyloidosis 78
Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis. 76
Sulfonated molecules that bind a partially structured species of beta2-microglobulin also influence refolding and fibrillogenesis. 75
Capillary electrophoresis analysis of different variants of the amyloidogenic protein β2 -microglobulin as a simple tool for misfolding and stability studies 74
“Separation and quantification of two beta2-microglobulin isoforms”. 70
Structural basis of ligand specificity in the human pentraxins, C-reactive protein and serum amyloid P component. 70
Amyloid fibrils derived from the apolipoprotein A1 Leu174Ser variant contain elements of ordered helical structure. 70
Metodo per la separazione e la quantificazione di due conformazioni di beta-2-microglobulina in equilibrio dinamico 68
beta 2-microglobulin H31Y variant 3D-structure highlights the protein natural propensity towards intermolecular aggregation 67
Beta2-microglobulin isoforms display an heterogeneous affinity for type I collagen. 67
Class I Major Histocompatibility Complex, the Trojan horse for secretion of amyloidogenic β2-microglobulin. 67
Capillary electrophoresis investigation of a partially unfolded conformation of Beta 2-microglobulin. 67
Use of anti-(beta2 microglobulin) mAb to study formation of amyloid fibrils 64
Proteomics of beta2-microglobulin amyloid fibrils. 64
Cinetiche di refolding e studi di affinità mediante elettroforesi capillare: effetto di ligandi di interesse farmaceutico sulla conformazione della Beta 2-microglobulina 64
Topological investigation of amyloid fibrils obtained from beta2-microglobulin 63
Detection of two partially structured species in the folding process of the amyloidogenic protein beta 2-microglobulin 62
Solution structure of beta(2)-microglobulin and insights into fibrillogenesis 61
Benefit of doxycycline treatment on articular disability caused by dialysis related amyloidosis 61
Co-fibrillogenesis of Wild-type and D76N β2-Microglobulin: THE CRUCIAL ROLE OF FIBRILLAR SEEDS 61
Citrate-stabilized gold nanoparticles hinder fibrillogenesis of a pathological variant of β2-microglobulin 60
A partially structured species of beta 2-microglobulin is significantly populated under physiological conditions and involved in fibrillogenesis 59
Enhanced toxicity of silver nanoparticles in transgenic Caenorhabditis elegans expressing amyloidogenic proteins 58
Effect of tetracyclines on the dynamics of formation and destructuration of {beta}2-microglobulin amyloid fibrils. 58
Preliminary crystallographic characterization of the human beta2 microglobulin His31Tyr mutant in a tetrameric assembly. 55
Conformational dynamics of the beta2-microglobulin C terminal in the cell-membrane-anchored major histocompatibility complex type I 55
Inhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel. 54
The two tryptophans of β2-microglobulin have distinct roles in function and folding and might represent two independent responses to evolutionary pressure. 53
Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component 53
Plasminogen activation triggers transthyretin amyloidogenesis in vitro 53
Effects of the Known Pathogenic Mutations on the Aggregation Pathway of the Amyloidogenic Peptide of Apolipoprotein A-I. 53
Bifunctional crosslinking ligands for transthyretin 52
Structural and folding dynamics properties of T70N variant of human lysozyme. 51
C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis 49
Isolation and characterization of pharmaceutical grade human pentraxins, serum amyloid P component and C-reactive protein, for clinical use. 48
A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis 48
Removal of the N-terminal hexapeptide from human beta2-microglobulin facilitates protein aggregation and fibril formation 48
Amyloid persistence in decellularized liver: Biochemical and histopathological characterization 47
Production and immunicytochemical characterization of monoclonal antibodies to SA gene product 46
The new apolipoprotein A-I variant leu(174) --> Ser causes hereditary cardiac amyloidosis, and the amyloid fibrils are constituted by the 93-residue N-terminal polypeptide 46
Recombinant amyloidogenic domain of ApoA-I: analysis of its fibrillogenic potential 45
DETECTION OF FRAGMENTS OF BETA2-MICROGLOBULIN IN AMYLOID FIBRILS 45
Hereditary systemic amyloidosis due to Asp76Asn variant β2-microglobulin. 44
D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile 44
Misidentification of transthyretin and immunoglobulin variants by proteomics due to methyl lysine formation in formalin-fixed paraffin-embedded amyloid tissue 43
Micro-heterogeneity and aggregation in beta2-microglobulin solutions: effects of temperature, pH, and conformational variant addition. 42
Structure, folding dynamics and amyloidogenesis of Asp76Asn β2-microglobulin: roles of shear flow, hydrophobic surfaces and α crystallin. 42
Trapping of palindromic ligands within native transthyretin prevents amyloid formation. 42
Structural and functional characterization of three human immunoglobulin kappa light chains with different pathological implications. 41
Conformational switching and fibrillogenesis in the amyloidogenic fragment of apolipoprotein A-I. 41
The solution structure of human ß2-microglobulin reveals the prodromes of its amyloid transition 41
Properties of some variants of human beta 2- microglobulin and amyloidogenesis. 38
Monitoring the interaction between β2-microglobulin and the molecular chaperone αB-crystallin by NMR and mass spectrometry: αB-crystallin dissociates β2-microglobulin oligomers. 38
Immunoglobulin light chain amyloidosis--the archetype of structural and pathogenic variability. 38
Multifaceted anti-amyloidogenic and pro-amyloidogenic effects of C-reactive protein and serum amyloid P component in vitro 36
The intracellular quality control system down-regulates the secretion of amyloidogenic apolipoprotein A-I variants: A possible impact on the natural history of the disease 36
Binding of Monovalent and Bivalent Ligands by Transthyretin Causes Different Short- And Long-Distance Conformational Changes 36
Proteomic Analysis for the Diagnosis of Fibrinogen Aα-chain Amyloidosis 36
Increasing the accuracy of proteomic typing by decellularisation of amyloid tissue biopsies 36
Effects of a vitamin E-modified dialyzer (Excebrane) on beta-2-microglobulin structure and removal. 35
Lysozyme amyloid: evidence for the W64R variant by proteomics in the absence of the wild type protein 35
Comparative study of the stabilities of synthetic in vitro and natural ex vivo transthyretin amyloid fibrils 35
Distribution and determinants of circulating complement factor H concentration determined by a high-throughput immunonephelometric assay 33
Evidence that amyloidogenic light chains undergo antigen-driven selection 33
Diagnostic amyloid proteomics: Experience of the UK National Amyloidosis Centre 33
Complement factor H binds to denatured rather than to native pentameric C-reactive protein. 32
null 30
Amyloid Formation by Globular Proteins: The Need to Narrow the Gap Between in Vitro and in Vivo Mechanisms 30
The complementary role of histology and proteomics for diagnosis and typing of systemic amyloidosis 26
Clinical ApoA-IV amyloid is associated with fibrillogenic signal sequence 26
Decoding the structural bases of D76N β2-microglobulin high amyloidogenicity through crystallography and asn-scan mutagenesis 18
Human wild-type and D76N β2-microglobulin variants are significant proteotoxic and metabolic stressors for transgenic C. elegans 17
Pathogenetic mechanisms of amyloid A amyloidosis. 14
Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis 12
Calcium Binds to Transthyretin with Low Affinity 10
Degradation versus fibrillogenesis, two alternative pathways modulated by seeds and glycosaminoglycans 9
Totale 4.347
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Categoria #
all - tutte 18.533
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 18.533
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020259 0 0 0 0 8 31 7 43 1 81 75 13
2020/2021383 68 33 11 34 8 45 5 56 22 49 42 10
2021/2022355 5 3 8 6 11 23 7 23 24 15 47 183
2022/20231.348 158 128 14 93 134 132 0 73 561 6 28 21
2023/2024442 76 89 15 19 41 106 8 24 2 16 27 19
2024/2025217 42 95 34 42 4 0 0 0 0 0 0 0
Totale 4.347