IRIS
MANGIONE, PALMA
 Distribuzione geografica
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Continente #
NA - Nord America 3.453
AS - Asia 2.483
EU - Europa 2.053
SA - Sud America 306
AF - Africa 77
OC - Oceania 9
Continente sconosciuto - Info sul continente non disponibili 1
Totale 8.382
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Nazione #
US - Stati Uniti d'America 3.370
CN - Cina 1.181
SG - Singapore 552
IE - Irlanda 484
HK - Hong Kong 299
FI - Finlandia 244
RU - Federazione Russa 238
BR - Brasile 232
IT - Italia 221
VN - Vietnam 198
DE - Germania 192
UA - Ucraina 179
FR - Francia 141
GB - Regno Unito 124
SE - Svezia 99
IN - India 66
CA - Canada 43
ZA - Sudafrica 40
PL - Polonia 31
BD - Bangladesh 28
MX - Messico 27
TR - Turchia 23
IQ - Iraq 21
BE - Belgio 19
AR - Argentina 18
JP - Giappone 17
ES - Italia 16
ID - Indonesia 16
NL - Olanda 16
CO - Colombia 14
EC - Ecuador 12
KE - Kenya 10
CZ - Repubblica Ceca 9
MA - Marocco 9
PH - Filippine 9
PK - Pakistan 9
UZ - Uzbekistan 9
CL - Cile 7
JO - Giordania 6
PE - Perù 6
VE - Venezuela 6
AE - Emirati Arabi Uniti 5
AU - Australia 5
BO - Bolivia 5
CH - Svizzera 5
JM - Giamaica 5
LT - Lituania 5
AT - Austria 4
AZ - Azerbaigian 4
EG - Egitto 4
OM - Oman 4
PY - Paraguay 4
TH - Thailandia 4
CR - Costa Rica 3
DK - Danimarca 3
HR - Croazia 3
KG - Kirghizistan 3
LV - Lettonia 3
NO - Norvegia 3
NZ - Nuova Zelanda 3
PT - Portogallo 3
RO - Romania 3
SA - Arabia Saudita 3
TN - Tunisia 3
BH - Bahrain 2
ET - Etiopia 2
HU - Ungheria 2
IL - Israele 2
IR - Iran 2
KZ - Kazakistan 2
LA - Repubblica Popolare Democratica del Laos 2
LY - Libia 2
MK - Macedonia 2
MN - Mongolia 2
MY - Malesia 2
PS - Palestinian Territory 2
SN - Senegal 2
SY - Repubblica araba siriana 2
AF - Afghanistan, Repubblica islamica di 1
AL - Albania 1
AM - Armenia 1
AO - Angola 1
BB - Barbados 1
CY - Cipro 1
DO - Repubblica Dominicana 1
EE - Estonia 1
EU - Europa 1
GN - Guinea 1
GR - Grecia 1
GT - Guatemala 1
HN - Honduras 1
KR - Corea 1
LB - Libano 1
LK - Sri Lanka 1
ML - Mali 1
MU - Mauritius 1
NG - Nigeria 1
NI - Nicaragua 1
NP - Nepal 1
RS - Serbia 1
Totale 8.378
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Città #
Chandler 484
Dublin 483
Ashburn 332
San Jose 318
Singapore 295
Hong Kong 289
Dallas 267
Beijing 263
Nanjing 230
Jacksonville 228
Boardman 124
Nanchang 96
Helsinki 92
Los Angeles 87
Princeton 87
Wilmington 79
Lawrence 78
Lauterbourg 77
Ann Arbor 76
Changsha 71
Hebei 68
Shenyang 65
New York 64
Hanoi 60
Medford 60
Munich 59
Ho Chi Minh City 58
Jiaxing 45
Milan 45
Moscow 43
Shanghai 40
Tianjin 39
Hangzhou 37
Buffalo 35
Orem 33
Johannesburg 32
Woodbridge 32
Redondo Beach 31
Turku 31
Pavia 30
São Paulo 29
The Dalles 25
Chennai 21
Warsaw 21
Frankfurt am Main 20
Toronto 20
Montreal 19
Brussels 18
Chicago 18
London 17
Santa Clara 17
Tokyo 16
Falls Church 15
Houston 14
Piscataway 14
Stockholm 13
Ankara 12
Atlanta 12
Norwalk 12
Da Nang 11
Denver 11
Haiphong 11
Manchester 11
Phoenix 11
Amsterdam 10
Brooklyn 10
Council Bluffs 10
Mexico City 10
Auburn Hills 9
Belo Horizonte 9
Fairfield 9
Nairobi 9
Poplar 9
Rio de Janeiro 9
Verona 9
Baghdad 8
Jinan 8
Mumbai 8
Tashkent 8
Washington 8
Boston 7
Charlotte 7
San Francisco 7
Sassari 7
Amman 6
Biên Hòa 6
Bogotá 6
Catania 6
Jakarta 6
Nuremberg 6
Seattle 6
Florence 5
Fuzhou 5
Guangzhou 5
Hefei 5
Istanbul 5
Rome 5
Shijiazhuang 5
Baku 4
Bologna 4
Totale 5.607
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Nome #
L'ipotesi della cascata amiloide nella malattia di Alzheimer: studi su strategie di neuroprotezione. 198
A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo 177
C. elegans expressing human beta2-microglobulin: a novel model for studying the relationship between the molecular assembly and the toxic phenotype. 169
Affinity capillary electrophoresis is a powerful tool to identify transthyretin binding drugs for potential therapeutic use in amyloidosis 157
Hepatitis C virus-associated cryoglobulinaemicglomerulonephritis with delayed appearance of monoclonal cryoglobulinaemia. 147
Biological activity and pathological implications of misfolded proteins. 145
Antibodies to human serum amyloid P component eliminate visceral amyloid deposits. 142
Class I Major Histocompatibility Complex, the Trojan horse for secretion of amyloidogenic β2-microglobulin. 139
Beta 2- microglobulin can be refolded into a native state from ex vivo amyloid fibrils 138
Capillary electrophoresis analysis of different variants of the amyloidogenic protein β2 -microglobulin as a simple tool for misfolding and stability studies 136
The H50Q mutation induces a tenfold decrease in the solubility of α-synuclein. 136
Amyloid fibrils derived from the apolipoprotein A1 Leu174Ser variant contain elements of ordered helical structure. 135
Beta2-microglobulin isoforms display an heterogeneous affinity for type I collagen. 128
Benefit of doxycycline treatment on articular disability caused by dialysis related amyloidosis 127
Sulfonated molecules that bind a partially structured species of beta2-microglobulin also influence refolding and fibrillogenesis. 126
A partially structured species of beta 2-microglobulin is significantly populated under physiological conditions and involved in fibrillogenesis 123
Co-fibrillogenesis of Wild-type and D76N β2-Microglobulin: THE CRUCIAL ROLE OF FIBRILLAR SEEDS 123
beta 2-microglobulin H31Y variant 3D-structure highlights the protein natural propensity towards intermolecular aggregation 119
Capillary electrophoresis investigation of a partially unfolded conformation of Beta 2-microglobulin. 119
“Separation and quantification of two beta2-microglobulin isoforms”. 118
C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis 116
Amyloid persistence in decellularized liver: Biochemical and histopathological characterization 115
Effect of tetracyclines on the dynamics of formation and destructuration of {beta}2-microglobulin amyloid fibrils. 115
Effects of the Known Pathogenic Mutations on the Aggregation Pathway of the Amyloidogenic Peptide of Apolipoprotein A-I. 115
Metodo per la separazione e la quantificazione di due conformazioni di beta-2-microglobulina in equilibrio dinamico 114
Use of anti-(beta2 microglobulin) mAb to study formation of amyloid fibrils 113
Enhanced toxicity of silver nanoparticles in transgenic Caenorhabditis elegans expressing amyloidogenic proteins 113
A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis 113
Amyloid Formation by Globular Proteins: The Need to Narrow the Gap Between in Vitro and in Vivo Mechanisms 111
Citrate-stabilized gold nanoparticles hinder fibrillogenesis of a pathological variant of β2-microglobulin 110
The two tryptophans of β2-microglobulin have distinct roles in function and folding and might represent two independent responses to evolutionary pressure. 109
Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis. 109
Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component 108
Plasminogen activation triggers transthyretin amyloidogenesis in vitro 108
Removal of the N-terminal hexapeptide from human beta2-microglobulin facilitates protein aggregation and fibril formation 105
Conformational dynamics of the beta2-microglobulin C terminal in the cell-membrane-anchored major histocompatibility complex type I 104
Inhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel. 101
Binding of Monovalent and Bivalent Ligands by Transthyretin Causes Different Short- And Long-Distance Conformational Changes 101
Cinetiche di refolding e studi di affinità mediante elettroforesi capillare: effetto di ligandi di interesse farmaceutico sulla conformazione della Beta 2-microglobulina 100
Proteomics of beta2-microglobulin amyloid fibrils. 99
DETECTION OF FRAGMENTS OF BETA2-MICROGLOBULIN IN AMYLOID FIBRILS 99
Hereditary systemic amyloidosis due to Asp76Asn variant β2-microglobulin. 98
Detection of two partially structured species in the folding process of the amyloidogenic protein beta 2-microglobulin 97
Comparative study of the stabilities of synthetic in vitro and natural ex vivo transthyretin amyloid fibrils 97
D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile 96
Structural basis of ligand specificity in the human pentraxins, C-reactive protein and serum amyloid P component. 95
Multifaceted anti-amyloidogenic and pro-amyloidogenic effects of C-reactive protein and serum amyloid P component in vitro 95
Proteomic Analysis for the Diagnosis of Fibrinogen Aα-chain Amyloidosis 95
Bifunctional crosslinking ligands for transthyretin 92
Solution structure of beta(2)-microglobulin and insights into fibrillogenesis 91
Misidentification of transthyretin and immunoglobulin variants by proteomics due to methyl lysine formation in formalin-fixed paraffin-embedded amyloid tissue 90
Structural and folding dynamics properties of T70N variant of human lysozyme. 90
Topological investigation of amyloid fibrils obtained from beta2-microglobulin 89
Clinical ApoA-IV amyloid is associated with fibrillogenic signal sequence 89
Preliminary crystallographic characterization of the human beta2 microglobulin His31Tyr mutant in a tetrameric assembly. 86
The new apolipoprotein A-I variant leu(174) --> Ser causes hereditary cardiac amyloidosis, and the amyloid fibrils are constituted by the 93-residue N-terminal polypeptide 86
Structural and functional characterization of three human immunoglobulin kappa light chains with different pathological implications. 84
Structure, folding dynamics and amyloidogenesis of Asp76Asn β2-microglobulin: roles of shear flow, hydrophobic surfaces and α crystallin. 82
Diagnostic amyloid proteomics: Experience of the UK National Amyloidosis Centre 82
Human wild-type and D76N β2-microglobulin variants are significant proteotoxic and metabolic stressors for transgenic C. elegans 81
Production and immunicytochemical characterization of monoclonal antibodies to SA gene product 80
Isolation and characterization of pharmaceutical grade human pentraxins, serum amyloid P component and C-reactive protein, for clinical use. 80
Increasing the accuracy of proteomic typing by decellularisation of amyloid tissue biopsies 80
Recombinant amyloidogenic domain of ApoA-I: analysis of its fibrillogenic potential 79
The complementary role of histology and proteomics for diagnosis and typing of systemic amyloidosis 78
Degradation versus fibrillogenesis, two alternative pathways modulated by seeds and glycosaminoglycans 77
Lysozyme amyloid: evidence for the W64R variant by proteomics in the absence of the wild type protein 76
Immunoglobulin light chain amyloidosis--the archetype of structural and pathogenic variability. 75
Trapping of palindromic ligands within native transthyretin prevents amyloid formation. 74
The solution structure of human ß2-microglobulin reveals the prodromes of its amyloid transition 73
Truncation of the constant domain drives amyloid formation by immunoglobulin light chains 72
Properties of some variants of human beta 2- microglobulin and amyloidogenesis. 70
Calcium Binds to Transthyretin with Low Affinity 69
Effects of a vitamin E-modified dialyzer (Excebrane) on beta-2-microglobulin structure and removal. 65
The intracellular quality control system down-regulates the secretion of amyloidogenic apolipoprotein A-I variants: A possible impact on the natural history of the disease 65
Micro-heterogeneity and aggregation in beta2-microglobulin solutions: effects of temperature, pH, and conformational variant addition. 64
Distribution and determinants of circulating complement factor H concentration determined by a high-throughput immunonephelometric assay 64
Complement factor H binds to denatured rather than to native pentameric C-reactive protein. 64
Monitoring the interaction between β2-microglobulin and the molecular chaperone αB-crystallin by NMR and mass spectrometry: αB-crystallin dissociates β2-microglobulin oligomers. 62
Pathogenetic mechanisms of amyloid A amyloidosis. 61
Design and Mechanistic Analysis of a Potent Bivalent Inhibitor of Transthyretin Amyloid Fibrillogenesis 60
Conformational switching and fibrillogenesis in the amyloidogenic fragment of apolipoprotein A-I. 59
Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis 58
Evidence that amyloidogenic light chains undergo antigen-driven selection 56
Decoding the structural bases of D76N β2-microglobulin high amyloidogenicity through crystallography and asn-scan mutagenesis 47
null 30
Totale 8.533
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Categoria #
all - tutte 33.804
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 33.804
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021101 0 0 0 0 0 0 0 0 0 49 42 10
2021/2022355 5 3 8 6 11 23 7 23 24 15 47 183
2022/20231.348 158 128 14 93 134 132 0 73 561 6 28 21
2023/2024455 76 89 15 19 41 106 8 24 2 20 36 19
2024/20251.371 44 96 34 42 23 54 53 97 379 50 185 314
2025/20263.019 252 238 364 392 403 152 648 112 295 163 0 0
Totale 8.533