MANGIONE, PALMA
 Distribuzione geografica
Continente #
NA - Nord America 1.807
EU - Europa 1.306
AS - Asia 824
OC - Oceania 3
AF - Africa 2
Continente sconosciuto - Info sul continente non disponibili 1
SA - Sud America 1
Totale 3.944
Nazione #
US - Stati Uniti d'America 1.798
CN - Cina 812
IE - Irlanda 479
FI - Finlandia 201
UA - Ucraina 170
IT - Italia 138
DE - Germania 103
SE - Svezia 86
GB - Regno Unito 65
FR - Francia 27
BE - Belgio 16
CA - Canada 9
IN - India 6
PL - Polonia 4
NL - Olanda 3
AU - Australia 2
CZ - Repubblica Ceca 2
HR - Croazia 2
LV - Lettonia 2
NO - Norvegia 2
RO - Romania 2
SG - Singapore 2
AT - Austria 1
CL - Cile 1
EU - Europa 1
GR - Grecia 1
HK - Hong Kong 1
IR - Iran 1
JP - Giappone 1
KE - Kenya 1
MU - Mauritius 1
NZ - Nuova Zelanda 1
PT - Portogallo 1
RU - Federazione Russa 1
TR - Turchia 1
Totale 3.944
Città #
Chandler 484
Dublin 479
Jacksonville 228
Nanjing 228
Ashburn 129
Beijing 114
Nanchang 96
Princeton 87
Helsinki 80
Wilmington 79
Lawrence 78
Ann Arbor 76
Changsha 69
Hebei 68
Shenyang 65
Medford 60
Jiaxing 45
Boardman 38
Hangzhou 36
Tianjin 35
Woodbridge 32
Milan 30
New York 25
Pavia 25
Shanghai 20
Brussels 16
Falls Church 15
Norwalk 12
Auburn Hills 9
Toronto 9
Verona 9
Fairfield 8
Washington 7
Houston 6
Jinan 6
Fuzhou 5
London 5
Borås 4
Formia 4
Padova 4
Saint Albans 4
Catania 3
Hefei 3
Los Angeles 3
Orange 3
Redwood City 3
Seattle 3
Berlin 2
Birmingham 2
Brescia 2
Des Moines 2
Feldthurns 2
Genova 2
Groningen 2
Guangzhou 2
Hyderabad 2
Kamien 2
Lucino 2
Marsciano 2
Narbonne 2
Ningbo 2
Oslo 2
Polska 2
Rho 2
Rome 2
Taizhou 2
Tappahannock 2
Zagreb 2
Zhengzhou 2
Athens 1
Auckland 1
Augusta 1
Cambridge 1
Central 1
Changchun 1
Como 1
Dearborn 1
Falkenstein 1
Focsani 1
Gragnano 1
Hanover 1
Kish 1
Kunming 1
Lanzhou 1
Leawood 1
Macomer 1
Magdeburg 1
Manassas 1
Melbourne 1
Montalcino 1
Nagold 1
Nairobi 1
Napoli 1
Pesaro 1
Piacenza 1
Polla 1
Redmond 1
Riga 1
Rivalta Di Torino 1
Roehampton 1
Totale 2.922
Nome #
L'ipotesi della cascata amiloide nella malattia di Alzheimer: studi su strategie di neuroprotezione. 140
Hepatitis C virus-associated cryoglobulinaemicglomerulonephritis with delayed appearance of monoclonal cryoglobulinaemia. 95
C. elegans expressing human beta2-microglobulin: a novel model for studying the relationship between the molecular assembly and the toxic phenotype. 88
A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo 84
The H50Q mutation induces a tenfold decrease in the solubility of α-synuclein. 83
Biological activity and pathological implications of misfolded proteins. 80
Antibodies to human serum amyloid P component eliminate visceral amyloid deposits. 77
Beta 2- microglobulin can be refolded into a native state from ex vivo amyloid fibrils 76
Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis. 75
Sulfonated molecules that bind a partially structured species of beta2-microglobulin also influence refolding and fibrillogenesis. 71
Affinity capillary electrophoresis is a powerful tool to identify transthyretin binding drugs for potential therapeutic use in amyloidosis 70
“Separation and quantification of two beta2-microglobulin isoforms”. 67
Capillary electrophoresis analysis of different variants of the amyloidogenic protein β2 -microglobulin as a simple tool for misfolding and stability studies 66
Amyloid fibrils derived from the apolipoprotein A1 Leu174Ser variant contain elements of ordered helical structure. 66
Metodo per la separazione e la quantificazione di due conformazioni di beta-2-microglobulina in equilibrio dinamico 65
beta 2-microglobulin H31Y variant 3D-structure highlights the protein natural propensity towards intermolecular aggregation 64
Beta2-microglobulin isoforms display an heterogeneous affinity for type I collagen. 64
Structural basis of ligand specificity in the human pentraxins, C-reactive protein and serum amyloid P component. 64
Class I Major Histocompatibility Complex, the Trojan horse for secretion of amyloidogenic β2-microglobulin. 63
Cinetiche di refolding e studi di affinità mediante elettroforesi capillare: effetto di ligandi di interesse farmaceutico sulla conformazione della Beta 2-microglobulina 62
Capillary electrophoresis investigation of a partially unfolded conformation of Beta 2-microglobulin. 62
Use of anti-(beta2 microglobulin) mAb to study formation of amyloid fibrils 61
Topological investigation of amyloid fibrils obtained from beta2-microglobulin 60
Proteomics of beta2-microglobulin amyloid fibrils. 60
Detection of two partially structured species in the folding process of the amyloidogenic protein beta 2-microglobulin 60
Citrate-stabilized gold nanoparticles hinder fibrillogenesis of a pathological variant of β2-microglobulin 58
Benefit of doxycycline treatment on articular disability caused by dialysis related amyloidosis 57
Solution structure of beta(2)-microglobulin and insights into fibrillogenesis 56
Enhanced toxicity of silver nanoparticles in transgenic Caenorhabditis elegans expressing amyloidogenic proteins 55
Effect of tetracyclines on the dynamics of formation and destructuration of {beta}2-microglobulin amyloid fibrils. 54
A partially structured species of beta 2-microglobulin is significantly populated under physiological conditions and involved in fibrillogenesis 54
Preliminary crystallographic characterization of the human beta2 microglobulin His31Tyr mutant in a tetrameric assembly. 53
Conformational dynamics of the beta2-microglobulin C terminal in the cell-membrane-anchored major histocompatibility complex type I 53
Co-fibrillogenesis of Wild-type and D76N β2-Microglobulin: THE CRUCIAL ROLE OF FIBRILLAR SEEDS 53
Plasminogen activation triggers transthyretin amyloidogenesis in vitro 51
Effects of the Known Pathogenic Mutations on the Aggregation Pathway of the Amyloidogenic Peptide of Apolipoprotein A-I. 51
The two tryptophans of β2-microglobulin have distinct roles in function and folding and might represent two independent responses to evolutionary pressure. 50
Bifunctional crosslinking ligands for transthyretin 50
Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component 50
Structural and folding dynamics properties of T70N variant of human lysozyme. 48
Inhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel. 47
Isolation and characterization of pharmaceutical grade human pentraxins, serum amyloid P component and C-reactive protein, for clinical use. 46
Amyloid persistence in decellularized liver: Biochemical and histopathological characterization 45
Removal of the N-terminal hexapeptide from human beta2-microglobulin facilitates protein aggregation and fibril formation 45
C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis 45
Production and immunicytochemical characterization of monoclonal antibodies to SA gene product 44
A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis 44
The new apolipoprotein A-I variant leu(174) --> Ser causes hereditary cardiac amyloidosis, and the amyloid fibrils are constituted by the 93-residue N-terminal polypeptide 43
DETECTION OF FRAGMENTS OF BETA2-MICROGLOBULIN IN AMYLOID FIBRILS 43
Recombinant amyloidogenic domain of ApoA-I: analysis of its fibrillogenic potential 42
Micro-heterogeneity and aggregation in beta2-microglobulin solutions: effects of temperature, pH, and conformational variant addition. 41
Misidentification of transthyretin and immunoglobulin variants by proteomics due to methyl lysine formation in formalin-fixed paraffin-embedded amyloid tissue 41
Hereditary systemic amyloidosis due to Asp76Asn variant β2-microglobulin. 41
D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile 41
Trapping of palindromic ligands within native transthyretin prevents amyloid formation. 40
Conformational switching and fibrillogenesis in the amyloidogenic fragment of apolipoprotein A-I. 39
The solution structure of human ß2-microglobulin reveals the prodromes of its amyloid transition 39
Structural and functional characterization of three human immunoglobulin kappa light chains with different pathological implications. 38
Structure, folding dynamics and amyloidogenesis of Asp76Asn β2-microglobulin: roles of shear flow, hydrophobic surfaces and α crystallin. 37
Properties of some variants of human beta 2- microglobulin and amyloidogenesis. 36
Monitoring the interaction between β2-microglobulin and the molecular chaperone αB-crystallin by NMR and mass spectrometry: αB-crystallin dissociates β2-microglobulin oligomers. 36
Immunoglobulin light chain amyloidosis--the archetype of structural and pathogenic variability. 36
Multifaceted anti-amyloidogenic and pro-amyloidogenic effects of C-reactive protein and serum amyloid P component in vitro 35
Increasing the accuracy of proteomic typing by decellularisation of amyloid tissue biopsies 35
The intracellular quality control system down-regulates the secretion of amyloidogenic apolipoprotein A-I variants: A possible impact on the natural history of the disease 34
Binding of Monovalent and Bivalent Ligands by Transthyretin Causes Different Short- And Long-Distance Conformational Changes 33
Lysozyme amyloid: evidence for the W64R variant by proteomics in the absence of the wild type protein 33
Comparative study of the stabilities of synthetic in vitro and natural ex vivo transthyretin amyloid fibrils 33
Distribution and determinants of circulating complement factor H concentration determined by a high-throughput immunonephelometric assay 32
Effects of a vitamin E-modified dialyzer (Excebrane) on beta-2-microglobulin structure and removal. 32
Evidence that amyloidogenic light chains undergo antigen-driven selection 31
Complement factor H binds to denatured rather than to native pentameric C-reactive protein. 31
Proteomic Analysis for the Diagnosis of Fibrinogen Aα-chain Amyloidosis 31
Diagnostic amyloid proteomics: Experience of the UK National Amyloidosis Centre 31
null 30
Amyloid Formation by Globular Proteins: The Need to Narrow the Gap Between in Vitro and in Vivo Mechanisms 27
The complementary role of histology and proteomics for diagnosis and typing of systemic amyloidosis 24
Clinical ApoA-IV amyloid is associated with fibrillogenic signal sequence 24
Decoding the structural bases of D76N β2-microglobulin high amyloidogenicity through crystallography and asn-scan mutagenesis 17
Pathogenetic mechanisms of amyloid A amyloidosis. 13
Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis 11
Human wild-type and D76N β2-microglobulin variants are significant proteotoxic and metabolic stressors for transgenic C. elegans 8
Calcium Binds to Transthyretin with Low Affinity 8
Degradation versus fibrillogenesis, two alternative pathways modulated by seeds and glycosaminoglycans 1
Totale 4.079
Categoria #
all - tutte 14.144
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 14.144


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/201915 0 0 0 0 0 0 0 0 0 7 3 5
2019/2020954 284 375 1 35 8 31 7 43 1 81 75 13
2020/2021383 68 33 11 34 8 45 5 56 22 49 42 10
2021/2022355 5 3 8 6 11 23 7 23 24 15 47 183
2022/20231.348 158 128 14 93 134 132 0 73 561 6 28 21
2023/2024391 76 89 15 19 41 106 8 24 2 11 0 0
Totale 4.079