IRIS
MANGIONE, PALMA
 Distribuzione geografica
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Continente #
NA - Nord America 1.953
EU - Europa 1.352
AS - Asia 970
OC - Oceania 3
AF - Africa 2
Continente sconosciuto - Info sul continente non disponibili 1
SA - Sud America 1
Totale 4.282
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Nazione #
US - Stati Uniti d'America 1.942
CN - Cina 844
IE - Irlanda 479
FI - Finlandia 207
UA - Ucraina 170
IT - Italia 163
DE - Germania 107
SG - Singapore 106
SE - Svezia 86
GB - Regno Unito 67
FR - Francia 27
BE - Belgio 17
CA - Canada 11
IN - India 6
CZ - Repubblica Ceca 5
HK - Hong Kong 4
NL - Olanda 4
PL - Polonia 4
AU - Australia 2
HR - Croazia 2
JP - Giappone 2
LT - Lituania 2
LV - Lettonia 2
NO - Norvegia 2
RO - Romania 2
RU - Federazione Russa 2
AE - Emirati Arabi Uniti 1
AT - Austria 1
CH - Svizzera 1
CL - Cile 1
EU - Europa 1
GR - Grecia 1
IR - Iran 1
KE - Kenya 1
LA - Repubblica Popolare Democratica del Laos 1
MU - Mauritius 1
NZ - Nuova Zelanda 1
PH - Filippine 1
PK - Pakistan 1
PT - Portogallo 1
TJ - Tagikistan 1
TR - Turchia 1
UZ - Uzbekistan 1
Totale 4.282
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Città #
Chandler 484
Dublin 479
Nanjing 230
Jacksonville 228
Ashburn 131
Boardman 121
Beijing 114
Nanchang 96
Princeton 87
Helsinki 86
Wilmington 79
Lawrence 78
Singapore 78
Ann Arbor 76
Changsha 70
Hebei 68
Shenyang 65
Medford 60
Jiaxing 45
Hangzhou 36
Shanghai 36
Milan 35
Tianjin 35
Woodbridge 32
Pavia 29
New York 25
Brussels 17
Falls Church 15
Norwalk 12
Piscataway 12
Toronto 11
Auburn Hills 9
Verona 9
Fairfield 8
London 7
Washington 7
Chicago 6
Houston 6
Jinan 6
Los Angeles 6
Fuzhou 5
Borås 4
Dallas 4
Formia 4
Munich 4
Padova 4
Saint Albans 4
Santa Clara 4
Catania 3
Hefei 3
Hong Kong 3
Ningbo 3
Orange 3
Redwood City 3
Seattle 3
Zhengzhou 3
Berlin 2
Birmingham 2
Brescia 2
Brno 2
Castino 2
Deiva Marina 2
Des Moines 2
Feldthurns 2
Genova 2
Groningen 2
Guangzhou 2
Hyderabad 2
Kamien 2
Lucino 2
Marsciano 2
Narbonne 2
Oslo 2
Palermo 2
Polska 2
Rho 2
Rome 2
San Francisco 2
Taizhou 2
Tappahannock 2
Zagreb 2
Athens 1
Auckland 1
Augusta 1
Cagliari 1
Cambridge 1
Central 1
Changchun 1
Como 1
Dearborn 1
Dushanbe 1
Falkenstein 1
Focsani 1
Forest City 1
Genoa 1
Giubiasco 1
Gragnano 1
Hanover 1
Islamabad 1
Kaifeng 1
Totale 3.160
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Nome #
L'ipotesi della cascata amiloide nella malattia di Alzheimer: studi su strategie di neuroprotezione. 153
Hepatitis C virus-associated cryoglobulinaemicglomerulonephritis with delayed appearance of monoclonal cryoglobulinaemia. 98
C. elegans expressing human beta2-microglobulin: a novel model for studying the relationship between the molecular assembly and the toxic phenotype. 95
A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo 93
Biological activity and pathological implications of misfolded proteins. 86
The H50Q mutation induces a tenfold decrease in the solubility of α-synuclein. 86
Beta 2- microglobulin can be refolded into a native state from ex vivo amyloid fibrils 80
Antibodies to human serum amyloid P component eliminate visceral amyloid deposits. 79
Affinity capillary electrophoresis is a powerful tool to identify transthyretin binding drugs for potential therapeutic use in amyloidosis 78
Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis. 76
Capillary electrophoresis analysis of different variants of the amyloidogenic protein β2 -microglobulin as a simple tool for misfolding and stability studies 76
Sulfonated molecules that bind a partially structured species of beta2-microglobulin also influence refolding and fibrillogenesis. 76
“Separation and quantification of two beta2-microglobulin isoforms”. 73
Amyloid fibrils derived from the apolipoprotein A1 Leu174Ser variant contain elements of ordered helical structure. 72
Class I Major Histocompatibility Complex, the Trojan horse for secretion of amyloidogenic β2-microglobulin. 70
Structural basis of ligand specificity in the human pentraxins, C-reactive protein and serum amyloid P component. 70
Metodo per la separazione e la quantificazione di due conformazioni di beta-2-microglobulina in equilibrio dinamico 69
beta 2-microglobulin H31Y variant 3D-structure highlights the protein natural propensity towards intermolecular aggregation 68
Beta2-microglobulin isoforms display an heterogeneous affinity for type I collagen. 68
Capillary electrophoresis investigation of a partially unfolded conformation of Beta 2-microglobulin. 68
Cinetiche di refolding e studi di affinità mediante elettroforesi capillare: effetto di ligandi di interesse farmaceutico sulla conformazione della Beta 2-microglobulina 65
Benefit of doxycycline treatment on articular disability caused by dialysis related amyloidosis 65
Use of anti-(beta2 microglobulin) mAb to study formation of amyloid fibrils 64
Proteomics of beta2-microglobulin amyloid fibrils. 64
Citrate-stabilized gold nanoparticles hinder fibrillogenesis of a pathological variant of β2-microglobulin 64
Topological investigation of amyloid fibrils obtained from beta2-microglobulin 63
Co-fibrillogenesis of Wild-type and D76N β2-Microglobulin: THE CRUCIAL ROLE OF FIBRILLAR SEEDS 63
Detection of two partially structured species in the folding process of the amyloidogenic protein beta 2-microglobulin 62
Solution structure of beta(2)-microglobulin and insights into fibrillogenesis 61
Effect of tetracyclines on the dynamics of formation and destructuration of {beta}2-microglobulin amyloid fibrils. 60
Enhanced toxicity of silver nanoparticles in transgenic Caenorhabditis elegans expressing amyloidogenic proteins 59
A partially structured species of beta 2-microglobulin is significantly populated under physiological conditions and involved in fibrillogenesis 59
Effects of the Known Pathogenic Mutations on the Aggregation Pathway of the Amyloidogenic Peptide of Apolipoprotein A-I. 57
Preliminary crystallographic characterization of the human beta2 microglobulin His31Tyr mutant in a tetrameric assembly. 56
Conformational dynamics of the beta2-microglobulin C terminal in the cell-membrane-anchored major histocompatibility complex type I 55
The two tryptophans of β2-microglobulin have distinct roles in function and folding and might represent two independent responses to evolutionary pressure. 54
Inhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel. 54
Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component 54
Plasminogen activation triggers transthyretin amyloidogenesis in vitro 54
Bifunctional crosslinking ligands for transthyretin 53
Structural and folding dynamics properties of T70N variant of human lysozyme. 51
C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis 51
A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis 49
Isolation and characterization of pharmaceutical grade human pentraxins, serum amyloid P component and C-reactive protein, for clinical use. 48
Amyloid persistence in decellularized liver: Biochemical and histopathological characterization 48
Removal of the N-terminal hexapeptide from human beta2-microglobulin facilitates protein aggregation and fibril formation 48
Production and immunicytochemical characterization of monoclonal antibodies to SA gene product 47
The new apolipoprotein A-I variant leu(174) --> Ser causes hereditary cardiac amyloidosis, and the amyloid fibrils are constituted by the 93-residue N-terminal polypeptide 47
Recombinant amyloidogenic domain of ApoA-I: analysis of its fibrillogenic potential 45
Hereditary systemic amyloidosis due to Asp76Asn variant β2-microglobulin. 45
DETECTION OF FRAGMENTS OF BETA2-MICROGLOBULIN IN AMYLOID FIBRILS 45
Structure, folding dynamics and amyloidogenesis of Asp76Asn β2-microglobulin: roles of shear flow, hydrophobic surfaces and α crystallin. 44
D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile 44
Misidentification of transthyretin and immunoglobulin variants by proteomics due to methyl lysine formation in formalin-fixed paraffin-embedded amyloid tissue 43
Micro-heterogeneity and aggregation in beta2-microglobulin solutions: effects of temperature, pH, and conformational variant addition. 42
Trapping of palindromic ligands within native transthyretin prevents amyloid formation. 42
The solution structure of human ß2-microglobulin reveals the prodromes of its amyloid transition 42
Structural and functional characterization of three human immunoglobulin kappa light chains with different pathological implications. 41
Conformational switching and fibrillogenesis in the amyloidogenic fragment of apolipoprotein A-I. 41
Properties of some variants of human beta 2- microglobulin and amyloidogenesis. 38
Monitoring the interaction between β2-microglobulin and the molecular chaperone αB-crystallin by NMR and mass spectrometry: αB-crystallin dissociates β2-microglobulin oligomers. 38
Immunoglobulin light chain amyloidosis--the archetype of structural and pathogenic variability. 38
Binding of Monovalent and Bivalent Ligands by Transthyretin Causes Different Short- And Long-Distance Conformational Changes 37
Comparative study of the stabilities of synthetic in vitro and natural ex vivo transthyretin amyloid fibrils 37
Multifaceted anti-amyloidogenic and pro-amyloidogenic effects of C-reactive protein and serum amyloid P component in vitro 36
The intracellular quality control system down-regulates the secretion of amyloidogenic apolipoprotein A-I variants: A possible impact on the natural history of the disease 36
Proteomic Analysis for the Diagnosis of Fibrinogen Aα-chain Amyloidosis 36
Increasing the accuracy of proteomic typing by decellularisation of amyloid tissue biopsies 36
Effects of a vitamin E-modified dialyzer (Excebrane) on beta-2-microglobulin structure and removal. 35
Lysozyme amyloid: evidence for the W64R variant by proteomics in the absence of the wild type protein 35
Distribution and determinants of circulating complement factor H concentration determined by a high-throughput immunonephelometric assay 34
Evidence that amyloidogenic light chains undergo antigen-driven selection 33
Diagnostic amyloid proteomics: Experience of the UK National Amyloidosis Centre 33
Complement factor H binds to denatured rather than to native pentameric C-reactive protein. 32
null 30
Amyloid Formation by Globular Proteins: The Need to Narrow the Gap Between in Vitro and in Vivo Mechanisms 30
Clinical ApoA-IV amyloid is associated with fibrillogenic signal sequence 27
The complementary role of histology and proteomics for diagnosis and typing of systemic amyloidosis 26
Human wild-type and D76N β2-microglobulin variants are significant proteotoxic and metabolic stressors for transgenic C. elegans 18
Decoding the structural bases of D76N β2-microglobulin high amyloidogenicity through crystallography and asn-scan mutagenesis 18
Pathogenetic mechanisms of amyloid A amyloidosis. 14
Degradation versus fibrillogenesis, two alternative pathways modulated by seeds and glycosaminoglycans 13
Calcium Binds to Transthyretin with Low Affinity 12
Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis 12
Totale 4.417
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Categoria #
all - tutte 19.574
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 19.574
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020251 0 0 0 0 0 31 7 43 1 81 75 13
2020/2021383 68 33 11 34 8 45 5 56 22 49 42 10
2021/2022355 5 3 8 6 11 23 7 23 24 15 47 183
2022/20231.348 158 128 14 93 134 132 0 73 561 6 28 21
2023/2024442 76 89 15 19 41 106 8 24 2 16 27 19
2024/2025287 42 95 34 42 23 51 0 0 0 0 0 0
Totale 4.417