IRIS
MANGIONE, PALMA
 Distribuzione geografica
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Continente #
NA - Nord America 3.638
AS - Asia 2.492
EU - Europa 2.069
SA - Sud America 306
AF - Africa 77
OC - Oceania 9
Continente sconosciuto - Info sul continente non disponibili 1
Totale 8.592
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Nazione #
US - Stati Uniti d'America 3.549
CN - Cina 1.182
SG - Singapore 559
IE - Irlanda 484
HK - Hong Kong 300
FI - Finlandia 244
RU - Federazione Russa 238
IT - Italia 235
BR - Brasile 232
VN - Vietnam 198
DE - Germania 192
UA - Ucraina 179
FR - Francia 141
GB - Regno Unito 124
SE - Svezia 99
IN - India 66
CA - Canada 46
ZA - Sudafrica 40
PL - Polonia 31
MX - Messico 29
BD - Bangladesh 28
TR - Turchia 23
IQ - Iraq 21
BE - Belgio 19
AR - Argentina 18
NL - Olanda 18
JP - Giappone 17
ES - Italia 16
ID - Indonesia 16
CO - Colombia 14
EC - Ecuador 12
KE - Kenya 10
CZ - Repubblica Ceca 9
MA - Marocco 9
PH - Filippine 9
PK - Pakistan 9
UZ - Uzbekistan 9
CL - Cile 7
JO - Giordania 6
PE - Perù 6
VE - Venezuela 6
AE - Emirati Arabi Uniti 5
AU - Australia 5
BO - Bolivia 5
CH - Svizzera 5
JM - Giamaica 5
LT - Lituania 5
AT - Austria 4
AZ - Azerbaigian 4
EG - Egitto 4
OM - Oman 4
PY - Paraguay 4
TH - Thailandia 4
CR - Costa Rica 3
DK - Danimarca 3
HR - Croazia 3
KG - Kirghizistan 3
LV - Lettonia 3
NO - Norvegia 3
NZ - Nuova Zelanda 3
PT - Portogallo 3
RO - Romania 3
SA - Arabia Saudita 3
TN - Tunisia 3
BH - Bahrain 2
ET - Etiopia 2
HU - Ungheria 2
IL - Israele 2
IR - Iran 2
KZ - Kazakistan 2
LA - Repubblica Popolare Democratica del Laos 2
LY - Libia 2
MK - Macedonia 2
MN - Mongolia 2
MY - Malesia 2
PS - Palestinian Territory 2
SN - Senegal 2
SY - Repubblica araba siriana 2
AF - Afghanistan, Repubblica islamica di 1
AL - Albania 1
AM - Armenia 1
AO - Angola 1
BB - Barbados 1
CY - Cipro 1
DO - Repubblica Dominicana 1
EE - Estonia 1
EU - Europa 1
GN - Guinea 1
GR - Grecia 1
GT - Guatemala 1
HN - Honduras 1
KR - Corea 1
LB - Libano 1
LK - Sri Lanka 1
ML - Mali 1
MU - Mauritius 1
NG - Nigeria 1
NI - Nicaragua 1
NP - Nepal 1
RS - Serbia 1
Totale 8.587
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Città #
Chandler 484
Dublin 483
San Jose 399
Ashburn 352
Singapore 295
Hong Kong 290
Dallas 273
Beijing 263
Nanjing 230
Jacksonville 228
Boardman 127
Nanchang 96
Helsinki 92
Los Angeles 88
Princeton 87
Wilmington 79
Lawrence 78
Lauterbourg 77
Ann Arbor 76
Changsha 71
Hebei 68
New York 67
Shenyang 65
Hanoi 60
Medford 60
Munich 59
Ho Chi Minh City 58
Jiaxing 45
Milan 45
Moscow 43
Shanghai 40
Tianjin 39
Hangzhou 37
Council Bluffs 36
Buffalo 35
Orem 33
Johannesburg 32
Woodbridge 32
Redondo Beach 31
Turku 31
Pavia 30
São Paulo 29
The Dalles 26
Chennai 21
Montreal 21
Warsaw 21
Frankfurt am Main 20
Santa Clara 20
Toronto 20
Chicago 19
Brussels 18
London 17
Tokyo 16
Falls Church 15
Houston 14
Piscataway 14
Stockholm 13
Ankara 12
Atlanta 12
Brooklyn 12
Denver 12
Mexico City 12
Norwalk 12
Phoenix 12
Da Nang 11
Haiphong 11
Manchester 11
Amsterdam 10
San Francisco 10
Auburn Hills 9
Belo Horizonte 9
Fairfield 9
Nairobi 9
Poplar 9
Rio de Janeiro 9
Verona 9
Baghdad 8
Jinan 8
Mumbai 8
Tashkent 8
Washington 8
Boston 7
Charlotte 7
Sassari 7
Amman 6
Biên Hòa 6
Bogotá 6
Catania 6
Jakarta 6
Nuremberg 6
Rome 6
Seattle 6
Florence 5
Fuzhou 5
Guangzhou 5
Hefei 5
Istanbul 5
Shijiazhuang 5
Baku 4
Bologna 4
Totale 5.765
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Nome #
L'ipotesi della cascata amiloide nella malattia di Alzheimer: studi su strategie di neuroprotezione. 200
A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo 179
C. elegans expressing human beta2-microglobulin: a novel model for studying the relationship between the molecular assembly and the toxic phenotype. 171
Affinity capillary electrophoresis is a powerful tool to identify transthyretin binding drugs for potential therapeutic use in amyloidosis 159
Hepatitis C virus-associated cryoglobulinaemicglomerulonephritis with delayed appearance of monoclonal cryoglobulinaemia. 149
Biological activity and pathological implications of misfolded proteins. 148
Antibodies to human serum amyloid P component eliminate visceral amyloid deposits. 142
Beta 2- microglobulin can be refolded into a native state from ex vivo amyloid fibrils 140
Class I Major Histocompatibility Complex, the Trojan horse for secretion of amyloidogenic β2-microglobulin. 139
The H50Q mutation induces a tenfold decrease in the solubility of α-synuclein. 139
Amyloid fibrils derived from the apolipoprotein A1 Leu174Ser variant contain elements of ordered helical structure. 139
Capillary electrophoresis analysis of different variants of the amyloidogenic protein β2 -microglobulin as a simple tool for misfolding and stability studies 136
Beta2-microglobulin isoforms display an heterogeneous affinity for type I collagen. 130
Benefit of doxycycline treatment on articular disability caused by dialysis related amyloidosis 130
Sulfonated molecules that bind a partially structured species of beta2-microglobulin also influence refolding and fibrillogenesis. 129
A partially structured species of beta 2-microglobulin is significantly populated under physiological conditions and involved in fibrillogenesis 126
Co-fibrillogenesis of Wild-type and D76N β2-Microglobulin: THE CRUCIAL ROLE OF FIBRILLAR SEEDS 126
Capillary electrophoresis investigation of a partially unfolded conformation of Beta 2-microglobulin. 123
“Separation and quantification of two beta2-microglobulin isoforms”. 121
beta 2-microglobulin H31Y variant 3D-structure highlights the protein natural propensity towards intermolecular aggregation 121
C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis 119
Metodo per la separazione e la quantificazione di due conformazioni di beta-2-microglobulina in equilibrio dinamico 118
Amyloid persistence in decellularized liver: Biochemical and histopathological characterization 118
Use of anti-(beta2 microglobulin) mAb to study formation of amyloid fibrils 117
Enhanced toxicity of silver nanoparticles in transgenic Caenorhabditis elegans expressing amyloidogenic proteins 117
A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis 116
Effect of tetracyclines on the dynamics of formation and destructuration of {beta}2-microglobulin amyloid fibrils. 116
Effects of the Known Pathogenic Mutations on the Aggregation Pathway of the Amyloidogenic Peptide of Apolipoprotein A-I. 116
The two tryptophans of β2-microglobulin have distinct roles in function and folding and might represent two independent responses to evolutionary pressure. 115
Citrate-stabilized gold nanoparticles hinder fibrillogenesis of a pathological variant of β2-microglobulin 112
Plasminogen activation triggers transthyretin amyloidogenesis in vitro 112
Amyloid Formation by Globular Proteins: The Need to Narrow the Gap Between in Vitro and in Vivo Mechanisms 112
Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis. 111
Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component 110
Removal of the N-terminal hexapeptide from human beta2-microglobulin facilitates protein aggregation and fibril formation 106
Conformational dynamics of the beta2-microglobulin C terminal in the cell-membrane-anchored major histocompatibility complex type I 105
Inhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel. 103
Binding of Monovalent and Bivalent Ligands by Transthyretin Causes Different Short- And Long-Distance Conformational Changes 103
DETECTION OF FRAGMENTS OF BETA2-MICROGLOBULIN IN AMYLOID FIBRILS 103
Proteomics of beta2-microglobulin amyloid fibrils. 102
Cinetiche di refolding e studi di affinità mediante elettroforesi capillare: effetto di ligandi di interesse farmaceutico sulla conformazione della Beta 2-microglobulina 102
Detection of two partially structured species in the folding process of the amyloidogenic protein beta 2-microglobulin 101
Hereditary systemic amyloidosis due to Asp76Asn variant β2-microglobulin. 101
Comparative study of the stabilities of synthetic in vitro and natural ex vivo transthyretin amyloid fibrils 100
D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile 99
Structural basis of ligand specificity in the human pentraxins, C-reactive protein and serum amyloid P component. 96
Multifaceted anti-amyloidogenic and pro-amyloidogenic effects of C-reactive protein and serum amyloid P component in vitro 96
Proteomic Analysis for the Diagnosis of Fibrinogen Aα-chain Amyloidosis 95
Solution structure of beta(2)-microglobulin and insights into fibrillogenesis 94
Structural and folding dynamics properties of T70N variant of human lysozyme. 94
Misidentification of transthyretin and immunoglobulin variants by proteomics due to methyl lysine formation in formalin-fixed paraffin-embedded amyloid tissue 93
Preliminary crystallographic characterization of the human beta2 microglobulin His31Tyr mutant in a tetrameric assembly. 92
Topological investigation of amyloid fibrils obtained from beta2-microglobulin 92
Bifunctional crosslinking ligands for transthyretin 92
Clinical ApoA-IV amyloid is associated with fibrillogenic signal sequence 90
The new apolipoprotein A-I variant leu(174) --> Ser causes hereditary cardiac amyloidosis, and the amyloid fibrils are constituted by the 93-residue N-terminal polypeptide 88
Diagnostic amyloid proteomics: Experience of the UK National Amyloidosis Centre 86
Structural and functional characterization of three human immunoglobulin kappa light chains with different pathological implications. 85
Human wild-type and D76N β2-microglobulin variants are significant proteotoxic and metabolic stressors for transgenic C. elegans 83
Degradation versus fibrillogenesis, two alternative pathways modulated by seeds and glycosaminoglycans 83
Structure, folding dynamics and amyloidogenesis of Asp76Asn β2-microglobulin: roles of shear flow, hydrophobic surfaces and α crystallin. 83
Isolation and characterization of pharmaceutical grade human pentraxins, serum amyloid P component and C-reactive protein, for clinical use. 81
Recombinant amyloidogenic domain of ApoA-I: analysis of its fibrillogenic potential 81
Increasing the accuracy of proteomic typing by decellularisation of amyloid tissue biopsies 81
Production and immunicytochemical characterization of monoclonal antibodies to SA gene product 80
The complementary role of histology and proteomics for diagnosis and typing of systemic amyloidosis 79
Lysozyme amyloid: evidence for the W64R variant by proteomics in the absence of the wild type protein 78
Immunoglobulin light chain amyloidosis--the archetype of structural and pathogenic variability. 77
Trapping of palindromic ligands within native transthyretin prevents amyloid formation. 76
The solution structure of human ß2-microglobulin reveals the prodromes of its amyloid transition 75
Properties of some variants of human beta 2- microglobulin and amyloidogenesis. 74
Truncation of the constant domain drives amyloid formation by immunoglobulin light chains 72
Calcium Binds to Transthyretin with Low Affinity 71
Micro-heterogeneity and aggregation in beta2-microglobulin solutions: effects of temperature, pH, and conformational variant addition. 67
Pathogenetic mechanisms of amyloid A amyloidosis. 67
Effects of a vitamin E-modified dialyzer (Excebrane) on beta-2-microglobulin structure and removal. 67
The intracellular quality control system down-regulates the secretion of amyloidogenic apolipoprotein A-I variants: A possible impact on the natural history of the disease 67
Design and Mechanistic Analysis of a Potent Bivalent Inhibitor of Transthyretin Amyloid Fibrillogenesis 66
Distribution and determinants of circulating complement factor H concentration determined by a high-throughput immunonephelometric assay 64
Monitoring the interaction between β2-microglobulin and the molecular chaperone αB-crystallin by NMR and mass spectrometry: αB-crystallin dissociates β2-microglobulin oligomers. 64
Complement factor H binds to denatured rather than to native pentameric C-reactive protein. 64
Conformational switching and fibrillogenesis in the amyloidogenic fragment of apolipoprotein A-I. 61
Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis 60
Evidence that amyloidogenic light chains undergo antigen-driven selection 58
Decoding the structural bases of D76N β2-microglobulin high amyloidogenicity through crystallography and asn-scan mutagenesis 51
null 30
Role of extracellular space and matrix remodeling in cardiac amyloidosis 10
Totale 8.744
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Categoria #
all - tutte 36.334
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 36.334
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202110 0 0 0 0 0 0 0 0 0 0 0 10
2021/2022355 5 3 8 6 11 23 7 23 24 15 47 183
2022/20231.348 158 128 14 93 134 132 0 73 561 6 28 21
2023/2024455 76 89 15 19 41 106 8 24 2 20 36 19
2024/20251.371 44 96 34 42 23 54 53 97 379 50 185 314
2025/20263.230 252 238 364 392 403 152 648 112 295 214 65 95
Totale 8.744