IRIS
TOSCA, ELENA MARIA
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 1.980
AS - Asia 1.266
EU - Europa 978
SA - Sud America 309
Continente sconosciuto - Info sul continente non disponibili 112
AF - Africa 50
OC - Oceania 9
Totale 4.704
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 1.920
CN - Cina 419
SG - Singapore 327
IT - Italia 259
BR - Brasile 228
VN - Vietnam 211
IE - Irlanda 186
RU - Federazione Russa 162
HK - Hong Kong 131
DE - Germania 86
FR - Francia 74
FI - Finlandia 41
GB - Regno Unito 41
IN - India 36
ZA - Sudafrica 31
AR - Argentina 27
MX - Messico 23
CA - Canada 20
JP - Giappone 20
SE - Svezia 20
NL - Olanda 18
ES - Italia 17
PL - Polonia 16
CO - Colombia 15
IQ - Iraq 15
BD - Bangladesh 14
EC - Ecuador 12
AT - Austria 11
IR - Iran 10
CL - Cile 9
ID - Indonesia 9
TR - Turchia 9
BE - Belgio 8
CZ - Repubblica Ceca 8
MY - Malesia 8
VE - Venezuela 7
AU - Australia 6
DO - Repubblica Dominicana 6
PK - Pakistan 6
SA - Arabia Saudita 6
JO - Giordania 5
UA - Ucraina 5
AE - Emirati Arabi Uniti 4
ET - Etiopia 4
LT - Lituania 4
PH - Filippine 4
PS - Palestinian Territory 4
UZ - Uzbekistan 4
AL - Albania 3
CH - Svizzera 3
HN - Honduras 3
KE - Kenya 3
LK - Sri Lanka 3
NZ - Nuova Zelanda 3
PE - Perù 3
RO - Romania 3
TN - Tunisia 3
TW - Taiwan 3
UY - Uruguay 3
AZ - Azerbaigian 2
BO - Bolivia 2
CR - Costa Rica 2
HU - Ungheria 2
IL - Israele 2
JM - Giamaica 2
KR - Corea 2
KZ - Kazakistan 2
LB - Libano 2
LV - Lettonia 2
MA - Marocco 2
PY - Paraguay 2
QA - Qatar 2
SI - Slovenia 2
BA - Bosnia-Erzegovina 1
BB - Barbados 1
BG - Bulgaria 1
BH - Bahrain 1
BY - Bielorussia 1
DM - Dominica 1
DZ - Algeria 1
EG - Egitto 1
EU - Europa 1
GE - Georgia 1
GR - Grecia 1
GT - Guatemala 1
GW - Guinea-Bissau 1
GY - Guiana 1
HR - Croazia 1
LA - Repubblica Popolare Democratica del Laos 1
LC - Santa Lucia 1
LU - Lussemburgo 1
MN - Mongolia 1
MU - Mauritius 1
NG - Nigeria 1
NO - Norvegia 1
NP - Nepal 1
OM - Oman 1
SN - Senegal 1
UG - Uganda 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 4.594
Salva come PNG Salva come JPEG
Città #
Dallas 297
San Jose 220
Ashburn 195
Dublin 186
Singapore 169
Chandler 148
Hong Kong 124
Beijing 114
Council Bluffs 110
Ho Chi Minh City 92
Boardman 78
Los Angeles 73
Pavia 72
Lauterbourg 47
New York 47
Hanoi 43
Shanghai 41
Moscow 38
Munich 36
Nanjing 32
Redondo Beach 32
Johannesburg 31
Milan 30
São Paulo 28
Buffalo 26
Lawrence 26
Medford 26
Princeton 26
Santa Clara 21
Helsinki 20
Wilmington 20
Turku 18
Dearborn 17
Jacksonville 17
Shenyang 17
Florence 16
Hebei 15
Nanchang 15
Orem 15
Warsaw 15
Tokyo 14
Brooklyn 13
Columbus 11
Atlanta 10
Da Nang 10
Guangzhou 10
Rome 10
Stockholm 10
Tianjin 10
Changsha 9
Frankfurt am Main 9
Nuremberg 9
Ann Arbor 8
Chennai 8
Denver 8
Houston 8
Jiaxing 8
Mexico City 8
Montreal 8
Paris 8
Rio de Janeiro 8
Washington 8
Brussels 7
Chicago 7
Eindhoven 7
London 7
Poplar 7
Brescia 6
Düsseldorf 6
Hyderabad 6
Medellín 6
Mira 6
Porto Alegre 6
San Francisco 6
Seattle 6
Boston 5
Bắc Ninh 5
Cagliari 5
Fortaleza 5
Girifalco 5
Guayaquil 5
Heemskerk 5
Kunming 5
Phoenix 5
Pittsburgh 5
Tehran 5
Addis Ababa 4
Amsterdam 4
Ankara 4
Baghdad 4
Biên Hòa 4
Bogotá 4
Brasília 4
Bắc Giang 4
Can Tho 4
Caracas 4
Castano Primo 4
Dhaka 4
Fairfield 4
Falkenstein 4
Totale 2.992
Salva come PNG Salva come JPEG
Nome #
Quantitative evaluation of RC-106 antitumor activity in GBM spheroids through tumor growth inhibition modeling based on cell counts data 180
Methods and tools for multiscale modelling in Systems Pharmacology: a review 135
Dynamic energy budget based models of tumor-in-host growth inhibition and cachexia onset in preclinical settings. 124
Leveraging Two-Stage delta Global Sensitivity Analysis method to inform parameter estimation in PBPK models 123
Artificial intelligence and machine learning: just a hype or a new opportunity for pharmacometrics? 122
Evaluation of software tools for Bayesian estimation on population models:an update based on current software versions 118
A PK/PD model for tumor-in-host growth kinetics following administration of an antiangiogenic agent given alone or in combination regimens 114
Translating Preclinical Insights into Clinical Outcomes: A Predictive Framework for Overall response rate and time to progression in Solid Tumors 105
An integrated pipeline for evaluating antitumor efficacy of RC-106 on glioblastoma spheroids 105
Modeling tumor growth inhibition and toxicity outcome after administration of anticancer agents in xenograft mice: A Dynamic Energy Budget (DEB) approach 104
Dealing with stochasticity in precision dosing decision-making processes by fully exploiting PK-PD modelling in Reinforcement Learning algorithms. A practical case-study on Vancomycin continuous infusion in ICU patients 103
Cancer Cachexia: A Dynamic Energy Budget ({DEB})-Based Model for Tumor-Related Anorexia and Sarcopenia 103
Model-based analysis of patient-derived organoids for evaluating anticancer drugs 101
A Dynamic Energy Budget (DEB) based modeling framework to describe tumor-in-host growth inhibition and cachexia onset during anticancer treatment in in vivo xenograft studies 99
Evaluation of a PK/PD DEB-based model for tumor-in-host growth kinetics under anticancer treatment 95
Application of Artificial Neural Networks to Predict the Intrinsic Solubility of Drug-Like Molecules 95
A genetic algorithm for covariate selection 94
In vitro-in vivo correlation (IVIVC) population modeling for the in silico bioequivalence of a long-acting release formulation of Progesterone 92
A Population Dynamic Energy Budget-Based Tumor Growth Inhibition Model for Etoposide Effects on Wistar Rats 92
In vitro– in vivo correlation (Ivivc) population modeling for the in silico bioequivalence of a long‐acting release formulation of progesterone 92
Combining Reinforcement Learning and PK-PD models to personalize multiple drug administration: an application to Axitinib-Anti-Hypertensive treatment in metastatic renal cancer patients 90
Facing the limits of the genetic algorithms for covariate selection 90
A translational model-based approach to inform the choice of the dose in phase 1 oncology trials: the case study of erdafitinib 87
Development of a genetic algorithm for covariate analysis in population pharmacokinetic models 87
Evaluation of a tumor growth inhibition (TGI) model integrating dynamic energy budget (DEB) theory 86
Modeling approaches for reducing safety-related attrition in drug discovery and development: a review on myelotoxicity, immunotoxicity, cardiovascular toxicity, and liver toxicity 86
Dynamic Energy Budget (DEB) based models of tumor-in-host growth inhibition and cachexia onset 83
A Two-Stages Global Sensitivity Analysis by using the delta sensitivity index in presence of correlated inputs: Application on a Tumor Growth Inhibition model based on the Dynamic Energy Budget theory 82
Modeling tumor growth inhibition in Glioblastoma spheroids after exposure to RC-106, a novel sigma receptors modulator 81
A tumor-in-host DEB-based approach for modeling cachexia and bevacizumab resistance 81
A tumor-in-host Dynamic Energy Budget (DEB)-based paradigm for preclinical to clinical translation: predictions of tumor-in-host growth dynamics 78
Modeling resistance development to Bevacizumab in xenograft experiments by coupling hypoxia-mediated mechanism and a Dynamic Energy Budget (DEB) based tumor-in-host model 74
Integrating Reinforcement Learning and PK-PD modelling to enable precision dosing: a multi-objective optimization for the treatment of Polycithemia Vera patients with Givinostat 73
Predicting tumor volume doubling time and progression-free survival curves in cancer patients from patient-derived-xenograft (PDX) models: a translational model-based population approach 73
Precision dosing by integrating Reinforcement Learning and PK-PD models: application to givinostat treatment of Polycythemia Vera 73
mvLognCorrEst: an R package for sampling from multivariate lognormal distributions and estimating correlations from uncomplete correlation matrix 72
How Modelling and Simulations combined with Artificial Intelligence can improve Precision Dosing 72
A Two-Stages Global Sensitivity Analysis in presence of correlated inputs: Application on a Tumor-in-host-growth Inhibition model based on the Dynamic Energy Budget theory 71
In silico trial for the assessment of givinostat dose adjustment rules based on the management of key hematological parameters in polycythemia vera patients 69
Predicting tumor dynamics in treated patients from patient-derived-xenograft mouse models: a translational model-based approach 69
Reduced food-intake and sarcopenia in animal models of cancer anorexia-cachexia syndrome: a Dynamic Energy Budget (DEB)-based modeling approach 68
Model-informed reinforcement learning for enabling precision dosing via adaptive dosing 67
PopPK-PD modelling of Carboplatin-induced myelosuppression to support therapeutic drug monitoring and dose individualization in cancer patients using Electronic Health Record Data 67
Replacement, Reduction, and Refinement of Animal Experiments in Anticancer Drug Development: The Contribution of 3D In Vitro Cancer Models in the Drug Efficacy Assessment 65
PKPD modelling of MEN1611 anti-tumor effect in xenograft models to predict efficacy threshold concentrations in HER2-positive advanced or metastatic breast cancer patient population 65
Go beyond the limits of genetic algorithm in daily covariate selection practice 63
Predicting ADMET properties from molecule SMILE: a bottom-up approach using attention-based Graph Neural Networks 62
Precision Dosing in Presence of Multiobjective Therapies by Integrating Reinforcement Learning and PK-PD Models: Application to Givinostat Treatment of Polycythemia Vera 61
A clinical trial simulator to predict the effect of an adaptive dosing regimen of an investigated compound on platelets, white blood cells and haematocrit in patients with Polycythemia Vera 60
Model-based prediction of effective target exposure for MEN1611 in combination with trastuzumab in HER2-positive advanced or metastatic breast cancer patients 58
Staggered Herringbone Microfluid Device for the Manufacturing of Chitosan/TPP Nanoparticles: Systematic Optimization and Preliminary Biological Evaluation 58
Translational modeling of tumor response to treatment: bridging preclinical to clinical studies 58
Reinforcement Learning and PK-PD Models Integration to Personalize the Adaptive Dosing Protocol of Erdafitinib in Patients with Metastatic Urothelial Carcinoma 51
Predicting Tumor Volume Doubling Time and Progression-Free Survival in Untreated Patients from Patient-Derived-Xenograft (PDX) Models: A Translational Model-Based Approach 47
Modeling restoration of gefitinib efficacy by co-administration of MET inhibitors in an EGFR inhibitor-resistant NSCLC xenograft model: A tumor-in-host DEB-based approach 41
Impact of sampling procedure on individual pharmacokinetic parameter estimation methods 40
Totale 4.704
Salva come PNG Salva come JPEG
Categoria #
all - tutte 18.743
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 18.743
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022149 0 2 10 0 4 4 7 27 10 5 18 62
2022/2023440 48 41 6 27 25 36 2 30 199 1 9 16
2023/2024303 27 62 15 14 25 54 18 20 6 16 8 38
2024/2025901 18 97 35 35 43 11 43 44 220 49 103 203
2025/20262.551 191 252 344 410 340 78 340 103 217 161 72 43
2026/2027103 25 78 0 0 0 0 0 0 0 0 0 0
Totale 4.704