IRIS
TOSCA, ELENA MARIA
 Distribuzione geografica
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Continente #
NA - Nord America 2.326
AS - Asia 1.281
EU - Europa 1.075
SA - Sud America 311
Continente sconosciuto - Info sul continente non disponibili 114
AF - Africa 56
OC - Oceania 9
Totale 5.172
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Nazione #
US - Stati Uniti d'America 2.218
CN - Cina 422
IT - Italia 340
SG - Singapore 327
BR - Brasile 230
VN - Vietnam 211
IE - Irlanda 186
RU - Federazione Russa 169
HK - Hong Kong 131
DE - Germania 87
FR - Francia 74
GB - Regno Unito 44
FI - Finlandia 41
CA - Canada 39
IN - India 37
ZA - Sudafrica 31
AR - Argentina 27
MX - Messico 23
JP - Giappone 20
SE - Svezia 20
ES - Italia 19
NL - Olanda 19
PL - Polonia 16
CO - Colombia 15
IQ - Iraq 15
BD - Bangladesh 14
EC - Ecuador 12
AT - Austria 11
IL - Israele 11
IR - Iran 10
TR - Turchia 10
CL - Cile 9
ID - Indonesia 9
BE - Belgio 8
CR - Costa Rica 8
CZ - Repubblica Ceca 8
MY - Malesia 8
VE - Venezuela 7
AU - Australia 6
DO - Repubblica Dominicana 6
PK - Pakistan 6
SA - Arabia Saudita 6
SC - Seychelles 6
UA - Ucraina 6
GT - Guatemala 5
JO - Giordania 5
SV - El Salvador 5
AE - Emirati Arabi Uniti 4
ET - Etiopia 4
HN - Honduras 4
JM - Giamaica 4
LT - Lituania 4
PH - Filippine 4
PR - Porto Rico 4
PS - Palestinian Territory 4
UZ - Uzbekistan 4
AL - Albania 3
CH - Svizzera 3
KE - Kenya 3
LK - Sri Lanka 3
LV - Lettonia 3
NI - Nicaragua 3
NZ - Nuova Zelanda 3
PE - Perù 3
RO - Romania 3
TN - Tunisia 3
TW - Taiwan 3
UY - Uruguay 3
AZ - Azerbaigian 2
BO - Bolivia 2
CW - ???statistics.table.value.countryCode.CW??? 2
GP - Guadalupe 2
HU - Ungheria 2
KR - Corea 2
KZ - Kazakistan 2
LB - Libano 2
MA - Marocco 2
NP - Nepal 2
PY - Paraguay 2
QA - Qatar 2
SI - Slovenia 2
TT - Trinidad e Tobago 2
BA - Bosnia-Erzegovina 1
BB - Barbados 1
BG - Bulgaria 1
BH - Bahrain 1
BY - Bielorussia 1
DM - Dominica 1
DZ - Algeria 1
EG - Egitto 1
EU - Europa 1
GE - Georgia 1
GR - Grecia 1
GW - Guinea-Bissau 1
GY - Guiana 1
HR - Croazia 1
LA - Repubblica Popolare Democratica del Laos 1
LC - Santa Lucia 1
LU - Lussemburgo 1
MN - Mongolia 1
Totale 5.055
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Città #
Dallas 300
San Jose 238
Ashburn 237
Dublin 186
Singapore 169
Chandler 148
Council Bluffs 145
Hong Kong 124
Beijing 114
Ho Chi Minh City 92
Boardman 78
Los Angeles 77
Pavia 72
New York 49
Lauterbourg 47
Hanoi 43
Shanghai 41
Moscow 38
Munich 36
Milan 35
Nanjing 32
Redondo Beach 32
Johannesburg 31
São Paulo 30
Buffalo 26
Lawrence 26
Medford 26
Princeton 26
Santa Clara 24
Helsinki 20
Wilmington 20
Florence 18
Turku 18
Brooklyn 17
Dearborn 17
Jacksonville 17
Shenyang 17
Columbus 16
Rome 16
Warsaw 16
Atlanta 15
Hebei 15
Nanchang 15
Orem 15
Tokyo 14
Phoenix 12
Da Nang 10
Guangzhou 10
Stockholm 10
Tianjin 10
Changsha 9
Denver 9
Frankfurt am Main 9
Montreal 9
Nuremberg 9
Washington 9
Ann Arbor 8
Chennai 8
Chicago 8
Houston 8
Jiaxing 8
London 8
Mexico City 8
Paris 8
Rio de Janeiro 8
San Francisco 8
Brescia 7
Brussels 7
Cagliari 7
Eindhoven 7
Poplar 7
Toronto 7
Boston 6
Düsseldorf 6
Hyderabad 6
Medellín 6
Mira 6
Porto Alegre 6
San José 6
Seattle 6
Bologna 5
Bắc Ninh 5
Fortaleza 5
Girifalco 5
Guayaquil 5
Heemskerk 5
Kunming 5
Naples 5
Pittsburgh 5
Tehran 5
Addis Ababa 4
Amsterdam 4
Ankara 4
Baghdad 4
Biên Hòa 4
Bogotá 4
Brasília 4
Bắc Giang 4
Can Tho 4
Caracas 4
Totale 3.154
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Nome #
Quantitative evaluation of RC-106 antitumor activity in GBM spheroids through tumor growth inhibition modeling based on cell counts data 196
Evaluation of software tools for Bayesian estimation on population models:an update based on current software versions 142
Methods and tools for multiscale modelling in Systems Pharmacology: a review 139
Dynamic energy budget based models of tumor-in-host growth inhibition and cachexia onset in preclinical settings. 138
A PK/PD model for tumor-in-host growth kinetics following administration of an antiangiogenic agent given alone or in combination regimens 137
Leveraging Two-Stage delta Global Sensitivity Analysis method to inform parameter estimation in PBPK models 131
Artificial intelligence and machine learning: just a hype or a new opportunity for pharmacometrics? 128
Dealing with stochasticity in precision dosing decision-making processes by fully exploiting PK-PD modelling in Reinforcement Learning algorithms. A practical case-study on Vancomycin continuous infusion in ICU patients 127
An integrated pipeline for evaluating antitumor efficacy of RC-106 on glioblastoma spheroids 115
Translating Preclinical Insights into Clinical Outcomes: A Predictive Framework for Overall response rate and time to progression in Solid Tumors 114
Modeling tumor growth inhibition and toxicity outcome after administration of anticancer agents in xenograft mice: A Dynamic Energy Budget (DEB) approach 110
Cancer Cachexia: A Dynamic Energy Budget ({DEB})-Based Model for Tumor-Related Anorexia and Sarcopenia 109
Combining Reinforcement Learning and PK-PD models to personalize multiple drug administration: an application to Axitinib-Anti-Hypertensive treatment in metastatic renal cancer patients 106
Model-based analysis of patient-derived organoids for evaluating anticancer drugs 105
A Dynamic Energy Budget (DEB) based modeling framework to describe tumor-in-host growth inhibition and cachexia onset during anticancer treatment in in vivo xenograft studies 105
Application of Artificial Neural Networks to Predict the Intrinsic Solubility of Drug-Like Molecules 103
A Population Dynamic Energy Budget-Based Tumor Growth Inhibition Model for Etoposide Effects on Wistar Rats 101
In vitro– in vivo correlation (Ivivc) population modeling for the in silico bioequivalence of a long‐acting release formulation of progesterone 100
Evaluation of a PK/PD DEB-based model for tumor-in-host growth kinetics under anticancer treatment 99
A genetic algorithm for covariate selection 99
In vitro-in vivo correlation (IVIVC) population modeling for the in silico bioequivalence of a long-acting release formulation of Progesterone 97
Facing the limits of the genetic algorithms for covariate selection 96
Development of a genetic algorithm for covariate analysis in population pharmacokinetic models 94
Modeling tumor growth inhibition in Glioblastoma spheroids after exposure to RC-106, a novel sigma receptors modulator 93
A translational model-based approach to inform the choice of the dose in phase 1 oncology trials: the case study of erdafitinib 93
Evaluation of a tumor growth inhibition (TGI) model integrating dynamic energy budget (DEB) theory 92
Modeling approaches for reducing safety-related attrition in drug discovery and development: a review on myelotoxicity, immunotoxicity, cardiovascular toxicity, and liver toxicity 91
A Two-Stages Global Sensitivity Analysis by using the delta sensitivity index in presence of correlated inputs: Application on a Tumor Growth Inhibition model based on the Dynamic Energy Budget theory 90
Dynamic Energy Budget (DEB) based models of tumor-in-host growth inhibition and cachexia onset 90
A tumor-in-host DEB-based approach for modeling cachexia and bevacizumab resistance 89
A tumor-in-host Dynamic Energy Budget (DEB)-based paradigm for preclinical to clinical translation: predictions of tumor-in-host growth dynamics 82
In silico trial for the assessment of givinostat dose adjustment rules based on the management of key hematological parameters in polycythemia vera patients 81
mvLognCorrEst: an R package for sampling from multivariate lognormal distributions and estimating correlations from uncomplete correlation matrix 81
Predicting tumor dynamics in treated patients from patient-derived-xenograft mouse models: a translational model-based approach 81
Predicting ADMET properties from molecule SMILE: a bottom-up approach using attention-based Graph Neural Networks 81
Modeling resistance development to Bevacizumab in xenograft experiments by coupling hypoxia-mediated mechanism and a Dynamic Energy Budget (DEB) based tumor-in-host model 80
Precision dosing by integrating Reinforcement Learning and PK-PD models: application to givinostat treatment of Polycythemia Vera 79
Integrating Reinforcement Learning and PK-PD modelling to enable precision dosing: a multi-objective optimization for the treatment of Polycithemia Vera patients with Givinostat 78
Predicting tumor volume doubling time and progression-free survival curves in cancer patients from patient-derived-xenograft (PDX) models: a translational model-based population approach 77
Model-informed reinforcement learning for enabling precision dosing via adaptive dosing 77
How Modelling and Simulations combined with Artificial Intelligence can improve Precision Dosing 77
A Two-Stages Global Sensitivity Analysis in presence of correlated inputs: Application on a Tumor-in-host-growth Inhibition model based on the Dynamic Energy Budget theory 75
Replacement, Reduction, and Refinement of Animal Experiments in Anticancer Drug Development: The Contribution of 3D In Vitro Cancer Models in the Drug Efficacy Assessment 73
PopPK-PD modelling of Carboplatin-induced myelosuppression to support therapeutic drug monitoring and dose individualization in cancer patients using Electronic Health Record Data 73
Staggered Herringbone Microfluid Device for the Manufacturing of Chitosan/TPP Nanoparticles: Systematic Optimization and Preliminary Biological Evaluation 71
Precision Dosing in Presence of Multiobjective Therapies by Integrating Reinforcement Learning and PK-PD Models: Application to Givinostat Treatment of Polycythemia Vera 70
Go beyond the limits of genetic algorithm in daily covariate selection practice 70
Reduced food-intake and sarcopenia in animal models of cancer anorexia-cachexia syndrome: a Dynamic Energy Budget (DEB)-based modeling approach 69
PKPD modelling of MEN1611 anti-tumor effect in xenograft models to predict efficacy threshold concentrations in HER2-positive advanced or metastatic breast cancer patient population 69
Model-based prediction of effective target exposure for MEN1611 in combination with trastuzumab in HER2-positive advanced or metastatic breast cancer patients 67
A clinical trial simulator to predict the effect of an adaptive dosing regimen of an investigated compound on platelets, white blood cells and haematocrit in patients with Polycythemia Vera 66
Predicting Tumor Volume Doubling Time and Progression-Free Survival in Untreated Patients from Patient-Derived-Xenograft (PDX) Models: A Translational Model-Based Approach 61
Translational modeling of tumor response to treatment: bridging preclinical to clinical studies 60
Reinforcement Learning and PK-PD Models Integration to Personalize the Adaptive Dosing Protocol of Erdafitinib in Patients with Metastatic Urothelial Carcinoma 59
Modeling restoration of gefitinib efficacy by co-administration of MET inhibitors in an EGFR inhibitor-resistant NSCLC xenograft model: A tumor-in-host DEB-based approach 44
Impact of sampling procedure on individual pharmacokinetic parameter estimation methods 42
Totale 5.172
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Categoria #
all - tutte 20.768
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 20.768
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022137 0 0 0 0 4 4 7 27 10 5 18 62
2022/2023440 48 41 6 27 25 36 2 30 199 1 9 16
2023/2024303 27 62 15 14 25 54 18 20 6 16 8 38
2024/2025901 18 97 35 35 43 11 43 44 220 49 103 203
2025/20262.551 191 252 344 410 340 78 340 103 217 161 72 43
2026/2027571 25 109 107 203 127 0 0 0 0 0 0 0
Totale 5.172