IRIS
LINCIANO, PASQUALE
 Distribuzione geografica
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Continente #
NA - Nord America 2.371
AS - Asia 1.724
EU - Europa 1.155
SA - Sud America 287
AF - Africa 83
Continente sconosciuto - Info sul continente non disponibili 5
OC - Oceania 3
AN - Antartide 1
Totale 5.629
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Nazione #
US - Stati Uniti d'America 2.295
CN - Cina 511
SG - Singapore 468
HK - Hong Kong 312
IE - Irlanda 296
BR - Brasile 208
RU - Federazione Russa 203
IT - Italia 183
VN - Vietnam 183
DE - Germania 105
FR - Francia 95
FI - Finlandia 70
GB - Regno Unito 67
IN - India 49
ZA - Sudafrica 46
BD - Bangladesh 44
CA - Canada 35
AR - Argentina 28
PL - Polonia 26
IQ - Iraq 23
JP - Giappone 23
AT - Austria 22
MX - Messico 22
ES - Italia 16
EC - Ecuador 15
VE - Venezuela 15
SE - Svezia 13
ID - Indonesia 12
BE - Belgio 11
TR - Turchia 11
NL - Olanda 10
PK - Pakistan 10
MA - Marocco 9
PH - Filippine 9
CO - Colombia 8
SA - Arabia Saudita 8
UZ - Uzbekistan 8
AE - Emirati Arabi Uniti 7
UA - Ucraina 7
JO - Giordania 6
CZ - Repubblica Ceca 5
EU - Europa 5
JM - Giamaica 5
KR - Corea 5
LT - Lituania 5
TW - Taiwan 5
BO - Bolivia 4
CL - Cile 4
DO - Repubblica Dominicana 4
EG - Egitto 4
KZ - Kazakistan 4
MY - Malesia 4
OM - Oman 4
SN - Senegal 4
TN - Tunisia 4
AZ - Azerbaigian 3
DZ - Algeria 3
HU - Ungheria 3
KE - Kenya 3
PA - Panama 3
PE - Perù 3
SI - Slovenia 3
AL - Albania 2
BG - Bulgaria 2
ET - Etiopia 2
GA - Gabon 2
HN - Honduras 2
IL - Israele 2
KG - Kirghizistan 2
LB - Libano 2
NZ - Nuova Zelanda 2
PS - Palestinian Territory 2
PT - Portogallo 2
TT - Trinidad e Tobago 2
AM - Armenia 1
AO - Angola 1
AQ - Antartide 1
AU - Australia 1
BA - Bosnia-Erzegovina 1
BJ - Benin 1
BY - Bielorussia 1
CI - Costa d'Avorio 1
CR - Costa Rica 1
CY - Cipro 1
DK - Danimarca 1
HR - Croazia 1
KW - Kuwait 1
LC - Santa Lucia 1
LK - Sri Lanka 1
LV - Lettonia 1
ME - Montenegro 1
ML - Mali 1
NA - Namibia 1
NO - Norvegia 1
NP - Nepal 1
PY - Paraguay 1
QA - Qatar 1
RS - Serbia 1
SK - Slovacchia (Repubblica Slovacca) 1
SV - El Salvador 1
Totale 5.626
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Città #
San Jose 409
Hong Kong 303
Dublin 295
Ashburn 270
Chandler 257
Dallas 251
Singapore 241
Beijing 136
Boardman 83
Lauterbourg 76
Council Bluffs 75
Los Angeles 73
Shanghai 67
Helsinki 59
Ho Chi Minh City 58
Hanoi 51
New York 50
Munich 45
Johannesburg 37
Buffalo 35
Pavia 34
Redondo Beach 33
Moscow 29
Orem 29
The Dalles 29
Seattle 24
Lawrence 23
Medford 23
Princeton 23
Tokyo 23
Warsaw 23
Santa Clara 22
Florence 19
Milan 17
Wilmington 16
Frankfurt am Main 15
São Paulo 15
Chicago 14
Columbus 14
Vienna 14
Atlanta 13
Washington 13
Da Nang 12
Nanjing 12
Stockholm 12
Brussels 11
Chennai 11
Baghdad 10
Mexico City 10
New Delhi 10
Turku 10
Montreal 9
Motta di Livenza 9
San Francisco 9
Boston 8
Dhaka 8
Palermo 8
Tashkent 8
Brooklyn 7
Denver 7
Guangzhou 7
Manchester 7
Nuremberg 7
Quito 7
Toronto 7
Amman 6
Amsterdam 6
Brasília 6
Curitiba 6
Falkenstein 6
London 6
Phoenix 6
Poplar 6
Ankara 5
Bari 5
Bolzaneto 5
Buenos Aires 5
Düsseldorf 5
Haiphong 5
Pune 5
Seoul 5
Woodbridge 5
Biên Hòa 4
Cairo 4
Caracas 4
Changsha 4
Chongqing 4
Dakar 4
Dubai 4
Hangzhou 4
Houston 4
Kingston 4
Kyiv 4
Lahore 4
Lucca 4
Lucknow 4
Muscat 4
Ninh Bình 4
Paris 4
Pretoria 4
Totale 3.707
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Nome #
Could the Oxidation of α1-Antitrypsin Prevent the Binding of Human Neutrophil Elastase in COVID-19 Patients? 121
COMPOSTI AD ATTIVITÀ ANTIPARASSITARIA 116
Identification of N,N-arylalkyl-picolinamide derivatives targeting the RNA-binding protein HuR, by combining biophysical fragment-screening and molecular hybridization 112
Microwave-Assisted Extraction and HPLC-UV-CD Determination of (S)-usnic Acid in Cladonia foliacea 109
Bitopic Sigma 1 Receptor Modulators to Shed Light on Molecular Mechanisms Underpinning Ligand Binding and Receptor Oligomerization 109
Effects of Bisphenols on RACK1 Expression and Their Immunological Implications in THP-1 Cells 107
1,3-Dithiolane as a Privileged Scaffold in Bioactive Derivatives: Chiral Resolution and Assignment of Absolute Configuration 105
Chiral 2-phenyl-3-hydroxypropyl esters as PKC-alpha modulators: HPLC enantioseparation, NMR absolute configuration assignment, and molecular docking studies 100
1,3-Dioxane as a scaffold for potent and selective 5-HT1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity 98
EFFECTS OF ENDOCRINE ACTIVE CONTAMINATING PESTICIDES ON RACK1 EXPRESSION AND IMMUNOLOGICAL CONSEQUENCES IN THP-1 CELLS 96
Identification of a Potent and Selective 5-HT1AReceptor Agonist with in Vitro and in Vivo Antinociceptive Activity 96
Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents 94
A green Heck reaction protocol towards trisubstituted alkenes, versatile pharmaceutical intermediates 92
Discovery of RC-752, a Novel Sigma-1 Receptor Antagonist with Antinociceptive Activity: A Promising Tool for Fighting Neuropathic Pain 92
Structural Insights into the Ligand-LsrK Kinase Binding Mode: A Step Forward in the Discovery of Novel Antimicrobial Agents 91
Identification of a 2,4-diaminopyrimidine scaffold targeting Trypanosoma brucei pteridine reductase 1 from the LIBRA compound library screening campaign 85
4-Amino-1,2,4-triazole-3-thione as a Promising Scaffold for the Inhibition of Serine and Metallo-β-Lactamases 84
Neurodegeneration: can metabolites from Eremurus persicus help? 82
Sigma receptor and aquaporin modulators: chiral resolution, configurational assignment, and preliminary biological profile of RC752 enantiomers 82
Aryl thiosemicarbazones for the treatment of trypanosomatidic infections 82
From Nature to Synthetic Compounds: Novel 1(N),2,3 Trisubstituted-5-oxopyrrolidines Targeting Multiple Myeloma Cells 81
Scouting Sigma Receptor Ligands As New Tools For The Treatment Of Neurodegenerative Diseases And Cancer 81
Sigma-1 receptor antagonists: promising players in fighting neuropathic pain 81
Setup and Validation of a Reliable Docking Protocol for the Development of Neuroprotective Agents by Targeting the Sigma-1 Receptor (S1R) 81
Tackling Antimicrobial Resistance with Small Molecules Targeting LsrK: Challenges and Opportunities 81
An Improved Synthesis of CENTA, a Chromogenic Substrate for β-Lactamases 80
Cannabinoid profiling of hemp seed oil by liquid chromatography coupled to high-resolution mass spectrometry 80
Analysis of impurities of cannabidiol from hemp. Isolation, characterization and synthesis of cannabidibutol, the novel cannabidiol butyl analog 79
Effect of the rigidification of propranolol, a mixed β-adrenoceptor and 5-HT1AR antagonist 78
Chemical and spectroscopic characterization data of ‘cannabidibutol’, a novel cannabidiol butyl analog 78
Investigation of the effect of different linker chemotypes on the inhibition of Histone Deacetylases (HDACs) 78
Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth 77
Development of therapeutic agents blocking SOS activation 73
A multidisciplinary approach to the design of novel inhibitors for KPC-2 72
Short- and Long-Term Regulation of HuD: A Molecular Switch Mediated by Folic Acid? 72
Druggability profile of stilbene-derived PPAR agonists: Determination of physicochemical properties and PAMPA study 72
Effects of endocrine disrupting chemicals on the expression of RACK1 and LPS-induced THP-1 cell activation 72
Biophysical Assays for Investigating Modulators of Macromolecular Complexes: An Overview 71
Sigma-1 receptor agonists acting on aquaporin-mediated h2o2 permeability: New tools for counteracting oxidative stress 71
A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol: Δ9-Tetrahydrocannabiphorol 70
The novel heptyl phorolic acid cannabinoids content in different Cannabis sativa L. accessions 68
New LsrK Ligands as AI-2 Quorum Sensing Interfering Compounds against Biofilm Formation 66
Evidence of pyrimethamine and cycloguanil analogues as dual inhibitors of trypanosoma brucei pteridine reductase and dihydrofolate reductase 65
Evolving Challenges and Opportunities in Plant-based Drug Discovery and Development 65
Peptide Nucleic Acids in Saturation Transfer Difference Nuclear Magnetic Resonance Experiments: A Simple and Valuable Tool for Studying HuR–Small Molecule Complexes 64
Peptides as Therapeutic Agents: Challenges and Opportunities in the Green Transition Era 64
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth 63
Is cannabidiol a scheduled controlled substance? Origin makes the difference 63
Identification of HuR-RNA Interfering Compounds by Dynamic Combinatorial Chemistry and Fluorescence Polarization 62
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics 61
Ten Years with New Delhi Metallo-β-lactamase-1 (NDM-1): From Structural Insights to Inhibitor Design 60
Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents 59
Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform 59
Repurposing the Antiplatelet Agent Ticlopidine to Counteract the Acute Phase of ER Stress Condition: An Opportunity for Fighting Coronavirus Infections and Cancer 59
Effect of stilbene and chalcone scaffolds incorporation in clofibric acid on PPARα agonistic activity 55
New weapons against antimicrobial resistance: 
Targeting SOS response to recover b
 actericidal activity of antibiotics
 55
Identification of a novel extracellular inhibitor of FGF2/FGFR signaling axis by combined virtual screening and NMR spectroscopy approach 55
Origin of Δ9-Tetrahydrocannabinol Impurity in Synthetic Cannabidiol 55
Discovery of potent pyrrolo-pyrimidine and purine HDAC inhibitors for the treatment of advanced prostate cancer 54
Discovery of semisynthetic derivatives of (R)- and (S)-usnic acids as potential antifungal agents against C. tropicalis and T. rubrum 53
High-resolution crystal structure of Trypanosoma brucei pteridine reductase 1 in complex with an innovative tricyclic-based inhibitor 53
Identification of a new cannabidiol n-hexyl homolog in a medicinal cannabis variety with an antinociceptive activity in mice: cannabidihexol 52
BS148 Reduces the Aggressiveness of Metastatic Melanoma via Sigma-2 Receptor Targeting 51
Geometric Isomerism of an Acetamidino Derivative Determined by NMR Investigations 45
Phenyl boronic acids development led to validated leads active in clinical strains overexpressing KPC-2: a step against bacterial resistance 44
Structural development studies of PPARs ligands based on tyrosine scaffold 43
Fibrate-derived N-(methylsulfonyl)amides with antagonistic properties on PPARa 42
Excited-state intramolecular proton transfer in a bioactive flavonoid provides fluorescence observables for recognizing its engagement with target proteins 42
Structural Insights into the Development of Cycloguanil Derivatives as Trypanosoma brucei Pteridine-Reductase-1 Inhibitors 41
Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1 41
Urea-based anticancer agents. Exploring 100-years of research with an eye to the future 41
Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds 41
First virtual screening and experimental validation of inhibitors targeting GES-5 carbapenemase 38
Isolation of a High-Affinity Cannabinoid for the Human CB1 Receptor from a Medicinal Cannabis sativa Variety: Δ9-Tetrahydrocannabutol, the Butyl Homologue of Δ9-Tetrahydrocannabinol 37
Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To InhibitTrypanosoma bruceiPteridine Reductase in Support of Early-Stage Drug Discovery 36
Synthesis and structure-activity relationships of fibrate-based analogues inside PPARs 35
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections 35
The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents 35
In Silico-Guided Discovery and In Vitro Evaluation of Natural Sortase A Inhibitors to Fight Multidrug-Resistant Staphylococcus aureus 33
Hits and Lead Discovery in the Identification of New Drugs against the Trypanosomatidic Infections 31
Inhibitors of histone deacetylase 6 based on a novel 3-hydroxy-isoxazole zinc binding group 31
High-Throughput Phenotypic Screening and Machine Learning Methods Enabled the Selection of Broad-Spectrum Low-Toxicity Antitrypanosomatidic Agents 31
Design of 2-Aminobenzothiazole Derivatives Targeting Trypanosomatid PTR1 by a Multidisciplinary Fragment Hybridization Approach 29
Use of primary amines for the selective N-Alkylation of anilines by a reusable heterogeneous catalyst 29
In silico identification and experimental validation of hits active against KPC-2 β-lactamase 29
Phenylboronic Acids Probing Molecular Recognition against Class A and Class C beta-Lactamases 28
Optimization of N-alkylation in the Synthesis of Methotrexate and Pteridine-based Derivatives Under Microwave-Irradiation 26
Sustainable chemistry and preclinical characterization of RC-106·HCl: A brain-penetrant pan sigma receptor modulator for glioblastoma 7
Targeting Autoinducer-2 Quorum Sensing: Novel Inhibitors Attenuate Virulence in Staphylococcus aureus and Pseudomonas aeruginosa 7
The Differential Redox Resilience of Alvelestat and Sivelestat: A Mechanistic Hypothesis for Inhibitor Performance Under Oxidative Stress 6
HuR-Targeted Small Molecules Reduce Pseudomonas aeruginosa Adhesion in Cystic Fibrosis Airway Epithelial Cells 3
Bioprospecting Italian biodiversity for identifying potential neuroprotective agents 2
Totale 5.730
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Categoria #
all - tutte 28.498
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 28.498
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022120 0 0 16 0 1 3 1 13 2 4 22 58
2022/2023729 33 45 14 65 56 76 0 47 341 9 27 16
2023/2024502 23 92 21 27 34 124 63 40 6 21 22 29
2024/20251.262 22 92 20 24 33 118 84 60 310 60 142 297
2025/20263.085 238 247 337 305 363 100 529 149 278 235 166 138
Totale 5.730