IRIS
COLLINA, SIMONA
 Distribuzione geografica
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Continente #
NA - Nord America 10.415
AS - Asia 8.159
EU - Europa 6.915
SA - Sud America 1.300
AF - Africa 299
Continente sconosciuto - Info sul continente non disponibili 12
OC - Oceania 1
Totale 27.101
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Nazione #
US - Stati Uniti d'America 10.120
CN - Cina 3.867
SG - Singapore 1.671
IE - Irlanda 1.508
BR - Brasile 971
IT - Italia 934
HK - Hong Kong 859
RU - Federazione Russa 828
VN - Vietnam 795
DE - Germania 743
UA - Ucraina 655
FI - Finlandia 607
FR - Francia 527
GB - Regno Unito 410
IN - India 260
SE - Svezia 257
ZA - Sudafrica 170
CA - Canada 163
AR - Argentina 116
JP - Giappone 104
BD - Bangladesh 100
IQ - Iraq 89
MX - Messico 89
BE - Belgio 77
ES - Italia 67
PL - Polonia 64
EC - Ecuador 51
TR - Turchia 48
VE - Venezuela 47
ID - Indonesia 45
NL - Olanda 45
CO - Colombia 42
PK - Pakistan 40
LT - Lituania 30
AT - Austria 29
MA - Marocco 28
PH - Filippine 28
UZ - Uzbekistan 27
CZ - Repubblica Ceca 24
SA - Arabia Saudita 24
CL - Cile 20
MY - Malesia 20
PT - Portogallo 19
AE - Emirati Arabi Uniti 18
IR - Iran 18
JO - Giordania 18
CH - Svizzera 17
PY - Paraguay 17
TN - Tunisia 16
AZ - Azerbaigian 14
KR - Corea 14
EG - Egitto 13
PE - Perù 13
NP - Nepal 12
KE - Kenya 11
BO - Bolivia 10
UY - Uruguay 10
AL - Albania 9
DZ - Algeria 9
IL - Israele 9
KZ - Kazakistan 9
DO - Repubblica Dominicana 8
EU - Europa 8
KG - Kirghizistan 8
PA - Panama 8
BG - Bulgaria 7
CI - Costa d'Avorio 7
ET - Etiopia 7
GR - Grecia 7
JM - Giamaica 7
AM - Armenia 6
DK - Danimarca 6
HU - Ungheria 6
LB - Libano 6
LV - Lettonia 6
NO - Norvegia 6
OM - Oman 6
RO - Romania 6
SN - Senegal 6
MU - Mauritius 5
PS - Palestinian Territory 5
TH - Thailandia 5
TT - Trinidad e Tobago 5
AO - Angola 4
CR - Costa Rica 4
GA - Gabon 4
HN - Honduras 4
HR - Croazia 4
LK - Sri Lanka 4
RS - Serbia 4
TL - Timor Orientale 4
EE - Estonia 3
GY - Guiana 3
KH - Cambogia 3
KW - Kuwait 3
LY - Libia 3
MG - Madagascar 3
MN - Mongolia 3
SK - Slovacchia (Repubblica Slovacca) 3
SY - Repubblica araba siriana 3
Totale 27.055
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Città #
Dublin 1.505
Chandler 1.365
Dallas 950
Ashburn 940
Singapore 894
San Jose 868
Beijing 842
Hong Kong 835
Jacksonville 788
Nanjing 736
Boardman 406
Los Angeles 319
Ho Chi Minh City 290
Ann Arbor 288
Nanchang 270
Lauterbourg 266
Princeton 237
Helsinki 233
New York 228
Lawrence 226
Munich 217
Hebei 214
Shanghai 196
Shenyang 196
Pavia 192
Wilmington 185
Changsha 174
Medford 173
Hanoi 165
Jiaxing 157
Johannesburg 151
Moscow 151
Tianjin 128
Milan 127
Hangzhou 123
Redondo Beach 120
Buffalo 106
São Paulo 95
Tokyo 94
Orem 89
Pune 78
Toronto 74
Brussels 73
Woodbridge 68
Chennai 67
Turku 66
Santa Clara 64
Seattle 60
The Dalles 55
Warsaw 55
Frankfurt am Main 51
London 46
Piscataway 46
Da Nang 45
Chicago 43
Norwalk 42
Stockholm 42
Council Bluffs 41
Denver 41
Montreal 39
Manchester 37
Atlanta 34
Haiphong 33
Rio de Janeiro 33
Columbus 31
Houston 31
Verona 31
Brooklyn 30
Florence 30
Mexico City 30
Poplar 30
Dearborn 28
Guangzhou 28
Amsterdam 27
Nuremberg 26
Fairfield 25
Falkenstein 25
Phoenix 25
San Francisco 24
Tashkent 24
Boston 23
Zhengzhou 23
Des Moines 22
Rome 22
Washington 22
Baghdad 21
Basingstoke 20
Sulaymaniyah 20
Mumbai 19
Quito 19
Naples 18
Biên Hòa 17
Jinan 17
Mountain View 17
Auburn Hills 16
Brasília 16
Caracas 16
Curitiba 16
Hải Dương 16
New Delhi 16
Totale 17.593
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Nome #
Estrazione mediante microonde (MASE) di cumarina e composti correlati da Melilotus officinalis, una valida alternativa all'estrazione con Soxhlet e con ultrasuoni (USAE). 431
Quantitative evaluation of RC-106 antitumor activity in GBM spheroids through tumor growth inhibition modeling based on cell counts data 173
Estrazione di flavonoidi da Crataegus monogyna Jacq. mediante microonde (MASE), un'alternativa alla macerazione, all'estrazione con Soxhlet e con ultrasuoni (USAE). 168
A step forward in understanding the binding of ELAV mimicking peptides to mRNA. An integrated computational and NMR approach 165
ASSESMENT OF MARRUBIUM VULGARE L. HERBAL RAW MATERIAL QUALITY. SET UP OF A COMBINED MASE AND HPLC-UV/PAD METHODOLOGY DRIVEN BY DOE 159
(R)-RC-33 as Promising Neuroprotective Agent Acting as Sigma1 Receptor Agonist 157
Fingerprint Analitico di estratti da Amygdalus Lycioides (Spach.) 152
A composite nanosystem as a potential tool for the local treatment of glioblastoma: Chitosan‐coated solid lipid nanoparticles embedded in electrospun nanofibers 151
Disegno razionale e sintesi di ligandi selettivi per il sottotipo recettoriale sigma1 150
Microwave assisted synthesis of chiral pyrrolines with biological activity 147
Approaches for multi-gram scale isolation of enantiomers for drug discovery 147
3-Piperidin-4-ylmethyl-3H-benzoxazol-2-one derivatives as sigma ligands 146
Formulation of microspheres containing Crataegus monogyna extract in feed design 146
An eco-friendly enantioselective access to (R)-Naringenin as inhibitor of proinflammatory cytokine release. 145
Studies on the Enantiomers of RC-33 as Neuroprotective Agents: Isolation, Configurational Assignment, and Preliminary Biological Profile 145
SAR Evaluation of Chiral Naphthylorfines with Antinociceptive Activity 143
A step forward in the sigma enigma: a role for chirality in the sigma1 receptor- ligand interaction? 143
Dialkylaminoalkylnaphthalenes as novel opioid-like analgesics 142
Sintesi parallela in soluzione di scaffolds olefinici per la preparazione di nuovi ligandi sigma 142
Disegno razionale, sintesi e valutazione biologica di nuovi ligandi ad elevata affinità per i recettori sigma 1 a struttura fenilalchenil- e fenilalchil- amminica 142
Chemical, pharmacological, and in vitro metabolic stability studies on enantiomerically pure RC-33 compounds, promising neuroprotective agents acting as sigma1 receptor agonists. 142
Design, synthesis and SAR analysis of novel selective sigma1 ligands (Part 2) 142
Progettazione e Sintesi di nuovi Ligandi Sigma 141
Beyond the affinity for protein kinase C: Exploring 2-phenyl-3-hydroxypropyl pivalate analogues as C1 domain-targeting ligands 140
Identification of RC-33 as a potent and selective sigma1 receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells. Part 2: g-scale synthesis, physicochemical characterization and in vitro metabolic stability. 137
Anti-inflammatory properties of ethanolic root extract of Eremurus persicus (Jaub and Spach) Boiss, a Kurdish herbal remedy 137
Preparation and Configuration of Racemic and Optically Active Analgesic Cycloaminoalkiynaphthalenes 136
Estrazione di cumarina da Melilotus officinalis (L.) Pallas. 136
New perspectives in cancer therapy: the biotin-antitumor molecule conjugates 136
Design and synthesis of a (N-alkylaminoalkyl-substituted)arylalkenylamide drug discovery library 136
Marrubium vulgare l. leave extract: Phytochemical composition, antioxidant and wound healing properties 136
Chiral Flavanones from Amygdalus lycioides Spach: Structural Elucidation and Identification of TNFalpha Inhibitors by Bioactivity-guided Fractionation 135
Anti-tumor efficacy assessment of the sigma receptor pan modulator RC-106. A promising therapeutic tool for pancreatic cancer 135
Novel sigma ligands: design, preparation and biological evaluation 134
Nature inspired new compounds against Leishmaniosis, from Eremurus persicus 133
Preparazione mediante reattivi supportati e riscaldamento a microonde di esteri alpha-beta-insaturi, intermedi chiave per la sintesi di nuovi ligandi sigma 132
An efficient procedure based on MW-assisted Horner–Wadsworth-Emmons reaction for the synthesis of (Z)-3,3-trisubstituted alpha, beta-unsaturated esters 132
(R)-(-)-Aloesaponol III 8-methyl ether from eremurus persicus: A novel compound against leishmaniosis 132
Sigma receptor modulators: a patent review. 131
Direct HPLC enantioseparation of new chiral sigma 1 ligands on coated polisaccharide-based chiral stationary phases. 131
Eremurus persicus Boiss: ethnobotanical relevance, analytical fingerprint and preliminary biological results of root extracts 130
Alginate-based electrospun fibers for the delivery of sigma-1 receptor agonists in the treatment of spinal cord injuries 130
Design, synthesis and biological evaluation of new sigma ligands based on arylalkenylaminic scaffold 129
Gaining in Pan-Affinity Towards Sigma 1 and Sigma 2 Receptors. SAR studies on arylalkylamines 129
Exploring the RC-106 Chemical Space: Design and Synthesis of Novel (E)-1-(3-Arylbut-2-en-1-yl)-4-(Substituted) Piperazine Derivatives as Potential Anticancer Agents. 129
Novel Compounds Targeting the RNA-Binding Protein HuR. Structure-Based Design, Synthesis, and Interaction Studies 128
Synthesis of novel sigma ligands. Investigation on the application of Pd(0) EnCatTM 30NP in conventional hydrogenation and CTH MW-assisted protocols 127
Synthesis and Pharmacological Evaluation of New N-methyl-arylpyrrolidinols with Analgesic Activity 127
Drug discovery from plants: antimicrobial evaluation of Amygdalus lycioides (Spach.) branch extracts 126
Influence of the Extraction Mode on the Yield of Hyperoside, Vitexin and Vitexin-2”-O-Rhamnoside from Crataegus monogyna Jacq. (Hawthorn) 126
ARE we stable? An integrated in vitro/in silico approach for the study of Embryonic Lethal Abnormal Vision protein and mRNA interactions. 126
Discovery of new and selective sigma 1 ligands potentiating nerve growth factor induced neurite outgrowth in PC12 cells 125
An Analytical and Scale-Up Separation by HPLC and SFC of theFlavonoid Naringenin on a RegisPack® Chiral Stationary Phase 125
Microwave and Polymer Assisted Synthesis of a Small Library of alpha,beta-Unsaturated Methyl Esters via the Witting Reaction 124
Identification of a potent and selective sigma1 receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells. 124
Synthesis and antinociceptive activity of Pyrrolidinylnaphthalenes 124
Are sigma modulators an effective opportunity for cancer treatment? A patent overview (1996-2016). 123
PAN-SIGMA RECEPTOR MODULATORS AS PROMISING ANTICANCER-AGENTS. THE STORY OF RC-106 123
Design, synthesis and pharmacological activity of new antinociceptive agents 122
Identification of Peptides with ELAV-like mRNA Stabilizing Effect: An Integrated In Vitro/In Silico Approach 122
Enantiomeric Resolution and Absolute Configuration of a Chiral δ-Lactam, Useful Intermediate for the Synthesis of Bioactive Compounds 122
Could the Oxidation of α1-Antitrypsin Prevent the Binding of Human Neutrophil Elastase in COVID-19 Patients? 121
Enantioselective chromatography and absolute configuration of N,N-dimethyl-3-(naphthalen-2-yl)-butan-1-amines: potential sigma 1 ligands. 121
A step forward in the sigma enigma: the role of chirality in the interaction ligand-sigma1 receptor 120
Highly diastereoselective synthesis of enantiopure naphthylaminoalcohols with analgesic properties 120
Identification of dual Sigma1 receptor modulators/acetylcholinesterase inhibitors with antioxidant and neurotrophic properties, as neuroprotective agents 120
DPD-Inspired Discovery of Novel LsrK Kinase Inhibitors: An Opportunity To Fight Antimicrobial Resistance 120
Insight into GEBR-32a: Chiral resolution, absolute configuration and enantiopreference in PDE4D inhibition 120
Epigenetic effect of naringenin: effects of (S)-naringenin and (R)-naringenin on miR-17-3p and miR-25-5p expression levels. 119
Derivati indolilalchilaminici. Approccio razionale alla progettazione di nuovi ligandi sigma 118
Efficient Microwave and Phosphane-free Synthesis of Trisubstituted Olefins via Heck Coupling 118
One-pot synthesis of alfa,beta-unsaturated carboxylic acid via tandem Wittig olefination-hydrolysis reaction under combined microwave and ultrasound irradiation. 118
NOVEL PKC ALPHA LIGANDS: RATIONAL DESIGN, PREPARATION AND BIOLOGICAL INVESTIGATION 118
Synthesis of pyrrolinylnaphthalenes and evaluation of their antinociceptive activity 118
Pistagremic acid, a glucosidase inhibitor from Pistacia integerrima 117
IDENTIFICATION OF NEW LIGANDS FOR SIGMA RECEPTORS.DESIGN AND SYNTHESIS OF A BETA-AMINOKETONIC DRUG DISCOVERY LIBRARY 116
Development of easy-to-use reverse-phase liquid chromatographic methods for determining PRE-084, RC-33 and RC-34 in biological matrices. The first step for in vivo analysis of sigma1 receptor agonists. 116
FLAVANONES FROM AMYGDALUS LYCIOIDES SPACH: ISOLATION, CHARACTERIZATION AND BIOLOGICAL EVALUATION 115
In silico exploration of the Embryonic Lethal Abnormal Visionprotein-mRNA interaction followed by in vitro bioassays for the identification of peptides potentially useful in neurodegenerative diseases treatment 115
A practical synthesis of (3-(phenanthren-9-yl)-4,5-dihydroisoxazol-5-yl)methyl (tert-butoxycarbonyl)-L-alaninate 115
Electrospun alginate-PEO fibers for the delivery of sigma-1 receptor agonists in the treatment of SCI: influence of PEO molecular weight on fiber production. 115
Antibacterial activity and metabolite profiling of manuka honey (Lectospermum scoparium L.) submitted to in vitro simulated digestion. 114
Chiral arylpyrrolidinols: preparation and biological profile 114
Chiral recognition of alkyl 2-aryloxypropionates by HPLC 114
Chemical and biological profile of racemic and optically active dialkylaminoalkylnaphthalenes with analgesic activity. 114
A novel composite nanosystem as a potential tool for the local treatment of glioblastoma. 113
Small peptides able to mimic ELAV RNA-binding proteins: preparation and biological evaluation 113
New biotinilated spacers for studying the interaction of ELAV mimicking peptides with the target mRNA 113
Enantioselective modulatory effects of (S)-naringenin and (R)-naringenin on miR-17-3p and miR-25-5p 113
Are sigma receptor modulators a weapon against multiple sclerosis disease? 113
A versatile strategy for the synthesis of 4,5-dihydroxy-2,3-pentanedione (DPD) and related compounds as potential modulators of bacterial quorum sensing 113
Synthesis and SAR of Novel Sigma1 Selective Ligands 112
New perspectives in neurodegenerative diseases: chiral resolution and configurational assignment of novel PKC alpha ligands 112
Nature aided drug discovery. Novel Compounds against Leishmaniasis from Eremurus persicus. 112
Influence of in Vitro Simulated Gastroduodenal Digestion on Methylglyoxal Concentration of Manuka ( Lectospermum scoparium ) Honey. 112
Risoluzione di ligandi selettivi sigma1 a struttura alchilamminoalchilarilica mediante HPLC chirale e studio configurazionale 111
Rational Approach to the Design of Selective Sigma 1 Ligands 111
Towards sigma1 receptor agonists as neuroprotective agents. Preparation, configurational assignment and in vitro biological profile 111
Beyond the affinity for the Protein Kinase C: a critical evaluation of 2-fenil-3hydroxypropyl pivalate analogs targeting the C1 domain 111
Diastereoselective synthesis of chiral nonracemic naphthylaminoalcohols with analgesic activity 111
Totale 13.146
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Categoria #
all - tutte 102.392
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 102.392
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021405 0 0 0 0 0 0 0 0 0 199 162 44
2021/20221.153 20 16 51 19 17 36 26 76 62 45 154 631
2022/20233.922 365 345 51 273 365 410 3 207 1.714 23 111 55
2023/20241.788 209 291 52 96 152 415 106 133 9 75 124 126
2024/20254.570 106 347 126 143 195 299 262 241 1.143 162 500 1.046
2025/20269.978 847 740 1.405 1.249 1.424 473 1.876 472 903 589 0 0
Totale 27.488