IRIS
CHIARELLI, LAURENT ROBERT
 Distribuzione geografica
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Continente #
NA - Nord America 7.556
AS - Asia 4.625
EU - Europa 3.703
SA - Sud America 658
Continente sconosciuto - Info sul continente non disponibili 441
AF - Africa 217
OC - Oceania 15
Totale 17.215
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Nazione #
US - Stati Uniti d'America 7.240
CN - Cina 2.083
SG - Singapore 963
IE - Irlanda 850
IT - Italia 618
HK - Hong Kong 558
BR - Brasile 484
RU - Federazione Russa 458
VN - Vietnam 427
DE - Germania 362
FI - Finlandia 349
UA - Ucraina 270
FR - Francia 230
GB - Regno Unito 188
IN - India 152
CA - Canada 145
ZA - Sudafrica 122
SE - Svezia 121
AR - Argentina 65
BD - Bangladesh 65
MX - Messico 55
ID - Indonesia 47
JP - Giappone 46
IQ - Iraq 40
NL - Olanda 40
TR - Turchia 40
AT - Austria 39
PL - Polonia 37
BE - Belgio 32
PK - Pakistan 32
CO - Colombia 29
ES - Italia 29
UZ - Uzbekistan 20
CL - Cile 19
EC - Ecuador 19
CR - Costa Rica 17
EG - Egitto 17
LT - Lituania 16
MA - Marocco 16
VE - Venezuela 16
CZ - Repubblica Ceca 15
SA - Arabia Saudita 15
AZ - Azerbaigian 14
CW - ???statistics.table.value.countryCode.CW??? 14
HN - Honduras 14
MY - Malesia 14
AE - Emirati Arabi Uniti 13
IL - Israele 13
AU - Australia 12
JM - Giamaica 12
PH - Filippine 12
TT - Trinidad e Tobago 12
SC - Seychelles 11
SV - El Salvador 11
PR - Porto Rico 10
NG - Nigeria 9
NI - Nicaragua 9
LV - Lettonia 8
GT - Guatemala 7
KR - Corea 7
LB - Libano 7
PA - Panama 7
TN - Tunisia 7
UY - Uruguay 7
BO - Bolivia 6
IR - Iran 6
JO - Giordania 6
KE - Kenya 6
KZ - Kazakistan 6
PE - Perù 6
PY - Paraguay 6
RO - Romania 6
ET - Etiopia 5
GP - Guadalupe 5
GR - Grecia 5
KG - Kirghizistan 5
NP - Nepal 5
OM - Oman 5
DO - Repubblica Dominicana 4
DZ - Algeria 4
MU - Mauritius 4
RS - Serbia 4
TH - Thailandia 4
AL - Albania 3
AO - Angola 3
DK - Danimarca 3
MD - Moldavia 3
PT - Portogallo 3
SK - Slovacchia (Repubblica Slovacca) 3
SY - Repubblica araba siriana 3
AG - Antigua e Barbuda 2
BB - Barbados 2
CG - Congo 2
CH - Svizzera 2
CY - Cipro 2
EU - Europa 2
GE - Georgia 2
HU - Ungheria 2
IM - Isola di Man 2
KW - Kuwait 2
Totale 16.755
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Città #
Dublin 818
Ashburn 804
San Jose 773
Chandler 677
Hong Kong 544
Singapore 487
Beijing 467
Council Bluffs 411
Dallas 388
Jacksonville 358
Nanjing 327
Boardman 235
Los Angeles 208
Helsinki 159
Ann Arbor 155
Nanchang 149
Ho Chi Minh City 146
Lauterbourg 143
Pavia 139
New York 138
Wilmington 136
Princeton 135
Lawrence 127
Medford 114
Munich 112
Shenyang 102
Hanoi 101
Johannesburg 97
Shanghai 97
Hebei 92
Hangzhou 90
Santa Clara 90
Changsha 83
Jiaxing 72
Moscow 72
Milan 71
Tianjin 69
Buffalo 60
Redondo Beach 60
São Paulo 54
Orem 53
Tokyo 44
The Dalles 39
Turku 38
Chicago 35
Montreal 35
Columbus 34
Woodbridge 34
Rome 33
Brooklyn 32
Vienna 32
Warsaw 32
Toronto 31
Brussels 30
Dearborn 30
Haiphong 29
Boston 27
Phoenix 27
Atlanta 26
Denver 26
Frankfurt am Main 25
London 25
Stockholm 25
Houston 24
Chennai 23
Naples 23
Seattle 23
Verona 23
Florence 22
Da Nang 21
Fairfield 21
Falkenstein 21
Mexico City 20
San Francisco 20
Tashkent 20
Piscataway 19
Nuremberg 17
Washington 17
Norwalk 16
Curitiba 15
Mumbai 15
San Genesio ed Uniti 15
Amsterdam 14
Baku 14
Charlotte 14
Des Moines 14
Willemstad 14
Cape Town 13
Guangzhou 13
Istanbul 13
Jinan 13
Rio de Janeiro 13
New Delhi 12
Ningbo 12
Ottawa 12
Baghdad 11
Dhaka 11
North Bergen 11
Olomouc 11
Poplar 11
Totale 10.703
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Nome #
2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1. 222
Biological and structural characterization of theMycobacterium smegmatis nitroreductase NfnB, and its rolein benzothiazinone resistance 179
Absence of interaction between doppel and GFAP, Grb2, PrPC proteins in human tumor astrocytic cells 177
Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis 176
Investigating the Mechanism of Action of Diketopiperazines Inhibitors of the Burkholderia cenocepacia Quorum Sensing Synthase CepI: A Site-Directed Mutagenesis Study 170
The prion-like doppel protein is soluble in astrocytic tumor 164
4-Aminoquinolone Piperidine Amides: Non-Covalent Inhibitors of DprE1 with Long Residence Time and Potent Antimycobacterial Activity. 163
Aberrant Doppel Protein Expression in Human Astrocytic Tumors 162
Letter to the editor regarding Shibayama et al.: Biochemical and pathophysiological characterization of Helicobacter pylori asparaginase. 156
A phenotypic based target screening approach delivers new antitubercular CTP synthetase inhibitors 155
Cell-cycle inhibition by Helicobacter pylori L-asparaginase. 153
Biochemical Characterization of Glutamate Racemase-A New Candidate Drug Target against Burkholderia cenocepacia Infections 149
A new mutation of the pgk1 gene detected in an italian patient affected by phosphoglycerate kinase deficiency. 147
Engineering of Helicobacter pylori L-asparaginase: characterization of two functionally distinct groups of mutants 146
Generation of Mutants of Helicobacter pylori L-Asparaginase 144
The prion protein-like gene Doppel is aberrantly expressed in astrocytic tumors 143
Phosphoglycerate Kinase Deficiency: Characterization of the Wild-Type Enzyme and Three Pathological Variants Generated from C.140T>a, C.491A>T and C.959G>a Mutations 142
Discovery of new diketopiperazines inhibiting Burkholderia cenocepacia quorum sensing in vitro and in vivo. 141
Chemical, Metabolic, and Cellular Characterization of a FtsZ Inhibitor Effective Against Burkholderia cenocepacia 141
A New Benzothiazolthiazolidine Derivative, 11726172, Is Active In Vitro, In Vivo, and against Nonreplicating Cells of Mycobacterium tuberculosis 140
Helicobacter pylori L-asparaginase: from Gene to Diagnostic Tool 140
Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis. 140
Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis. 140
Molecular and cellular insights into the aberrant expression of the prion protein-like gene doppel in astrocytic tumors 140
Biochemistry of Lipolytic Enzymes Secreted by Penicillium solitum and Cladosporium cladosporioides 140
Mycobacterium tuberculosis Phosphoribosylpyrophosphate Synthetase: Biochemical Features of a Crucial Enzyme for Mycobacterial Cell Wall Biosynthesis. 139
A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK 136
Expanding targets for a metabolic therapy of cancer: L-asparaginase 135
Helicobacter pylori: from gene to Diagnostic Tool 134
Could the Oxidation of α1-Antitrypsin Prevent the Binding of Human Neutrophil Elastase in COVID-19 Patients? 132
BEL β-trefoil: a novel lectin with antineoplastic properties in king bolete (Boletus edulis) mushrooms. 132
Molecular Insights on Pathogenic Effects of MutationsCausing Phosphoglycerate Kinase Deficiency 131
Ectopic expression of the prion-like protein doppel in human astrocytoma cells 131
New prodrugs against tuberculosis 131
A new promising bactericidal compound against Burkholderia cenocepacia. 131
The allosteric regulation of pyruvate kinase. 131
Competitive fitness of essential gene knockdowns reveals a broad-spectrum antibacterial inhibitor of the cell division protein FtsZ 131
Expanding Targets for a Metabolic Therapy of Cancer: L- Asparaginase 129
From virulence factors to drug development: MbtI as an effective Mycobacterium tuberculosis target 128
SELECTION OF MICROFUNGI WITH HIGH LIPOLYTIC ACTIVITYAND THEIR LIPASE CHARACTERIZATION 128
An Overview on the Potential Antimycobacterial Agents Targeting Serine/Threonine Protein Kinases from Mycobacterium tuberculosis 128
Biochemical signatures of doppel (Dpl) protein in human glioblastoma to support prediction in tumor malignancy 127
Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG. 127
A Coumarin-Based Analogue of Thiacetazone as Dual Covalent Inhibitor and Potential Fluorescent Label of HadA in Mycobacterium tuberculosis 127
Pyruvate kinase deficiency: Biochemical characterization of two mutations causing inability of the enzyme to properly bind substrates 126
Nuclear mRNA retention and aberrant doppel protein expression in human astrocytic tumor cells 126
New and old hot drug targets in tuberculosis 126
The cell division protein FtsZ as a cellular target to hit cystic fibrosis pathogens 125
Burkholderia cenocepacia infections in cystic fibrosis patients: Drug resistance and therapeutic approaches 124
ThermoFAD, a Thermofluor®-adapted flavin ad hoc detection system for protein folding and ligand binding 123
PYRUVATE KINASE DEFICIENCY: MOLECULAR AND FUNCTIONAL CHARACTERISATION OF A LETHAL VARIANT 122
Structural and Activity Relationships of 6-Sulfonyl-8-Nitrobenzothiazinones as Antitubercular Agents 122
Design, Syntheses, and Anti-TB Activity of 1,3-Benzothiazinone Azide and Click Chemistry Products Inspired by BTZ043 121
New insights into the mechanism of action of the thienopyrimidine antitubercular prodrug TP053 121
CanB, a Druggable Cellular Target in Mycobacterium tuberculosis 119
PHOSPHOGLYCERATE KINASE DEFICIENCY: FUNCTIONAL PROPERTIES OF THE L89P, K191DEL, C316R AND A354P PATHOLOGICAL VARIANTS 119
Characterization of a pyrimidine 5'-nucleotidase mutant form (G214R) causing hereditary hemolytic anemia. 119
Rv0579 Is Involved in the Resistance to the TP053 Antitubercular Prodrug 119
Molecular cloning and characterisation of Helicobacter pylori L-asparaginase 118
Protein Recognition by Short Peptide Reversible Inhibitors of the Chromatin-Modifying LSD1/CoREST Lysine Demethylase. 118
A new variant of phosphoglycerate kinase deficiency (p.I371K) with multiple tissue involvement: molecular and functional characterization. 118
Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia 117
Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents 117
Micellar electrokinetic chromatography as a complementary method to sodium dodecyl sulfate-polyacrylamide gel electrophoresis for studying limited proteolysis of proteins. 115
Targeting iron uptake pathway for the development of novel antitubercular drugs. 115
The crystal structure of Burkholderia cenocepacia DfsA provides insights into substrate recognition and quorum sensing fatty acid biosynthesis 114
Improve protection to prevent infections: application of reverse vaccinology against cystic fibrosis pathogens. 114
Mycobacterium tuberculosis Sulfate Ester Dioxygenase Rv3406 Is Able to Inactivate the RCB18350 Compound. 113
Premio Ricercatissimi 2008 110
Design, synthesis and evaluation of covalent inhibitors of DprE1 as antitubercular agents 109
Functional investigation of the antitubercular drug target Decaprenylphosphoryl-β-D-ribofuranose-2-epimerase DprE1/DprE2 complex 109
Investigating the Molecular Bases of the Phosphoglycerate Kinase Deficiency: Characterization ofG158V, R206P, V266M and D285V Pathological Variants. 108
Erythrocyte adenylate kinase deficiency: characterization of recombinant mutant forms and relationship with nonspherocytic hemolytic anemia 107
Antivirulence compounds: a future direction to overcome antibiotic resistance? 107
The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis. 106
Molecular basis of pyrimidine 5'-nucleotidase deficiency caused by 3 newly identified missense mutations (c.187T>C, c.469G>C and c.740T>C) and a tabulation of known mutations 106
Mechanochemical Synthesis and Biological Evaluation of Novel Isoniazid Derivatives with Potent Antitubercular Activity. 103
Molecular Characterization of Three New Mutant Enzymes of Pyrimidine 5-Nucleotidase Causing Hereditary Hemolytic Anemia. 103
EXPRESSION AND CHARACTERIZATION OF THE BOVINE PRION DOPPEL 102
Erythrocyte Adenylate Kinase Deficiency: First In-Depth Biochemical Characterization of the Y164C Mutant Enzyme Causing Hemolytic Anemia 101
Aeroplane shaped crystal of a mutant ofHelicobacter pylori L-asparaginase. 101
Pyrimidine 5' Nucleotidase Deficiency: Clinical and Molecular Characterization of Two New Italian Patients 101
Nitric oxide-releasing compounds for the treatment of lung infections 101
Mycobacterium abscessus siderophores biosynthesis as a target to inhibit the iron uptake mechanism 100
The antimalarial mefloquine shows activity against mycobacterium abscessus, inhibiting mycolic acid metabolism 100
Molecular and functional characterization of a lethal variant of pyruvate kinase deficiency 99
Repurposing of FDA-Approved Drugs to Disrupt Iron Uptake in Mycobacterium abscessus: Targeting Salicylate Synthase as a Novel Approach 98
Pyrimidine 5'-nucleotidase activities detected in real samples by means of micellar electrokinetic chromatography. 98
6-Hydroxy-2-methylbenzofuran-4-carboxylic Acid 98
Molecular Basis of Hemolytic Anemia: First Biochemical Characterization of Wild-Type and N190S Mutant Human Erythrocyte Pyrimidine 5'-Nucleotidase. 97
Multitargeting Compounds: A Promising Strategy to Overcome Multi-Drug Resistant Tuberculosis 96
Inosine monophosphate dehydrogenase activity after mycophenolate mofetil in renal transplant patients receiving different immunosupressive combined therapy and stable after at least three months' administration. 95
Red cell pyruvate kinase deficiency: 17 new mutations of the PK-LR gene 95
Structural and Energetic Basis of Protein Kinetic Destabilization in Human Phosphoglycerate Kinase 1 Deficiency 95
Pharmacokinetic-pharmacodynamic (PK/PD) monitoring of mycophenolate mofetil in de novo and long-term renal transplant patients 95
Exploring the role of the heterocyclic moiety of 5-(4-nitrophenyl)-2-furoic acid, a promising inhibitor of MbtI from Mycobacterium tuberculosis. 95
Benzothiozinone derivatives with anti-tubercular Activity−Further side chain investigation 94
New antivirulence compounds affecting Burkholderia cenocepacia quorum sensing in vitro and in vivo. 94
Pyruvate kinase deficiency : The genotype-phenotype association 93
Molecular Cloning and Characterisation of Helicobacter Pylori L-Asparaginase: A Cytotoxic Factor with Potential Biomedical Applications 93
Totale 12.438
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Categoria #
all - tutte 74.614
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 74.614
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022570 0 0 0 0 19 15 15 47 44 22 79 329
2022/20232.055 188 181 25 156 177 195 5 109 934 13 50 22
2023/20241.048 160 175 41 85 88 228 46 69 5 49 46 56
2024/20252.590 77 191 76 54 92 106 178 158 659 103 321 575
2025/20265.883 494 348 672 702 698 252 1.043 279 593 429 208 165
2026/20271.951 96 354 436 761 304 0 0 0 0 0 0 0
Totale 17.215