IRIS
CHIARELLI, LAURENT ROBERT
 Distribuzione geografica
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Continente #
NA - Nord America 6.230
AS - Asia 4.600
EU - Europa 3.482
SA - Sud America 637
Continente sconosciuto - Info sul continente non disponibili 425
AF - Africa 205
OC - Oceania 15
Totale 15.594
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Nazione #
US - Stati Uniti d'America 6.043
CN - Cina 2.076
SG - Singapore 963
IE - Irlanda 849
HK - Hong Kong 556
BR - Brasile 466
RU - Federazione Russa 444
IT - Italia 437
VN - Vietnam 426
DE - Germania 362
FI - Finlandia 349
UA - Ucraina 269
FR - Francia 225
GB - Regno Unito 178
IN - India 151
ZA - Sudafrica 121
SE - Svezia 119
CA - Canada 96
AR - Argentina 65
BD - Bangladesh 63
MX - Messico 55
ID - Indonesia 46
JP - Giappone 46
IQ - Iraq 40
TR - Turchia 40
AT - Austria 39
NL - Olanda 37
PL - Polonia 36
BE - Belgio 32
PK - Pakistan 31
CO - Colombia 27
ES - Italia 27
CL - Cile 19
UZ - Uzbekistan 19
EC - Ecuador 18
EG - Egitto 17
LT - Lituania 16
MA - Marocco 16
VE - Venezuela 16
CZ - Repubblica Ceca 15
SA - Arabia Saudita 15
AZ - Azerbaigian 14
MY - Malesia 14
AE - Emirati Arabi Uniti 13
AU - Australia 12
PH - Filippine 12
NG - Nigeria 9
LV - Lettonia 8
CR - Costa Rica 7
KR - Corea 7
LB - Libano 7
PA - Panama 7
TN - Tunisia 7
UY - Uruguay 7
BO - Bolivia 6
IR - Iran 6
JM - Giamaica 6
JO - Giordania 6
KE - Kenya 6
PE - Perù 6
PY - Paraguay 6
RO - Romania 6
ET - Etiopia 5
GR - Grecia 5
IL - Israele 5
KG - Kirghizistan 5
KZ - Kazakistan 5
NP - Nepal 5
OM - Oman 5
DO - Repubblica Dominicana 4
DZ - Algeria 4
MU - Mauritius 4
RS - Serbia 4
TH - Thailandia 4
AL - Albania 3
AO - Angola 3
HN - Honduras 3
MD - Moldavia 3
PT - Portogallo 3
SK - Slovacchia (Repubblica Slovacca) 3
SY - Repubblica araba siriana 3
CG - Congo 2
CH - Svizzera 2
CY - Cipro 2
DK - Danimarca 2
EU - Europa 2
GE - Georgia 2
HU - Ungheria 2
IM - Isola di Man 2
KW - Kuwait 2
LA - Repubblica Popolare Democratica del Laos 2
NI - Nicaragua 2
NO - Norvegia 2
NZ - Nuova Zelanda 2
PS - Palestinian Territory 2
SN - Senegal 2
TJ - Tagikistan 2
AG - Antigua e Barbuda 1
AM - Armenia 1
BG - Bulgaria 1
Totale 15.148
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Città #
Dublin 818
San Jose 691
Chandler 676
Ashburn 593
Hong Kong 543
Singapore 487
Beijing 463
Dallas 379
Jacksonville 355
Nanjing 327
Boardman 235
Council Bluffs 211
Los Angeles 191
Helsinki 159
Ann Arbor 155
Nanchang 149
Ho Chi Minh City 146
Lauterbourg 143
Pavia 137
Princeton 135
Wilmington 135
Lawrence 127
New York 127
Medford 114
Munich 112
Shenyang 102
Hanoi 100
Shanghai 97
Johannesburg 96
Hebei 92
Hangzhou 90
Changsha 83
Jiaxing 72
Moscow 72
Santa Clara 71
Tianjin 69
Milan 60
Redondo Beach 60
Buffalo 55
Orem 50
Tokyo 44
São Paulo 42
The Dalles 39
Turku 38
Woodbridge 34
Montreal 32
Vienna 32
Warsaw 32
Columbus 31
Brussels 30
Chicago 30
Dearborn 30
Haiphong 29
Denver 25
Frankfurt am Main 25
Brooklyn 24
London 24
Chennai 23
Stockholm 23
Boston 22
Seattle 22
Toronto 22
Da Nang 21
Fairfield 21
Falkenstein 21
Verona 21
Atlanta 20
Houston 20
Mexico City 20
Piscataway 19
Tashkent 19
San Francisco 18
Nuremberg 17
Phoenix 16
Washington 16
Mumbai 15
Norwalk 15
San Genesio ed Uniti 15
Amsterdam 14
Baku 14
Curitiba 14
Cape Town 13
Des Moines 13
Florence 13
Guangzhou 13
Istanbul 13
Jinan 13
Rio de Janeiro 13
New Delhi 12
Ningbo 12
Ottawa 12
Baghdad 11
Dhaka 11
Olomouc 11
Poplar 11
Biên Hòa 10
Buenos Aires 10
Hyderabad 10
Recife 10
Rome 10
Totale 9.987
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Nome #
2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1. 208
Absence of interaction between doppel and GFAP, Grb2, PrPC proteins in human tumor astrocytic cells 169
Biological and structural characterization of theMycobacterium smegmatis nitroreductase NfnB, and its rolein benzothiazinone resistance 165
Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis 160
Aberrant Doppel Protein Expression in Human Astrocytic Tumors 154
4-Aminoquinolone Piperidine Amides: Non-Covalent Inhibitors of DprE1 with Long Residence Time and Potent Antimycobacterial Activity. 152
Letter to the editor regarding Shibayama et al.: Biochemical and pathophysiological characterization of Helicobacter pylori asparaginase. 148
Investigating the Mechanism of Action of Diketopiperazines Inhibitors of the Burkholderia cenocepacia Quorum Sensing Synthase CepI: A Site-Directed Mutagenesis Study 148
A phenotypic based target screening approach delivers new antitubercular CTP synthetase inhibitors 144
Cell-cycle inhibition by Helicobacter pylori L-asparaginase. 139
Generation of Mutants of Helicobacter pylori L-Asparaginase 136
The prion-like doppel protein is soluble in astrocytic tumor 135
Phosphoglycerate Kinase Deficiency: Characterization of the Wild-Type Enzyme and Three Pathological Variants Generated from C.140T>a, C.491A>T and C.959G>a Mutations 135
Engineering of Helicobacter pylori L-asparaginase: characterization of two functionally distinct groups of mutants 135
Biochemical Characterization of Glutamate Racemase-A New Candidate Drug Target against Burkholderia cenocepacia Infections 134
Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis. 132
Molecular and cellular insights into the aberrant expression of the prion protein-like gene doppel in astrocytic tumors 132
Expanding targets for a metabolic therapy of cancer: L-asparaginase 131
Chemical, Metabolic, and Cellular Characterization of a FtsZ Inhibitor Effective Against Burkholderia cenocepacia 131
Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis. 130
Biochemistry of Lipolytic Enzymes Secreted by Penicillium solitum and Cladosporium cladosporioides 130
Discovery of new diketopiperazines inhibiting Burkholderia cenocepacia quorum sensing in vitro and in vivo. 130
Mycobacterium tuberculosis Phosphoribosylpyrophosphate Synthetase: Biochemical Features of a Crucial Enzyme for Mycobacterial Cell Wall Biosynthesis. 129
New prodrugs against tuberculosis 128
A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK 128
Expanding Targets for a Metabolic Therapy of Cancer: L- Asparaginase 126
A New Benzothiazolthiazolidine Derivative, 11726172, Is Active In Vitro, In Vivo, and against Nonreplicating Cells of Mycobacterium tuberculosis 125
The prion protein-like gene Doppel is aberrantly expressed in astrocytic tumors 125
Ectopic expression of the prion-like protein doppel in human astrocytoma cells 125
BEL β-trefoil: a novel lectin with antineoplastic properties in king bolete (Boletus edulis) mushrooms. 124
An Overview on the Potential Antimycobacterial Agents Targeting Serine/Threonine Protein Kinases from Mycobacterium tuberculosis 123
Could the Oxidation of α1-Antitrypsin Prevent the Binding of Human Neutrophil Elastase in COVID-19 Patients? 122
Pyruvate kinase deficiency: Biochemical characterization of two mutations causing inability of the enzyme to properly bind substrates 121
The allosteric regulation of pyruvate kinase. 121
From virulence factors to drug development: MbtI as an effective Mycobacterium tuberculosis target 120
A new mutation of the pgk1 gene detected in an italian patient affected by phosphoglycerate kinase deficiency. 120
A Coumarin-Based Analogue of Thiacetazone as Dual Covalent Inhibitor and Potential Fluorescent Label of HadA in Mycobacterium tuberculosis 120
Biochemical signatures of doppel (Dpl) protein in human glioblastoma to support prediction in tumor malignancy 119
New and old hot drug targets in tuberculosis 119
Helicobacter pylori L-asparaginase: from Gene to Diagnostic Tool 118
Burkholderia cenocepacia infections in cystic fibrosis patients: Drug resistance and therapeutic approaches 118
Nuclear mRNA retention and aberrant doppel protein expression in human astrocytic tumor cells 117
Competitive fitness of essential gene knockdowns reveals a broad-spectrum antibacterial inhibitor of the cell division protein FtsZ 117
A new promising bactericidal compound against Burkholderia cenocepacia. 116
Structural and Activity Relationships of 6-Sulfonyl-8-Nitrobenzothiazinones as Antitubercular Agents 116
ThermoFAD, a Thermofluor®-adapted flavin ad hoc detection system for protein folding and ligand binding 115
Helicobacter pylori: from gene to Diagnostic Tool 115
Molecular Insights on Pathogenic Effects of MutationsCausing Phosphoglycerate Kinase Deficiency 115
Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG. 115
New insights into the mechanism of action of the thienopyrimidine antitubercular prodrug TP053 114
Molecular cloning and characterisation of Helicobacter pylori L-asparaginase 113
CanB, a Druggable Cellular Target in Mycobacterium tuberculosis 112
Design, Syntheses, and Anti-TB Activity of 1,3-Benzothiazinone Azide and Click Chemistry Products Inspired by BTZ043 112
A new variant of phosphoglycerate kinase deficiency (p.I371K) with multiple tissue involvement: molecular and functional characterization. 112
The cell division protein FtsZ as a cellular target to hit cystic fibrosis pathogens 112
Rv0579 Is Involved in the Resistance to the TP053 Antitubercular Prodrug 112
Characterization of a pyrimidine 5'-nucleotidase mutant form (G214R) causing hereditary hemolytic anemia. 111
Protein Recognition by Short Peptide Reversible Inhibitors of the Chromatin-Modifying LSD1/CoREST Lysine Demethylase. 110
Micellar electrokinetic chromatography as a complementary method to sodium dodecyl sulfate-polyacrylamide gel electrophoresis for studying limited proteolysis of proteins. 110
Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents 110
SELECTION OF MICROFUNGI WITH HIGH LIPOLYTIC ACTIVITYAND THEIR LIPASE CHARACTERIZATION 109
Improve protection to prevent infections: application of reverse vaccinology against cystic fibrosis pathogens. 109
Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia 108
Premio Ricercatissimi 2008 106
PHOSPHOGLYCERATE KINASE DEFICIENCY: FUNCTIONAL PROPERTIES OF THE L89P, K191DEL, C316R AND A354P PATHOLOGICAL VARIANTS 104
Investigating the Molecular Bases of the Phosphoglycerate Kinase Deficiency: Characterization ofG158V, R206P, V266M and D285V Pathological Variants. 102
Targeting iron uptake pathway for the development of novel antitubercular drugs. 102
Design, synthesis and evaluation of covalent inhibitors of DprE1 as antitubercular agents 102
Functional investigation of the antitubercular drug target Decaprenylphosphoryl-β-D-ribofuranose-2-epimerase DprE1/DprE2 complex 102
The crystal structure of Burkholderia cenocepacia DfsA provides insights into substrate recognition and quorum sensing fatty acid biosynthesis 101
Erythrocyte adenylate kinase deficiency: characterization of recombinant mutant forms and relationship with nonspherocytic hemolytic anemia 100
Antivirulence compounds: a future direction to overcome antibiotic resistance? 100
Molecular Characterization of Three New Mutant Enzymes of Pyrimidine 5-Nucleotidase Causing Hereditary Hemolytic Anemia. 99
Mycobacterium tuberculosis Sulfate Ester Dioxygenase Rv3406 Is Able to Inactivate the RCB18350 Compound. 98
EXPRESSION AND CHARACTERIZATION OF THE BOVINE PRION DOPPEL 97
Mycobacterium abscessus siderophores biosynthesis as a target to inhibit the iron uptake mechanism 96
Erythrocyte Adenylate Kinase Deficiency: First In-Depth Biochemical Characterization of the Y164C Mutant Enzyme Causing Hemolytic Anemia 96
Molecular basis of pyrimidine 5'-nucleotidase deficiency caused by 3 newly identified missense mutations (c.187T>C, c.469G>C and c.740T>C) and a tabulation of known mutations 96
Pyrimidine 5' Nucleotidase Deficiency: Clinical and Molecular Characterization of Two New Italian Patients 96
Aeroplane shaped crystal of a mutant ofHelicobacter pylori L-asparaginase. 95
The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis. 95
Mechanochemical Synthesis and Biological Evaluation of Novel Isoniazid Derivatives with Potent Antitubercular Activity. 95
Nitric oxide-releasing compounds for the treatment of lung infections 95
6-Hydroxy-2-methylbenzofuran-4-carboxylic Acid 93
Molecular and functional characterization of a lethal variant of pyruvate kinase deficiency 92
Pyrimidine 5'-nucleotidase activities detected in real samples by means of micellar electrokinetic chromatography. 92
Multitargeting Compounds: A Promising Strategy to Overcome Multi-Drug Resistant Tuberculosis 92
Inosine monophosphate dehydrogenase activity after mycophenolate mofetil in renal transplant patients receiving different immunosupressive combined therapy and stable after at least three months' administration. 90
Molecular Basis of Hemolytic Anemia: First Biochemical Characterization of Wild-Type and N190S Mutant Human Erythrocyte Pyrimidine 5'-Nucleotidase. 90
PYRUVATE KINASE DEFICIENCY: MOLECULAR AND FUNCTIONAL CHARACTERISATION OF A LETHAL VARIANT 89
Exploring the role of the heterocyclic moiety of 5-(4-nitrophenyl)-2-furoic acid, a promising inhibitor of MbtI from Mycobacterium tuberculosis. 89
Structural and Energetic Basis of Protein Kinetic Destabilization in Human Phosphoglycerate Kinase 1 Deficiency 88
Pyruvate kinase deficiency : The genotype-phenotype association 87
Antibiotics sustainability: another issue in the fight against antimicrobial resistance. 87
Repurposing of FDA-Approved Drugs to Disrupt Iron Uptake in Mycobacterium abscessus: Targeting Salicylate Synthase as a Novel Approach 86
Red cell pyruvate kinase deficiency: 17 new mutations of the PK-LR gene 86
Multi-target antitubercular drugs: identification of novel dual MbtI and MptpB inhibitors. 85
Two new mutations of the P5'N-1 gene found in Italian patients with hereditary hemolytic anemia: the molecular basis of the red cell enzyme disorder. 84
Benzothiozinone derivatives with anti-tubercular Activity−Further side chain investigation 83
Functional analysis of pyrimidine 5'-nucleotidase mutants causing nonspherocytic hemolytic anemia 83
Totale 11.462
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Categoria #
all - tutte 67.951
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 67.951
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022634 0 6 12 46 19 15 15 47 44 22 79 329
2022/20232.055 188 181 25 156 177 195 5 109 934 13 50 22
2023/20241.048 160 175 41 85 88 228 46 69 5 49 46 56
2024/20252.590 77 191 76 54 92 106 178 158 659 103 321 575
2025/20265.883 494 348 672 702 698 252 1.043 279 593 429 208 165
2026/2027330 96 234 0 0 0 0 0 0 0 0 0 0
Totale 15.594