IRIS
CHIARELLI, LAURENT ROBERT
 Distribuzione geografica
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Continente #
NA - Nord America 2.861
EU - Europa 2.092
AS - Asia 1.354
AF - Africa 14
OC - Oceania 8
SA - Sud America 7
Continente sconosciuto - Info sul continente non disponibili 2
Totale 6.338
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Nazione #
US - Stati Uniti d'America 2.839
CN - Cina 1.313
IE - Irlanda 841
IT - Italia 278
FI - Finlandia 275
UA - Ucraina 252
DE - Germania 173
SE - Svezia 96
GB - Regno Unito 70
FR - Francia 33
BE - Belgio 26
CA - Canada 20
AT - Austria 19
IN - India 17
EG - Egitto 10
RU - Federazione Russa 9
AU - Australia 7
CL - Cile 6
ES - Italia 6
NL - Olanda 6
MU - Mauritius 4
TR - Turchia 4
GR - Grecia 3
IR - Iran 3
PK - Pakistan 3
EU - Europa 2
HK - Hong Kong 2
KR - Corea 2
MX - Messico 2
MY - Malesia 2
RO - Romania 2
SA - Arabia Saudita 2
SG - Singapore 2
AR - Argentina 1
CZ - Repubblica Ceca 1
ID - Indonesia 1
IM - Isola di Man 1
IQ - Iraq 1
JO - Giordania 1
JP - Giappone 1
MD - Moldavia 1
NZ - Nuova Zelanda 1
Totale 6.338
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Città #
Dublin 811
Chandler 676
Jacksonville 353
Nanjing 324
Ashburn 250
Beijing 197
Ann Arbor 155
Nanchang 147
Princeton 135
Wilmington 135
Lawrence 127
Helsinki 123
Medford 114
Pavia 110
Shenyang 99
Hebei 92
Hangzhou 84
Changsha 79
Shanghai 75
Jiaxing 71
New York 61
Tianjin 61
Boardman 47
Milan 38
Woodbridge 34
Dearborn 30
Brussels 25
Verona 21
Fairfield 20
Los Angeles 18
Vienna 18
Seattle 16
Norwalk 15
San Genesio ed Uniti 15
Washington 14
Toronto 12
Des Moines 11
Ningbo 11
Jinan 9
Menlo Park 9
Kunming 7
Taizhou 7
Cambridge 6
Cinisello Balsamo 6
Corteolona 6
Falkenstein 6
Melbourne 6
Ottawa 6
Pune 6
Redwood City 6
Tappahannock 6
Auburn Hills 5
Coventry 4
Falls Church 4
Fuzhou 4
Hefei 4
Houston 4
Nürnberg 4
Zhengzhou 4
Delhi 3
Guangzhou 3
Islamabad 3
Marcallo Con Casone 3
Monmouth Junction 3
Norwich 3
Orange 3
Palma 3
Rockville 3
Saint Petersburg 3
San Francisco 3
St Petersburg 3
Borås 2
Corsico 2
Costa Mesa 2
Fremont 2
Haikou 2
Hyderabad 2
Ismailia 2
Leawood 2
London 2
Phoenix 2
Riyadh 2
Sassari 2
Shenzhen 2
Shimla 2
Singapore 2
Tlalpan 2
Valparaíso 2
Verolanuova 2
Amman 1
Andover 1
Baghdad 1
Bengaluru 1
Bruges 1
Buenos Aires 1
Castletown 1
Central Coast 1
Changchun 1
Charlottetown 1
Chisinau 1
Totale 4.826
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Nome #
2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1. 107
The prion-like doppel protein is soluble in astrocytic tumor 87
Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis 83
Expanding targets for a metabolic therapy of cancer: L-asparaginase 83
Letter to the editor regarding Shibayama et al.: Biochemical and pathophysiological characterization of Helicobacter pylori asparaginase. 80
Molecular and cellular insights into the aberrant expression of the prion protein-like gene doppel in astrocytic tumors 78
Phosphoglycerate Kinase Deficiency: Characterization of the Wild-Type Enzyme and Three Pathological Variants Generated from C.140T>a, C.491A>T and C.959G>a Mutations 77
Biological and structural characterization of theMycobacterium smegmatis nitroreductase NfnB, and its rolein benzothiazinone resistance 77
Generation of Mutants of Helicobacter pylori L-Asparaginase 76
BEL β-trefoil: a novel lectin with antineoplastic properties in king bolete (Boletus edulis) mushrooms. 76
The prion protein-like gene Doppel is aberrantly expressed in astrocytic tumors 74
ThermoFAD, a Thermofluor®-adapted flavin ad hoc detection system for protein folding and ligand binding 73
Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia 72
Structural and Activity Relationships of 6-Sulfonyl-8-Nitrobenzothiazinones as Antitubercular Agents 72
Mycobacterium tuberculosis Phosphoribosylpyrophosphate Synthetase: Biochemical Features of a Crucial Enzyme for Mycobacterial Cell Wall Biosynthesis. 70
Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG. 70
Engineering of Helicobacter pylori L-asparaginase: characterization of two functionally distinct groups of mutants 69
4-Aminoquinolone Piperidine Amides: Non-Covalent Inhibitors of DprE1 with Long Residence Time and Potent Antimycobacterial Activity. 69
Pyruvate kinase deficiency: Biochemical characterization of two mutations causing inability of the enzyme to properly bind substrates 68
Absence of interaction between doppel and GFAP, Grb2, PrPC proteins in human tumor astrocytic cells 68
Aberrant Doppel Protein Expression in Human Astrocytic Tumors 67
Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis. 67
New prodrugs against tuberculosis 67
Erythrocyte Adenylate Kinase Deficiency: First In-Depth Biochemical Characterization of the Y164C Mutant Enzyme Causing Hemolytic Anemia 65
A phenotypic based target screening approach delivers new antitubercular CTP synthetase inhibitors 64
Molecular cloning and characterisation of Helicobacter pylori L-asparaginase 63
Ectopic expression of the prion-like protein doppel in human astrocytoma cells 63
Biochemical signatures of doppel (Dpl) protein in human glioblastoma to support prediction in tumor malignancy 62
Helicobacter pylori: from gene to Diagnostic Tool 61
Helicobacter pylori L-asparaginase: from Gene to Diagnostic Tool 61
SELECTION OF MICROFUNGI WITH HIGH LIPOLYTIC ACTIVITYAND THEIR LIPASE CHARACTERIZATION 60
Inosine monophosphate dehydrogenase activity after mycophenolate mofetil in renal transplant patients receiving different immunosupressive combined therapy and stable after at least three months' administration. 60
Investigating the Mechanism of Action of Diketopiperazines Inhibitors of the Burkholderia cenocepacia Quorum Sensing Synthase CepI: A Site-Directed Mutagenesis Study 60
Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis. 59
Premio Ricercatissimi 2008 59
Biochemistry of Lipolytic Enzymes Secreted by Penicillium solitum and Cladosporium cladosporioides 59
Discovery of new diketopiperazines inhibiting Burkholderia cenocepacia quorum sensing in vitro and in vivo. 59
Pyrimidine 5' Nucleotidase Deficiency: Clinical and Molecular Characterization of Two New Italian Patients 59
Targeting iron uptake pathway for the development of novel antitubercular drugs. 58
New and old hot drug targets in tuberculosis 57
Expanding Targets for a Metabolic Therapy of Cancer: L- Asparaginase 56
Competitive fitness of essential gene knockdowns reveals a broad-spectrum antibacterial inhibitor of the cell division protein FtsZ 56
Molecular and functional characterization of a lethal variant of pyruvate kinase deficiency 55
Cell-cycle inhibition by Helicobacter pylori L-asparaginase. 55
Biochemical Characterization of Glutamate Racemase-A New Candidate Drug Target against Burkholderia cenocepacia Infections 55
Micellar electrokinetic chromatography as a complementary method to sodium dodecyl sulfate-polyacrylamide gel electrophoresis for studying limited proteolysis of proteins. 55
Design, Syntheses, and Anti-TB Activity of 1,3-Benzothiazinone Azide and Click Chemistry Products Inspired by BTZ043 55
Molecular Characterization of Three New Mutant Enzymes of Pyrimidine 5-Nucleotidase Causing Hereditary Hemolytic Anemia. 55
Characterization of a pyrimidine 5'-nucleotidase mutant form (G214R) causing hereditary hemolytic anemia. 55
Chemical, Metabolic, and Cellular Characterization of a FtsZ Inhibitor Effective Against Burkholderia cenocepacia 55
Protein Recognition by Short Peptide Reversible Inhibitors of the Chromatin-Modifying LSD1/CoREST Lysine Demethylase. 54
PYRUVATE KINASE DEFICIENCY: MOLECULAR AND FUNCTIONAL CHARACTERISATION OF A LETHAL VARIANT 54
Structural and Energetic Basis of Protein Kinetic Destabilization in Human Phosphoglycerate Kinase 1 Deficiency 54
The redox state regulates the conformation of Rv2466c to activate the antitubercular prodrug TP053. 54
A new mutation of the pgk1 gene detected in an italian patient affected by phosphoglycerate kinase deficiency. 54
Hereditary erythrocyte pyrimidine 5'-nucleotidase deficiency: a biochemical, genetic and clinical overview 53
EXPRESSION AND CHARACTERIZATION OF THE BOVINE PRION DOPPEL 53
Molecular basis of pyrimidine 5'-nucleotidase deficiency caused by 3 newly identified missense mutations (c.187T>C, c.469G>C and c.740T>C) and a tabulation of known mutations 53
The allosteric regulation of pyruvate kinase. 53
Molecular Insights on Pathogenic Effects of MutationsCausing Phosphoglycerate Kinase Deficiency 51
Red cell pyruvate kinase deficiency: 17 new mutations of the PK-LR gene 51
Nuclear mRNA retention and aberrant doppel protein expression in human astrocytic tumor cells 51
Burkholderia cenocepacia infections in cystic fibrosis patients: Drug resistance and therapeutic approaches 51
Pyrimidine 5'-nucleotidase activities detected in real samples by means of micellar electrokinetic chromatography. 50
Pyruvate kinase deficiency : The genotype-phenotype association 50
L-ASPARAGINASE FROM HELICOBACTER PYLORI 49
Investigating the Molecular Bases of the Phosphoglycerate Kinase Deficiency: Characterization ofG158V, R206P, V266M and D285V Pathological Variants. 49
Aeroplane shaped crystal of a mutant ofHelicobacter pylori L-asparaginase. 49
A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK 49
Two new mutations of the P5'N-1 gene found in Italian patients with hereditary hemolytic anemia: the molecular basis of the red cell enzyme disorder. 48
The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis. 48
Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents 48
Molecular Basis of Hemolytic Anemia: First Biochemical Characterization of Wild-Type and N190S Mutant Human Erythrocyte Pyrimidine 5'-Nucleotidase. 47
Iron acquisition pathways as targets for antitubercular drugs. 46
Functional Analysis of Two Mutants of Pyrimidine 5’ Nucleotidase Causing Nonspherocytic Hemolytic Anemia 46
Erythrocyte adenylate kinase deficiency: characterization of recombinant mutant forms and relationship with nonspherocytic hemolytic anemia 46
Mechanochemical Synthesis and Biological Evaluation of Novel Isoniazid Derivatives with Potent Antitubercular Activity. 45
Exploring the role of the heterocyclic moiety of 5-(4-nitrophenyl)-2-furoic acid, a promising inhibitor of MbtI from Mycobacterium tuberculosis. 44
Functional analysis of pyrimidine 5'-nucleotidase mutants causing nonspherocytic hemolytic anemia 43
Monitoring Inosine monophosphate dehydrogenase (IMPDH) in kidney transplant recipients 43
An Overview on the Potential Antimycobacterial Agents Targeting Serine/Threonine Protein Kinases from Mycobacterium tuberculosis 43
The cell division protein FtsZ as a cellular target to hit cystic fibrosis pathogens 43
A new variant of phosphoglycerate kinase deficiency (p.I371K) with multiple tissue involvement: molecular and functional characterization. 42
Multi-target antitubercular drugs: identification of novel dual MbtI and MptpB inhibitors. 42
6-Hydroxy-2-methylbenzofuran-4-carboxylic Acid 41
Pharmacokinetic-pharmacodynamic (PK/PD) monitoring of mycophenolate mofetil in de novo and long-term renal transplant patients 40
Structure of a lectin with antitumoral properties in king bolete (Boletus edulis) mushrooms. 40
Rv0579 Is Involved in the Resistance to the TP053 Antitubercular Prodrug 40
Antivirulence compounds: a future direction to overcome antibiotic resistance? 40
New insights into the mechanism of action of the thienopyrimidine antitubercular prodrug TP053 38
Nitric oxide-releasing compounds for the treatment of lung infections 38
The mechanism of action of 5-nitrothiophenes against Mycobacterium tuberculosis 37
Molecular Cloning and Characterisation of Helicobacter Pylori L-Asparaginase: A Cytotoxic Factor with Potential Biomedical Applications 37
Helicobacter pylori L-asparaginase: A promising chemotherapeutic agent 37
Various evolutionary trajectories lead to loss of the tobramycin-potentiating activity of the quorum sensing inhibitor baicalin hydrate in Burkholderia cenocepacia biofilms 37
Structural insights for the development of novel antituberculars targeting the iron uptake pathway. 37
Quorum sensing as antivirulence target in cystic fibrosis pathogens 37
Mycobacterium abscessus, an Emerging and Worrisome Pathogen among Cystic Fibrosis Patients. 37
A Coumarin-Based Analogue of Thiacetazone as Dual Covalent Inhibitor and Potential Fluorescent Label of HadA in Mycobacterium tuberculosis 36
Functional investigation of the antitubercular drug target Decaprenylphosphoryl-β-D-ribofuranose-2-epimerase DprE1/DprE2 complex 36
Totale 5.575
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Categoria #
all - tutte 23.598
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 23.598
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/201912 0 0 0 0 0 0 0 0 0 0 4 8
2019/20201.553 407 570 11 57 12 54 46 101 26 155 94 20
2020/2021688 89 41 19 49 30 68 19 165 42 87 63 16
2021/2022647 13 6 12 46 19 15 15 47 44 22 79 329
2022/20232.055 188 181 25 156 177 195 5 109 934 13 50 22
2023/2024946 160 175 41 85 88 228 46 69 5 49 0 0
Totale 6.689