IRIS
CHIARELLI, LAURENT ROBERT
 Distribuzione geografica
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Continente #
NA - Nord America 3.121
EU - Europa 2.159
AS - Asia 1.513
AF - Africa 16
OC - Oceania 9
SA - Sud America 7
Continente sconosciuto - Info sul continente non disponibili 2
Totale 6.827
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Nazione #
US - Stati Uniti d'America 3.098
CN - Cina 1.353
IE - Irlanda 841
IT - Italia 301
FI - Finlandia 280
UA - Ucraina 252
DE - Germania 187
SG - Singapore 104
SE - Svezia 96
GB - Regno Unito 73
FR - Francia 34
BE - Belgio 27
IN - India 22
CA - Canada 21
AT - Austria 19
RU - Federazione Russa 14
EG - Egitto 11
AU - Australia 7
JP - Giappone 7
NL - Olanda 7
CL - Cile 6
CZ - Repubblica Ceca 6
ES - Italia 6
GR - Grecia 4
IR - Iran 4
MU - Mauritius 4
PK - Pakistan 4
RO - Romania 4
TR - Turchia 4
SK - Slovacchia (Repubblica Slovacca) 3
EU - Europa 2
HK - Hong Kong 2
KR - Corea 2
MX - Messico 2
MY - Malesia 2
NZ - Nuova Zelanda 2
SA - Arabia Saudita 2
TH - Thailandia 2
AR - Argentina 1
CH - Svizzera 1
ID - Indonesia 1
IM - Isola di Man 1
IQ - Iraq 1
JO - Giordania 1
KG - Kirghizistan 1
LT - Lituania 1
LV - Lettonia 1
MD - Moldavia 1
VN - Vietnam 1
ZA - Sudafrica 1
Totale 6.827
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Città #
Dublin 811
Chandler 676
Jacksonville 353
Nanjing 324
Ashburn 259
Boardman 224
Beijing 197
Ann Arbor 155
Nanchang 147
Princeton 135
Wilmington 135
Helsinki 128
Lawrence 127
Pavia 118
Medford 114
Shenyang 100
Hebei 92
Shanghai 92
Hangzhou 84
Changsha 79
Jiaxing 71
New York 61
Singapore 61
Tianjin 61
Milan 38
Woodbridge 34
Dearborn 30
Brussels 26
Los Angeles 21
Verona 21
Fairfield 20
Vienna 18
Piscataway 17
Seattle 16
Norwalk 15
San Genesio ed Uniti 15
Munich 14
Washington 14
Toronto 12
Des Moines 11
Ningbo 11
Chicago 10
Jinan 9
Menlo Park 9
Kunming 7
Ottawa 7
Taizhou 7
Cambridge 6
Cinisello Balsamo 6
Corteolona 6
Falkenstein 6
Melbourne 6
Pune 6
Redwood City 6
Tappahannock 6
Tokyo 6
Auburn Hills 5
Coventry 4
Dallas 4
Delhi 4
Falls Church 4
Fuzhou 4
Hefei 4
Houston 4
London 4
Nürnberg 4
Olomouc 4
St Petersburg 4
Zhengzhou 4
Florence 3
Guangzhou 3
Islamabad 3
Marcallo Con Casone 3
Monmouth Junction 3
Norwich 3
Orange 3
Palma 3
Phoenix 3
Rockville 3
Saint Petersburg 3
San Francisco 3
Santa Clara 3
Bangkok 2
Borås 2
Castenaso 2
Changchun 2
Cluj-Napoca 2
Corsico 2
Costa Mesa 2
Fremont 2
Gatchina 2
Haikou 2
Hyderabad 2
Ismailia 2
Leawood 2
Ludhiana 2
Riyadh 2
Sassari 2
Shenzhen 2
Shimla 2
Totale 5.168
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Nome #
2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1. 112
The prion-like doppel protein is soluble in astrocytic tumor 92
Expanding targets for a metabolic therapy of cancer: L-asparaginase 86
Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis 85
Biological and structural characterization of theMycobacterium smegmatis nitroreductase NfnB, and its rolein benzothiazinone resistance 83
Letter to the editor regarding Shibayama et al.: Biochemical and pathophysiological characterization of Helicobacter pylori asparaginase. 82
Phosphoglycerate Kinase Deficiency: Characterization of the Wild-Type Enzyme and Three Pathological Variants Generated from C.140T>a, C.491A>T and C.959G>a Mutations 80
The prion protein-like gene Doppel is aberrantly expressed in astrocytic tumors 80
Molecular and cellular insights into the aberrant expression of the prion protein-like gene doppel in astrocytic tumors 80
Generation of Mutants of Helicobacter pylori L-Asparaginase 79
BEL β-trefoil: a novel lectin with antineoplastic properties in king bolete (Boletus edulis) mushrooms. 79
ThermoFAD, a Thermofluor®-adapted flavin ad hoc detection system for protein folding and ligand binding 76
Absence of interaction between doppel and GFAP, Grb2, PrPC proteins in human tumor astrocytic cells 75
Aberrant Doppel Protein Expression in Human Astrocytic Tumors 74
Structural and Activity Relationships of 6-Sulfonyl-8-Nitrobenzothiazinones as Antitubercular Agents 74
Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia 73
Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG. 73
Pyruvate kinase deficiency: Biochemical characterization of two mutations causing inability of the enzyme to properly bind substrates 72
4-Aminoquinolone Piperidine Amides: Non-Covalent Inhibitors of DprE1 with Long Residence Time and Potent Antimycobacterial Activity. 72
Mycobacterium tuberculosis Phosphoribosylpyrophosphate Synthetase: Biochemical Features of a Crucial Enzyme for Mycobacterial Cell Wall Biosynthesis. 71
Engineering of Helicobacter pylori L-asparaginase: characterization of two functionally distinct groups of mutants 70
Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis. 69
Ectopic expression of the prion-like protein doppel in human astrocytoma cells 69
New prodrugs against tuberculosis 69
A phenotypic based target screening approach delivers new antitubercular CTP synthetase inhibitors 69
Helicobacter pylori: from gene to Diagnostic Tool 67
Erythrocyte Adenylate Kinase Deficiency: First In-Depth Biochemical Characterization of the Y164C Mutant Enzyme Causing Hemolytic Anemia 67
Molecular cloning and characterisation of Helicobacter pylori L-asparaginase 66
Biochemical signatures of doppel (Dpl) protein in human glioblastoma to support prediction in tumor malignancy 66
Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis. 65
Helicobacter pylori L-asparaginase: from Gene to Diagnostic Tool 64
Inosine monophosphate dehydrogenase activity after mycophenolate mofetil in renal transplant patients receiving different immunosupressive combined therapy and stable after at least three months' administration. 63
Biochemistry of Lipolytic Enzymes Secreted by Penicillium solitum and Cladosporium cladosporioides 63
Discovery of new diketopiperazines inhibiting Burkholderia cenocepacia quorum sensing in vitro and in vivo. 63
A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK 63
SELECTION OF MICROFUNGI WITH HIGH LIPOLYTIC ACTIVITYAND THEIR LIPASE CHARACTERIZATION 62
Premio Ricercatissimi 2008 62
New and old hot drug targets in tuberculosis 62
Pyrimidine 5' Nucleotidase Deficiency: Clinical and Molecular Characterization of Two New Italian Patients 62
Cell-cycle inhibition by Helicobacter pylori L-asparaginase. 61
Investigating the Mechanism of Action of Diketopiperazines Inhibitors of the Burkholderia cenocepacia Quorum Sensing Synthase CepI: A Site-Directed Mutagenesis Study 61
Targeting iron uptake pathway for the development of novel antitubercular drugs. 60
Chemical, Metabolic, and Cellular Characterization of a FtsZ Inhibitor Effective Against Burkholderia cenocepacia 60
Molecular Characterization of Three New Mutant Enzymes of Pyrimidine 5-Nucleotidase Causing Hereditary Hemolytic Anemia. 59
Competitive fitness of essential gene knockdowns reveals a broad-spectrum antibacterial inhibitor of the cell division protein FtsZ 59
EXPRESSION AND CHARACTERIZATION OF THE BOVINE PRION DOPPEL 58
Expanding Targets for a Metabolic Therapy of Cancer: L- Asparaginase 58
Biochemical Characterization of Glutamate Racemase-A New Candidate Drug Target against Burkholderia cenocepacia Infections 58
Micellar electrokinetic chromatography as a complementary method to sodium dodecyl sulfate-polyacrylamide gel electrophoresis for studying limited proteolysis of proteins. 58
A new mutation of the pgk1 gene detected in an italian patient affected by phosphoglycerate kinase deficiency. 58
Molecular and functional characterization of a lethal variant of pyruvate kinase deficiency 57
PYRUVATE KINASE DEFICIENCY: MOLECULAR AND FUNCTIONAL CHARACTERISATION OF A LETHAL VARIANT 57
Design, Syntheses, and Anti-TB Activity of 1,3-Benzothiazinone Azide and Click Chemistry Products Inspired by BTZ043 57
Molecular basis of pyrimidine 5'-nucleotidase deficiency caused by 3 newly identified missense mutations (c.187T>C, c.469G>C and c.740T>C) and a tabulation of known mutations 57
Characterization of a pyrimidine 5'-nucleotidase mutant form (G214R) causing hereditary hemolytic anemia. 57
The allosteric regulation of pyruvate kinase. 57
Protein Recognition by Short Peptide Reversible Inhibitors of the Chromatin-Modifying LSD1/CoREST Lysine Demethylase. 56
Molecular Insights on Pathogenic Effects of MutationsCausing Phosphoglycerate Kinase Deficiency 55
Structural and Energetic Basis of Protein Kinetic Destabilization in Human Phosphoglycerate Kinase 1 Deficiency 55
The redox state regulates the conformation of Rv2466c to activate the antitubercular prodrug TP053. 55
Hereditary erythrocyte pyrimidine 5'-nucleotidase deficiency: a biochemical, genetic and clinical overview 54
L-ASPARAGINASE FROM HELICOBACTER PYLORI 54
Nuclear mRNA retention and aberrant doppel protein expression in human astrocytic tumor cells 54
Red cell pyruvate kinase deficiency: 17 new mutations of the PK-LR gene 53
Pyrimidine 5'-nucleotidase activities detected in real samples by means of micellar electrokinetic chromatography. 52
Pyruvate kinase deficiency : The genotype-phenotype association 52
Burkholderia cenocepacia infections in cystic fibrosis patients: Drug resistance and therapeutic approaches 52
Two new mutations of the P5'N-1 gene found in Italian patients with hereditary hemolytic anemia: the molecular basis of the red cell enzyme disorder. 51
Investigating the Molecular Bases of the Phosphoglycerate Kinase Deficiency: Characterization ofG158V, R206P, V266M and D285V Pathological Variants. 51
Aeroplane shaped crystal of a mutant ofHelicobacter pylori L-asparaginase. 51
Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents 51
The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis. 50
Mechanochemical Synthesis and Biological Evaluation of Novel Isoniazid Derivatives with Potent Antitubercular Activity. 50
Functional Analysis of Two Mutants of Pyrimidine 5’ Nucleotidase Causing Nonspherocytic Hemolytic Anemia 49
Molecular Basis of Hemolytic Anemia: First Biochemical Characterization of Wild-Type and N190S Mutant Human Erythrocyte Pyrimidine 5'-Nucleotidase. 49
Erythrocyte adenylate kinase deficiency: characterization of recombinant mutant forms and relationship with nonspherocytic hemolytic anemia 49
The cell division protein FtsZ as a cellular target to hit cystic fibrosis pathogens 48
Iron acquisition pathways as targets for antitubercular drugs. 47
Exploring the role of the heterocyclic moiety of 5-(4-nitrophenyl)-2-furoic acid, a promising inhibitor of MbtI from Mycobacterium tuberculosis. 47
An Overview on the Potential Antimycobacterial Agents Targeting Serine/Threonine Protein Kinases from Mycobacterium tuberculosis 45
Functional analysis of pyrimidine 5'-nucleotidase mutants causing nonspherocytic hemolytic anemia 44
Monitoring Inosine monophosphate dehydrogenase (IMPDH) in kidney transplant recipients 44
Multi-target antitubercular drugs: identification of novel dual MbtI and MptpB inhibitors. 44
Rv0579 Is Involved in the Resistance to the TP053 Antitubercular Prodrug 44
Antivirulence compounds: a future direction to overcome antibiotic resistance? 44
A new variant of phosphoglycerate kinase deficiency (p.I371K) with multiple tissue involvement: molecular and functional characterization. 43
New insights into the mechanism of action of the thienopyrimidine antitubercular prodrug TP053 43
A Coumarin-Based Analogue of Thiacetazone as Dual Covalent Inhibitor and Potential Fluorescent Label of HadA in Mycobacterium tuberculosis 43
Pharmacokinetic-pharmacodynamic (PK/PD) monitoring of mycophenolate mofetil in de novo and long-term renal transplant patients 42
Structure of a lectin with antitumoral properties in king bolete (Boletus edulis) mushrooms. 42
6-Hydroxy-2-methylbenzofuran-4-carboxylic Acid 42
Improve protection to prevent infections: application of reverse vaccinology against cystic fibrosis pathogens. 41
Molecular Cloning and Characterisation of Helicobacter Pylori L-Asparaginase: A Cytotoxic Factor with Potential Biomedical Applications 40
Nitric oxide-releasing compounds for the treatment of lung infections 40
The mechanism of action of 5-nitrothiophenes against Mycobacterium tuberculosis 39
Helicobacter pylori L-asparaginase: A promising chemotherapeutic agent 39
Structural insights for the development of novel antituberculars targeting the iron uptake pathway. 39
Quorum sensing as antivirulence target in cystic fibrosis pathogens 39
Functional investigation of the antitubercular drug target Decaprenylphosphoryl-β-D-ribofuranose-2-epimerase DprE1/DprE2 complex 39
A new promising bactericidal compound against Burkholderia cenocepacia. 38
Totale 5.890
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Categoria #
all - tutte 31.320
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 31.320
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020508 0 0 0 0 12 54 46 101 26 155 94 20
2020/2021688 89 41 19 49 30 68 19 165 42 87 63 16
2021/2022647 13 6 12 46 19 15 15 47 44 22 79 329
2022/20232.055 188 181 25 156 177 195 5 109 934 13 50 22
2023/20241.048 160 175 41 85 88 228 46 69 5 49 46 56
2024/2025401 77 191 76 54 3 0 0 0 0 0 0 0
Totale 7.192