IRIS
CHIARELLI, LAURENT ROBERT
 Distribuzione geografica
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Continente #
NA - Nord America 5.615
AS - Asia 4.503
EU - Europa 3.430
SA - Sud America 626
AF - Africa 198
OC - Oceania 15
Continente sconosciuto - Info sul continente non disponibili 2
Totale 14.389
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Nazione #
US - Stati Uniti d'America 5.457
CN - Cina 2.041
SG - Singapore 926
IE - Irlanda 849
HK - Hong Kong 548
BR - Brasile 463
RU - Federazione Russa 444
VN - Vietnam 425
IT - Italia 390
DE - Germania 362
FI - Finlandia 349
UA - Ucraina 269
FR - Francia 223
GB - Regno Unito 178
IN - India 149
SE - Svezia 119
ZA - Sudafrica 119
CA - Canada 83
AR - Argentina 63
BD - Bangladesh 55
MX - Messico 52
JP - Giappone 46
ID - Indonesia 45
IQ - Iraq 40
AT - Austria 39
TR - Turchia 39
NL - Olanda 36
PL - Polonia 36
BE - Belgio 31
PK - Pakistan 31
ES - Italia 27
CO - Colombia 25
UZ - Uzbekistan 19
CL - Cile 18
EC - Ecuador 18
EG - Egitto 17
LT - Lituania 16
MA - Marocco 16
CZ - Repubblica Ceca 15
SA - Arabia Saudita 15
VE - Venezuela 15
AZ - Azerbaigian 14
AE - Emirati Arabi Uniti 13
MY - Malesia 13
AU - Australia 12
PH - Filippine 12
LV - Lettonia 8
KR - Corea 7
PA - Panama 7
TN - Tunisia 7
BO - Bolivia 6
IR - Iran 6
JO - Giordania 6
KE - Kenya 6
LB - Libano 6
PE - Perù 6
RO - Romania 6
UY - Uruguay 6
CR - Costa Rica 5
GR - Grecia 5
IL - Israele 5
KZ - Kazakistan 5
NG - Nigeria 5
NP - Nepal 5
OM - Oman 5
PY - Paraguay 5
DO - Repubblica Dominicana 4
DZ - Algeria 4
ET - Etiopia 4
KG - Kirghizistan 4
MU - Mauritius 4
RS - Serbia 4
TH - Thailandia 4
AL - Albania 3
AO - Angola 3
MD - Moldavia 3
PT - Portogallo 3
SK - Slovacchia (Repubblica Slovacca) 3
SY - Repubblica araba siriana 3
CG - Congo 2
CH - Svizzera 2
CY - Cipro 2
DK - Danimarca 2
EU - Europa 2
GE - Georgia 2
HN - Honduras 2
HU - Ungheria 2
IM - Isola di Man 2
JM - Giamaica 2
KW - Kuwait 2
LA - Repubblica Popolare Democratica del Laos 2
NO - Norvegia 2
NZ - Nuova Zelanda 2
PS - Palestinian Territory 2
SN - Senegal 2
TJ - Tagikistan 2
AM - Armenia 1
BJ - Benin 1
BN - Brunei Darussalam 1
BS - Bahamas 1
Totale 14.373
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Città #
Dublin 818
Chandler 676
Ashburn 547
Hong Kong 536
San Jose 529
Singapore 467
Beijing 446
Dallas 366
Jacksonville 353
Nanjing 327
Boardman 226
Los Angeles 185
Helsinki 159
Ann Arbor 155
Nanchang 149
Ho Chi Minh City 145
Lauterbourg 143
Pavia 137
Princeton 135
Wilmington 135
Lawrence 127
New York 122
Medford 114
Munich 112
Shenyang 102
Hanoi 100
Johannesburg 96
Shanghai 96
Hebei 92
Hangzhou 90
Changsha 83
Jiaxing 72
Moscow 72
Tianjin 69
Redondo Beach 60
Buffalo 53
Milan 50
Orem 49
Tokyo 44
São Paulo 42
The Dalles 39
Turku 38
Santa Clara 37
Woodbridge 34
Vienna 32
Warsaw 32
Brussels 30
Dearborn 30
Haiphong 29
Montreal 29
Chicago 27
Denver 25
Frankfurt am Main 25
London 24
Chennai 23
Stockholm 23
Brooklyn 22
Seattle 22
Toronto 22
Boston 21
Da Nang 21
Falkenstein 21
Verona 21
Atlanta 20
Fairfield 20
Council Bluffs 19
Houston 19
Piscataway 19
Tashkent 19
Columbus 18
Mexico City 18
Nuremberg 17
San Francisco 16
Washington 16
Mumbai 15
Norwalk 15
Phoenix 15
San Genesio ed Uniti 15
Amsterdam 14
Baku 14
Curitiba 14
Cape Town 13
Des Moines 13
Guangzhou 13
Jinan 13
Rio de Janeiro 13
Istanbul 12
New Delhi 12
Ningbo 12
Baghdad 11
Dhaka 11
Olomouc 11
Ottawa 11
Poplar 11
Biên Hòa 10
Buenos Aires 10
Hyderabad 10
Recife 10
Florence 9
Lahore 9
Totale 9.423
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Nome #
2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1. 202
Biological and structural characterization of theMycobacterium smegmatis nitroreductase NfnB, and its rolein benzothiazinone resistance 159
Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis 156
Absence of interaction between doppel and GFAP, Grb2, PrPC proteins in human tumor astrocytic cells 151
4-Aminoquinolone Piperidine Amides: Non-Covalent Inhibitors of DprE1 with Long Residence Time and Potent Antimycobacterial Activity. 149
Aberrant Doppel Protein Expression in Human Astrocytic Tumors 148
Letter to the editor regarding Shibayama et al.: Biochemical and pathophysiological characterization of Helicobacter pylori asparaginase. 142
A phenotypic based target screening approach delivers new antitubercular CTP synthetase inhibitors 140
Investigating the Mechanism of Action of Diketopiperazines Inhibitors of the Burkholderia cenocepacia Quorum Sensing Synthase CepI: A Site-Directed Mutagenesis Study 139
The prion-like doppel protein is soluble in astrocytic tumor 132
Generation of Mutants of Helicobacter pylori L-Asparaginase 132
Engineering of Helicobacter pylori L-asparaginase: characterization of two functionally distinct groups of mutants 132
Biochemical Characterization of Glutamate Racemase-A New Candidate Drug Target against Burkholderia cenocepacia Infections 130
Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis. 129
Cell-cycle inhibition by Helicobacter pylori L-asparaginase. 129
Phosphoglycerate Kinase Deficiency: Characterization of the Wild-Type Enzyme and Three Pathological Variants Generated from C.140T>a, C.491A>T and C.959G>a Mutations 128
Expanding targets for a metabolic therapy of cancer: L-asparaginase 128
Chemical, Metabolic, and Cellular Characterization of a FtsZ Inhibitor Effective Against Burkholderia cenocepacia 128
Molecular and cellular insights into the aberrant expression of the prion protein-like gene doppel in astrocytic tumors 126
Biochemistry of Lipolytic Enzymes Secreted by Penicillium solitum and Cladosporium cladosporioides 126
New prodrugs against tuberculosis 126
Discovery of new diketopiperazines inhibiting Burkholderia cenocepacia quorum sensing in vitro and in vivo. 126
Mycobacterium tuberculosis Phosphoribosylpyrophosphate Synthetase: Biochemical Features of a Crucial Enzyme for Mycobacterial Cell Wall Biosynthesis. 125
Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis. 124
A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK 123
Expanding Targets for a Metabolic Therapy of Cancer: L- Asparaginase 122
Could the Oxidation of α1-Antitrypsin Prevent the Binding of Human Neutrophil Elastase in COVID-19 Patients? 121
The prion protein-like gene Doppel is aberrantly expressed in astrocytic tumors 121
Ectopic expression of the prion-like protein doppel in human astrocytoma cells 121
BEL β-trefoil: a novel lectin with antineoplastic properties in king bolete (Boletus edulis) mushrooms. 120
An Overview on the Potential Antimycobacterial Agents Targeting Serine/Threonine Protein Kinases from Mycobacterium tuberculosis 117
Biochemical signatures of doppel (Dpl) protein in human glioblastoma to support prediction in tumor malignancy 116
Helicobacter pylori L-asparaginase: from Gene to Diagnostic Tool 116
Burkholderia cenocepacia infections in cystic fibrosis patients: Drug resistance and therapeutic approaches 116
A new mutation of the pgk1 gene detected in an italian patient affected by phosphoglycerate kinase deficiency. 116
A Coumarin-Based Analogue of Thiacetazone as Dual Covalent Inhibitor and Potential Fluorescent Label of HadA in Mycobacterium tuberculosis 116
New and old hot drug targets in tuberculosis 115
Competitive fitness of essential gene knockdowns reveals a broad-spectrum antibacterial inhibitor of the cell division protein FtsZ 115
Pyruvate kinase deficiency: Biochemical characterization of two mutations causing inability of the enzyme to properly bind substrates 114
Nuclear mRNA retention and aberrant doppel protein expression in human astrocytic tumor cells 114
Helicobacter pylori: from gene to Diagnostic Tool 113
The allosteric regulation of pyruvate kinase. 113
A New Benzothiazolthiazolidine Derivative, 11726172, Is Active In Vitro, In Vivo, and against Nonreplicating Cells of Mycobacterium tuberculosis 112
Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG. 112
Structural and Activity Relationships of 6-Sulfonyl-8-Nitrobenzothiazinones as Antitubercular Agents 112
A new promising bactericidal compound against Burkholderia cenocepacia. 111
From virulence factors to drug development: MbtI as an effective Mycobacterium tuberculosis target 109
Molecular cloning and characterisation of Helicobacter pylori L-asparaginase 109
Molecular Insights on Pathogenic Effects of MutationsCausing Phosphoglycerate Kinase Deficiency 109
Protein Recognition by Short Peptide Reversible Inhibitors of the Chromatin-Modifying LSD1/CoREST Lysine Demethylase. 109
Design, Syntheses, and Anti-TB Activity of 1,3-Benzothiazinone Azide and Click Chemistry Products Inspired by BTZ043 109
A new variant of phosphoglycerate kinase deficiency (p.I371K) with multiple tissue involvement: molecular and functional characterization. 109
Micellar electrokinetic chromatography as a complementary method to sodium dodecyl sulfate-polyacrylamide gel electrophoresis for studying limited proteolysis of proteins. 108
Characterization of a pyrimidine 5'-nucleotidase mutant form (G214R) causing hereditary hemolytic anemia. 108
New insights into the mechanism of action of the thienopyrimidine antitubercular prodrug TP053 108
Rv0579 Is Involved in the Resistance to the TP053 Antitubercular Prodrug 107
Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia 106
Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents 106
SELECTION OF MICROFUNGI WITH HIGH LIPOLYTIC ACTIVITYAND THEIR LIPASE CHARACTERIZATION 105
Improve protection to prevent infections: application of reverse vaccinology against cystic fibrosis pathogens. 105
CanB, a Druggable Cellular Target in Mycobacterium tuberculosis 104
Premio Ricercatissimi 2008 104
The cell division protein FtsZ as a cellular target to hit cystic fibrosis pathogens 103
ThermoFAD, a Thermofluor®-adapted flavin ad hoc detection system for protein folding and ligand binding 102
Design, synthesis and evaluation of covalent inhibitors of DprE1 as antitubercular agents 101
Targeting iron uptake pathway for the development of novel antitubercular drugs. 100
Erythrocyte adenylate kinase deficiency: characterization of recombinant mutant forms and relationship with nonspherocytic hemolytic anemia 99
Functional investigation of the antitubercular drug target Decaprenylphosphoryl-β-D-ribofuranose-2-epimerase DprE1/DprE2 complex 98
Investigating the Molecular Bases of the Phosphoglycerate Kinase Deficiency: Characterization ofG158V, R206P, V266M and D285V Pathological Variants. 96
EXPRESSION AND CHARACTERIZATION OF THE BOVINE PRION DOPPEL 95
Erythrocyte Adenylate Kinase Deficiency: First In-Depth Biochemical Characterization of the Y164C Mutant Enzyme Causing Hemolytic Anemia 95
Molecular Characterization of Three New Mutant Enzymes of Pyrimidine 5-Nucleotidase Causing Hereditary Hemolytic Anemia. 95
Pyrimidine 5' Nucleotidase Deficiency: Clinical and Molecular Characterization of Two New Italian Patients 95
Aeroplane shaped crystal of a mutant ofHelicobacter pylori L-asparaginase. 94
Mycobacterium abscessus siderophores biosynthesis as a target to inhibit the iron uptake mechanism 92
The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis. 91
Molecular basis of pyrimidine 5'-nucleotidase deficiency caused by 3 newly identified missense mutations (c.187T>C, c.469G>C and c.740T>C) and a tabulation of known mutations 91
6-Hydroxy-2-methylbenzofuran-4-carboxylic Acid 91
Nitric oxide-releasing compounds for the treatment of lung infections 91
Mechanochemical Synthesis and Biological Evaluation of Novel Isoniazid Derivatives with Potent Antitubercular Activity. 90
Antivirulence compounds: a future direction to overcome antibiotic resistance? 90
Molecular and functional characterization of a lethal variant of pyruvate kinase deficiency 88
Inosine monophosphate dehydrogenase activity after mycophenolate mofetil in renal transplant patients receiving different immunosupressive combined therapy and stable after at least three months' administration. 88
The crystal structure of Burkholderia cenocepacia DfsA provides insights into substrate recognition and quorum sensing fatty acid biosynthesis 88
Multitargeting Compounds: A Promising Strategy to Overcome Multi-Drug Resistant Tuberculosis 88
Pyrimidine 5'-nucleotidase activities detected in real samples by means of micellar electrokinetic chromatography. 87
PYRUVATE KINASE DEFICIENCY: MOLECULAR AND FUNCTIONAL CHARACTERISATION OF A LETHAL VARIANT 87
Structural and Energetic Basis of Protein Kinetic Destabilization in Human Phosphoglycerate Kinase 1 Deficiency 87
Molecular Basis of Hemolytic Anemia: First Biochemical Characterization of Wild-Type and N190S Mutant Human Erythrocyte Pyrimidine 5'-Nucleotidase. 87
Mycobacterium tuberculosis Sulfate Ester Dioxygenase Rv3406 Is Able to Inactivate the RCB18350 Compound. 84
Exploring the role of the heterocyclic moiety of 5-(4-nitrophenyl)-2-furoic acid, a promising inhibitor of MbtI from Mycobacterium tuberculosis. 84
Red cell pyruvate kinase deficiency: 17 new mutations of the PK-LR gene 83
PHOSPHOGLYCERATE KINASE DEFICIENCY: FUNCTIONAL PROPERTIES OF THE L89P, K191DEL, C316R AND A354P PATHOLOGICAL VARIANTS 83
Pyruvate kinase deficiency : The genotype-phenotype association 82
Benzothiozinone derivatives with anti-tubercular Activity−Further side chain investigation 81
Repurposing of FDA-Approved Drugs to Disrupt Iron Uptake in Mycobacterium abscessus: Targeting Salicylate Synthase as a Novel Approach 81
Two new mutations of the P5'N-1 gene found in Italian patients with hereditary hemolytic anemia: the molecular basis of the red cell enzyme disorder. 81
The antimalarial mefloquine shows activity against mycobacterium abscessus, inhibiting mycolic acid metabolism 81
Antibiotics sustainability: another issue in the fight against antimicrobial resistance. 81
Quorum sensing as antivirulence target in cystic fibrosis pathogens 80
Totale 10.988
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Categoria #
all - tutte 60.259
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 60.259
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021166 0 0 0 0 0 0 0 0 0 87 63 16
2021/2022647 13 6 12 46 19 15 15 47 44 22 79 329
2022/20232.055 188 181 25 156 177 195 5 109 934 13 50 22
2023/20241.048 160 175 41 85 88 228 46 69 5 49 46 56
2024/20252.590 77 191 76 54 92 106 178 158 659 103 321 575
2025/20265.423 494 348 672 702 698 252 1.043 279 593 342 0 0
Totale 14.804