IRIS
CHIARELLI, LAURENT ROBERT
 Distribuzione geografica
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Continente #
NA - Nord America 5.951
AS - Asia 4.571
EU - Europa 3.454
SA - Sud America 626
AF - Africa 201
OC - Oceania 15
Continente sconosciuto - Info sul continente non disponibili 2
Totale 14.820
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Nazione #
US - Stati Uniti d'America 5.782
CN - Cina 2.065
SG - Singapore 954
IE - Irlanda 849
HK - Hong Kong 553
BR - Brasile 463
RU - Federazione Russa 444
VN - Vietnam 426
IT - Italia 414
DE - Germania 362
FI - Finlandia 349
UA - Ucraina 269
FR - Francia 223
GB - Regno Unito 178
IN - India 150
ZA - Sudafrica 121
SE - Svezia 119
CA - Canada 87
AR - Argentina 63
BD - Bangladesh 62
MX - Messico 54
JP - Giappone 46
ID - Indonesia 45
IQ - Iraq 40
AT - Austria 39
TR - Turchia 39
NL - Olanda 36
PL - Polonia 36
BE - Belgio 31
PK - Pakistan 31
ES - Italia 27
CO - Colombia 25
UZ - Uzbekistan 19
CL - Cile 18
EC - Ecuador 18
EG - Egitto 17
LT - Lituania 16
MA - Marocco 16
CZ - Repubblica Ceca 15
SA - Arabia Saudita 15
VE - Venezuela 15
AZ - Azerbaigian 14
MY - Malesia 14
AE - Emirati Arabi Uniti 13
AU - Australia 12
PH - Filippine 12
LV - Lettonia 8
KR - Corea 7
LB - Libano 7
PA - Panama 7
TN - Tunisia 7
BO - Bolivia 6
CR - Costa Rica 6
IR - Iran 6
JO - Giordania 6
KE - Kenya 6
PE - Perù 6
RO - Romania 6
UY - Uruguay 6
ET - Etiopia 5
GR - Grecia 5
IL - Israele 5
KZ - Kazakistan 5
NG - Nigeria 5
NP - Nepal 5
OM - Oman 5
PY - Paraguay 5
DO - Repubblica Dominicana 4
DZ - Algeria 4
KG - Kirghizistan 4
MU - Mauritius 4
RS - Serbia 4
TH - Thailandia 4
AL - Albania 3
AO - Angola 3
HN - Honduras 3
JM - Giamaica 3
MD - Moldavia 3
PT - Portogallo 3
SK - Slovacchia (Repubblica Slovacca) 3
SY - Repubblica araba siriana 3
CG - Congo 2
CH - Svizzera 2
CY - Cipro 2
DK - Danimarca 2
EU - Europa 2
GE - Georgia 2
HU - Ungheria 2
IM - Isola di Man 2
KW - Kuwait 2
LA - Repubblica Popolare Democratica del Laos 2
NO - Norvegia 2
NZ - Nuova Zelanda 2
PS - Palestinian Territory 2
SN - Senegal 2
TJ - Tagikistan 2
AM - Armenia 1
BJ - Benin 1
BN - Brunei Darussalam 1
BS - Bahamas 1
Totale 14.802
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Città #
Dublin 818
San Jose 682
Chandler 676
Ashburn 575
Hong Kong 541
Singapore 480
Beijing 460
Dallas 375
Jacksonville 354
Nanjing 327
Boardman 235
Los Angeles 188
Helsinki 159
Ann Arbor 155
Nanchang 149
Ho Chi Minh City 146
Lauterbourg 143
Pavia 137
Princeton 135
Wilmington 135
Lawrence 127
New York 126
Medford 114
Munich 112
Shenyang 102
Hanoi 100
Johannesburg 96
Shanghai 96
Hebei 92
Hangzhou 90
Changsha 83
Council Bluffs 77
Jiaxing 72
Moscow 72
Tianjin 69
Redondo Beach 60
Buffalo 54
Milan 53
Orem 50
Santa Clara 50
Tokyo 44
São Paulo 42
The Dalles 39
Turku 38
Woodbridge 34
Vienna 32
Warsaw 32
Montreal 31
Brussels 30
Chicago 30
Dearborn 30
Haiphong 29
Denver 25
Frankfurt am Main 25
Brooklyn 24
London 24
Chennai 23
Stockholm 23
Boston 22
Seattle 22
Toronto 22
Da Nang 21
Fairfield 21
Falkenstein 21
Verona 21
Atlanta 20
Houston 19
Mexico City 19
Piscataway 19
Tashkent 19
Columbus 18
San Francisco 18
Nuremberg 17
Phoenix 16
Washington 16
Mumbai 15
Norwalk 15
San Genesio ed Uniti 15
Amsterdam 14
Baku 14
Curitiba 14
Cape Town 13
Des Moines 13
Guangzhou 13
Jinan 13
Rio de Janeiro 13
Istanbul 12
New Delhi 12
Ningbo 12
Ottawa 12
Baghdad 11
Dhaka 11
Olomouc 11
Poplar 11
Biên Hòa 10
Buenos Aires 10
Florence 10
Hyderabad 10
Recife 10
Lahore 9
Totale 9.754
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Nome #
2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1. 208
Absence of interaction between doppel and GFAP, Grb2, PrPC proteins in human tumor astrocytic cells 168
Biological and structural characterization of theMycobacterium smegmatis nitroreductase NfnB, and its rolein benzothiazinone resistance 163
Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis 159
Aberrant Doppel Protein Expression in Human Astrocytic Tumors 151
4-Aminoquinolone Piperidine Amides: Non-Covalent Inhibitors of DprE1 with Long Residence Time and Potent Antimycobacterial Activity. 151
Letter to the editor regarding Shibayama et al.: Biochemical and pathophysiological characterization of Helicobacter pylori asparaginase. 146
A phenotypic based target screening approach delivers new antitubercular CTP synthetase inhibitors 143
Investigating the Mechanism of Action of Diketopiperazines Inhibitors of the Burkholderia cenocepacia Quorum Sensing Synthase CepI: A Site-Directed Mutagenesis Study 142
The prion-like doppel protein is soluble in astrocytic tumor 135
Generation of Mutants of Helicobacter pylori L-Asparaginase 134
Engineering of Helicobacter pylori L-asparaginase: characterization of two functionally distinct groups of mutants 134
Phosphoglycerate Kinase Deficiency: Characterization of the Wild-Type Enzyme and Three Pathological Variants Generated from C.140T>a, C.491A>T and C.959G>a Mutations 132
Biochemical Characterization of Glutamate Racemase-A New Candidate Drug Target against Burkholderia cenocepacia Infections 131
Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis. 130
Expanding targets for a metabolic therapy of cancer: L-asparaginase 130
Molecular and cellular insights into the aberrant expression of the prion protein-like gene doppel in astrocytic tumors 129
Cell-cycle inhibition by Helicobacter pylori L-asparaginase. 129
Biochemistry of Lipolytic Enzymes Secreted by Penicillium solitum and Cladosporium cladosporioides 129
Chemical, Metabolic, and Cellular Characterization of a FtsZ Inhibitor Effective Against Burkholderia cenocepacia 129
Discovery of new diketopiperazines inhibiting Burkholderia cenocepacia quorum sensing in vitro and in vivo. 128
Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis. 127
A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK 127
Mycobacterium tuberculosis Phosphoribosylpyrophosphate Synthetase: Biochemical Features of a Crucial Enzyme for Mycobacterial Cell Wall Biosynthesis. 126
New prodrugs against tuberculosis 126
Expanding Targets for a Metabolic Therapy of Cancer: L- Asparaginase 125
A New Benzothiazolthiazolidine Derivative, 11726172, Is Active In Vitro, In Vivo, and against Nonreplicating Cells of Mycobacterium tuberculosis 123
Ectopic expression of the prion-like protein doppel in human astrocytoma cells 123
BEL β-trefoil: a novel lectin with antineoplastic properties in king bolete (Boletus edulis) mushrooms. 122
The prion protein-like gene Doppel is aberrantly expressed in astrocytic tumors 122
Could the Oxidation of α1-Antitrypsin Prevent the Binding of Human Neutrophil Elastase in COVID-19 Patients? 121
An Overview on the Potential Antimycobacterial Agents Targeting Serine/Threonine Protein Kinases from Mycobacterium tuberculosis 120
From virulence factors to drug development: MbtI as an effective Mycobacterium tuberculosis target 119
A Coumarin-Based Analogue of Thiacetazone as Dual Covalent Inhibitor and Potential Fluorescent Label of HadA in Mycobacterium tuberculosis 119
Biochemical signatures of doppel (Dpl) protein in human glioblastoma to support prediction in tumor malignancy 118
New and old hot drug targets in tuberculosis 118
A new mutation of the pgk1 gene detected in an italian patient affected by phosphoglycerate kinase deficiency. 118
Pyruvate kinase deficiency: Biochemical characterization of two mutations causing inability of the enzyme to properly bind substrates 117
Burkholderia cenocepacia infections in cystic fibrosis patients: Drug resistance and therapeutic approaches 117
Helicobacter pylori L-asparaginase: from Gene to Diagnostic Tool 116
Nuclear mRNA retention and aberrant doppel protein expression in human astrocytic tumor cells 116
Competitive fitness of essential gene knockdowns reveals a broad-spectrum antibacterial inhibitor of the cell division protein FtsZ 116
Structural and Activity Relationships of 6-Sulfonyl-8-Nitrobenzothiazinones as Antitubercular Agents 116
The allosteric regulation of pyruvate kinase. 115
Helicobacter pylori: from gene to Diagnostic Tool 113
Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG. 113
A new promising bactericidal compound against Burkholderia cenocepacia. 113
Molecular Insights on Pathogenic Effects of MutationsCausing Phosphoglycerate Kinase Deficiency 112
Molecular cloning and characterisation of Helicobacter pylori L-asparaginase 111
Design, Syntheses, and Anti-TB Activity of 1,3-Benzothiazinone Azide and Click Chemistry Products Inspired by BTZ043 111
A new variant of phosphoglycerate kinase deficiency (p.I371K) with multiple tissue involvement: molecular and functional characterization. 111
New insights into the mechanism of action of the thienopyrimidine antitubercular prodrug TP053 111
CanB, a Druggable Cellular Target in Mycobacterium tuberculosis 110
Characterization of a pyrimidine 5'-nucleotidase mutant form (G214R) causing hereditary hemolytic anemia. 110
Rv0579 Is Involved in the Resistance to the TP053 Antitubercular Prodrug 110
Protein Recognition by Short Peptide Reversible Inhibitors of the Chromatin-Modifying LSD1/CoREST Lysine Demethylase. 109
Micellar electrokinetic chromatography as a complementary method to sodium dodecyl sulfate-polyacrylamide gel electrophoresis for studying limited proteolysis of proteins. 109
Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents 109
SELECTION OF MICROFUNGI WITH HIGH LIPOLYTIC ACTIVITYAND THEIR LIPASE CHARACTERIZATION 107
Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia 107
Improve protection to prevent infections: application of reverse vaccinology against cystic fibrosis pathogens. 107
ThermoFAD, a Thermofluor®-adapted flavin ad hoc detection system for protein folding and ligand binding 106
The cell division protein FtsZ as a cellular target to hit cystic fibrosis pathogens 106
Premio Ricercatissimi 2008 104
Investigating the Molecular Bases of the Phosphoglycerate Kinase Deficiency: Characterization ofG158V, R206P, V266M and D285V Pathological Variants. 101
Design, synthesis and evaluation of covalent inhibitors of DprE1 as antitubercular agents 101
Targeting iron uptake pathway for the development of novel antitubercular drugs. 100
Erythrocyte adenylate kinase deficiency: characterization of recombinant mutant forms and relationship with nonspherocytic hemolytic anemia 100
Antivirulence compounds: a future direction to overcome antibiotic resistance? 100
The crystal structure of Burkholderia cenocepacia DfsA provides insights into substrate recognition and quorum sensing fatty acid biosynthesis 99
Functional investigation of the antitubercular drug target Decaprenylphosphoryl-β-D-ribofuranose-2-epimerase DprE1/DprE2 complex 99
Mycobacterium tuberculosis Sulfate Ester Dioxygenase Rv3406 Is Able to Inactivate the RCB18350 Compound. 97
Molecular Characterization of Three New Mutant Enzymes of Pyrimidine 5-Nucleotidase Causing Hereditary Hemolytic Anemia. 97
EXPRESSION AND CHARACTERIZATION OF THE BOVINE PRION DOPPEL 96
Erythrocyte Adenylate Kinase Deficiency: First In-Depth Biochemical Characterization of the Y164C Mutant Enzyme Causing Hemolytic Anemia 96
Mycobacterium abscessus siderophores biosynthesis as a target to inhibit the iron uptake mechanism 95
Aeroplane shaped crystal of a mutant ofHelicobacter pylori L-asparaginase. 95
The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis. 95
Pyrimidine 5' Nucleotidase Deficiency: Clinical and Molecular Characterization of Two New Italian Patients 95
Molecular basis of pyrimidine 5'-nucleotidase deficiency caused by 3 newly identified missense mutations (c.187T>C, c.469G>C and c.740T>C) and a tabulation of known mutations 93
Nitric oxide-releasing compounds for the treatment of lung infections 93
Mechanochemical Synthesis and Biological Evaluation of Novel Isoniazid Derivatives with Potent Antitubercular Activity. 92
6-Hydroxy-2-methylbenzofuran-4-carboxylic Acid 92
Pyrimidine 5'-nucleotidase activities detected in real samples by means of micellar electrokinetic chromatography. 89
Molecular Basis of Hemolytic Anemia: First Biochemical Characterization of Wild-Type and N190S Mutant Human Erythrocyte Pyrimidine 5'-Nucleotidase. 89
Multitargeting Compounds: A Promising Strategy to Overcome Multi-Drug Resistant Tuberculosis 89
Molecular and functional characterization of a lethal variant of pyruvate kinase deficiency 88
Inosine monophosphate dehydrogenase activity after mycophenolate mofetil in renal transplant patients receiving different immunosupressive combined therapy and stable after at least three months' administration. 88
PYRUVATE KINASE DEFICIENCY: MOLECULAR AND FUNCTIONAL CHARACTERISATION OF A LETHAL VARIANT 87
Structural and Energetic Basis of Protein Kinetic Destabilization in Human Phosphoglycerate Kinase 1 Deficiency 87
PHOSPHOGLYCERATE KINASE DEFICIENCY: FUNCTIONAL PROPERTIES OF THE L89P, K191DEL, C316R AND A354P PATHOLOGICAL VARIANTS 86
Exploring the role of the heterocyclic moiety of 5-(4-nitrophenyl)-2-furoic acid, a promising inhibitor of MbtI from Mycobacterium tuberculosis. 86
Antibiotics sustainability: another issue in the fight against antimicrobial resistance. 84
Repurposing of FDA-Approved Drugs to Disrupt Iron Uptake in Mycobacterium abscessus: Targeting Salicylate Synthase as a Novel Approach 83
Pyruvate kinase deficiency : The genotype-phenotype association 83
Red cell pyruvate kinase deficiency: 17 new mutations of the PK-LR gene 83
Multi-target antitubercular drugs: identification of novel dual MbtI and MptpB inhibitors. 83
Two new mutations of the P5'N-1 gene found in Italian patients with hereditary hemolytic anemia: the molecular basis of the red cell enzyme disorder. 82
The antimalarial mefloquine shows activity against mycobacterium abscessus, inhibiting mycolic acid metabolism 82
Benzothiozinone derivatives with anti-tubercular Activity−Further side chain investigation 81
Totale 11.243
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Categoria #
all - tutte 64.641
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 64.641
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202116 0 0 0 0 0 0 0 0 0 0 0 16
2021/2022647 13 6 12 46 19 15 15 47 44 22 79 329
2022/20232.055 188 181 25 156 177 195 5 109 934 13 50 22
2023/20241.048 160 175 41 85 88 228 46 69 5 49 46 56
2024/20252.590 77 191 76 54 92 106 178 158 659 103 321 575
2025/20265.859 494 348 672 702 698 252 1.043 279 593 429 208 141
Totale 15.240