IRIS
COLOMBO, GIORGIO
 Distribuzione geografica
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Continente #
AS - Asia 6.607
NA - Nord America 6.342
EU - Europa 2.698
SA - Sud America 1.876
AF - Africa 252
OC - Oceania 9
Continente sconosciuto - Info sul continente non disponibili 3
Totale 17.787
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Nazione #
US - Stati Uniti d'America 6.161
CN - Cina 2.624
BR - Brasile 1.453
SG - Singapore 1.389
VN - Vietnam 948
IE - Irlanda 887
HK - Hong Kong 865
RU - Federazione Russa 459
IT - Italia 354
FR - Francia 282
DE - Germania 193
AR - Argentina 160
FI - Finlandia 145
BD - Bangladesh 142
IN - India 126
GB - Regno Unito 108
ZA - Sudafrica 96
EC - Ecuador 86
ID - Indonesia 84
MX - Messico 68
CA - Canada 66
IQ - Iraq 55
TR - Turchia 50
CO - Colombia 49
JP - Giappone 49
PK - Pakistan 42
ES - Italia 35
PL - Polonia 34
SE - Svezia 34
UZ - Uzbekistan 34
CL - Cile 33
MA - Marocco 31
NL - Olanda 30
PY - Paraguay 29
VE - Venezuela 28
PH - Filippine 26
TN - Tunisia 25
UA - Ucraina 22
AT - Austria 20
SA - Arabia Saudita 20
BE - Belgio 19
EG - Egitto 19
KE - Kenya 19
MY - Malesia 18
MU - Mauritius 17
PE - Perù 16
AE - Emirati Arabi Uniti 14
DZ - Algeria 12
BO - Bolivia 11
NP - Nepal 10
UY - Uruguay 10
KR - Corea 9
NI - Nicaragua 9
BH - Bahrain 8
ET - Etiopia 8
GR - Grecia 8
IL - Israele 8
KZ - Kazakistan 8
PS - Palestinian Territory 8
TH - Thailandia 8
AL - Albania 7
AZ - Azerbaigian 7
RO - Romania 7
RS - Serbia 7
DO - Repubblica Dominicana 6
JM - Giamaica 6
JO - Giordania 6
OM - Oman 6
PA - Panama 6
SN - Senegal 6
AU - Australia 5
LB - Libano 5
LT - Lituania 5
MD - Moldavia 5
SY - Repubblica araba siriana 5
TW - Taiwan 5
AM - Armenia 4
BA - Bosnia-Erzegovina 4
GE - Georgia 4
KG - Kirghizistan 4
NG - Nigeria 4
PT - Portogallo 4
TT - Trinidad e Tobago 4
CH - Svizzera 3
CR - Costa Rica 3
CZ - Repubblica Ceca 3
EE - Estonia 3
GT - Guatemala 3
KW - Kuwait 3
LK - Sri Lanka 3
LV - Lettonia 3
SI - Slovenia 3
AO - Angola 2
BG - Bulgaria 2
BY - Bielorussia 2
CI - Costa d'Avorio 2
CY - Cipro 2
IR - Iran 2
LY - Libia 2
ME - Montenegro 2
Totale 17.746
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Città #
Dublin 887
Dallas 844
Hong Kong 843
San Jose 763
Ashburn 680
Singapore 594
Chandler 549
Nanjing 524
Ho Chi Minh City 329
Beijing 292
Boardman 264
Lauterbourg 240
Princeton 228
Lawrence 217
Nanchang 211
Hanoi 209
Los Angeles 184
Hebei 181
Jacksonville 174
Changsha 162
Shenyang 158
Wilmington 149
São Paulo 141
Council Bluffs 131
Jiaxing 126
Medford 123
Redondo Beach 119
Helsinki 107
Tianjin 104
Buffalo 94
Hangzhou 91
Shanghai 87
Moscow 85
Johannesburg 71
Pavia 70
New York 60
Munich 54
Da Nang 48
Milan 47
Santa Clara 47
The Dalles 42
Haiphong 41
Rio de Janeiro 41
Tokyo 41
Turku 37
Orem 34
Curitiba 32
Norwalk 31
Brasília 30
Tashkent 30
Biên Hòa 29
Warsaw 29
Chicago 28
Washington 28
Brooklyn 27
Frankfurt am Main 27
Guayaquil 27
Guangzhou 26
Belo Horizonte 24
Quito 24
Seattle 24
Campinas 22
Montreal 22
Nuremberg 21
Atlanta 20
Buenos Aires 20
Mexico City 20
San Francisco 20
Thái Bình 20
Columbus 19
Fairfield 19
Sassari 19
Brussels 18
Porto Alegre 18
Zhengzhou 18
Chennai 17
Dhaka 17
London 17
Rome 17
Bogotá 16
Boston 16
Hải Dương 16
Nairobi 16
Phoenix 16
Stockholm 16
Toronto 16
Woodbridge 16
Asunción 15
Baghdad 15
Jinan 15
Amsterdam 14
Bắc Ninh 14
Denver 14
Houston 14
Manchester 14
Ann Arbor 13
Cambridge 13
Can Tho 13
Florence 13
Jakarta 13
Totale 11.591
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Nome #
Design of multi-target peptide modulators for protein chaperone networks 291
Molecular structure and enzymatic mechanism of the human collagen hydroxylysine galactosyltransferase GLT25D1/COLGALT1 132
Biocompatible graft copolymers from bacterial poly(γ-glutamic acid) and poly(lactic acid) 127
Investigating allostery with atomistic biomolecular simulations 122
A Local Allosteric Network in Heat Shock Protein 70 (Hsp70) Links Inhibitor Binding to Enzyme Activity and Distal Protein-Protein Interactions 120
A protease-resistant Escherichia coli asparaginase with outstanding stability and enhanced anti-leukaemic activity in vitro 119
Impact of Mutations on NPAC Structural Dynamics: Mechanistic Insights from MD Simulations 115
A novel chemical chaperone ameliorates osteoblast homeostasis and extracellular matrix in osteogenesis imperfecta 111
AICAR: A rational identified small molecule targeting Hsp90 chaperone function in cancer cells 110
All-atom folding simulations of the villin headpiece from stochastically selected coarse-grained structures 107
The Answer Lies in the Energy: How Simple Atomistic Molecular Dynamics Simulations May Hold the Key to Epitope Prediction on the Fully Glycosylated SARS-CoV-2 Spike Protein 106
Designing Molecular Spanners to Throw in the Protein Networks 105
A Fe2+-dependent self-inhibited state influences the druggability of human collagen lysyl hydroxylase (LH/PLOD) enzymes 105
Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands 103
Ab initio protein structure prediction with a dipeptide-assembly evolutionary algorithm 102
Exploiting the folding and degradation machineries to target undruggable proteins: What can the computational approach tell us? 102
On the binding of naphthalene diimides to a human telomeric G-quadruplex multimer model 102
Molecular Mechanisms of Chaperone Directed Protein Folding: Insights from Atomistic Simulations 101
Rational Design of Allosteric and Selective Inhibitors of the Molecular Chaperone TRAP1 101
New perspectives in cancer drug development: computational advances with an eye to design 101
A Hamiltonian Replica Exchange Molecular Dynamics (MD) Method for the Study of Folding, Based on the Analysis of the Stabilization Determinants of Proteins 100
AlphaFold predicted structure of the Hsp90-like domains of the neurodegeneration linked protein sacsin reveals key residues for ATPase activity 99
Conformational Behavior of SARS-Cov-2 Spike Protein Variants: Evolutionary Jumps in Sequence Reverberate in Structural Dynamic Differences 98
A Multiscale Approach to Characterize the Early Aggregation Steps of the Amyloid-Forming Peptide GNNQQNY from the Yeast Prion Sup-35 97
Atomistic Simulations of the Mechanisms of the Poorly Catalytic Mitochondrial Chaperone Trap1: Insights into the Effects of Structural Asymmetry on Reactivity 97
Chemical Perturbation of Oncogenic Protein Folding: from the Prediction of Locally Unstable Structures to the Design of Disruptors of Hsp90–Client Interactions 96
Allosteric Regulation Points Control the Conformational Dynamics of the Molecular Chaperone Hsp90 95
A Computational Assay of Estrogen Receptor alpha Antagonists Reveals the Key Common Structural Traits of Drugs Effectively Fighting Refractory Breast Cancers 95
Design of Disruptors of the Hsp90–Cdc37 Interface 95
3D-QSAR-Assisted Design, Synthesis, and Evaluation of Novobiocin Analogues 93
2 `-O-Alkyl Derivatives and 5 `-Analogues of 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) as Potential Hsp90 Inhibitors 92
A Structure-Based Strategy for Epitope Discovery in Burkholderia pseudomallei OppA Antigen 92
A dynamic perspective on the molecular recognition of chitooligosaccharide ligands by hevein domains 90
Dynamically Shaping Chaperones. Allosteric Modulators of HSP90 Family as Regulatory Tools of Cell Metabolism in Neoplastic Progression 90
ADAMDEC1 maintains a growth factor signaling loop in cancer stem cells 89
A decoy set for the thermostable subdomain from chicken villin headpiece, comparison of different free energy estimators 85
Protein Allostery and Ligand Design: Computational Design Meets Experiments to Discover Novel Chemical Probes 85
Antiangiogenic small molecule ligands of FGF2 derived from the endogenous inhibitor thrombospondin-1 84
Application of structure-based thermodynamic calculations to the rationalization of the enantioselectivity of subtilisin in organic solvents 84
Probing the hirudin-thrombin interaction by incorporation of noncoded amino acids and molecular dynamics simulation 84
Structures, dynamics, complexes, and functions: From classic computation to artificial intelligence 83
Assessment of Mutational Effects on Peptide Stability through Confinement Simulations 83
SARS-CoV-2 Spike Protein Mutations and Escape from Antibodies: A Computational Model of Epitope Loss in Variants of Concern 83
Assessing the influence of electrostatic schemes on molecular dynamics simulations of secondary structure forming peptides 82
Direct and Allosteric Inhibition of the FGF2/HSPGs/FGFR1 Ternary Complex Formation by an Antiangiogenic, Thrombospondin-1-Mimic Small Molecule 82
Dynamic Diagnosis of Familial Prion Diseases Supports the beta 2-alpha 2 Loop as a Universal Interference Target 81
Protein design: from computer models to artificial intelligence 81
Setup and Validation of a Reliable Docking Protocol for the Development of Neuroprotective Agents by Targeting the Sigma-1 Receptor (S1R) 81
The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect 79
Modelling the enantioselectivity of subtilisin in water and organic solvents: insights from molecular dynamics and quantum mechanical/molecular mechanical studies 79
Synthesis, structure and conformation of partially-modified retro- and retro-inverso psi[NHCH(CF3)]Gly peptides 79
Antileukemic activity of shepherdin and molecular diversity of Hsp90 inhibitors 79
Design and Test of Molecules that Interfere with the Recognition Mechanisms between the SARS-CoV-2 Spike Protein and Its Host Cell Receptors 78
Allosteric modulators of Hsp90 and Hsp70: Dynamics meets Function through Structure-Based Drug Design 78
Designing molecular spanners to throw in the protein networks. 78
Integrating Molecular Dynamics and Machine Learning Algorithms to Predict the Functional Profile of Kinase Ligands 77
Dimerization Capacities of FGF2 Purified with or without Heparin-Affinity Chromatography 77
Solvent dynamics and mechanism of proton transfer in human carbonic anhydrase II 77
Chemo-enzymatic synthesis of (: E)-2,3-diaryl-5-styryl- trans -2,3-dihydrobenzofuran-based scaffolds and their in vitro and in silico evaluation as a novel sub-family of potential allosteric modulators of the 90 kDa heat shock protein (Hsp90) 77
Mechanistic Model for the Hsp90-Driven Opening of Human Argonaute 77
Folding and stability of the three-stranded beta-sheet peptide betanova: Insights from molecular dynamics simulations 76
Anharmonicity and self-similarity of the free energy landscape of protein G 76
Remote control of enzyme selectivity: the case of stevioside and steviolbioside 76
The Subtle Trade-Off between Evolutionary and Energetic Constraints in Protein-Protein Interactions 76
Antileukemic activity of shepherdin, a novel targeted inhibitor of the survivin-HSP90 complex. 76
Tryptophan scanning mutagenesis as a way to mimic the compound-bound state and probe the selectivity of allosteric inhibitors in cells 76
Bow to the enemy: How flexibility of host protein receptors can favor SARS-CoV-2 75
Flexible vs Rigid Epitope Conformations for Diagnostic- and Vaccine-Oriented Applications: Novel Insights from the Burkholderia pseudomallei BPSL2765 Pa13 Epitope 74
Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug 74
The Binding Pocket at the Interface of Multimeric Telomere G-quadruplexes: Myth or Reality? 74
Revealing Escherichia coli type II l-asparaginase active site flexible loop in its open, ligand-free conformation 74
A Molecular Dynamics Study of the Interaction of D-Peptide Amyloid Inhibitors with Their Target Sequence Reveals a Potential Inhibitory Pharmacophore Conformation 73
Enzymatic and Inhibition Mechanism of Human Aromatase (CYP19A1) Enzyme. A Computational Perspective from QM/MM and Classical Molecular Dynamics Simulations 73
Are Amyloid Fibrils RNA-Traps? A Molecular Dynamics Perspective 73
Computational Epitope Prediction and Design for Antibody Development and Detection 72
Two amino acid substitutions within the first external loop of CCR5 induce human immunodeficiency virus-blocking antibodies in mice and chickens 72
Screening Complex Biological Samples with Peptide Microarrays: The Favorable Impact of Probe Orientation via Chemoselective Immobilization Strategies on Clickable Polymeric Coatings 72
Molecular dynamics simulation of the aggregation of the core-recognition motif of the islet amylolid polypeptide in explicit water 72
Expedient Access to 2-Benzazepines by Palladium-Catalyzed C-H activation: Identification of a Unique HSP90 Inhibitor Scaffold 72
Structure-activity relationships of linear and cyclic peptides containing the NGR tumor-homing motif 71
Surface energetics and protein-protein interactions: analysis and mechanistic implications 71
Structure and sequence determinants of aggregation investigated with molecular dynamics 71
Studying the Dynamics of a Complex G-Quadruplex System: Insights into the Comparison of MD and NMR Data 70
Decrypting Allostery in Membrane-Bound K-Ras4B Using Complementary In Silico Approaches Based on Unbiased Molecular Dynamics Simulations 70
Rational design of shepherdin, a novel anticancer agent 70
Molecular Dynamics Simulations Reveal the Mechanisms of Allosteric Activation of Hsp90 by Designed Ligands 70
Machine Learning Prediction of Allosteric Drug Activity from Molecular Dynamics 70
Enantioselective Mukaiyama-Michael reactions of 2-carbomethoxy cyclopentenone catalyzed by chiral bis(oxazoline)-Cu(II) complexes 69
An efficient steroid pharmacophore-based strategy to identify new aromatase inhibitors 69
Structure elucidation and 3D solution conformation of the antibiotic enduracidin determined by NMR spectroscopy and molecular dynamics. 69
Disruption of protein phosphatase 1 complexes with the use of bioportides as a novel approach to target sperm motility 69
Ligand‐driven modulation of chaperone–cochaperone networks shapes proteostasis outcomes 69
LIGAND-BASED DESIGN AND BIOCHEMICAL EVALUATION OF NEW POTENT AROMATASE INHIBITORS 68
Combining computational and biochemical studies for a rationale on the anti-aromatase activity of natural polyphenols 68
Identification of a New Scaffold for Hsp90 C-Terminal Inhibition 68
Molecular Simulations of Peptides: A Useful Tool for the Development of New Drugs and for the Study of Molecular Recognition 68
Dehydrogenase versus Oxidase Function: The Interplay between Substrate Binding and Flavin Microenvironment 67
Modelling of enzyme properties in organic solvents 67
Structural Stability and Flexibility Direct the Selection of Activating Mutations in Epidermal Growth Factor Receptor Kinase 67
Non-peptidic Thrombospondin-1 Mimics as Fibroblast Growth Factor-2 Inhibitors AN INTEGRATED STRATEGY FOR THE DEVELOPMENT OF NEW ANTIANGIOGENIC COMPOUNDS 67
Totale 8.667
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Categoria #
all - tutte 89.717
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 89.717
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20213 0 0 0 0 0 0 0 0 0 0 0 3
2021/2022732 1 4 3 6 9 5 16 67 52 5 134 430
2022/20232.101 338 116 64 109 119 167 6 83 983 20 76 20
2023/2024801 75 119 40 61 107 209 78 47 1 18 22 24
2024/20252.870 35 294 36 84 65 99 148 173 711 115 295 815
2025/20269.411 556 953 1.492 1.717 893 248 1.334 387 677 598 367 189
Totale 18.136