COLOMBO, GIORGIO
 Distribuzione geografica
Continente #
NA - Nord America 2.892
AS - Asia 2.003
EU - Europa 1.341
SA - Sud America 115
AF - Africa 24
OC - Oceania 2
Continente sconosciuto - Info sul continente non disponibili 1
Totale 6.378
Nazione #
US - Stati Uniti d'America 2.875
CN - Cina 1.790
IE - Irlanda 881
IT - Italia 173
SG - Singapore 156
BR - Brasile 107
FI - Finlandia 101
DE - Germania 79
GB - Regno Unito 22
BE - Belgio 18
SE - Svezia 18
MU - Mauritius 17
CA - Canada 13
IN - India 11
RU - Federazione Russa 10
JP - Giappone 9
NL - Olanda 8
UA - Ucraina 7
GR - Grecia 5
HK - Hong Kong 5
PK - Pakistan 5
TR - Turchia 5
AE - Emirati Arabi Uniti 3
EC - Ecuador 3
FR - Francia 3
IL - Israele 3
MA - Marocco 3
NP - Nepal 3
RO - Romania 3
TW - Taiwan 3
AT - Austria 2
AU - Australia 2
BO - Bolivia 2
IQ - Iraq 2
LT - Lituania 2
PA - Panama 2
UZ - Uzbekistan 2
AL - Albania 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BD - Bangladesh 1
CH - Svizzera 1
CL - Cile 1
CO - Colombia 1
CZ - Repubblica Ceca 1
DZ - Algeria 1
EE - Estonia 1
EU - Europa 1
IR - Iran 1
JM - Giamaica 1
KE - Kenya 1
KZ - Kazakistan 1
MD - Moldavia 1
MK - Macedonia 1
MX - Messico 1
PH - Filippine 1
PL - Polonia 1
PT - Portogallo 1
SA - Arabia Saudita 1
TM - Turkmenistan 1
TN - Tunisia 1
VE - Venezuela 1
Totale 6.378
Città #
Dublin 881
Chandler 549
Nanjing 523
Ashburn 317
Boardman 262
Princeton 228
Lawrence 217
Nanchang 210
Hebei 181
Jacksonville 172
Shenyang 156
Changsha 149
Wilmington 149
Jiaxing 126
Medford 123
Helsinki 101
Tianjin 96
Hangzhou 86
Beijing 80
Shanghai 74
Pavia 64
Singapore 61
Norwalk 31
Washington 24
Fairfield 19
Milan 19
Seattle 19
Brussels 18
Los Angeles 16
Woodbridge 15
Ann Arbor 13
Cambridge 12
Chicago 12
Guangzhou 11
São Paulo 11
Zhengzhou 11
Falkenstein 10
New York 10
Redwood City 9
Tokyo 9
Jinan 8
Toronto 8
Travaco Siccomario 8
Barbianello 7
Fuzhou 6
London 6
San Francisco 6
Santa Clara 6
Southend 6
Harlow 5
Ningbo 5
Orange 5
Sesto Fiorentino 5
Borås 4
Dallas 4
Florence 4
Hong Kong 4
Nuremberg 4
Pune 4
Rockville 4
Udine 4
Belo Horizonte 3
Campinas 3
Erbusco 3
Esslingen am Neckar 3
Frankfurt am Main 3
Fremont 3
Groningen 3
Karachi 3
Novara 3
Rio de Janeiro 3
Tel Aviv 3
Anzio 2
Anápolis 2
Bodio Lomnago 2
Bologna 2
Bom Despacho 2
Borgosatollo 2
Brescia 2
Cascavel 2
Cremona 2
Curitiba 2
Dearborn 2
Des Moines 2
Doncaster 2
Fortaleza 2
Giussano 2
Guayaquil 2
Hefei 2
Houston 2
Jiujiang 2
João Pessoa 2
Kaohsiung 2
Monza 2
Osasco 2
Pedrengo 2
Phoenix 2
Portland 2
Recanati 2
San Cipriano Po 2
Totale 5.276
Nome #
A Local Allosteric Network in Heat Shock Protein 70 (Hsp70) Links Inhibitor Binding to Enzyme Activity and Distal Protein-Protein Interactions 68
AICAR: A rational identified small molecule targeting Hsp90 chaperone function in cancer cells 60
Rational Design of Allosteric and Selective Inhibitors of the Molecular Chaperone TRAP1 59
Probing the hirudin-thrombin interaction by incorporation of noncoded amino acids and molecular dynamics simulation 56
Biocompatible graft copolymers from bacterial poly(γ-glutamic acid) and poly(lactic acid) 55
Ab initio protein structure prediction with a dipeptide-assembly evolutionary algorithm 54
The Answer Lies in the Energy: How Simple Atomistic Molecular Dynamics Simulations May Hold the Key to Epitope Prediction on the Fully Glycosylated SARS-CoV-2 Spike Protein 53
All-atom folding simulations of the villin headpiece from stochastically selected coarse-grained structures 52
Allosteric Regulation Points Control the Conformational Dynamics of the Molecular Chaperone Hsp90 51
A protease-resistant Escherichia coli asparaginase with outstanding stability and enhanced anti-leukaemic activity in vitro 50
Designing Molecular Spanners to Throw in the Protein Networks 50
3D-QSAR-Assisted Design, Synthesis, and Evaluation of Novobiocin Analogues 49
On the binding of naphthalene diimides to a human telomeric G-quadruplex multimer model 49
Antileukemic activity of shepherdin, a novel targeted inhibitor of the survivin-HSP90 complex. 47
New perspectives in cancer drug development: computational advances with an eye to design 47
A Computational Assay of Estrogen Receptor alpha Antagonists Reveals the Key Common Structural Traits of Drugs Effectively Fighting Refractory Breast Cancers 46
Solvent dynamics and mechanism of proton transfer in human carbonic anhydrase II 44
A Multiscale Approach to Characterize the Early Aggregation Steps of the Amyloid-Forming Peptide GNNQQNY from the Yeast Prion Sup-35 43
2 `-O-Alkyl Derivatives and 5 `-Analogues of 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) as Potential Hsp90 Inhibitors 43
Allosteric modulators of Hsp90 and Hsp70: Dynamics meets Function through Structure-Based Drug Design 43
A Structure-Based Strategy for Epitope Discovery in Burkholderia pseudomallei OppA Antigen 43
Chemical Perturbation of Oncogenic Protein Folding: from the Prediction of Locally Unstable Structures to the Design of Disruptors of Hsp90–Client Interactions 43
Atomistic Simulations of the Mechanisms of the Poorly Catalytic Mitochondrial Chaperone Trap1: Insights into the Effects of Structural Asymmetry on Reactivity 43
Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands 42
Anharmonicity and self-similarity of the free energy landscape of protein G 42
Antileukemic activity of shepherdin and molecular diversity of Hsp90 inhibitors 42
Dynamically Shaping Chaperones. Allosteric Modulators of HSP90 Family as Regulatory Tools of Cell Metabolism in Neoplastic Progression 42
Are Amyloid Fibrils RNA-Traps? A Molecular Dynamics Perspective 42
A dynamic perspective on the molecular recognition of chitooligosaccharide ligands by hevein domains 41
Analyzing the free energy landscape of natural peptides: Insights from atomistic MD Simulations 41
A Hamiltonian Replica Exchange Molecular Dynamics (MD) Method for the Study of Folding, Based on the Analysis of the Stabilization Determinants of Proteins 41
Impact of Mutations on NPAC Structural Dynamics: Mechanistic Insights from MD Simulations 41
Antiangiogenic small molecule ligands of FGF2 derived from the endogenous inhibitor thrombospondin-1 40
ADAMDEC1 maintains a growth factor signaling loop in cancer stem cells 40
Molecular Simulations of Peptides: A Useful Tool for the Development of New Drugs and for the Study of Molecular Recognition 39
Tryptophan scanning mutagenesis as a way to mimic the compound-bound state and probe the selectivity of allosteric inhibitors in cells 39
Exploiting the folding and degradation machineries to target undruggable proteins: What can the computational approach tell us? 39
The Binding Pocket at the Interface of Multimeric Telomere G-quadruplexes: Myth or Reality? 39
Assessing the influence of electrostatic schemes on molecular dynamics simulations of secondary structure forming peptides 38
Application of structure-based thermodynamic calculations to the rationalization of the enantioselectivity of subtilisin in organic solvents 38
Structure and sequence determinants of aggregation investigated with molecular dynamics 38
A Molecular Dynamics Study of the Interaction of D-Peptide Amyloid Inhibitors with Their Target Sequence Reveals a Potential Inhibitory Pharmacophore Conformation 36
A decoy set for the thermostable subdomain from chicken villin headpiece, comparison of different free energy estimators 36
Coupling high enzyme activity and stability: a challenging target 36
Corresponding Functional Dynamics across the Hsp90 Chaperone Family: Insights from a Multiscale Analysis of MD Simulations 36
Ligand selection from the analysis of protein conformational substates: new leads targeting the N-terminal domain of Hsp90 36
The Subtle Trade-Off between Evolutionary and Energetic Constraints in Protein-Protein Interactions 36
Setup and Validation of a Reliable Docking Protocol for the Development of Neuroprotective Agents by Targeting the Sigma-1 Receptor (S1R) 36
An atomistic view of Hsp70 allosteric crosstalk: from the nucleotide to the substrate binding domain and back 35
Protein design: from computer models to artificial intelligence 35
Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90 35
Mechanistic Model for the Hsp90-Driven Opening of Human Argonaute 35
The Interplay between Structural Stability and Plasticity Determines Mutation Profiles and Chaperone Dependence in Protein Kinases 34
Inhibiting Peptide and Protein Self-Aggregation: What Can Simulations Tell Us? 34
Enhancing Antibody Serodiagnosis Using a Controlled Peptide Coimmobilization Strategy 34
Structure determination and dynamics of peptides overlapping the catalytic hairpin of the Ras-specific GEF Cdc25(Mm) 34
Non-peptidic Thrombospondin-1 Mimics as Fibroblast Growth Factor-2 Inhibitors AN INTEGRATED STRATEGY FOR THE DEVELOPMENT OF NEW ANTIANGIOGENIC COMPOUNDS 34
Design of Disruptors of the Hsp90–Cdc37 Interface 34
Covalent docking of selected boron-based serine beta-lactamase inhibitors 33
Expedient Access to 2-Benzazepines by Palladium-Catalyzed C-H activation: Identification of a Unique HSP90 Inhibitor Scaffold 33
Disruption of protein phosphatase 1 complexes with the use of bioportides as a novel approach to target sperm motility 33
The Five-To-Six-Coordination Transition of Ferric Human Serum Heme-Albumin Is Allosterically-Modulated by Ibuprofen and Warfarin: A Combined XAS and MD Study 32
Understanding Complex Mechanisms of Enzyme Reactivity: The Case of Limonene-1,2-Epoxide Hydrolases 32
Study of the villin headpiece folding dynamics by combining coarse-grained Monte Carlo evolution and all-atom molecular dynamics 32
From crystal structure to in silico epitope discovery in the Burkholderia pseudomallei flagellar hook-associated protein FlgK 32
SARS-CoV-2 Spike Protein Mutations and Escape from Antibodies: A Computational Model of Epitope Loss in Variants of Concern 32
A Fe2+-dependent self-inhibited state influences the druggability of human collagen lysyl hydroxylase (LH/PLOD) enzymes 32
Protein Allostery and Ligand Design: Computational Design Meets Experiments to Discover Novel Chemical Probes 32
Modeling enzyme reactivity in organic solvents and water through computer simulations 31
Synthesis of Functionalized 2-(4-Hydroxyphenyl)-3-methylbenzofuran Allosteric Modulators of Hsp90 Activity 31
Structural determinants of the unusual helix stability of a De Novo engineered vascular endothelial growth factor (VEGF) mimicking peptide 31
The Structural Asymmetry of Mitochondrial Hsp90 (Trap1) Determines Fine Tuning of Functional Dynamics 31
beta(3)-adrenergic receptor ligands: insight into structure-activity relationships using Monte-Carlo conformational analysis in water 31
Modeling enzymatic processes: A molecular simulation analysis of the origins of regioselectivity 31
The calcium-binding type III repeats domain of thrombospondin-2 binds to fibroblast growth factor 2 (FGF2) 31
Assessment of Mutational Effects on Peptide Stability through Confinement Simulations 30
Combining computational and biochemical studies for a rationale on the anti-aromatase activity of natural polyphenols 30
Chemo-enzymatic synthesis of (: E)-2,3-diaryl-5-styryl- trans -2,3-dihydrobenzofuran-based scaffolds and their in vitro and in silico evaluation as a novel sub-family of potential allosteric modulators of the 90 kDa heat shock protein (Hsp90) 30
The Importance of Detail: How Differences in Ligand Structures Determine Distinct Functional Responses in Integrin αv β3 30
Revealing Escherichia coli type II l-asparaginase active site flexible loop in its open, ligand-free conformation 30
Bow to the enemy: How flexibility of host protein receptors can favor SARS-CoV-2 30
Sequence dependence of amyloid fibril formation: Insights from molecular dynamics simulations 29
Flagellar subunits as targets for structure-based epitope discovery approaches and melioidosis vaccine development 29
Interplay between hydrophobic cluster and loop propensity in beta-hairpin formation: A mechanistic study 29
Computational Study of the Resistance Shown by the Subtype B/HIV-1 Protease to Currently Known Inhibitors 29
Folding and stability of the three-stranded beta-sheet peptide betanova: Insights from molecular dynamics simulations 28
The Dynamics of Drug Discovery 28
Molecular Mechanism of Allosteric Communication in Hsp70 Revealed by Molecular Dynamics Simulations 28
Targeting difficult protein-protein interactions with plain and general computational approaches 28
HMGB1-Carbenoxolone Interactions: Dynamics Insights from Combined Nuclear Magnetic Resonance and Molecular Dynamics 28
Designing molecular spanners to throw in the protein networks. 28
AlphaFold predicted structure of the Hsp90-like domains of the neurodegeneration linked protein sacsin reveals key residues for ATPase activity 27
Dynamic Diagnosis of Familial Prion Diseases Supports the beta 2-alpha 2 Loop as a Universal Interference Target 27
Dimerization Capacities of FGF2 Purified with or without Heparin-Affinity Chromatography 27
Identification of a New Scaffold for Hsp90 C-Terminal Inhibition 27
Modelling the enantioselectivity of subtilisin in water and organic solvents: insights from molecular dynamics and quantum mechanical/molecular mechanical studies 27
Remote control of enzyme selectivity: the case of stevioside and steviolbioside 27
The molecular dynamics of assembly of the ubiquitous aortic medial amyloidal medin fragment 27
Honokiol Bis-Dichloroacetate Is a Selective Allosteric Inhibitor of the Mitochondrial Chaperone TRAP1 27
Investigating Allostery in Molecular Recognition: Insights from a Computational Study of Multiple Antibody-Antigen Complexes 27
Totale 3.715
Categoria #
all - tutte 46.943
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 46.943


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/202072 0 0 0 0 0 0 0 3 0 38 29 2
2020/2021103 0 2 0 9 4 23 2 52 1 7 0 3
2021/2022732 1 4 3 6 9 5 16 67 52 5 134 430
2022/20232.101 338 116 64 109 119 167 6 83 983 20 76 20
2023/2024801 75 119 40 61 107 209 78 47 1 18 22 24
2024/2025847 35 294 36 84 65 99 148 86 0 0 0 0
Totale 6.702