IRIS
COLOMBO, GIORGIO
 Distribuzione geografica
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Continente #
AS - Asia 5.259
NA - Nord America 4.909
EU - Europa 2.228
SA - Sud America 1.667
AF - Africa 154
OC - Oceania 6
Continente sconosciuto - Info sul continente non disponibili 3
Totale 14.226
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Nazione #
US - Stati Uniti d'America 4.780
CN - Cina 2.418
BR - Brasile 1.355
SG - Singapore 1.074
IE - Irlanda 885
HK - Hong Kong 741
VN - Vietnam 608
RU - Federazione Russa 449
IT - Italia 261
DE - Germania 167
FI - Finlandia 142
AR - Argentina 129
GB - Regno Unito 90
ID - Indonesia 74
EC - Ecuador 70
BD - Bangladesh 65
IN - India 61
MX - Messico 53
ZA - Sudafrica 50
CA - Canada 48
JP - Giappone 34
SE - Svezia 32
PL - Polonia 30
CO - Colombia 27
PY - Paraguay 26
ES - Italia 24
IQ - Iraq 24
TR - Turchia 24
FR - Francia 22
MA - Marocco 22
UZ - Uzbekistan 22
CL - Cile 20
AT - Austria 19
BE - Belgio 19
PK - Pakistan 19
UA - Ucraina 18
MU - Mauritius 17
NL - Olanda 17
EG - Egitto 14
TN - Tunisia 14
VE - Venezuela 14
KE - Kenya 12
PE - Perù 11
AE - Emirati Arabi Uniti 10
IL - Israele 8
SA - Arabia Saudita 8
UY - Uruguay 8
AZ - Azerbaigian 7
KR - Corea 7
NI - Nicaragua 7
BO - Bolivia 6
DO - Repubblica Dominicana 6
NP - Nepal 6
AL - Albania 5
DZ - Algeria 5
ET - Etiopia 5
GR - Grecia 5
LB - Libano 5
LT - Lituania 5
MD - Moldavia 5
RO - Romania 5
BA - Bosnia-Erzegovina 4
BH - Bahrain 4
KZ - Kazakistan 4
NG - Nigeria 4
PT - Portogallo 4
TW - Taiwan 4
AM - Armenia 3
AU - Australia 3
CZ - Repubblica Ceca 3
LK - Sri Lanka 3
OM - Oman 3
PA - Panama 3
PH - Filippine 3
PS - Palestinian Territory 3
RS - Serbia 3
SN - Senegal 3
SY - Repubblica araba siriana 3
AO - Angola 2
CH - Svizzera 2
EE - Estonia 2
GT - Guatemala 2
IR - Iran 2
JM - Giamaica 2
JO - Giordania 2
KW - Kuwait 2
LV - Lettonia 2
ME - Montenegro 2
MY - Malesia 2
PF - Polinesia Francese 2
SK - Slovacchia (Repubblica Slovacca) 2
TT - Trinidad e Tobago 2
BG - Bulgaria 1
BJ - Benin 1
BY - Bielorussia 1
CI - Costa d'Avorio 1
CW - ???statistics.table.value.countryCode.CW??? 1
CY - Cipro 1
DK - Danimarca 1
DM - Dominica 1
Totale 14.207
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Città #
Dublin 885
Dallas 820
Hong Kong 737
Chandler 549
Nanjing 524
Ashburn 486
Singapore 371
Beijing 268
Boardman 262
Princeton 228
Ho Chi Minh City 223
Lawrence 217
Nanchang 211
Hebei 181
Jacksonville 174
Changsha 160
Shenyang 158
Los Angeles 152
Wilmington 149
São Paulo 132
Hanoi 127
Jiaxing 126
Medford 123
Redondo Beach 119
Helsinki 104
Tianjin 104
Hangzhou 90
Buffalo 88
Moscow 83
Shanghai 81
Pavia 65
Munich 53
New York 51
The Dalles 39
Rio de Janeiro 38
Milan 37
Turku 37
Da Nang 34
Norwalk 31
Johannesburg 30
Curitiba 29
Haiphong 29
Tokyo 29
Brasília 28
Washington 27
Brooklyn 26
Warsaw 25
Guangzhou 24
Guayaquil 24
Santa Clara 24
Seattle 24
Belo Horizonte 23
Campinas 22
Chicago 22
Biên Hòa 21
Tashkent 21
Columbus 19
Fairfield 19
Mexico City 19
Brussels 18
Zhengzhou 18
Porto Alegre 17
Quito 17
Thái Bình 17
Boston 16
Atlanta 15
Buenos Aires 15
Dhaka 15
Jinan 15
Montreal 15
San Francisco 15
Toronto 15
Woodbridge 15
Denver 14
Nuremberg 14
Stockholm 14
Ann Arbor 13
Asunción 13
Cambridge 13
Jakarta 13
London 13
Manaus 13
Phoenix 13
Salvador 13
Falkenstein 12
Poplar 12
Rome 12
Itaquaquecetuba 11
Nairobi 11
Vienna 11
Ankara 10
Bogotá 10
Frankfurt am Main 10
Guarulhos 10
Ribeirão Preto 10
Thái Nguyên 10
Chennai 9
Düsseldorf 9
Houston 9
Hải Dương 9
Totale 9.336
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Nome #
Design of multi-target peptide modulators for protein chaperone networks 270
Molecular structure and enzymatic mechanism of the human collagen hydroxylysine galactosyltransferase GLT25D1/COLGALT1 110
A Local Allosteric Network in Heat Shock Protein 70 (Hsp70) Links Inhibitor Binding to Enzyme Activity and Distal Protein-Protein Interactions 106
Biocompatible graft copolymers from bacterial poly(γ-glutamic acid) and poly(lactic acid) 105
A protease-resistant Escherichia coli asparaginase with outstanding stability and enhanced anti-leukaemic activity in vitro 99
AICAR: A rational identified small molecule targeting Hsp90 chaperone function in cancer cells 99
Ab initio protein structure prediction with a dipeptide-assembly evolutionary algorithm 93
All-atom folding simulations of the villin headpiece from stochastically selected coarse-grained structures 90
Rational Design of Allosteric and Selective Inhibitors of the Molecular Chaperone TRAP1 90
A Multiscale Approach to Characterize the Early Aggregation Steps of the Amyloid-Forming Peptide GNNQQNY from the Yeast Prion Sup-35 89
Investigating allostery with atomistic biomolecular simulations 86
3D-QSAR-Assisted Design, Synthesis, and Evaluation of Novobiocin Analogues 86
Impact of Mutations on NPAC Structural Dynamics: Mechanistic Insights from MD Simulations 86
Designing Molecular Spanners to Throw in the Protein Networks 86
On the binding of naphthalene diimides to a human telomeric G-quadruplex multimer model 86
New perspectives in cancer drug development: computational advances with an eye to design 86
The Answer Lies in the Energy: How Simple Atomistic Molecular Dynamics Simulations May Hold the Key to Epitope Prediction on the Fully Glycosylated SARS-CoV-2 Spike Protein 85
Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands 83
Exploiting the folding and degradation machineries to target undruggable proteins: What can the computational approach tell us? 83
2 `-O-Alkyl Derivatives and 5 `-Analogues of 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) as Potential Hsp90 Inhibitors 82
Allosteric Regulation Points Control the Conformational Dynamics of the Molecular Chaperone Hsp90 82
A Computational Assay of Estrogen Receptor alpha Antagonists Reveals the Key Common Structural Traits of Drugs Effectively Fighting Refractory Breast Cancers 80
A dynamic perspective on the molecular recognition of chitooligosaccharide ligands by hevein domains 79
Atomistic Simulations of the Mechanisms of the Poorly Catalytic Mitochondrial Chaperone Trap1: Insights into the Effects of Structural Asymmetry on Reactivity 79
Conformational Behavior of SARS-Cov-2 Spike Protein Variants: Evolutionary Jumps in Sequence Reverberate in Structural Dynamic Differences 77
Antiangiogenic small molecule ligands of FGF2 derived from the endogenous inhibitor thrombospondin-1 77
A Structure-Based Strategy for Epitope Discovery in Burkholderia pseudomallei OppA Antigen 77
Design of Disruptors of the Hsp90–Cdc37 Interface 77
A novel chemical chaperone ameliorates osteoblast homeostasis and extracellular matrix in osteogenesis imperfecta 77
Application of structure-based thermodynamic calculations to the rationalization of the enantioselectivity of subtilisin in organic solvents 76
Probing the hirudin-thrombin interaction by incorporation of noncoded amino acids and molecular dynamics simulation 75
A Fe2+-dependent self-inhibited state influences the druggability of human collagen lysyl hydroxylase (LH/PLOD) enzymes 75
A Hamiltonian Replica Exchange Molecular Dynamics (MD) Method for the Study of Folding, Based on the Analysis of the Stabilization Determinants of Proteins 74
ADAMDEC1 maintains a growth factor signaling loop in cancer stem cells 74
Chemical Perturbation of Oncogenic Protein Folding: from the Prediction of Locally Unstable Structures to the Design of Disruptors of Hsp90–Client Interactions 74
Dynamically Shaping Chaperones. Allosteric Modulators of HSP90 Family as Regulatory Tools of Cell Metabolism in Neoplastic Progression 74
Dynamic Diagnosis of Familial Prion Diseases Supports the beta 2-alpha 2 Loop as a Universal Interference Target 71
A decoy set for the thermostable subdomain from chicken villin headpiece, comparison of different free energy estimators 70
Dimerization Capacities of FGF2 Purified with or without Heparin-Affinity Chromatography 70
Protein design: from computer models to artificial intelligence 70
Synthesis, structure and conformation of partially-modified retro- and retro-inverso psi[NHCH(CF3)]Gly peptides 70
Allosteric modulators of Hsp90 and Hsp70: Dynamics meets Function through Structure-Based Drug Design 70
Assessing the influence of electrostatic schemes on molecular dynamics simulations of secondary structure forming peptides 69
Modelling the enantioselectivity of subtilisin in water and organic solvents: insights from molecular dynamics and quantum mechanical/molecular mechanical studies 69
Protein Allostery and Ligand Design: Computational Design Meets Experiments to Discover Novel Chemical Probes 69
AlphaFold predicted structure of the Hsp90-like domains of the neurodegeneration linked protein sacsin reveals key residues for ATPase activity 68
Remote control of enzyme selectivity: the case of stevioside and steviolbioside 68
Chemo-enzymatic synthesis of (: E)-2,3-diaryl-5-styryl- trans -2,3-dihydrobenzofuran-based scaffolds and their in vitro and in silico evaluation as a novel sub-family of potential allosteric modulators of the 90 kDa heat shock protein (Hsp90) 68
Designing molecular spanners to throw in the protein networks. 68
Assessment of Mutational Effects on Peptide Stability through Confinement Simulations 67
Direct and Allosteric Inhibition of the FGF2/HSPGs/FGFR1 Ternary Complex Formation by an Antiangiogenic, Thrombospondin-1-Mimic Small Molecule 67
Folding and stability of the three-stranded beta-sheet peptide betanova: Insights from molecular dynamics simulations 66
Screening Complex Biological Samples with Peptide Microarrays: The Favorable Impact of Probe Orientation via Chemoselective Immobilization Strategies on Clickable Polymeric Coatings 66
Setup and Validation of a Reliable Docking Protocol for the Development of Neuroprotective Agents by Targeting the Sigma-1 Receptor (S1R) 66
Tryptophan scanning mutagenesis as a way to mimic the compound-bound state and probe the selectivity of allosteric inhibitors in cells 66
A Molecular Dynamics Study of the Interaction of D-Peptide Amyloid Inhibitors with Their Target Sequence Reveals a Potential Inhibitory Pharmacophore Conformation 65
Antileukemic activity of shepherdin and molecular diversity of Hsp90 inhibitors 65
Structure and sequence determinants of aggregation investigated with molecular dynamics 65
Molecular Mechanisms of Chaperone Directed Protein Folding: Insights from Atomistic Simulations 64
Antileukemic activity of shepherdin, a novel targeted inhibitor of the survivin-HSP90 complex. 64
Are Amyloid Fibrils RNA-Traps? A Molecular Dynamics Perspective 64
Two amino acid substitutions within the first external loop of CCR5 induce human immunodeficiency virus-blocking antibodies in mice and chickens 63
Flexible vs Rigid Epitope Conformations for Diagnostic- and Vaccine-Oriented Applications: Novel Insights from the Burkholderia pseudomallei BPSL2765 Pa13 Epitope 63
Enantioselective Mukaiyama-Michael reactions of 2-carbomethoxy cyclopentenone catalyzed by chiral bis(oxazoline)-Cu(II) complexes 63
Surface energetics and protein-protein interactions: analysis and mechanistic implications 63
Structure-activity relationships of linear and cyclic peptides containing the NGR tumor-homing motif 62
Identification of a New Scaffold for Hsp90 C-Terminal Inhibition 62
Molecular dynamics simulation of the aggregation of the core-recognition motif of the islet amylolid polypeptide in explicit water 62
Anharmonicity and self-similarity of the free energy landscape of protein G 62
Solvent dynamics and mechanism of proton transfer in human carbonic anhydrase II 61
The Subtle Trade-Off between Evolutionary and Energetic Constraints in Protein-Protein Interactions 61
The Binding Pocket at the Interface of Multimeric Telomere G-quadruplexes: Myth or Reality? 61
SARS-CoV-2 Spike Protein Mutations and Escape from Antibodies: A Computational Model of Epitope Loss in Variants of Concern 61
Structural Stability and Flexibility Direct the Selection of Activating Mutations in Epidermal Growth Factor Receptor Kinase 60
Rational design of shepherdin, a novel anticancer agent 60
Folding and mis-folding of peptides and proteins: Insights from molecular simulations 60
Enzymatic and Inhibition Mechanism of Human Aromatase (CYP19A1) Enzyme. A Computational Perspective from QM/MM and Classical Molecular Dynamics Simulations 60
Structure elucidation and 3D solution conformation of the antibiotic enduracidin determined by NMR spectroscopy and molecular dynamics. 60
Expedient Access to 2-Benzazepines by Palladium-Catalyzed C-H activation: Identification of a Unique HSP90 Inhibitor Scaffold 60
The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect 59
Sequence- and Structure-Based Immunoreactive Epitope Discovery for Burkholderia pseudomallei Flagellin 59
Analyzing the free energy landscape of natural peptides: Insights from atomistic MD Simulations 59
Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads 59
Dynamics-Based Discovery of Allosteric Inhibitors: Selection of New Ligands for the C-terminal Domain of Hsp90 59
Molecular Dynamics Simulations Reveal the Mechanisms of Allosteric Activation of Hsp90 by Designed Ligands 59
Selecting sequences that fold into a defined 3D structure: A new approach for protein design based on molecular dynamics and energetics 59
Mechanistic Model for the Hsp90-Driven Opening of Human Argonaute 59
Studying the Dynamics of a Complex G-Quadruplex System: Insights into the Comparison of MD and NMR Data 58
LIGAND-BASED DESIGN AND BIOCHEMICAL EVALUATION OF NEW POTENT AROMATASE INHIBITORS 58
Design, synthesis and biological evaluation of biphenylamide derivatives as Hsp90 C-terminal inhibitors 58
Structural Analysis of a Helical Peptide Unfolding Pathway 58
Novel PARP-1 Inhibitor Scaffolds Disclosed by a Dynamic Structure-Based Pharmacophore Approach 58
Simulation of carbohydrate-protein interactions: Computer-aided design of a second generation GM1 mimic 58
Molecular Simulations of Peptides: A Useful Tool for the Development of New Drugs and for the Study of Molecular Recognition 58
Design and Test of Molecules that Interfere with the Recognition Mechanisms between the SARS-CoV-2 Spike Protein and Its Host Cell Receptors 57
Misfolding of the amyloid beta-protein: A molecular dynamics study 57
An efficient steroid pharmacophore-based strategy to identify new aromatase inhibitors 57
Molecular simulation of multistate peptide dynamics: A comparison between microsecond timescale sampling and multiple shorter trajectories 57
Revealing Escherichia coli type II l-asparaginase active site flexible loop in its open, ligand-free conformation 57
Structures, dynamics, complexes, and functions: From classic computation to artificial intelligence 56
Totale 7.235
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Categoria #
all - tutte 77.694
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 77.694
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202188 0 0 0 0 0 23 2 52 1 7 0 3
2021/2022732 1 4 3 6 9 5 16 67 52 5 134 430
2022/20232.101 338 116 64 109 119 167 6 83 983 20 76 20
2023/2024801 75 119 40 61 107 209 78 47 1 18 22 24
2024/20252.870 35 294 36 84 65 99 148 173 711 115 295 815
2025/20265.840 556 953 1.492 1.717 893 229 0 0 0 0 0 0
Totale 14.565