IRIS
COLOMBO, GIORGIO
 Distribuzione geografica
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Continente #
NA - Nord America 6.718
AS - Asia 6.639
EU - Europa 2.771
SA - Sud America 1.896
Continente sconosciuto - Info sul continente non disponibili 353
AF - Africa 253
OC - Oceania 9
Totale 18.639
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Nazione #
US - Stati Uniti d'America 6.511
CN - Cina 2.637
BR - Brasile 1.464
SG - Singapore 1.398
VN - Vietnam 948
IE - Irlanda 887
HK - Hong Kong 870
RU - Federazione Russa 459
IT - Italia 416
FR - Francia 282
DE - Germania 193
AR - Argentina 161
FI - Finlandia 145
BD - Bangladesh 143
IN - India 126
GB - Regno Unito 108
ZA - Sudafrica 97
EC - Ecuador 87
ID - Indonesia 84
CA - Canada 74
MX - Messico 71
IQ - Iraq 55
CO - Colombia 52
TR - Turchia 50
JP - Giappone 49
PK - Pakistan 42
ES - Italia 37
SE - Svezia 35
CL - Cile 34
NL - Olanda 34
PL - Polonia 34
UZ - Uzbekistan 34
MA - Marocco 31
PY - Paraguay 31
VE - Venezuela 28
PH - Filippine 26
TN - Tunisia 25
UA - Ucraina 23
AT - Austria 20
BE - Belgio 20
SA - Arabia Saudita 20
EG - Egitto 19
KE - Kenya 19
MY - Malesia 19
MU - Mauritius 17
AE - Emirati Arabi Uniti 16
PE - Perù 16
BO - Bolivia 12
DZ - Algeria 12
NP - Nepal 11
NI - Nicaragua 10
UY - Uruguay 10
KR - Corea 9
BH - Bahrain 8
ET - Etiopia 8
GR - Grecia 8
IL - Israele 8
JM - Giamaica 8
KZ - Kazakistan 8
PS - Palestinian Territory 8
TH - Thailandia 8
AL - Albania 7
AZ - Azerbaigian 7
PA - Panama 7
RO - Romania 7
RS - Serbia 7
DO - Repubblica Dominicana 6
JO - Giordania 6
OM - Oman 6
PT - Portogallo 6
SN - Senegal 6
TT - Trinidad e Tobago 6
AU - Australia 5
CR - Costa Rica 5
LB - Libano 5
LT - Lituania 5
MD - Moldavia 5
SY - Repubblica araba siriana 5
TW - Taiwan 5
AM - Armenia 4
BA - Bosnia-Erzegovina 4
GE - Georgia 4
GT - Guatemala 4
KG - Kirghizistan 4
NG - Nigeria 4
CH - Svizzera 3
CZ - Repubblica Ceca 3
EE - Estonia 3
HN - Honduras 3
KW - Kuwait 3
LK - Sri Lanka 3
LV - Lettonia 3
SI - Slovenia 3
AO - Angola 2
BG - Bulgaria 2
BM - Bermuda 2
BY - Bielorussia 2
CI - Costa d'Avorio 2
CY - Cipro 2
IR - Iran 2
Totale 18.243
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Città #
Dublin 887
Dallas 847
Hong Kong 847
San Jose 771
Ashburn 715
Singapore 601
Chandler 549
Nanjing 524
Ho Chi Minh City 329
Beijing 292
Council Bluffs 279
Boardman 264
Lauterbourg 240
Princeton 229
Lawrence 217
Nanchang 211
Hanoi 209
Los Angeles 184
Hebei 181
Jacksonville 174
Changsha 162
Shenyang 158
Wilmington 150
São Paulo 144
Jiaxing 126
Medford 123
Redondo Beach 119
Helsinki 107
Tianjin 104
Buffalo 95
Hangzhou 91
Shanghai 89
Moscow 85
Santa Clara 78
Pavia 75
Johannesburg 72
New York 62
Milan 56
Munich 54
Da Nang 48
The Dalles 42
Columbus 41
Haiphong 41
Rio de Janeiro 41
Tokyo 41
Turku 37
Orem 34
Curitiba 32
Norwalk 31
Brasília 30
Chicago 30
Tashkent 30
Biên Hòa 29
Warsaw 29
Brooklyn 28
Washington 28
Frankfurt am Main 27
Guayaquil 27
Guangzhou 26
Belo Horizonte 24
Quito 24
Seattle 24
Campinas 23
Rome 23
Mexico City 22
Montreal 22
Atlanta 21
Nuremberg 21
Sassari 21
Buenos Aires 20
San Francisco 20
Thái Bình 20
Fairfield 19
Brussels 18
Phoenix 18
Porto Alegre 18
Woodbridge 18
Zhengzhou 18
Chennai 17
Dhaka 17
London 17
Bogotá 16
Boston 16
Hải Dương 16
Nairobi 16
Stockholm 16
Toronto 16
Asunción 15
Baghdad 15
Houston 15
Jinan 15
Amsterdam 14
Bắc Ninh 14
Denver 14
Manchester 14
Salvador 14
Turin 14
Ann Arbor 13
Cambridge 13
Can Tho 13
Totale 11.896
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Nome #
Design of multi-target peptide modulators for protein chaperone networks 297
Molecular structure and enzymatic mechanism of the human collagen hydroxylysine galactosyltransferase GLT25D1/COLGALT1 134
Investigating allostery with atomistic biomolecular simulations 129
Biocompatible graft copolymers from bacterial poly(γ-glutamic acid) and poly(lactic acid) 127
A Local Allosteric Network in Heat Shock Protein 70 (Hsp70) Links Inhibitor Binding to Enzyme Activity and Distal Protein-Protein Interactions 120
A protease-resistant Escherichia coli asparaginase with outstanding stability and enhanced anti-leukaemic activity in vitro 119
Impact of Mutations on NPAC Structural Dynamics: Mechanistic Insights from MD Simulations 118
A novel chemical chaperone ameliorates osteoblast homeostasis and extracellular matrix in osteogenesis imperfecta 115
All-atom folding simulations of the villin headpiece from stochastically selected coarse-grained structures 112
AICAR: A rational identified small molecule targeting Hsp90 chaperone function in cancer cells 112
The Answer Lies in the Energy: How Simple Atomistic Molecular Dynamics Simulations May Hold the Key to Epitope Prediction on the Fully Glycosylated SARS-CoV-2 Spike Protein 110
Designing Molecular Spanners to Throw in the Protein Networks 107
Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands 106
A Fe2+-dependent self-inhibited state influences the druggability of human collagen lysyl hydroxylase (LH/PLOD) enzymes 106
Ab initio protein structure prediction with a dipeptide-assembly evolutionary algorithm 104
Conformational Behavior of SARS-Cov-2 Spike Protein Variants: Evolutionary Jumps in Sequence Reverberate in Structural Dynamic Differences 103
Molecular Mechanisms of Chaperone Directed Protein Folding: Insights from Atomistic Simulations 103
Exploiting the folding and degradation machineries to target undruggable proteins: What can the computational approach tell us? 103
A Hamiltonian Replica Exchange Molecular Dynamics (MD) Method for the Study of Folding, Based on the Analysis of the Stabilization Determinants of Proteins 102
Rational Design of Allosteric and Selective Inhibitors of the Molecular Chaperone TRAP1 102
On the binding of naphthalene diimides to a human telomeric G-quadruplex multimer model 102
New perspectives in cancer drug development: computational advances with an eye to design 101
AlphaFold predicted structure of the Hsp90-like domains of the neurodegeneration linked protein sacsin reveals key residues for ATPase activity 100
Allosteric Regulation Points Control the Conformational Dynamics of the Molecular Chaperone Hsp90 100
Atomistic Simulations of the Mechanisms of the Poorly Catalytic Mitochondrial Chaperone Trap1: Insights into the Effects of Structural Asymmetry on Reactivity 99
A Multiscale Approach to Characterize the Early Aggregation Steps of the Amyloid-Forming Peptide GNNQQNY from the Yeast Prion Sup-35 98
Chemical Perturbation of Oncogenic Protein Folding: from the Prediction of Locally Unstable Structures to the Design of Disruptors of Hsp90–Client Interactions 97
3D-QSAR-Assisted Design, Synthesis, and Evaluation of Novobiocin Analogues 96
Design of Disruptors of the Hsp90–Cdc37 Interface 96
A Computational Assay of Estrogen Receptor alpha Antagonists Reveals the Key Common Structural Traits of Drugs Effectively Fighting Refractory Breast Cancers 95
A Structure-Based Strategy for Epitope Discovery in Burkholderia pseudomallei OppA Antigen 94
2 `-O-Alkyl Derivatives and 5 `-Analogues of 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) as Potential Hsp90 Inhibitors 93
ADAMDEC1 maintains a growth factor signaling loop in cancer stem cells 93
Dynamically Shaping Chaperones. Allosteric Modulators of HSP90 Family as Regulatory Tools of Cell Metabolism in Neoplastic Progression 92
A dynamic perspective on the molecular recognition of chitooligosaccharide ligands by hevein domains 91
Direct and Allosteric Inhibition of the FGF2/HSPGs/FGFR1 Ternary Complex Formation by an Antiangiogenic, Thrombospondin-1-Mimic Small Molecule 90
Probing the hirudin-thrombin interaction by incorporation of noncoded amino acids and molecular dynamics simulation 90
Antiangiogenic small molecule ligands of FGF2 derived from the endogenous inhibitor thrombospondin-1 88
Integrating Molecular Dynamics and Machine Learning Algorithms to Predict the Functional Profile of Kinase Ligands 87
Application of structure-based thermodynamic calculations to the rationalization of the enantioselectivity of subtilisin in organic solvents 87
A decoy set for the thermostable subdomain from chicken villin headpiece, comparison of different free energy estimators 86
Protein Allostery and Ligand Design: Computational Design Meets Experiments to Discover Novel Chemical Probes 86
Antileukemic activity of shepherdin and molecular diversity of Hsp90 inhibitors 85
The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect 84
Structures, dynamics, complexes, and functions: From classic computation to artificial intelligence 84
Assessing the influence of electrostatic schemes on molecular dynamics simulations of secondary structure forming peptides 84
Assessment of Mutational Effects on Peptide Stability through Confinement Simulations 83
Protein design: from computer models to artificial intelligence 83
Setup and Validation of a Reliable Docking Protocol for the Development of Neuroprotective Agents by Targeting the Sigma-1 Receptor (S1R) 83
SARS-CoV-2 Spike Protein Mutations and Escape from Antibodies: A Computational Model of Epitope Loss in Variants of Concern 83
Dynamic Diagnosis of Familial Prion Diseases Supports the beta 2-alpha 2 Loop as a Universal Interference Target 81
Synthesis, structure and conformation of partially-modified retro- and retro-inverso psi[NHCH(CF3)]Gly peptides 81
Dimerization Capacities of FGF2 Purified with or without Heparin-Affinity Chromatography 80
Designing molecular spanners to throw in the protein networks. 80
Mechanistic Model for the Hsp90-Driven Opening of Human Argonaute 80
Design and Test of Molecules that Interfere with the Recognition Mechanisms between the SARS-CoV-2 Spike Protein and Its Host Cell Receptors 79
Modelling the enantioselectivity of subtilisin in water and organic solvents: insights from molecular dynamics and quantum mechanical/molecular mechanical studies 79
Anharmonicity and self-similarity of the free energy landscape of protein G 78
Solvent dynamics and mechanism of proton transfer in human carbonic anhydrase II 78
Chemo-enzymatic synthesis of (: E)-2,3-diaryl-5-styryl- trans -2,3-dihydrobenzofuran-based scaffolds and their in vitro and in silico evaluation as a novel sub-family of potential allosteric modulators of the 90 kDa heat shock protein (Hsp90) 78
Allosteric modulators of Hsp90 and Hsp70: Dynamics meets Function through Structure-Based Drug Design 78
Tryptophan scanning mutagenesis as a way to mimic the compound-bound state and probe the selectivity of allosteric inhibitors in cells 78
Decrypting Allostery in Membrane-Bound K-Ras4B Using Complementary In Silico Approaches Based on Unbiased Molecular Dynamics Simulations 77
A Molecular Dynamics Study of the Interaction of D-Peptide Amyloid Inhibitors with Their Target Sequence Reveals a Potential Inhibitory Pharmacophore Conformation 77
Remote control of enzyme selectivity: the case of stevioside and steviolbioside 77
The Subtle Trade-Off between Evolutionary and Energetic Constraints in Protein-Protein Interactions 77
Antileukemic activity of shepherdin, a novel targeted inhibitor of the survivin-HSP90 complex. 77
Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug 77
The Binding Pocket at the Interface of Multimeric Telomere G-quadruplexes: Myth or Reality? 77
Folding and stability of the three-stranded beta-sheet peptide betanova: Insights from molecular dynamics simulations 76
Expedient Access to 2-Benzazepines by Palladium-Catalyzed C-H activation: Identification of a Unique HSP90 Inhibitor Scaffold 75
Disruption of protein phosphatase 1 complexes with the use of bioportides as a novel approach to target sperm motility 75
Are Amyloid Fibrils RNA-Traps? A Molecular Dynamics Perspective 75
Bow to the enemy: How flexibility of host protein receptors can favor SARS-CoV-2 75
Computational Epitope Prediction and Design for Antibody Development and Detection 74
Flexible vs Rigid Epitope Conformations for Diagnostic- and Vaccine-Oriented Applications: Novel Insights from the Burkholderia pseudomallei BPSL2765 Pa13 Epitope 74
Enzymatic and Inhibition Mechanism of Human Aromatase (CYP19A1) Enzyme. A Computational Perspective from QM/MM and Classical Molecular Dynamics Simulations 74
Revealing Escherichia coli type II l-asparaginase active site flexible loop in its open, ligand-free conformation 74
Studying the Dynamics of a Complex G-Quadruplex System: Insights into the Comparison of MD and NMR Data 73
Two amino acid substitutions within the first external loop of CCR5 induce human immunodeficiency virus-blocking antibodies in mice and chickens 73
Rational design of shepherdin, a novel anticancer agent 73
Surface energetics and protein-protein interactions: analysis and mechanistic implications 73
Screening Complex Biological Samples with Peptide Microarrays: The Favorable Impact of Probe Orientation via Chemoselective Immobilization Strategies on Clickable Polymeric Coatings 73
Molecular dynamics simulation of the aggregation of the core-recognition motif of the islet amylolid polypeptide in explicit water 73
Structure and sequence determinants of aggregation investigated with molecular dynamics 73
Ligand‐driven modulation of chaperone–cochaperone networks shapes proteostasis outcomes 73
Structure-activity relationships of linear and cyclic peptides containing the NGR tumor-homing motif 71
Molecular Dynamics Simulations Reveal the Mechanisms of Allosteric Activation of Hsp90 by Designed Ligands 71
Understanding Complex Mechanisms of Enzyme Reactivity: The Case of Limonene-1,2-Epoxide Hydrolases 71
Structure elucidation and 3D solution conformation of the antibiotic enduracidin determined by NMR spectroscopy and molecular dynamics. 70
Machine Learning Prediction of Allosteric Drug Activity from Molecular Dynamics 70
Dehydrogenase versus Oxidase Function: The Interplay between Substrate Binding and Flavin Microenvironment 69
Enantioselective Mukaiyama-Michael reactions of 2-carbomethoxy cyclopentenone catalyzed by chiral bis(oxazoline)-Cu(II) complexes 69
An efficient steroid pharmacophore-based strategy to identify new aromatase inhibitors 69
Combining computational and biochemical studies for a rationale on the anti-aromatase activity of natural polyphenols 69
Identification of a New Scaffold for Hsp90 C-Terminal Inhibition 69
Molecular Simulations of Peptides: A Useful Tool for the Development of New Drugs and for the Study of Molecular Recognition 69
Non-peptidic Thrombospondin-1 Mimics as Fibroblast Growth Factor-2 Inhibitors AN INTEGRATED STRATEGY FOR THE DEVELOPMENT OF NEW ANTIANGIOGENIC COMPOUNDS 69
LIGAND-BASED DESIGN AND BIOCHEMICAL EVALUATION OF NEW POTENT AROMATASE INHIBITORS 68
Structural Stability and Flexibility Direct the Selection of Activating Mutations in Epidermal Growth Factor Receptor Kinase 68
Totale 8.876
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Categoria #
all - tutte 94.859
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 94.859
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022731 0 4 3 6 9 5 16 67 52 5 134 430
2022/20232.101 338 116 64 109 119 167 6 83 983 20 76 20
2023/2024801 75 119 40 61 107 209 78 47 1 18 22 24
2024/20252.870 35 294 36 84 65 99 148 173 711 115 295 815
2025/20269.458 556 953 1.492 1.717 893 248 1.334 387 677 598 367 236
2026/2027456 178 278 0 0 0 0 0 0 0 0 0 0
Totale 18.639