IRIS
COLOMBO, GIORGIO
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
AS - Asia 6.491
NA - Nord America 5.869
EU - Europa 2.646
SA - Sud America 1.875
AF - Africa 252
OC - Oceania 9
Continente sconosciuto - Info sul continente non disponibili 3
Totale 17.145
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 5.707
CN - Cina 2.597
BR - Brasile 1.453
SG - Singapore 1.349
VN - Vietnam 947
IE - Irlanda 887
HK - Hong Kong 861
RU - Federazione Russa 459
IT - Italia 309
FR - Francia 281
DE - Germania 193
AR - Argentina 159
FI - Finlandia 145
IN - India 126
GB - Regno Unito 108
BD - Bangladesh 103
ZA - Sudafrica 96
EC - Ecuador 86
ID - Indonesia 84
MX - Messico 68
CA - Canada 55
IQ - Iraq 55
CO - Colombia 49
JP - Giappone 49
TR - Turchia 49
PK - Pakistan 42
PL - Polonia 34
SE - Svezia 34
UZ - Uzbekistan 34
CL - Cile 33
MA - Marocco 31
ES - Italia 30
NL - Olanda 29
PY - Paraguay 29
VE - Venezuela 28
PH - Filippine 26
TN - Tunisia 25
UA - Ucraina 22
AT - Austria 20
SA - Arabia Saudita 20
BE - Belgio 19
EG - Egitto 19
KE - Kenya 19
MU - Mauritius 17
MY - Malesia 17
PE - Perù 16
AE - Emirati Arabi Uniti 14
DZ - Algeria 12
BO - Bolivia 11
UY - Uruguay 10
NP - Nepal 9
BH - Bahrain 8
ET - Etiopia 8
GR - Grecia 8
IL - Israele 8
KZ - Kazakistan 8
NI - Nicaragua 8
PS - Palestinian Territory 8
TH - Thailandia 8
AL - Albania 7
AZ - Azerbaigian 7
KR - Corea 7
RO - Romania 7
RS - Serbia 7
DO - Repubblica Dominicana 6
JO - Giordania 6
OM - Oman 6
PA - Panama 6
SN - Senegal 6
AU - Australia 5
LB - Libano 5
LT - Lituania 5
MD - Moldavia 5
SY - Repubblica araba siriana 5
TW - Taiwan 5
AM - Armenia 4
BA - Bosnia-Erzegovina 4
GE - Georgia 4
KG - Kirghizistan 4
NG - Nigeria 4
PT - Portogallo 4
CH - Svizzera 3
CR - Costa Rica 3
CZ - Repubblica Ceca 3
EE - Estonia 3
JM - Giamaica 3
KW - Kuwait 3
LK - Sri Lanka 3
LV - Lettonia 3
SI - Slovenia 3
TT - Trinidad e Tobago 3
AO - Angola 2
BG - Bulgaria 2
BY - Bielorussia 2
CI - Costa d'Avorio 2
CY - Cipro 2
GT - Guatemala 2
IR - Iran 2
LY - Libia 2
ME - Montenegro 2
Totale 17.106
Salva come PNG Salva come JPEG
Città #
Dublin 887
Hong Kong 839
Dallas 822
Ashburn 634
San Jose 616
Singapore 589
Chandler 549
Nanjing 524
Ho Chi Minh City 329
Beijing 283
Boardman 262
Lauterbourg 240
Princeton 228
Lawrence 217
Nanchang 211
Hanoi 208
Hebei 181
Jacksonville 174
Los Angeles 174
Changsha 162
Shenyang 158
Wilmington 149
São Paulo 141
Jiaxing 126
Medford 123
Redondo Beach 119
Helsinki 107
Tianjin 104
Hangzhou 91
Buffalo 90
Moscow 85
Shanghai 85
Johannesburg 71
Pavia 65
Munich 54
New York 54
Da Nang 48
Haiphong 41
Rio de Janeiro 41
Tokyo 41
Milan 40
The Dalles 39
Turku 37
Santa Clara 36
Curitiba 32
Norwalk 31
Brasília 30
Tashkent 30
Biên Hòa 29
Warsaw 29
Frankfurt am Main 27
Guayaquil 27
Washington 27
Brooklyn 26
Council Bluffs 26
Guangzhou 26
Chicago 25
Orem 25
Belo Horizonte 24
Quito 24
Seattle 24
Campinas 22
Montreal 22
Nuremberg 21
Buenos Aires 20
Mexico City 20
Thái Bình 20
Columbus 19
Fairfield 19
Brussels 18
Porto Alegre 18
Zhengzhou 18
Chennai 17
Dhaka 17
London 17
Atlanta 16
Bogotá 16
Boston 16
Hải Dương 16
Nairobi 16
Stockholm 16
Asunción 15
Baghdad 15
Jinan 15
Rome 15
San Francisco 15
Toronto 15
Woodbridge 15
Amsterdam 14
Bắc Ninh 14
Denver 14
Manchester 14
Phoenix 14
Ann Arbor 13
Cambridge 13
Can Tho 13
Jakarta 13
Lima 13
Manaus 13
Salvador 13
Totale 11.166
Salva come PNG Salva come JPEG
Nome #
Design of multi-target peptide modulators for protein chaperone networks 286
Molecular structure and enzymatic mechanism of the human collagen hydroxylysine galactosyltransferase GLT25D1/COLGALT1 125
Biocompatible graft copolymers from bacterial poly(γ-glutamic acid) and poly(lactic acid) 124
A protease-resistant Escherichia coli asparaginase with outstanding stability and enhanced anti-leukaemic activity in vitro 118
A Local Allosteric Network in Heat Shock Protein 70 (Hsp70) Links Inhibitor Binding to Enzyme Activity and Distal Protein-Protein Interactions 118
Impact of Mutations on NPAC Structural Dynamics: Mechanistic Insights from MD Simulations 115
Investigating allostery with atomistic biomolecular simulations 112
All-atom folding simulations of the villin headpiece from stochastically selected coarse-grained structures 107
AICAR: A rational identified small molecule targeting Hsp90 chaperone function in cancer cells 107
A novel chemical chaperone ameliorates osteoblast homeostasis and extracellular matrix in osteogenesis imperfecta 106
Ab initio protein structure prediction with a dipeptide-assembly evolutionary algorithm 102
Designing Molecular Spanners to Throw in the Protein Networks 102
On the binding of naphthalene diimides to a human telomeric G-quadruplex multimer model 102
The Answer Lies in the Energy: How Simple Atomistic Molecular Dynamics Simulations May Hold the Key to Epitope Prediction on the Fully Glycosylated SARS-CoV-2 Spike Protein 101
Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands 100
Rational Design of Allosteric and Selective Inhibitors of the Molecular Chaperone TRAP1 100
New perspectives in cancer drug development: computational advances with an eye to design 100
A Hamiltonian Replica Exchange Molecular Dynamics (MD) Method for the Study of Folding, Based on the Analysis of the Stabilization Determinants of Proteins 99
Exploiting the folding and degradation machineries to target undruggable proteins: What can the computational approach tell us? 98
Conformational Behavior of SARS-Cov-2 Spike Protein Variants: Evolutionary Jumps in Sequence Reverberate in Structural Dynamic Differences 97
A Multiscale Approach to Characterize the Early Aggregation Steps of the Amyloid-Forming Peptide GNNQQNY from the Yeast Prion Sup-35 96
A Computational Assay of Estrogen Receptor alpha Antagonists Reveals the Key Common Structural Traits of Drugs Effectively Fighting Refractory Breast Cancers 95
Atomistic Simulations of the Mechanisms of the Poorly Catalytic Mitochondrial Chaperone Trap1: Insights into the Effects of Structural Asymmetry on Reactivity 94
A Fe2+-dependent self-inhibited state influences the druggability of human collagen lysyl hydroxylase (LH/PLOD) enzymes 94
AlphaFold predicted structure of the Hsp90-like domains of the neurodegeneration linked protein sacsin reveals key residues for ATPase activity 93
Design of Disruptors of the Hsp90–Cdc37 Interface 93
2 `-O-Alkyl Derivatives and 5 `-Analogues of 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) as Potential Hsp90 Inhibitors 92
3D-QSAR-Assisted Design, Synthesis, and Evaluation of Novobiocin Analogues 92
Chemical Perturbation of Oncogenic Protein Folding: from the Prediction of Locally Unstable Structures to the Design of Disruptors of Hsp90–Client Interactions 92
Allosteric Regulation Points Control the Conformational Dynamics of the Molecular Chaperone Hsp90 91
A Structure-Based Strategy for Epitope Discovery in Burkholderia pseudomallei OppA Antigen 90
A dynamic perspective on the molecular recognition of chitooligosaccharide ligands by hevein domains 88
ADAMDEC1 maintains a growth factor signaling loop in cancer stem cells 88
Dynamically Shaping Chaperones. Allosteric Modulators of HSP90 Family as Regulatory Tools of Cell Metabolism in Neoplastic Progression 87
A decoy set for the thermostable subdomain from chicken villin headpiece, comparison of different free energy estimators 84
Protein Allostery and Ligand Design: Computational Design Meets Experiments to Discover Novel Chemical Probes 84
Molecular Mechanisms of Chaperone Directed Protein Folding: Insights from Atomistic Simulations 83
Antiangiogenic small molecule ligands of FGF2 derived from the endogenous inhibitor thrombospondin-1 83
Application of structure-based thermodynamic calculations to the rationalization of the enantioselectivity of subtilisin in organic solvents 82
Assessing the influence of electrostatic schemes on molecular dynamics simulations of secondary structure forming peptides 81
Assessment of Mutational Effects on Peptide Stability through Confinement Simulations 81
Dynamic Diagnosis of Familial Prion Diseases Supports the beta 2-alpha 2 Loop as a Universal Interference Target 81
Probing the hirudin-thrombin interaction by incorporation of noncoded amino acids and molecular dynamics simulation 81
Direct and Allosteric Inhibition of the FGF2/HSPGs/FGFR1 Ternary Complex Formation by an Antiangiogenic, Thrombospondin-1-Mimic Small Molecule 80
SARS-CoV-2 Spike Protein Mutations and Escape from Antibodies: A Computational Model of Epitope Loss in Variants of Concern 80
Protein design: from computer models to artificial intelligence 78
Synthesis, structure and conformation of partially-modified retro- and retro-inverso psi[NHCH(CF3)]Gly peptides 78
Setup and Validation of a Reliable Docking Protocol for the Development of Neuroprotective Agents by Targeting the Sigma-1 Receptor (S1R) 78
Allosteric modulators of Hsp90 and Hsp70: Dynamics meets Function through Structure-Based Drug Design 77
Designing molecular spanners to throw in the protein networks. 77
The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect 76
Folding and stability of the three-stranded beta-sheet peptide betanova: Insights from molecular dynamics simulations 76
Modelling the enantioselectivity of subtilisin in water and organic solvents: insights from molecular dynamics and quantum mechanical/molecular mechanical studies 76
Chemo-enzymatic synthesis of (: E)-2,3-diaryl-5-styryl- trans -2,3-dihydrobenzofuran-based scaffolds and their in vitro and in silico evaluation as a novel sub-family of potential allosteric modulators of the 90 kDa heat shock protein (Hsp90) 76
Remote control of enzyme selectivity: the case of stevioside and steviolbioside 75
Flexible vs Rigid Epitope Conformations for Diagnostic- and Vaccine-Oriented Applications: Novel Insights from the Burkholderia pseudomallei BPSL2765 Pa13 Epitope 74
Antileukemic activity of shepherdin and molecular diversity of Hsp90 inhibitors 74
Mechanistic Model for the Hsp90-Driven Opening of Human Argonaute 74
Design and Test of Molecules that Interfere with the Recognition Mechanisms between the SARS-CoV-2 Spike Protein and Its Host Cell Receptors 73
Dimerization Capacities of FGF2 Purified with or without Heparin-Affinity Chromatography 73
Anharmonicity and self-similarity of the free energy landscape of protein G 73
Antileukemic activity of shepherdin, a novel targeted inhibitor of the survivin-HSP90 complex. 73
Tryptophan scanning mutagenesis as a way to mimic the compound-bound state and probe the selectivity of allosteric inhibitors in cells 73
Revealing Escherichia coli type II l-asparaginase active site flexible loop in its open, ligand-free conformation 73
Bow to the enemy: How flexibility of host protein receptors can favor SARS-CoV-2 73
A Molecular Dynamics Study of the Interaction of D-Peptide Amyloid Inhibitors with Their Target Sequence Reveals a Potential Inhibitory Pharmacophore Conformation 72
Enzymatic and Inhibition Mechanism of Human Aromatase (CYP19A1) Enzyme. A Computational Perspective from QM/MM and Classical Molecular Dynamics Simulations 72
The Subtle Trade-Off between Evolutionary and Energetic Constraints in Protein-Protein Interactions 72
Are Amyloid Fibrils RNA-Traps? A Molecular Dynamics Perspective 72
The Binding Pocket at the Interface of Multimeric Telomere G-quadruplexes: Myth or Reality? 72
Two amino acid substitutions within the first external loop of CCR5 induce human immunodeficiency virus-blocking antibodies in mice and chickens 71
Screening Complex Biological Samples with Peptide Microarrays: The Favorable Impact of Probe Orientation via Chemoselective Immobilization Strategies on Clickable Polymeric Coatings 71
Molecular dynamics simulation of the aggregation of the core-recognition motif of the islet amylolid polypeptide in explicit water 71
Solvent dynamics and mechanism of proton transfer in human carbonic anhydrase II 71
Structure and sequence determinants of aggregation investigated with molecular dynamics 71
Studying the Dynamics of a Complex G-Quadruplex System: Insights into the Comparison of MD and NMR Data 69
Rational design of shepherdin, a novel anticancer agent 69
Molecular Dynamics Simulations Reveal the Mechanisms of Allosteric Activation of Hsp90 by Designed Ligands 69
Expedient Access to 2-Benzazepines by Palladium-Catalyzed C-H activation: Identification of a Unique HSP90 Inhibitor Scaffold 69
Computational Epitope Prediction and Design for Antibody Development and Detection 68
Structures, dynamics, complexes, and functions: From classic computation to artificial intelligence 68
Decrypting Allostery in Membrane-Bound K-Ras4B Using Complementary In Silico Approaches Based on Unbiased Molecular Dynamics Simulations 68
LIGAND-BASED DESIGN AND BIOCHEMICAL EVALUATION OF NEW POTENT AROMATASE INHIBITORS 68
Structure-activity relationships of linear and cyclic peptides containing the NGR tumor-homing motif 68
Enantioselective Mukaiyama-Michael reactions of 2-carbomethoxy cyclopentenone catalyzed by chiral bis(oxazoline)-Cu(II) complexes 68
An efficient steroid pharmacophore-based strategy to identify new aromatase inhibitors 68
Combining computational and biochemical studies for a rationale on the anti-aromatase activity of natural polyphenols 68
Surface energetics and protein-protein interactions: analysis and mechanistic implications 68
Structure elucidation and 3D solution conformation of the antibiotic enduracidin determined by NMR spectroscopy and molecular dynamics. 68
Disruption of protein phosphatase 1 complexes with the use of bioportides as a novel approach to target sperm motility 68
Modelling of enzyme properties in organic solvents 67
Identification of a New Scaffold for Hsp90 C-Terminal Inhibition 67
Machine Learning Prediction of Allosteric Drug Activity from Molecular Dynamics 67
Sequence- and Structure-Based Immunoreactive Epitope Discovery for Burkholderia pseudomallei Flagellin 66
Structural Stability and Flexibility Direct the Selection of Activating Mutations in Epidermal Growth Factor Receptor Kinase 66
Balancing Accuracy and Cost of Confinement Simulations by Interpolation and Extrapolation of Confinement Energies 66
Long range Trp-Trp interaction initiates the folding pathway of a pro-angiogenic beta-hairpin peptide 65
Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads 65
SAGE: A Fast Computational Tool for Linear Epitope Grafting onto a Foreign Protein Scaffold 65
Structural Analysis of a Helical Peptide Unfolding Pathway 65
Totale 8.402
Salva come PNG Salva come JPEG
Categoria #
all - tutte 82.339
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 82.339
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202110 0 0 0 0 0 0 0 0 0 7 0 3
2021/2022732 1 4 3 6 9 5 16 67 52 5 134 430
2022/20232.101 338 116 64 109 119 167 6 83 983 20 76 20
2023/2024801 75 119 40 61 107 209 78 47 1 18 22 24
2024/20252.870 35 294 36 84 65 99 148 173 711 115 295 815
2025/20268.765 556 953 1.492 1.717 893 248 1.334 387 677 508 0 0
Totale 17.490