IRIS
COLOMBO, GIORGIO
 Distribuzione geografica
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Continente #
NA - Nord America 2.559
AS - Asia 1.782
EU - Europa 1.247
AF - Africa 18
SA - Sud America 7
OC - Oceania 2
Continente sconosciuto - Info sul continente non disponibili 1
Totale 5.616
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Nazione #
US - Stati Uniti d'America 2.552
CN - Cina 1.739
IE - Irlanda 886
IT - Italia 135
FI - Finlandia 97
DE - Germania 62
MU - Mauritius 17
SE - Svezia 17
BE - Belgio 15
SG - Singapore 15
GB - Regno Unito 13
IN - India 11
JP - Giappone 9
BR - Brasile 7
CA - Canada 6
UA - Ucraina 6
NL - Olanda 5
GR - Grecia 4
PK - Pakistan 3
AU - Australia 2
RO - Romania 2
RU - Federazione Russa 2
AE - Emirati Arabi Uniti 1
CZ - Repubblica Ceca 1
EE - Estonia 1
EU - Europa 1
FR - Francia 1
HK - Hong Kong 1
IR - Iran 1
MA - Marocco 1
NP - Nepal 1
PA - Panama 1
TR - Turchia 1
Totale 5.616
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Città #
Dublin 886
Chandler 552
Nanjing 522
Ashburn 318
Princeton 229
Lawrence 218
Nanchang 210
Hebei 181
Jacksonville 172
Shenyang 155
Wilmington 149
Changsha 146
Jiaxing 126
Medford 124
Helsinki 97
Tianjin 96
Hangzhou 86
Beijing 77
Shanghai 70
Pavia 60
Norwalk 31
Washington 24
Seattle 20
Fairfield 19
Brussels 15
Woodbridge 15
Ann Arbor 13
Milan 13
Cambridge 12
Chicago 11
Boardman 10
Los Angeles 10
New York 10
Zhengzhou 10
Redwood City 9
Singapore 9
Tokyo 9
Guangzhou 8
Travaco Siccomario 8
Jinan 7
São Paulo 7
San Francisco 6
Southend 6
Fuzhou 5
Ningbo 5
Orange 5
Sesto Fiorentino 5
Borås 4
Pune 4
Rockville 4
Udine 4
Erbusco 3
Esslingen am Neckar 3
Falkenstein 3
Fremont 3
Groningen 3
Karachi 3
London 3
Novara 3
Anzio 2
Borgosatollo 2
Brescia 2
Cremona 2
Dearborn 2
Des Moines 2
Doncaster 2
Giussano 2
Hefei 2
Houston 2
Phoenix 2
Portland 2
San Cipriano Po 2
Santa Clara 2
Springfield 2
Taizhou 2
Toronto 2
Turin 2
Andover 1
Atlanta 1
Bangalore 1
Bellinzago Lombardo 1
Brooklyn 1
Buccinasco 1
Buffalo 1
Canary Wharf 1
Canberra 1
Clifton 1
Cosenza 1
Geislingen an der Steige 1
Gunzenhausen 1
Imola 1
Jawalakhel 1
Kemerovo 1
Kunming 1
Las Vegas 1
Mainz 1
Maitland 1
Nagold 1
Nashua 1
Nave 1
Totale 4.875
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Nome #
A Local Allosteric Network in Heat Shock Protein 70 (Hsp70) Links Inhibitor Binding to Enzyme Activity and Distal Protein-Protein Interactions 64
Ab initio protein structure prediction with a dipeptide-assembly evolutionary algorithm 49
AICAR: A rational identified small molecule targeting Hsp90 chaperone function in cancer cells 48
Designing Molecular Spanners to Throw in the Protein Networks 46
Biocompatible graft copolymers from bacterial poly(γ-glutamic acid) and poly(lactic acid) 46
A protease-resistant Escherichia coli asparaginase with outstanding stability and enhanced anti-leukaemic activity in vitro 45
Antileukemic activity of shepherdin, a novel targeted inhibitor of the survivin-HSP90 complex. 44
All-atom folding simulations of the villin headpiece from stochastically selected coarse-grained structures 43
Allosteric Regulation Points Control the Conformational Dynamics of the Molecular Chaperone Hsp90 43
3D-QSAR-Assisted Design, Synthesis, and Evaluation of Novobiocin Analogues 42
2 `-O-Alkyl Derivatives and 5 `-Analogues of 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) as Potential Hsp90 Inhibitors 41
Solvent dynamics and mechanism of proton transfer in human carbonic anhydrase II 41
Allosteric modulators of Hsp90 and Hsp70: Dynamics meets Function through Structure-Based Drug Design 40
The Answer Lies in the Energy: How Simple Atomistic Molecular Dynamics Simulations May Hold the Key to Epitope Prediction on the Fully Glycosylated SARS-CoV-2 Spike Protein 40
Chemical Perturbation of Oncogenic Protein Folding: from the Prediction of Locally Unstable Structures to the Design of Disruptors of Hsp90–Client Interactions 40
Are Amyloid Fibrils RNA-Traps? A Molecular Dynamics Perspective 40
On the binding of naphthalene diimides to a human telomeric G-quadruplex multimer model 40
Anharmonicity and self-similarity of the free energy landscape of protein G 39
Antileukemic activity of shepherdin and molecular diversity of Hsp90 inhibitors 39
Dynamically Shaping Chaperones. Allosteric Modulators of HSP90 Family as Regulatory Tools of Cell Metabolism in Neoplastic Progression 39
New perspectives in cancer drug development: computational advances with an eye to design 39
Analyzing the free energy landscape of natural peptides: Insights from atomistic MD Simulations 38
Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands 38
Antiangiogenic small molecule ligands of FGF2 derived from the endogenous inhibitor thrombospondin-1 38
A dynamic perspective on the molecular recognition of chitooligosaccharide ligands by hevein domains 37
Molecular Simulations of Peptides: A Useful Tool for the Development of New Drugs and for the Study of Molecular Recognition 37
Impact of Mutations on NPAC Structural Dynamics: Mechanistic Insights from MD Simulations 37
ADAMDEC1 maintains a growth factor signaling loop in cancer stem cells 36
Assessing the influence of electrostatic schemes on molecular dynamics simulations of secondary structure forming peptides 35
A Computational Assay of Estrogen Receptor alpha Antagonists Reveals the Key Common Structural Traits of Drugs Effectively Fighting Refractory Breast Cancers 35
Structure and sequence determinants of aggregation investigated with molecular dynamics 35
The Binding Pocket at the Interface of Multimeric Telomere G-quadruplexes: Myth or Reality? 35
A Multiscale Approach to Characterize the Early Aggregation Steps of the Amyloid-Forming Peptide GNNQQNY from the Yeast Prion Sup-35 34
Coupling high enzyme activity and stability: a challenging target 34
Application of structure-based thermodynamic calculations to the rationalization of the enantioselectivity of subtilisin in organic solvents 34
Ligand selection from the analysis of protein conformational substates: new leads targeting the N-terminal domain of Hsp90 34
Atomistic Simulations of the Mechanisms of the Poorly Catalytic Mitochondrial Chaperone Trap1: Insights into the Effects of Structural Asymmetry on Reactivity 34
Corresponding Functional Dynamics across the Hsp90 Chaperone Family: Insights from a Multiscale Analysis of MD Simulations 33
Structure determination and dynamics of peptides overlapping the catalytic hairpin of the Ras-specific GEF Cdc25(Mm) 33
Non-peptidic Thrombospondin-1 Mimics as Fibroblast Growth Factor-2 Inhibitors AN INTEGRATED STRATEGY FOR THE DEVELOPMENT OF NEW ANTIANGIOGENIC COMPOUNDS 33
An atomistic view of Hsp70 allosteric crosstalk: from the nucleotide to the substrate binding domain and back 32
A Hamiltonian Replica Exchange Molecular Dynamics (MD) Method for the Study of Folding, Based on the Analysis of the Stabilization Determinants of Proteins 32
The Interplay between Structural Stability and Plasticity Determines Mutation Profiles and Chaperone Dependence in Protein Kinases 32
A Structure-Based Strategy for Epitope Discovery in Burkholderia pseudomallei OppA Antigen 32
The Five-To-Six-Coordination Transition of Ferric Human Serum Heme-Albumin Is Allosterically-Modulated by Ibuprofen and Warfarin: A Combined XAS and MD Study 31
Enhancing Antibody Serodiagnosis Using a Controlled Peptide Coimmobilization Strategy 31
Expedient Access to 2-Benzazepines by Palladium-Catalyzed C-H activation: Identification of a Unique HSP90 Inhibitor Scaffold 31
Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90 31
Design of Disruptors of the Hsp90–Cdc37 Interface 31
Tryptophan scanning mutagenesis as a way to mimic the compound-bound state and probe the selectivity of allosteric inhibitors in cells 31
A Molecular Dynamics Study of the Interaction of D-Peptide Amyloid Inhibitors with Their Target Sequence Reveals a Potential Inhibitory Pharmacophore Conformation 30
A decoy set for the thermostable subdomain from chicken villin headpiece, comparison of different free energy estimators 30
Structural determinants of the unusual helix stability of a De Novo engineered vascular endothelial growth factor (VEGF) mimicking peptide 30
Protein design: from computer models to artificial intelligence 30
Covalent docking of selected boron-based serine beta-lactamase inhibitors 30
Inhibiting Peptide and Protein Self-Aggregation: What Can Simulations Tell Us? 30
Understanding Complex Mechanisms of Enzyme Reactivity: The Case of Limonene-1,2-Epoxide Hydrolases 30
The Subtle Trade-Off between Evolutionary and Energetic Constraints in Protein-Protein Interactions 30
Exploiting the folding and degradation machineries to target undruggable proteins: What can the computational approach tell us? 30
Modeling enzyme reactivity in organic solvents and water through computer simulations 29
The Structural Asymmetry of Mitochondrial Hsp90 (Trap1) Determines Fine Tuning of Functional Dynamics 29
beta(3)-adrenergic receptor ligands: insight into structure-activity relationships using Monte-Carlo conformational analysis in water 29
Modeling enzymatic processes: A molecular simulation analysis of the origins of regioselectivity 29
The calcium-binding type III repeats domain of thrombospondin-2 binds to fibroblast growth factor 2 (FGF2) 29
Study of the villin headpiece folding dynamics by combining coarse-grained Monte Carlo evolution and all-atom molecular dynamics 29
From crystal structure to in silico epitope discovery in the Burkholderia pseudomallei flagellar hook-associated protein FlgK 29
Mechanistic Model for the Hsp90-Driven Opening of Human Argonaute 29
Synthesis of Functionalized 2-(4-Hydroxyphenyl)-3-methylbenzofuran Allosteric Modulators of Hsp90 Activity 28
Assessment of Mutational Effects on Peptide Stability through Confinement Simulations 28
Interplay between hydrophobic cluster and loop propensity in beta-hairpin formation: A mechanistic study 28
Chemo-enzymatic synthesis of (: E)-2,3-diaryl-5-styryl- trans -2,3-dihydrobenzofuran-based scaffolds and their in vitro and in silico evaluation as a novel sub-family of potential allosteric modulators of the 90 kDa heat shock protein (Hsp90) 28
The Importance of Detail: How Differences in Ligand Structures Determine Distinct Functional Responses in Integrin αv β3 28
Setup and Validation of a Reliable Docking Protocol for the Development of Neuroprotective Agents by Targeting the Sigma-1 Receptor (S1R) 28
Bow to the enemy: How flexibility of host protein receptors can favor SARS-CoV-2 28
Combining computational and biochemical studies for a rationale on the anti-aromatase activity of natural polyphenols 27
The Dynamics of Drug Discovery 27
Sequence dependence of amyloid fibril formation: Insights from molecular dynamics simulations 27
Computational Study of the Resistance Shown by the Subtype B/HIV-1 Protease to Currently Known Inhibitors 27
Protein Allostery and Ligand Design: Computational Design Meets Experiments to Discover Novel Chemical Probes 27
Folding and stability of the three-stranded beta-sheet peptide betanova: Insights from molecular dynamics simulations 26
Molecular Mechanism of Allosteric Communication in Hsp70 Revealed by Molecular Dynamics Simulations 26
Flagellar subunits as targets for structure-based epitope discovery approaches and melioidosis vaccine development 26
Targeting difficult protein-protein interactions with plain and general computational approaches 26
HMGB1-Carbenoxolone Interactions: Dynamics Insights from Combined Nuclear Magnetic Resonance and Molecular Dynamics 26
Honokiol Bis-Dichloroacetate Is a Selective Allosteric Inhibitor of the Mitochondrial Chaperone TRAP1 26
Investigating Allostery in Molecular Recognition: Insights from a Computational Study of Multiple Antibody-Antigen Complexes 26
Revealing Escherichia coli type II l-asparaginase active site flexible loop in its open, ligand-free conformation 26
Rationalization of the enantioselectivity of subtilisin in DMF 25
Dimerization Capacities of FGF2 Purified with or without Heparin-Affinity Chromatography 25
Rational Epitope Design for Protein Targeting 25
Identification of a New Scaffold for Hsp90 C-Terminal Inhibition 25
Modelling the enantioselectivity of subtilisin in water and organic solvents: insights from molecular dynamics and quantum mechanical/molecular mechanical studies 25
Exploiting Conformational Dynamics in Drug Discovery: Design of C-Terminal Inhibitors of Hsp90 with Improved Activities 25
The molecular dynamics of assembly of the ubiquitous aortic medial amyloidal medin fragment 25
Designing molecular spanners to throw in the protein networks. 25
Rational Design of Allosteric and Selective Inhibitors of the Molecular Chaperone TRAP1 25
Methionine Sulfoxides on Prion Protein Helix-3 Switch on the alpha-Fold Destabilization Required for Conversion 25
SARS-CoV-2 Spike Protein Mutations and Escape from Antibodies: A Computational Model of Epitope Loss in Variants of Concern 25
The molecular chaperone TRAP1 in cancer: From the basics of biology to pharmacological targeting 25
Remote control of enzyme selectivity: the case of stevioside and steviolbioside 24
Totale 3.257
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Categoria #
all - tutte 35.706
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 35.706
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.700 700 888 0 0 3 30 7 3 0 38 29 2
2020/2021103 0 2 0 9 4 23 2 52 1 7 0 3
2021/2022735 1 4 3 6 9 5 16 68 52 5 134 432
2022/20232.113 339 119 65 109 120 168 6 83 988 20 76 20
2023/2024809 75 120 40 62 107 210 80 48 1 18 23 25
2024/202529 29 0 0 0 0 0 0 0 0 0 0 0
Totale 5.907