IRIS
CURTI, DANIELA
 Distribuzione geografica
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Continente #
NA - Nord America 2.328
EU - Europa 1.887
AS - Asia 1.223
OC - Oceania 4
AF - Africa 3
Continente sconosciuto - Info sul continente non disponibili 1
Totale 5.446
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Nazione #
US - Stati Uniti d'America 2.317
CN - Cina 1.187
IE - Irlanda 540
UA - Ucraina 364
FI - Finlandia 269
DE - Germania 202
IT - Italia 173
SE - Svezia 144
GB - Regno Unito 92
FR - Francia 74
IN - India 19
BE - Belgio 18
SG - Singapore 12
CA - Canada 11
AU - Australia 3
MU - Mauritius 3
NL - Olanda 3
RU - Federazione Russa 3
IR - Iran 2
JP - Giappone 2
LU - Lussemburgo 2
ES - Italia 1
EU - Europa 1
GR - Grecia 1
KR - Corea 1
LV - Lettonia 1
NZ - Nuova Zelanda 1
Totale 5.446
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Città #
Chandler 570
Dublin 540
Jacksonville 444
Nanjing 369
Ashburn 150
Nanchang 137
Beijing 121
Princeton 105
Lawrence 104
Hebei 98
Shenyang 94
Jiaxing 86
Changsha 85
Helsinki 80
Medford 79
Wilmington 79
Ann Arbor 75
Boardman 65
Pavia 55
Tianjin 52
Shanghai 47
Hangzhou 45
Milan 42
New York 36
Piscataway 31
Verona 30
Woodbridge 27
Los Angeles 19
Norwalk 18
Seattle 17
Brussels 14
Pune 14
Toronto 10
Falls Church 9
Couilly-pont-aux-dames 8
Fairfield 7
Jinan 7
Auburn Hills 6
Chicago 6
Houston 6
Kunming 6
Singapore 6
Ningbo 5
Taizhou 5
Des Moines 4
Fuzhou 4
Redwood City 4
Tappahannock 4
Washington 4
Zhengzhou 4
Dundee 3
San Francisco 3
Borås 2
Brisbane 2
Casorate Primo 2
Dearborn 2
Falkenstein 2
Genoa 2
Godiasco 2
Guangzhou 2
Luxembourg 2
Munich 2
Orange 2
Reggio Emilia 2
Stockholm 2
Tokyo 2
Turin 2
Amsterdam 1
Ardabil 1
Augusta 1
Baltimore 1
Berlin 1
Böblingen 1
Changchun 1
Christchurch 1
Colmenar Viejo 1
Dallas 1
Gallarate 1
Geislingen an der Steige 1
Genova 1
Henderson 1
Huntington 1
Jinhua 1
Kemerovo 1
Las Vegas 1
Leawood 1
Leipzig 1
Montreal 1
Padova 1
Paris 1
Peterborough 1
Phoenix 1
Prineville 1
Qingdao 1
Redmond 1
Riverside 1
Rockville 1
Rome 1
Rovellasca 1
Samarate 1
Totale 3.902
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Nome #
Studies on the Enantiomers of RC-33 as Neuroprotective Agents: Isolation, Configurational Assignment, and Preliminary Biological Profile 87
Clustering of ALS patients in central Italy due to the occurrence of the L84F SOD1 gene mutation 85
Analysis of the early mitochondrial damage in G93A-SOD1 transgenic mice (SOD1-TG) 80
(R)-RC-33 as Promising Neuroprotective Agent Acting as Sigma1 Receptor Agonist 79
Effect of hypoxia on brain energy metabolism during aging 77
Oxidative metabolism in cultured fibroblasts derived from sporadic Alzheimer's disease (AD) patients 74
Apoptosis or necrosis in motoneurons: intracellular responses to excitotoxic insults 73
Amyotrophic lateral sclerosis: oxidative energy metabolism and calcium homeostasis in peripheral blood lymphocytes 72
Age-dependent modification of drug interference on the enzymatic activities of the rat brain 72
Identification of RC-33 as a potent and selective sigma1 receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells. Part 2: g-scale synthesis, physicochemical characterization and in vitro metabolic stability. 72
Early effects of AZT on mitochondrial functions in the absence of mitochondrial DNA depletetion in rat myotubes 71
Chemical, pharmacological, and in vitro metabolic stability studies on enantiomerically pure RC-33 compounds, promising neuroprotective agents acting as sigma1 receptor agonists. 71
SOD1 activity and protective factors in familial ALS patients with L84F SOD1 mutation 71
Basic and clinical research on amyotrophic lateral sclerosis and other motor neuron disorders in Italy: recent findings and achievements from a network of laboratories 70
A small-molecule RGD-integrin antagonist inhibits cell adhesion, cell migration and induces anoikis in glioblastoma cells. 70
A step forward in the sigma enigma: a role for chirality in the sigma1 receptor- ligand interaction? 69
Experimental diets for the prevention of the development of familial amyotrophic lateral sclerosis 67
Identification of dual Sigma1 receptor modulators/acetylcholinesterase inhibitors with antioxidant and neurotrophic properties, as neuroprotective agents 67
Age-related acute depletion of cerebral glutathione by peroxidative stress 66
Discovery of new and selective sigma 1 ligands potentiating nerve growth factor induced neurite outgrowth in PC12 cells 66
Effect of ischemia and pharmacological treatment on subcellular from neonatal rat brain 65
Heterogeneous distribution of amyotrophic lateral sclerosis patient with SOD-1 gene mulations: preliminary data on an Italian survey 63
Cerebral enzymatic activities during chronic hyperammonemia and treatment with S-adenosyl-L-methionine, adenosine and methionine in the rat 63
Sequential damage in mitochondrial complexes by peroxidative stress 63
Identification of a potent and selective sigma1 receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells. 63
Experimental diets for the prevention of the development of familial amyotrophic lateral sclerosis 62
Mitochondrial dysfunction in a murine model of motor neuron disease 62
Kinetics of irreversible inhibition of choline transport in synaptosomes by ethylcholine mustard aziridinium 62
Age-related modification of enzyme activities in synaptosomes isolated from rat cerebral cortex 62
S-Adenosyl-L-methionine, related compounds, and cerebral enzymatic activities during chronic hyperammonemia in rats 62
Mitochondrial oxidative metabolism in motor neuron degeneration (mnd) mouse central nervous system 61
Effect of energy shortage and oxidative stress on amyloid precursor protein metabolism in COS cells 61
Modified expression of Bcl-2 and SOD1 proteins in lymphocytes from sporadic ALS patients 61
Age-related modifications of cytochrome C oxidase activity in discrete brain regions 61
Effect of prolonged and intermittent hypoxia on some cerebral enzymatic activities related to energy transduction 60
Influence of intermittent hypoxia and pyrimidinic nucleosides on cerebral enzymatic activities related to energy transduction 60
Neural precursor-derived astrocytes of wobbler mice induce apoptotic death of motor neurons through reduced glutamate uptake 60
Characterisation of adult neural stem cells from wobbler motor neuron disease mice 59
Amyotrophic lateral sclerosis and SOD1 gene: an overview 59
Dose/action and time/action relationships of some biological molecules evaluated on the cerebral enzymatic activities 58
Alteration of pallidal cholinergic activity in MPTP-treated monkeys: effect of dihydro-alpha-ergocryptine (DEK) 58
Effect of aging and acetyl-L-carnitine on energetic and cholinergic metabolism in rat brain regions 58
Evidence for chronic mitochondrial impairment in the cervical spinal cord of a murine model of motor neuron disease 57
Les modifications enzymatiques du cerveau age chez le rat 57
Astrocytes derived from neural precursor cells of wobbler mice induce apoptotic death of motor neurons through reduced glutamate transport 56
Synaptosomes and mitochondria from rat brain cerebral cortex: in vivo interference on some enzymatic activities by SAMe and CDP-choline 56
Early alterations of mitochondrial function and morphology in the cervical spinal cord of the wobbler mouse 55
Effect of vincamine on some enzymatic activities from various areas of the beagle dog cerebral cortex 55
Mitochondrial alterations in asymptomatic G93A-SOD1 transgenic mice (SOD1-TG) 55
Modified expression of antioxidant enzymes in lymphocytes of sporadic amyotrophic lateral sclerosis patients 55
Novel chiral sigma 1 receptor ligand potentiating NGF-induced neurite outgrowth in PC12 cells 55
Energy metabolism inhibition impairs amyloid precursor protein secretion from Alzheimer's fibroblasts 54
Heterogeneous distribution of amyotrophic lateral sclerosis patients with SOD-1 gene mutations: preliminary data on an Italian survey. 54
Development of easy-to-use reverse-phase liquid chromatographic methods for determining PRE-084, RC-33 and RC-34 in biological matrices. The first step for in vivo analysis of sigma1 receptor agonists. 54
Metabolic changes induced by acute hypoxia on the synaptosomes from dog brain 53
Influence of age upon the cerebral metabolic changes induced by acute hypoxia on the synaptosomes from dog brain 53
Role of cerebral enzymatic activities in the relationships between energy metabolism and amino acid acting as neurotrasmitters 53
Experimental diets for the prevention of the development of familial amyotrophic lateral sclerosis 53
Drug interference on the age-dependent modification of the cerebral enzymatic activities related to energy transduction 53
Brain enzyme adaptation to mild normobaric intermittent hypoxia 52
Effect of Ca2+-homopantothenate and mild hypoxia on some enzyme activities evaluated in subcellular fractions from different rat brain regions 51
Alteration of complex IV and acethylcholine-related enzymes in experimental spinal cord injury 51
Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084,in a mouse model of motor neuron disease not linked to SOD1 mutation 50
Mitochondrial involvement in schizophrenia and other functional psychoses 50
Enzymes related to energy metabolism in human gliomas 50
Use of arylalkanolamines as sigma-1 receptor antagonists 49
Effect of a ubiquinone-like molecule on oxidative energy metabolism in rat cortical synaptosomes at different ages 49
Are sigma receptor modulators a weapon against multiple sclerosis disease? 49
Studies on the enantiomers of RC-33, promising neuroprotective agents acting as sigma1 receptor agonists. Isolation, configurational assignment and biological profile 48
Synthesis and biological evaluation of new aryl-alkyl(alkenyl)-4-benzylpiperidines, novel Sigma Receptor (SR) modulators, as potential anticancer-agents 48
In vivo pharmacokinetic study and CNS distribution of the sigma1 receptor agonist (R)-RC-33, a promising neuroprotective agent 48
The mitochondrial electron transfer alteration as a factor involved in the brain aging 47
Effect of hypoxia and pharmacological treatment on some enzyme activities in dog brain areas 47
Rapid flow cytometric assessment of cell membrane integrity by Hoechst 33342 and Propidium Iodide labeling 45
Synthesis and in vitro evaluation of novel pan-SR modulators: Identification of (E)-4-benzyl-1-[3-(naphthalen-2-yl)but-2-en-1-yl]piperidine (RC-106) as potential anticancer agent. 45
Mitochondrial energy metabolism is preserved in the lumbar spinal cord of the wobbler mouse 44
Chemical, pharmacological and in vivo pharmacokinetic studies on enantiomerically pure RC-33 compounds, promising neuroprotective agents acting as sigma1 receptor agonists 44
Endothelin B receptor antagonists block proliferation and induce apoptosis in glioma cells 44
Sigma receptors as endoplasmic reticulum stress "gatekeepers" and their modulators as emerging new weapons in the fight against cancer 44
Mitochondrial function in lymphocytes from sporadic ALS and familial ALS patients 43
Effects of ionotropic glutamate receptor stimulation and mitochondrial inhibition in rat spinal cord motor neurons 42
Phenobarbital and 6-aminonicotinamide effect on cerebral enzymatic activities related to energy metabolism in different rat brain areas 42
Neural precursors (NPCs) from adult L967Q mice display early commitment to "in vitro" neuronal differentiation and hyperexcitability 42
Erythropoietin protects primary motor neuron cultures from apoptotic but not necrotic death in vitro 42
Sigma1 Receptor Agonists in motor dysfunction pathologies treatment – a medicinal chemistry perspective 40
Implication of the antioxidant pathway in lymphocytes of sporadic amyotrophic lateral sclerosis patients 39
SOD1 activity and protective factors in familial ALS patients with L84F SOD1 mutation 39
Effect of chronic treatment with some drugs on the enzymatic activities of the rat brain 38
Proteomic profiling of cervical and lumbar spinal cord reveals potential protective mechanisms in the wobbler mouse, a model of motor neuron degeneration. 37
The effect of ischemia and pharmacological treatment evaluated on synaptosomes and purified mitochondria from rat cerebral cortex 37
Superoxide, neuroleptics and ubiquinone and cytochrome b5 reductases in brain and lymphocytes from normals and schizophrenic patients 37
Toward the identification of neuroprotective agents: G-scale synthesis, pharmacokinetic evaluation and CNS distribution of (R)-RC-33, a promising SIGMA1 receptor agonist 36
Oxidative metabolism of non-synaptic mitochondria isolated from rat brain hippocampus: a comparative regional study 32
Towards the identification of neuroprotective agents. Pharmacokinetic evaluation and CNS distribution of (R)-RC-33, a promising sigma1 receptor agonist 30
Role of synaptosomal enzymatic alterations and drug treatment in brain aging 29
Bitopic Sigma 1 Receptor Modulators to Shed Light on Molecular Mechanisms Underpinning Ligand Binding and Receptor Oligomerization 29
Modification produced by ischemia on some cerebral enzyme activities related to energy transduction 27
High resolution AP-MALDI MS imaging as an aid to develop new strategies to improve ALS therapy 23
Towards sigma1 receptor agonists as neuroprotective agents. Chemical and pharmacological studies of RC-33 enantiomers 23
Do lymphocytes from sporadic ALS patients show disease traits ? 23
Totale 5.415
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Categoria #
all - tutte 19.899
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 19.899
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.402 418 559 1 68 3 69 6 77 9 100 90 2
2020/2021678 75 62 20 69 5 96 5 94 33 104 90 25
2021/2022460 7 1 11 8 6 21 10 23 27 15 65 266
2022/20231.589 179 137 5 138 175 166 2 80 648 3 36 20
2023/2024534 85 83 10 33 49 133 13 44 4 19 50 11
2024/202519 19 0 0 0 0 0 0 0 0 0 0 0
Totale 5.513