IRIS
CURTI, DANIELA
 Distribuzione geografica
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Continente #
NA - Nord America 3.233
EU - Europa 2.415
AS - Asia 2.265
SA - Sud America 291
AF - Africa 24
OC - Oceania 4
Continente sconosciuto - Info sul continente non disponibili 1
Totale 8.233
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Nazione #
US - Stati Uniti d'America 3.187
CN - Cina 1.531
IE - Irlanda 542
UA - Ucraina 370
SG - Singapore 321
DE - Germania 305
FI - Finlandia 301
HK - Hong Kong 265
RU - Federazione Russa 259
BR - Brasile 247
IT - Italia 207
SE - Svezia 154
GB - Regno Unito 115
FR - Francia 83
VN - Vietnam 51
IN - India 36
CA - Canada 28
BE - Belgio 21
AR - Argentina 18
JP - Giappone 12
MX - Messico 10
ZA - Sudafrica 10
EC - Ecuador 9
ES - Italia 8
PL - Polonia 8
ID - Indonesia 7
LT - Lituania 7
NL - Olanda 7
CO - Colombia 6
TR - Turchia 5
AT - Austria 4
BD - Bangladesh 4
IL - Israele 4
IQ - Iraq 4
MA - Marocco 4
UZ - Uzbekistan 4
VE - Venezuela 4
AU - Australia 3
CZ - Repubblica Ceca 3
DK - Danimarca 3
KG - Kirghizistan 3
KR - Corea 3
LU - Lussemburgo 3
MU - Mauritius 3
PY - Paraguay 3
BY - Bielorussia 2
CG - Congo 2
DO - Repubblica Dominicana 2
EE - Estonia 2
IR - Iran 2
LV - Lettonia 2
PE - Perù 2
PH - Filippine 2
PK - Pakistan 2
AE - Emirati Arabi Uniti 1
AL - Albania 1
AM - Armenia 1
AZ - Azerbaigian 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
BG - Bulgaria 1
CH - Svizzera 1
CL - Cile 1
CY - Cipro 1
DZ - Algeria 1
EG - Egitto 1
EU - Europa 1
GI - Gibilterra 1
GR - Grecia 1
HU - Ungheria 1
JM - Giamaica 1
KZ - Kazakistan 1
LB - Libano 1
LC - Santa Lucia 1
LK - Sri Lanka 1
ML - Mali 1
MY - Malesia 1
MZ - Mozambico 1
NI - Nicaragua 1
NZ - Nuova Zelanda 1
PA - Panama 1
PR - Porto Rico 1
PT - Portogallo 1
RS - Serbia 1
TH - Thailandia 1
TN - Tunisia 1
UY - Uruguay 1
Totale 8.233
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Città #
Chandler 570
Dublin 542
Jacksonville 444
Nanjing 371
Beijing 294
Hong Kong 265
Ashburn 222
Dallas 216
Boardman 170
Nanchang 137
Singapore 129
Princeton 105
Lawrence 104
Hebei 98
Shenyang 97
Helsinki 93
Changsha 92
Los Angeles 90
Jiaxing 87
Munich 86
Medford 79
Wilmington 79
Ann Arbor 75
Pavia 57
New York 55
Milan 54
Tianjin 53
Buffalo 50
Shanghai 49
Moscow 48
Hangzhou 45
São Paulo 33
Piscataway 31
Verona 30
Woodbridge 27
Redondo Beach 23
Ho Chi Minh City 21
The Dalles 19
Norwalk 18
Turku 18
Brussels 17
Seattle 17
Toronto 16
Pune 15
Chicago 12
Tokyo 12
Falkenstein 11
Houston 11
San Francisco 11
Santa Clara 11
Stockholm 11
Columbus 10
Falls Church 9
Hanoi 9
Rio de Janeiro 9
Rome 9
Boston 8
Couilly-pont-aux-dames 8
Curitiba 8
Jinan 8
Brooklyn 7
Fairfield 7
Johannesburg 7
Zhengzhou 7
Auburn Hills 6
Brasília 6
Chennai 6
Denver 6
Guangzhou 6
Kunming 6
London 6
Orem 6
Shijiazhuang 6
Warsaw 6
Atlanta 5
Montreal 5
Ningbo 5
Taizhou 5
Amsterdam 4
Des Moines 4
Frankfurt am Main 4
Fuzhou 4
Jakarta 4
Mumbai 4
Newark 4
Padova 4
Phoenix 4
Pittsburgh 4
Poplar 4
Porto Alegre 4
Recife 4
Redwood City 4
Sorocaba 4
Tappahannock 4
Tashkent 4
Washington 4
Wuhan 4
Ankara 3
Bishkek 3
Buenos Aires 3
Totale 5.491
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Nome #
Studies on the Enantiomers of RC-33 as Neuroprotective Agents: Isolation, Configurational Assignment, and Preliminary Biological Profile 129
(R)-RC-33 as Promising Neuroprotective Agent Acting as Sigma1 Receptor Agonist 129
SOD1 activity and protective factors in familial ALS patients with L84F SOD1 mutation 128
A small-molecule RGD-integrin antagonist inhibits cell adhesion, cell migration and induces anoikis in glioblastoma cells. 121
Chemical, pharmacological, and in vitro metabolic stability studies on enantiomerically pure RC-33 compounds, promising neuroprotective agents acting as sigma1 receptor agonists. 118
Analysis of the early mitochondrial damage in G93A-SOD1 transgenic mice (SOD1-TG) 117
A step forward in the sigma enigma: a role for chirality in the sigma1 receptor- ligand interaction? 116
Clustering of ALS patients in central Italy due to the occurrence of the L84F SOD1 gene mutation 115
Identification of RC-33 as a potent and selective sigma1 receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells. Part 2: g-scale synthesis, physicochemical characterization and in vitro metabolic stability. 114
Amyotrophic lateral sclerosis: oxidative energy metabolism and calcium homeostasis in peripheral blood lymphocytes 112
Age-dependent modification of drug interference on the enzymatic activities of the rat brain 112
Discovery of new and selective sigma 1 ligands potentiating nerve growth factor induced neurite outgrowth in PC12 cells 111
Identification of a potent and selective sigma1 receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells. 105
Early effects of AZT on mitochondrial functions in the absence of mitochondrial DNA depletetion in rat myotubes 104
Age-related acute depletion of cerebral glutathione by peroxidative stress 103
Identification of dual Sigma1 receptor modulators/acetylcholinesterase inhibitors with antioxidant and neurotrophic properties, as neuroprotective agents 100
Age-related modification of enzyme activities in synaptosomes isolated from rat cerebral cortex 99
Brain enzyme adaptation to mild normobaric intermittent hypoxia 99
Modified expression of Bcl-2 and SOD1 proteins in lymphocytes from sporadic ALS patients 98
SOD1 activity and protective factors in familial ALS patients with L84F SOD1 mutation 97
Development of easy-to-use reverse-phase liquid chromatographic methods for determining PRE-084, RC-33 and RC-34 in biological matrices. The first step for in vivo analysis of sigma1 receptor agonists. 97
Effect of hypoxia on brain energy metabolism during aging 96
Effect of ischemia and pharmacological treatment on subcellular from neonatal rat brain 96
Apoptosis or necrosis in motoneurons: intracellular responses to excitotoxic insults 95
Experimental diets for the prevention of the development of familial amyotrophic lateral sclerosis 92
Basic and clinical research on amyotrophic lateral sclerosis and other motor neuron disorders in Italy: recent findings and achievements from a network of laboratories 92
Oxidative metabolism in cultured fibroblasts derived from sporadic Alzheimer's disease (AD) patients 92
Effect of vincamine on some enzymatic activities from various areas of the beagle dog cerebral cortex 92
Influence of intermittent hypoxia and pyrimidinic nucleosides on cerebral enzymatic activities related to energy transduction 90
Heterogeneous distribution of amyotrophic lateral sclerosis patient with SOD-1 gene mulations: preliminary data on an Italian survey 89
Mitochondrial oxidative metabolism in motor neuron degeneration (mnd) mouse central nervous system 88
Are sigma receptor modulators a weapon against multiple sclerosis disease? 88
Experimental diets for the prevention of the development of familial amyotrophic lateral sclerosis 87
Age-related modifications of cytochrome C oxidase activity in discrete brain regions 87
Effect of aging and acetyl-L-carnitine on energetic and cholinergic metabolism in rat brain regions 87
Cerebral enzymatic activities during chronic hyperammonemia and treatment with S-adenosyl-L-methionine, adenosine and methionine in the rat 85
Characterisation of adult neural stem cells from wobbler motor neuron disease mice 85
Alteration of pallidal cholinergic activity in MPTP-treated monkeys: effect of dihydro-alpha-ergocryptine (DEK) 85
Alteration of complex IV and acethylcholine-related enzymes in experimental spinal cord injury 85
Effect of prolonged and intermittent hypoxia on some cerebral enzymatic activities related to energy transduction 84
S-Adenosyl-L-methionine, related compounds, and cerebral enzymatic activities during chronic hyperammonemia in rats 84
Novel chiral sigma 1 receptor ligand potentiating NGF-induced neurite outgrowth in PC12 cells 84
Amyotrophic lateral sclerosis and SOD1 gene: an overview 84
Kinetics of irreversible inhibition of choline transport in synaptosomes by ethylcholine mustard aziridinium 83
Astrocytes derived from neural precursor cells of wobbler mice induce apoptotic death of motor neurons through reduced glutamate transport 83
Effect of Ca2+-homopantothenate and mild hypoxia on some enzyme activities evaluated in subcellular fractions from different rat brain regions 83
Synthesis and biological evaluation of new aryl-alkyl(alkenyl)-4-benzylpiperidines, novel Sigma Receptor (SR) modulators, as potential anticancer-agents 83
Effect of hypoxia and pharmacological treatment on some enzyme activities in dog brain areas 83
Dose/action and time/action relationships of some biological molecules evaluated on the cerebral enzymatic activities 82
Sequential damage in mitochondrial complexes by peroxidative stress 81
In vivo pharmacokinetic study and CNS distribution of the sigma1 receptor agonist (R)-RC-33, a promising neuroprotective agent 80
Mitochondrial dysfunction in a murine model of motor neuron disease 79
Effect of energy shortage and oxidative stress on amyloid precursor protein metabolism in COS cells 79
Modified expression of antioxidant enzymes in lymphocytes of sporadic amyotrophic lateral sclerosis patients 79
Synthesis and in vitro evaluation of novel pan-SR modulators: Identification of (E)-4-benzyl-1-[3-(naphthalen-2-yl)but-2-en-1-yl]piperidine (RC-106) as potential anticancer agent. 79
Drug interference on the age-dependent modification of the cerebral enzymatic activities related to energy transduction 78
Neural precursor-derived astrocytes of wobbler mice induce apoptotic death of motor neurons through reduced glutamate uptake 77
Enzymes related to energy metabolism in human gliomas 75
Metabolic changes induced by acute hypoxia on the synaptosomes from dog brain 74
Mitochondrial alterations in asymptomatic G93A-SOD1 transgenic mice (SOD1-TG) 74
Endothelin B receptor antagonists block proliferation and induce apoptosis in glioma cells 74
Bitopic Sigma 1 Receptor Modulators to Shed Light on Molecular Mechanisms Underpinning Ligand Binding and Receptor Oligomerization 74
Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084,in a mouse model of motor neuron disease not linked to SOD1 mutation 73
Les modifications enzymatiques du cerveau age chez le rat 73
Role of cerebral enzymatic activities in the relationships between energy metabolism and amino acid acting as neurotrasmitters 72
Evidence for chronic mitochondrial impairment in the cervical spinal cord of a murine model of motor neuron disease 72
Early alterations of mitochondrial function and morphology in the cervical spinal cord of the wobbler mouse 71
Heterogeneous distribution of amyotrophic lateral sclerosis patients with SOD-1 gene mutations: preliminary data on an Italian survey. 71
Synaptosomes and mitochondria from rat brain cerebral cortex: in vivo interference on some enzymatic activities by SAMe and CDP-choline 71
The mitochondrial electron transfer alteration as a factor involved in the brain aging 71
Towards the identification of neuroprotective agents. Pharmacokinetic evaluation and CNS distribution of (R)-RC-33, a promising sigma1 receptor agonist 69
Effect of chronic treatment with some drugs on the enzymatic activities of the rat brain 69
Energy metabolism inhibition impairs amyloid precursor protein secretion from Alzheimer's fibroblasts 68
Experimental diets for the prevention of the development of familial amyotrophic lateral sclerosis 68
Use of arylalkanolamines as sigma-1 receptor antagonists 68
Chemical, pharmacological and in vivo pharmacokinetic studies on enantiomerically pure RC-33 compounds, promising neuroprotective agents acting as sigma1 receptor agonists 68
Studies on the enantiomers of RC-33, promising neuroprotective agents acting as sigma1 receptor agonists. Isolation, configurational assignment and biological profile 66
Mitochondrial function in lymphocytes from sporadic ALS and familial ALS patients 64
Sigma receptors as endoplasmic reticulum stress "gatekeepers" and their modulators as emerging new weapons in the fight against cancer 63
Modification produced by ischemia on some cerebral enzyme activities related to energy transduction 62
Influence of age upon the cerebral metabolic changes induced by acute hypoxia on the synaptosomes from dog brain 61
Mitochondrial involvement in schizophrenia and other functional psychoses 61
Effect of a ubiquinone-like molecule on oxidative energy metabolism in rat cortical synaptosomes at different ages 61
Mitochondrial energy metabolism is preserved in the lumbar spinal cord of the wobbler mouse 60
Phenobarbital and 6-aminonicotinamide effect on cerebral enzymatic activities related to energy metabolism in different rat brain areas 60
Implication of the antioxidant pathway in lymphocytes of sporadic amyotrophic lateral sclerosis patients 58
Rapid flow cytometric assessment of cell membrane integrity by Hoechst 33342 and Propidium Iodide labeling 58
Neural precursors (NPCs) from adult L967Q mice display early commitment to "in vitro" neuronal differentiation and hyperexcitability 57
Sigma1 Receptor Agonists in motor dysfunction pathologies treatment – a medicinal chemistry perspective 57
Erythropoietin protects primary motor neuron cultures from apoptotic but not necrotic death in vitro 56
Proteomic profiling of cervical and lumbar spinal cord reveals potential protective mechanisms in the wobbler mouse, a model of motor neuron degeneration. 55
Effects of ionotropic glutamate receptor stimulation and mitochondrial inhibition in rat spinal cord motor neurons 54
Toward the identification of neuroprotective agents: G-scale synthesis, pharmacokinetic evaluation and CNS distribution of (R)-RC-33, a promising SIGMA1 receptor agonist 54
Do lymphocytes from sporadic ALS patients show disease traits ? 53
The effect of ischemia and pharmacological treatment evaluated on synaptosomes and purified mitochondria from rat cerebral cortex 52
Discovery of RC-752, a Novel Sigma-1 Receptor Antagonist with Antinociceptive Activity: A Promising Tool for Fighting Neuropathic Pain 51
Oxidative metabolism of non-synaptic mitochondria isolated from rat brain hippocampus: a comparative regional study 51
Superoxide, neuroleptics and ubiquinone and cytochrome b5 reductases in brain and lymphocytes from normals and schizophrenic patients 49
High resolution AP-MALDI MS imaging as an aid to develop new strategies to improve ALS therapy 45
Role of synaptosomal enzymatic alterations and drug treatment in brain aging 44
Totale 8.107
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Categoria #
all - tutte 35.474
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 35.474
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021452 0 0 0 0 5 96 5 94 33 104 90 25
2021/2022460 7 1 11 8 6 21 10 23 27 15 65 266
2022/20231.589 179 137 5 138 175 166 2 80 648 3 36 20
2023/2024534 85 83 10 33 49 133 13 44 4 19 50 11
2024/20251.437 23 118 45 48 55 70 40 98 354 43 168 375
2025/20261.371 273 262 410 344 82 0 0 0 0 0 0 0
Totale 8.302